{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:36:12Z","timestamp":1783398972691,"version":"3.54.6"},"reference-count":55,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":4225,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1074\/jbc.m809056200","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T01:14:37Z","timestamp":1235092477000},"page":"10514-10522","source":"Crossref","is-referenced-by-count":27,"title":["VHL Mutations Linked to Type 2C von Hippel-Lindau Disease Cause Extensive Structural Perturbations in pVHL"],"prefix":"10.1016","volume":"284","author":[{"given":"Katja","family":"Knauth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Cartwright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Freund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bycroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Buchberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M809056200_bib1","first-page":"2059","article-title":"Lancet","volume":"361","author":"Lonser","year":"2003"},{"key":"10.1074\/jbc.M809056200_bib2","first-page":"145","article-title":"Annu. Rev. Pathol.","volume":"2","author":"Kaelin","year":"2007"},{"key":"10.1074\/jbc.M809056200_bib3","first-page":"9","article-title":"Nat. Rev. Mol. Cell Biol.","volume":"6","author":"Petroski","year":"2005"},{"key":"10.1074\/jbc.M809056200_bib4","first-page":"271","article-title":"Nature","volume":"399","author":"Maxwell","year":"1999"},{"key":"10.1074\/jbc.M809056200_bib5","first-page":"25733","article-title":"J. Biol. Chem.","volume":"275","author":"Cockman","year":"2000"},{"key":"10.1074\/jbc.M809056200_bib6","first-page":"423","article-title":"Nat. Cell Biol.","volume":"2","author":"Ohh","year":"2000"},{"key":"10.1074\/jbc.M809056200_bib7","first-page":"10430","article-title":"Proc. Natl. Acad. Sci. U. S. A.","volume":"97","author":"Kamura","year":"2000"},{"key":"10.1074\/jbc.M809056200_bib8","first-page":"468","article-title":"Science","volume":"292","author":"Jaakkola","year":"2001"},{"key":"10.1074\/jbc.M809056200_bib9","first-page":"43","article-title":"Cell","volume":"107","author":"Epstein","year":"2001"},{"key":"10.1074\/jbc.M809056200_bib10","first-page":"464","article-title":"Science","volume":"292","author":"Ivan","year":"2001"},{"key":"10.1074\/jbc.M809056200_bib11","first-page":"1337","article-title":"Science","volume":"294","author":"Bruick","year":"2001"},{"key":"10.1074\/jbc.M809056200_bib12","first-page":"5197","article-title":"EMBO J.","volume":"20","author":"Masson","year":"2001"},{"key":"10.1074\/jbc.M809056200_bib13","first-page":"393","article-title":"Mol. Cell","volume":"30","author":"Kaelin Jr.","year":"2008"},{"key":"10.1074\/jbc.M809056200_bib14","first-page":"455","article-title":"Science","volume":"284","author":"Stebbins","year":"1999"},{"key":"10.1074\/jbc.M809056200_bib15","first-page":"370","article-title":"Oncogene","volume":"25","author":"Knauth","year":"2006"},{"key":"10.1074\/jbc.M809056200_bib16","first-page":"5381","article-title":"Mol. Cell. Biol.","volume":"27","author":"Li","year":"2007"},{"key":"10.1074\/jbc.M809056200_bib17","first-page":"588","article-title":"Nat. Cell Biol.","volume":"9","author":"Thoma","year":"2007"},{"key":"10.1074\/jbc.M809056200_bib18","first-page":"237","article-title":"Cancer Cell","volume":"1","author":"Kondo","year":"2002"},{"key":"10.1074\/jbc.M809056200_bib19","first-page":"439","article-title":"PLoS Biol.","volume":"1","author":"Kondo","year":"2003"},{"key":"10.1074\/jbc.M809056200_bib20","first-page":"685","article-title":"Curr. Opin. Cell Biol.","volume":"19","author":"Frew","year":"2007"},{"key":"10.1074\/jbc.M809056200_bib21","first-page":"83","article-title":"Curr. Opin. Oncol","volume":"20","author":"Roberts","year":"2008"},{"key":"10.1074\/jbc.M809056200_bib22","first-page":"1809","article-title":"Cell Cycle","volume":"6","author":"Thoma","year":"2007"},{"key":"10.1074\/jbc.M809056200_bib23","first-page":"64","article-title":"Nat. Cell Biol.","volume":"5","author":"Hergovich","year":"2003"},{"key":"10.1074\/jbc.M809056200_bib24","first-page":"959","article-title":"Mol. Cell","volume":"1","author":"Ohh","year":"1998"},{"key":"10.1074\/jbc.M809056200_bib25","first-page":"1019","article-title":"Hum. Mol. Genet.","volume":"10","author":"Hoffman","year":"2001"},{"key":"10.1074\/jbc.M809056200_bib26","first-page":"1029","article-title":"Hum. Mol. Genet.","volume":"10","author":"Clifford","year":"2001"},{"key":"10.1074\/jbc.M809056200_bib27","first-page":"155","article-title":"Cancer