{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:48Z","timestamp":1790776608420,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"49","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T00:00:00Z","timestamp":1600473600000},"content-version":"vor","delay-in-days":4310,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1074\/jbc.m806992200","type":"journal-article","created":{"date-parts":[[2008,10,4]],"date-time":"2008-10-04T00:13:29Z","timestamp":1223079209000},"page":"34445-34456","source":"Crossref","is-referenced-by-count":33,"title":["A Disease-causing Point Mutation in Human Mitochondrial tRNAMet Results in tRNA Misfolding Leading to Defects in Translational Initiation and Elongation"],"prefix":"10.1016","volume":"283","author":[{"given":"Christie N.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher I.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Agris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda L.","family":"Spremulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M806992200_bib1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0074-7696(08)61373-X","volume":"93","author":"Attardi","year":"1985","journal-title":"Int. Rev. Cytol."},{"key":"10.1074\/jbc.M806992200_bib2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0022-2836(82)90137-1","volume":"156","author":"Anderson","year":"1982","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M806992200_bib3","series-title":"tRNA: Structure, Biosynthesis and Function","first-page":"93","author":"Dirheimer","year":"1995"},{"key":"10.1074\/jbc.M806992200_bib4","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.1093\/nar\/22.24.5378","volume":"22","author":"Watanabe","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M806992200_bib5","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1093\/nar\/19.22.6101","volume":"19","author":"Yokogawa","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M806992200_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/nar\/22.3.347","volume":"22","author":"Wakita","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M806992200_bib7","doi-asserted-by":"crossref","first-page":"13338","DOI":"10.1021\/bi991061g","volume":"38","author":"Helm","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M806992200_bib8","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1017\/S1355838200001047","volume":"6","author":"Helm","year":"2000","journal-title":"RNA (N. Y.)"},{"key":"10.1074\/jbc.M806992200_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.tibs.2003.09.006","volume":"28","author":"Wittenhagen","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M806992200_bib10","first-page":"480","volume":"12","author":"King","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M806992200_bib11","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/brain\/124.5.984","volume":"124","author":"Sternberg","year":"2001","journal-title":"Brain"},{"key":"10.1074\/jbc.M806992200_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng0595-47","volume":"10","author":"Enriquez","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M806992200_bib13","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1093\/nar\/29.21.4334","volume":"29","author":"Levinger","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M806992200_bib14","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1128\/MCB.17.12.6831","volume":"17","author":"Hao","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M806992200_bib15","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/79612","volume":"7","author":"Kelley","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M806992200_bib16","doi-asserted-by":"crossref","first-page":"15299","DOI":"10.1073\/pnas.0704441104","volume":"104","author":"Ling","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M806992200_bib17","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1021\/bi00390a028","volume":"26","author":"Cenatiempo","year":"1987","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M806992200_bib18","doi-asserted-by":"crossref","first-page":"15070","DOI":"10.1073\/pnas.0405173101","volume":"101","author":"Kirino","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M806992200_bib19","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.1093\/nar\/gkh886","volume":"32","author":"Spencer","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M806992200_bib20","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1212\/WNL.50.6.1875","volume":"50","author":"Vissing","year":"1998","journal-title":"Neurology"},{"key":"10.1074\/jbc.M806992200_bib21","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1167\/iovs.05-0665","volume":"47","author":"Qu","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M806992200_bib22","doi-asserted-by":"crossref","first-page":"S175","DOI":"10.1002\/humu.1380110158","volume":"1","author":"Lombes","year":"1998","journal-title":"Hum. Mutat."},{"key":"10.1074\/jbc.M806992200_bib23","doi-asserted-by":"crossref","first-page":"9743","DOI":"10.1021\/bi049639w","volume":"43","author":"Spencer","year":"2004","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M806992200_bib24","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/nprot.2006.249","volume":"1","author":"Wilkinson","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1074\/jbc.M806992200_bib25","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jmb.2006.07.036","volume":"362","author":"Jones","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M806992200_bib26","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0167-4781(99)00077-9","volume":"1446","author":"Bullard","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M806992200_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4161\/rna.1.2.1034","volume":"2","author":"Hunter","year":"2004","journal-title":"RNA Biol."},{"key":"10.1074\/jbc.M806992200_bib28","doi-asserted-by":"crossref","first-page":"20308","DOI":"10.1074\/jbc.M001899200","volume":"275","author":"Cai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M806992200_bib29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0076-6879(96)64025-7","volume":"264","author":"Schwartzbach","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M806992200_bib30","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1261\/rna.7214405","volume":"11","author":"Das","year":"2005","journal-title":"RNA (N. Y.)"},{"key":"10.1074\/jbc.M806992200_bib31","doi-asserted-by":"crossref","first-page":"12664","DOI":"10.1021\/bi060521k","volume":"45","author":"Badorrek","year":"2006","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M806992200_bib32","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1021\/ja0436749","volume":"127","author":"Wilkinson","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M806992200_bib33","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1021\/ja043822v","volume":"127","author":"Merino","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M806992200_bib34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1385\/CBB:33:3:241","volume":"33","author":"Ashraf","year":"2000","journal-title":"Cell Biochem. Biophys."},{"key":"10.1074\/jbc.M806992200_bib35","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1093\/nar\/27.17.3543","volume":"27","author":"Yarian","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M806992200_bib36","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1126\/science.3055296","volume":"242","author":"Schulman","year":"1988","journal-title":"Science"},{"key":"10.1074\/jbc.M806992200_bib37","doi-asserted-by":"crossref","first-page":"15085","DOI":"10.1074\/jbc.273.24.15085","volume":"273","author":"Takeuchi","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M806992200_bib38","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1016\/S0021-9258(17)42947-4","volume":"259","author":"Louie","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M806992200_bib39","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1126\/science.1064242","volume":"294","author":"LaRiviere","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M806992200_bib40","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1093\/nar\/8.20.4737","volume":"8","author":"Sprinzl","year":"1980","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M806992200_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mito.2004.04.003","volume":"4","author":"Hunter","year":"2004","journal-title":"Mitochondrion (Kidlington)"},{"key":"10.1074\/jbc.M806992200_bib42","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.1021\/ja0704028","volume":"129","author":"Mortimer","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M806992200_bib43","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1007\/s00018-003-2343-1","volume":"60","author":"Florentz","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M806992200_bib44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/bj20030222","volume":"374","author":"Bacman","year":"2003","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M806992200_bib45","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/emboj.2008.99","volume":"27","author":"Pavlov","year":"2008","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M806992200_bib46","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nsb0195-56","volume":"2","author":"Baeyens","year":"1995","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M806992200_bib47","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0092-8674(03)00762-1","volume":"115","author":"Sharma","year":"2003","journal-title":"Cell"},{"key":"10.1074\/jbc.M806992200_bib48","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4161\/rna.4.1.4548","volume":"4","author":"Zifa","year":"2007","journal-title":"RNA Biol."},{"key":"10.1074\/jbc.M806992200_bib49","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/nar\/gkg131","volume":"31","author":"Wittenhagen","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M806992200_bib50","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1261\/rna.938108","volume":"14","author":"Bonnefond","year":"2008","journal-title":"RNA"},{"key":"10.1074\/jbc.M806992200_bib51","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1021\/bi00646a025","volume":"15","author":"Stein","year":"1976","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M806992200_bib52","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1006\/jmbi.2000.3950","volume":"301","author":"Jovine","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M806992200_bib53","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/nar\/26.1.148","volume":"26","author":"Sprinzl","year":"1998","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820653017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820653017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M806992200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T17:41:02Z","timestamp":1625593262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820653017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":53,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0021925820653017"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m806992200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}