{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:20:50Z","timestamp":1790860850503,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"25","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":7432,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1074\/jbc.m908734199","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:11:04Z","timestamp":1027696264000},"page":"19198-19209","source":"Crossref","is-referenced-by-count":162,"title":["The Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episode Syndrome-associated Human Mitochondrial tRNALeu(UUR) Mutation Causes Aminoacylation Deficiency and Concomitant Reduced Association of mRNA with Ribosomes"],"prefix":"10.1016","volume":"275","author":[{"given":"Anne","family":"Chomyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Enriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Micol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Fernandez-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Attardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M908734199_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1022685929755","volume":"29","author":"Schon","year":"1997","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1074\/jbc.M908734199_bib2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0092-8674(90)90059-N","volume":"61","author":"Shoffner","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.M908734199_bib3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/humu.1380030311","volume":"3","author":"Reid","year":"1994","journal-title":"Hum. Mutat."},{"key":"10.1074\/jbc.M908734199_bib4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0196-0709(95)90078-0","volume":"16","author":"Fischel-Ghodsian","year":"1995","journal-title":"Am. J. Otolaryngol."},{"key":"10.1074\/jbc.M908734199_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng0595-47","volume":"10","author":"Enriquez","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M908734199_bib6","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1128\/MCB.18.10.5868","volume":"18","author":"Guan","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M908734199_bib7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/348651a0","volume":"348","author":"Goto","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.M908734199_bib8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/ng0892-368","volume":"1","author":"van den Ouweland","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M908734199_bib9","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0140-6736(91)90272-Q","volume":"337","author":"Johns","year":"1991","journal-title":"Lancet"},{"key":"10.1074\/jbc.M908734199_bib10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0092-8674(89)90853-2","volume":"58","author":"Kruse","year":"1989","journal-title":"Cell"},{"key":"10.1074\/jbc.M908734199_bib11","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.89.10.4221","volume":"89","author":"Chomyn","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M908734199_bib12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/351236a0","volume":"351","author":"Hess","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M908734199_bib13","first-page":"480","volume":"12","author":"King","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M908734199_bib14","first-page":"206","volume":"1101","author":"Schon","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M908734199_bib15","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/nar\/27.3.756","volume":"27","author":"Helm","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M908734199_bib16","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1074\/jbc.275.6.4251","volume":"275","author":"Yasukawa","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M908734199_bib17","doi-asserted-by":"crossref","first-page":"27189","DOI":"10.1074\/jbc.272.43.27189","volume":"272","author":"Flierl","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M908734199_bib18","doi-asserted-by":"crossref","first-page":"29744","DOI":"10.1074\/jbc.274.42.29744","volume":"274","author":"Janssen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M908734199_bib19","first-page":"2236","volume":"11","author":"Chomyn","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M908734199_bib20","doi-asserted-by":"crossref","first-page":"11164","DOI":"10.1073\/pnas.89.23.11164","volume":"89","author":"Yoneda","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M908734199_bib21","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.2814477","volume":"246","author":"King","year":"1989","journal-title":"Science"},{"key":"10.1074\/jbc.M908734199_bib22","doi-asserted-by":"crossref","first-page":"18896","DOI":"10.1074\/jbc.272.30.18896","volume":"272","author":"Micol","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M908734199_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(96)64003-8","volume":"264","author":"Micol","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M908734199_bib24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0076-6879(80)65059-9","volume":"65","author":"Maxam","year":"1980","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M908734199_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0076-6879(96)64019-1","volume":"264","author":"Enriquez","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M908734199_bib26","doi-asserted-by":"crossref","first-page":"24712","DOI":"10.1016\/S0021-9258(18)54288-5","volume":"266","author":"Varshney","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M908734199_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0076-6879(96)64020-8","volume":"264","author":"Chomyn","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M908734199_bib28","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0022-2836(72)90282-3","volume":"65","author":"Ojala","year":"1972","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M908734199_bib29","doi-asserted-by":"crossref","first-page":"10228","DOI":"10.1016\/S0021-9258(18)82194-9","volume":"268","author":"King","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M908734199_bib30","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0003-2697(84)90381-6","volume":"137","author":"Feinberg","year":"1984","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M908734199_bib31","first-page":"427","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"10.1074\/jbc.M908734199_bib32","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ng0498-350","volume":"18","author":"El Meziane","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M908734199_bib33","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/nar\/21.3.657","volume":"21","author":"Koga","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M908734199_bib34","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1016\/S0021-9258(18)62239-2","volume":"246","author":"O'Brien","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M908734199_bib35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0079-6107(78)90021-4","volume":"32","author":"Goddard","year":"1977","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1074\/jbc.M908734199_bib36","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1146\/annurev.bi.58.070189.005121","volume":"58","author":"Normanly","year":"1989","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M908734199_bib37","doi-asserted-by":"crossref","first-page":"8763","DOI":"10.1073\/pnas.90.19.8763","volume":"90","author":"Schimmel","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M908734199_bib38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1126\/science.7506844","volume":"263","author":"Saks","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.M908734199_bib39","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.1073\/pnas.90.14.6776","volume":"90","author":"Hou","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M908734199_bib40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/nar\/21.1.41","volume":"21","author":"Puglisi","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M908734199_bib41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0300-9084(96)80006-X","volume":"78","author":"Senger","year":"1996","journal-title":"Biochimie (Paris)"},{"key":"10.1074\/jbc.M908734199_bib42","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/344787a0","volume":"344","author":"Perret","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.M908734199_bib43","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0022-2836(82)90252-2","volume":"158","author":"Goldman","year":"1982","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M908734199_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0005-2787(72)90480-7","volume":"259","author":"Van Venrooij","year":"1972","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M908734199_bib45","doi-asserted-by":"crossref","first-page":"14538","DOI":"10.1016\/S0021-9258(18)47829-5","volume":"262","author":"Scorsone","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M908734199_bib46","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1016\/S0021-9258(19)43365-6","volume":"248","author":"Vaughan","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M908734199_bib47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1432-1033.1986.tb09635.x","volume":"157","author":"Austin","year":"1986","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M908734199_bib48","series-title":"The RNA World","first-page":"157","author":"S\u00f6ll","year":"1993"},{"key":"10.1074\/jbc.M908734199_bib49","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1365-2958.1994.tb01309.x","volume":"14","author":"Py","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M908734199_bib50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0092-8674(00)80975-7","volume":"84","author":"Margossian","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M908734199_bib51","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/j.1460-2075.1996.tb00451.x","volume":"15","author":"Hayes","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M908734199_bib52","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/hmg\/5.1.123","volume":"5","author":"Dunbar","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M908734199_bib53","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1128\/MCB.15.2.964","volume":"15","author":"Hofhaus","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M908734199_bib54","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1128\/MCB.20.3.805-815.2000","volume":"20","author":"Bai","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M908734199_bib55","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-291X(86)91061-2","volume":"140","author":"Tanaka","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M908734199_bib56","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0022-3476(87)80158-0","volume":"110","author":"Kobayashi","year":"1987","journal-title":"J. Pediatr."},{"key":"10.1074\/jbc.M908734199_bib57","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ana.410230312","volume":"23","author":"Ichiki","year":"1988","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M908734199_bib58","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1093\/emboj\/17.16.4848","volume":"17","author":"Bai","year":"1998","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M908734199_bib59","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1074\/jbc.270.4.1859","volume":"270","author":"Ma","year":"1995","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819801862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819801862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M908734199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T23:19:05Z","timestamp":1641251945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819801862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":59,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0021925819801862"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m908734199","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}