Cell","volume":"8","author":"Lee","year":"2005"},{"key":"10.1074\/jbc.M809056200_bib28","first-page":"91","article-title":"Cancer Cell","volume":"8","author":"Maxwell","year":"2005"},{"key":"10.1074\/jbc.M809056200_bib29","first-page":"3386","article-title":"Mol. Cell. Biol.","volume":"28","author":"Bishop","year":"2008"},{"key":"10.1074\/jbc.M809056200_bib30","first-page":"911","article-title":"J. Cell Biol.","volume":"168","author":"Xie","year":"2005"},{"key":"10.1074\/jbc.M809056200_bib31","first-page":"1149","article-title":"JAMA","volume":"274","author":"Neumann","year":"1995"},{"key":"10.1074\/jbc.M809056200_bib32","first-page":"1035","article-title":"J. Clin. Endocrinol. Metab.","volume":"81","author":"Ritter","year":"1996"},{"key":"10.1074\/jbc.M809056200_bib33","first-page":"885","article-title":"J. Med. Genet.","volume":"32","author":"Crossey","year":"1995"},{"key":"10.1074\/jbc.M809056200_bib34","first-page":"685","article-title":"Am. J. Med. Genet. A","volume":"140","author":"Abbott","year":"2006"},{"key":"10.1074\/jbc.M809056200_bib35","first-page":"5241","article-title":"J. Clin. Endocrinol. Metab.","volume":"87","author":"Weirich","year":"2002"},{"key":"10.1074\/jbc.M809056200_bib36","first-page":"939","article-title":"J. Med. Genet.","volume":"37","author":"Hes","year":"2000"},{"key":"10.1074\/jbc.M809056200_bib37","first-page":"854","article-title":"J. Natl. Cancer Inst.","volume":"91","author":"Brauch","year":"1999"},{"key":"10.1074\/jbc.M809056200_bib38","first-page":"301","article-title":"Toxicol. Lett.","volume":"151","author":"Brauch","year":"2004"},{"key":"10.1074\/jbc.M809056200_bib39","first-page":"224","article-title":"Protein Expr. Purif.","volume":"21","author":"Tan","year":"2001"},{"key":"10.1074\/jbc.M809056200_bib40","first-page":"3587","article-title":"Nucleic Acids Res.","volume":"18","author":"Morgenstern","year":"1990"},{"key":"10.1074\/jbc.M809056200_bib41","first-page":"1769","article-title":"Genes Dev.","volume":"12","author":"Wang","year":"1998"},{"key":"10.1074\/jbc.M809056200_bib42","first-page":"e142","article-title":"Nucleic Acids Res.","volume":"35","author":"Bex","year":"2007"},{"key":"10.1074\/jbc.M809056200_bib43","first-page":"975","article-title":"Nature","volume":"417","author":"Hon","year":"2002"},{"key":"10.1074\/jbc.M809056200_bib44","first-page":"1886","article-title":"Science","volume":"296","author":"Min","year":"2002"},{"key":"10.1074\/jbc.M809056200_bib45","first-page":"1213","article-title":"Mol. Cell","volume":"12","author":"Feldman","year":"2003"},{"key":"10.1074\/jbc.M809056200_bib46","first-page":"1947","article-title":"Mol. Cell. Biol.","volume":"22","author":"Hansen","year":"2002"},{"key":"10.1074\/jbc.M809056200_bib47","first-page":"1051","article-title":"Mol. Cell","volume":"4","author":"Feldman","year":"1999"},{"key":"10.1074\/jbc.M809056200_bib48","first-page":"8507","article-title":"Proc. Natl. Acad. Sci. U. S. A.","volume":"97","author":"Schoenfeld","year":"2000"},{"key":"10.1074\/jbc.M809056200_bib49","first-page":"30388","article-title":"J. Biol. Chem.","volume":"277","author":"Kamura","year":"2002"},{"key":"10.1074\/jbc.M809056200_bib50","first-page":"3055","article-title":"Genes Dev.","volume":"18","author":"Kamura","year":"2004"},{"key":"10.1074\/jbc.M809056200_bib51","first-page":"1801","article-title":"J. Am. Soc. Nephrol.","volume":"17","author":"Esteban","year":"2006"},{"key":"10.1074\/jbc.M809056200_bib52","first-page":"3567","article-title":"Cancer Res.","volume":"66","author":"Esteban","year":"2006"},{"key":"10.1074\/jbc.M809056200_bib53","first-page":"1313","article-title":"Cancer Res.","volume":"66","author":"Kurban","year":"2006"},{"key":"10.1074\/jbc.M809056200_bib54","first-page":"13264","article-title":"J. Biol. Chem.","volume":"282","author":"Grosfeld","year":"2007"},{"key":"10.1074\/jbc.M809056200_bib55","first-page":"1004","article-title":"Oncogene","volume":"27","author":"Kurban","year":"2008"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820398938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820398938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M809056200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T10:13:22Z","timestamp":1641291202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820398938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":55,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0021925820398938"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m809056200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}