{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:48:23Z","timestamp":1791287303126,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":4196,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1074\/jbc.m806944200","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T01:13:11Z","timestamp":1230772391000},"page":"7687-7696","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"title":["Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione"],"prefix":"10.1016","volume":"284","author":[{"given":"Dipak Kumar","family":"Raj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbing","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Kabat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subash","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margery","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Fay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"McCutchan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-zhuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M806944200_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.genom.6.080604.162122","volume":"6","author":"Dean","year":"2005","journal-title":"Annu. Re.v Genomics Hum. Genet."},{"key":"10.1074\/jbc.M806944200_bib2","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/molbev\/msh226","volume":"21","author":"Igarashi","year":"2004","journal-title":"Mol. Biol. Evol."},{"key":"10.1074\/jbc.M806944200_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.33549\/physiolres.930432","volume":"53","author":"Stefkova","year":"2004","journal-title":"Physiol. Res."},{"key":"10.1074\/jbc.M806944200_bib4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0076-6879(05)00024-8","volume":"400","author":"Dean","year":"2005","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M806944200_bib5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0076-6879(05)00026-1","volume":"400","author":"Ernst","year":"2005","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M806944200_bib6","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.febslet.2005.12.009","volume":"580","author":"Yazaki","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M806944200_bib7","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.febslet.2005.12.050","volume":"580","author":"Jungwirth","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M806944200_bib8","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0966-842X(94)90620-3","volume":"2","author":"Ouellette","year":"1994","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M806944200_bib9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1023\/A:1020598324663","volume":"19","author":"Chakraborti","year":"1999","journal-title":"Biosci. Rep."},{"key":"10.1074\/jbc.M806944200_bib10","first-page":"5761","volume":"60","author":"Allen","year":"2000","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M806944200_bib11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.canlet.2005.01.061","volume":"234","author":"Cervenak","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1074\/jbc.M806944200_bib12","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature01097","volume":"419","author":"Gardner","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M806944200_bib13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0092-8674(89)90330-9","volume":"57","author":"Foote","year":"1989","journal-title":"Cell"},{"key":"10.1074\/jbc.M806944200_bib14","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/35002615","volume":"403","author":"Reed","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M806944200_bib15","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1046\/j.1365-2958.2000.01914.x","volume":"36","author":"Duraisingh","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M806944200_bib16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1365-2958.2004.04035.x","volume":"52","author":"Ferdig","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M806944200_bib17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0140-6736(04)16767-6","volume":"364","author":"Price","year":"2004","journal-title":"Lancet"},{"key":"10.1074\/jbc.M806944200_bib18","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1365-2958.2005.04729.x","volume":"57","author":"Sidhu","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M806944200_bib19","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1126\/science.2658061","volume":"244","author":"Wilson","year":"1989","journal-title":"Science"},{"key":"10.1074\/jbc.M806944200_bib20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/expr.1994.1073","volume":"79","author":"Rubio","year":"1994","journal-title":"Exp. Parasitol."},{"key":"10.1074\/jbc.M806944200_bib21","doi-asserted-by":"crossref","first-page":"27039","DOI":"10.1074\/jbc.M601686200","volume":"281","author":"Rosenberg","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M806944200_bib22","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1073\/pnas.97.6.2674","volume":"97","author":"Dent","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M806944200_bib23","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S1097-2765(05)00077-8","volume":"6","author":"Fidock","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M806944200_bib24","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1046\/j.1365-2958.2003.03627.x","volume":"49","author":"Mu","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M806944200_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182099006022","volume":"121","author":"Duraisingh","year":"2000","journal-title":"Parasitology"},{"key":"10.1074\/jbc.M806944200_bib26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0005-2736(01)00454-0","volume":"1559","author":"Rebbeor","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M806944200_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2004.06.135","volume":"321","author":"Klokouzas","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M806944200_bib28","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1087025","volume":"301","author":"Le Roch","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M806944200_bib29","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.1371\/journal.pbio.0000005","volume":"1","author":"Bozdech","year":"2003","journal-title":"PLoS Biol."