{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:37:46Z","timestamp":1769582266658,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":4286,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1074\/jbc.m807850200","type":"journal-article","created":{"date-parts":[[2008,11,5]],"date-time":"2008-11-05T02:14:26Z","timestamp":1225851266000},"page":"284-291","source":"Crossref","is-referenced-by-count":67,"title":["Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State"],"prefix":"10.1016","volume":"284","author":[{"given":"Neal K.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle S.","family":"Lucet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Peter","family":"Klinken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan","family":"Ingley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Rossjohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M807850200_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1097-2765(00)80356-1","volume":"3","author":"Xu","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M807850200_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbapap.2007.08.012","volume":"1784","author":"Ingley","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M807850200_bib3","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1101\/gad.14.9.1027","volume":"14","author":"Pawson","year":"2000","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M807850200_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V93.1.1","volume":"93","author":"Corey","year":"1999","journal-title":"Blood"},{"key":"10.1074\/jbc.M807850200_bib5","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1038\/sj.onc.1205398","volume":"21","author":"Rane","year":"2002","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M807850200_bib6","doi-asserted-by":"crossref","first-page":"7906","DOI":"10.1038\/sj.onc.1208160","volume":"23","author":"Parsons","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M807850200_bib7","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1093\/emboj\/16.7.1610","volume":"16","author":"Tilbrook","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M807850200_bib8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1172\/JCI119150","volume":"99","author":"De Franceschi","year":"1997","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M807850200_bib9","first-page":"93","volume":"5","author":"Robinson","year":"1998","journal-title":"J. Biochem. Sci."},{"key":"10.1074\/jbc.M807850200_bib10","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1158\/0008-5472.CAN-03-2420","volume":"64","author":"Goldenberg-Furmanov","year":"2004","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M807850200_bib11","first-page":"5275","volume":"61","author":"Bates","year":"2001","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M807850200_bib12","first-page":"2453","volume":"61","author":"Tilbrook","year":"2001","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M807850200_bib13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/sj.onc.1208199","volume":"24","author":"Ingley","year":"2005","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M807850200_bib14","doi-asserted-by":"crossref","first-page":"27450","DOI":"10.1074\/jbc.272.43.27450","volume":"272","author":"Linnekin","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M807850200_bib15","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1182\/blood-2003-10-3566","volume":"103","author":"Lannutti","year":"2004","journal-title":"Blood"},{"key":"10.1074\/jbc.M807850200_bib16","doi-asserted-by":"crossref","first-page":"7887","DOI":"10.1074\/jbc.275.11.7887","volume":"275","author":"Ingley","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M807850200_bib17","doi-asserted-by":"crossref","first-page":"31920","DOI":"10.1016\/S0021-9258(19)84106-6","volume":"281","author":"Ingley","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M807850200_bib18","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1182\/blood.V91.10.3734","volume":"91","author":"Chin","year":"1998","journal-title":"Blood"},{"key":"10.1074\/jbc.M807850200_bib19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(95)90171-X","volume":"83","author":"Hibbs","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M807850200_bib20","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1182\/blood-2003-12-4396","volume":"104","author":"Harder","year":"2004","journal-title":"Blood"},{"key":"10.1074\/jbc.M807850200_bib21","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/sj.leu.2401429","volume":"13","author":"Roginskaya","year":"1999","journal-title":"Leukaemia"},{"key":"10.1074\/jbc.M807850200_bib22","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1182\/blood.V101.2.690","volume":"101","author":"Donato","year":"2003","journal-title":"Blood"},{"key":"10.1074\/jbc.M807850200_bib23","first-page":"375","volume":"63","author":"Golas","year":"2003","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M807850200_bib24","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1182\/blood-2002-01-0288","volume":"101","author":"Warmuth","year":"2003","journal-title":"Blood"},{"key":"10.1074\/jbc.M807850200_bib25","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1038\/sj.onc.1206008","volume":"21","author":"Wilson","year":"2002","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M807850200_bib26","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1182\/blood-2007-04-082099","volume":"111","author":"Dos Santos","year":"2008","journal-title":"Blood"},{"key":"10.1074\/jbc.M807850200_bib27","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1182\/blood-2007-08-109330","volume":"111","author":"Wu","year":"2008","journal-title":"Blood"},{"key":"10.1074\/jbc.M807850200_bib28","doi-asserted-by":"crossref","first-page":"30907","DOI":"10.1074\/jbc.M605902200","volume":"281","author":"Meyn","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M807850200_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0092-8674(05)80094-7","volume":"75","author":"Pendergast","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M807850200_bib30","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nm1127","volume":"10","author":"Ptasznik","year":"2004","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M807850200_bib31","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1172\/JCI10536","volume":"106","author":"Sumitomo","year":"2000","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M807850200_bib32","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","volume":"344","author":"Druker","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M807850200_bib33","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1056\/NEJMoa055229","volume":"354","author":"Talpaz","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M807850200_bib34","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/385595a0","volume":"385","author":"Xu","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M807850200_bib35","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/385602a0","volume":"385","author":"Sicheri","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M807850200_bib36","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1097-2765(00)80357-3","volume":"3","author":"Schindler","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M807850200_bib37","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/384484a0","volume":"384","author":"Yamaguchi","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M807850200_bib38","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0969-2126(99)80086-0","volume":"7","author":"Zhu","year":"1999","journal-title":"Structure"},{"key":"10.1074\/jbc.M807850200_bib39","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/pmic.200700948","volume":"8","author":"Bringans","year":"2008","journal-title":"Proteomics"},{"key":"10.1074\/jbc.M807850200_bib40","doi-asserted-by":"crossref","first-page":"43428","DOI":"10.1074\/jbc.M106645200","volume":"276","author":"Ingley","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M807850200_bib41","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1158\/0008-5472.CAN-05-4187","volume":"66","author":"Tokarski","year":"2006","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M807850200_bib42","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1021\/jm049486a","volume":"47","author":"Lombardo","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M807850200_bib43","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.1099480","volume":"305","author":"Shah","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M807850200_bib44","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1126\/science.289.5486.1938","volume":"289","author":"Schindler","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M807850200_bib45","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ccr.2005.01.007","volume":"7","author":"Weisberg","year":"2005","journal-title":"Cancer Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820683168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820683168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M807850200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:42:29Z","timestamp":1684618949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820683168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0021925820683168"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m807850200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}