},{"key":"10.1074\/jbc.M806944200_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molbiopara.2005.05.007","volume":"143","author":"Young","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M806944200_bib31","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1128\/AAC.49.6.2180-2188.2005","volume":"49","author":"Anderson","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M806944200_bib32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1475-2875-5-24","volume":"5","author":"Cojean","year":"2006","journal-title":"Malaria J."},{"key":"10.1074\/jbc.M806944200_bib33","doi-asserted-by":"crossref","first-page":"16813","DOI":"10.1073\/pnas.0501858102","volume":"102","author":"Furuya","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M806944200_bib34","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1074\/jbc.M806944200_bib35","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.vaccine.2005.07.085","volume":"24","author":"Oliveira","year":"2006","journal-title":"Vaccine"},{"key":"10.1074\/jbc.M806944200_bib36","doi-asserted-by":"crossref","first-page":"20043","DOI":"10.1073\/pnas.0709999104","volume":"104","author":"Singh","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M806944200_bib37","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1073\/pnas.94.20.10931","volume":"94","author":"Fidock","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M806944200_bib38","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","volume":"65","author":"Lambros","year":"1979","journal-title":"J. Parasitol."},{"key":"10.1074\/jbc.M806944200_bib39","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1128\/IAI.66.6.2969-2975.1998","volume":"66","author":"Fernandez","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M806944200_bib40","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1073\/pnas.93.3.1130","volume":"93","author":"Wu","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M806944200_bib41","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1128\/AAC.48.5.1803-1806.2004","volume":"48","author":"Smilkstein","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M806944200_bib42","series-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2008"},{"key":"10.1074\/jbc.M806944200_bib43","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.286.5443.1351","volume":"286","author":"Su","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M806944200_bib44","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1006\/expr.1998.4299","volume":"89","author":"Su","year":"1998","journal-title":"Exp. Parasitol."},{"key":"10.1074\/jbc.M806944200_bib45","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrg2126","volume":"8","author":"Su","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1074\/jbc.M806944200_bib46","doi-asserted-by":"crossref","first-page":"763","DOI":"10.18388\/abp.2000_3994","volume":"47","author":"Rychlik","year":"2000","journal-title":"Acta Biochim. Pol."},{"key":"10.1074\/jbc.M806944200_bib47","doi-asserted-by":"crossref","first-page":"911","DOI":"10.2174\/138945006778019264","volume":"7","author":"Liang","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1074\/jbc.M806944200_bib48","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0169-4758(99)01608-7","volume":"16","author":"Dyer","year":"2000","journal-title":"Parasitol. Today"},{"key":"10.1074\/jbc.M806944200_bib49","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0006-2952(98)00184-1","volume":"56","author":"Ginsburg","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M806944200_bib50","series-title":"Malaria: Parasite Biology, Pathogenesis, and Protection","author":"Sinden","year":"1998"},{"key":"10.1074\/jbc.M806944200_bib51","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nature00813","volume":"418","author":"Wootton","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M806944200_bib52","doi-asserted-by":"crossref","first-page":"e335","DOI":"10.1371\/journal.pbio.0030335","volume":"3","author":"Mu","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1074\/jbc.M806944200_bib53","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1124\/mol.61.1.35","volume":"61","author":"Cooper","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M806944200_bib54","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3201\/eid1405.071601","volume":"14","author":"Wongsrichanalai","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"10.1074\/jbc.M806944200_bib55","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1179\/135100003225002907","volume":"8","author":"Ginsburg","year":"2003","journal-title":"Redox. Rep."},{"key":"10.1074\/jbc.M806944200_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parint.2007.08.001","volume":"57","author":"Kawazu","year":"2008","journal-title":"Parasitol. Int."},{"key":"10.1074\/jbc.M806944200_bib57","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/jnci\/92.16.1295","volume":"92","author":"Borst","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1074\/jbc.M806944200_bib58","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1021\/bi047810y","volume":"44","author":"Peklak-Scott","year":"2005","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1074\/jbc.M806944200_bib59","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1365-2958.2008.06413.x","volume":"70","author":"Sanchez","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M806944200_bib60","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1083\/jcb.113.5.1033","volume":"113","author":"Cowman","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M806944200_bib61","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/345255a0","volume":"345","author":"Foote","year":"1990","journal-title":"Nature"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820324819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820324819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M806944200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T22:53:19Z","timestamp":1725663199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820324819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0021925820324819"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m806944200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M806944200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}