{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:39:09Z","timestamp":1778704749807,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":997,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1074\/jbc.ra117.000113","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T14:40:13Z","timestamp":1510238413000},"page":"21490-21503","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["The cell adhesion molecule BT-IgSF is essential for a functional blood\u2013testis barrier and male fertility in mice"],"prefix":"10.1016","volume":"292","author":[{"given":"Laura","family":"Pelz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Purf\u00fcrst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz G.","family":"Rathjen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA117.000113_bib1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S0006-291X(02)02025-9","article-title":"Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis","volume":"296","author":"Suzu","year":"2002","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA117.000113_bib2","first-page":"525","article-title":"IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM","volume":"23","author":"Katoh","year":"2003","journal-title":"Int. J. Oncol"},{"key":"10.1074\/jbc.RA117.000113_bib3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mcn.2016.11.009","article-title":"Cell\u2013cell communication mediated by the CAR subgroup of immunoglobulin cell adhesion molecules in health and disease","volume":"81","author":"Matth\u00e4us","year":"2017","journal-title":"Mol. Cell. Neurosci"},{"key":"10.1074\/jbc.RA117.000113_bib4","doi-asserted-by":"crossref","first-page":"e1002899","DOI":"10.1371\/journal.pgen.1002899","article-title":"Melanophore migration and survival during zebrafish adult pigment stripe development require the immunoglobulin superfamily adhesion molecule Igsf11","volume":"8","author":"Eom","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA117.000113_bib5","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/jcp.20361","article-title":"BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule","volume":"204","author":"Harada","year":"2005","journal-title":"J. Cell. Physiol"},{"key":"10.1074\/jbc.RA117.000113_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nn.4176","article-title":"Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity","volume":"19","author":"Jang","year":"2016","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.RA117.000113_bib7","doi-asserted-by":"crossref","first-page":"e2843","DOI":"10.7717\/peerj.2843","article-title":"A gene expression study of dorso-ventrally restricted pigment pattern in adult fins of Neolamprologus meeli, an African cichlid species","volume":"5","author":"Ahi","year":"2017","journal-title":"PeerJ"},{"key":"10.1074\/jbc.RA117.000113_bib8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4161\/spmg.19878","article-title":"In search of suitable in vitro models to study germ cell movement across the blood\u2013testis barrier","volume":"2","author":"Mruk","year":"2012","journal-title":"Spermatogenesis"},{"key":"10.1074\/jbc.RA117.000113_bib9","first-page":"286","article-title":"Germ cell transport across the seminiferous epithelium during spermatogenesis","volume":"29","author":"Xiao","year":"2014","journal-title":"Physiology (Bethesda)"},{"key":"10.1074\/jbc.RA117.000113_bib10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(00)81553-6","article-title":"CNS myelin and Sertoli cell tight junction strands are absent in Osp\/Claudin-11 null mice","volume":"99","author":"Gow","year":"1999","journal-title":"Cell"},{"key":"10.1074\/jbc.RA117.000113_bib11","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1091\/mbc.11.12.4131","article-title":"Complex phenotype of mice lacking occludin, a component of tight junction strands","volume":"11","author":"Saitou","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.RA117.000113_bib12","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1091\/mbc.e08-12-1236","article-title":"Zona occludens-2 is critical for blood\u2013testis barrier integrity and male fertility","volume":"20","author":"Xu","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.RA117.000113_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2353\/ajpath.2007.061171","article-title":"A Sertoli cell\u2013specific knockout of connexin43 prevents initiation of spermatogenesis","volume":"171","author":"Brehm","year":"2007","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.RA117.000113_bib14","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1095\/biolreprod.106.059212","article-title":"Proliferation of adult Sertoli cells following conditional knockout of the gap junctional protein GJA1 (connexin 43) in mice","volume":"76","author":"Sridharan","year":"2007","journal-title":"Biol. Reprod"},{"key":"10.1074\/jbc.RA117.000113_bib15","doi-asserted-by":"crossref","first-page":"572","DOI":"10.4103\/1008-682X.125401","article-title":"Blood\u2013testis barrier and spermatogenesis: lessons from genetically-modified mice","volume":"16","author":"Jiang","year":"2014","journal-title":"Asian J. Androl"},{"key":"10.1074\/jbc.RA117.000113_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/andr.12165","article-title":"The Sertoli cell: one hundred fifty years of beauty and plasticity","volume":"4","author":"Fran\u00e7a","year":"2016","journal-title":"Andrology"},{"key":"10.1074\/jbc.RA117.000113_bib17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/bies.20513","article-title":"Ectoplasmic specialization: a friend or a foe of spermatogenesis?","volume":"29","author":"Yan","year":"2007","journal-title":"Bioessays"},{"key":"10.1074\/jbc.RA117.000113_bib18","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrendo.2010.71","article-title":"A local autocrine axis in the testes that regulates spermatogenesis","volume":"6","author":"Cheng","year":"2010","journal-title":"Nat. Rev. Endocrinol"},{"key":"10.1074\/jbc.RA117.000113_bib19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/mrd.20391","article-title":"Stem cell protein Piwil2 modulates expression of murine spermatogonial stem cell expressed genes","volume":"73","author":"Lee","year":"2006","journal-title":"Mol. Reprod. Dev"},{"key":"10.1074\/jbc.RA117.000113_bib20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ydbio.2015.09.002","article-title":"TOPAZ1, a germ cell specific factor, is essential for male meiotic progression","volume":"406","author":"Luangpraseuth-Prosper","year":"2015","journal-title":"Dev. Biol"},{"key":"10.1074\/jbc.RA117.000113_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/mrd.20925","article-title":"Expression profile of male germ cell-associated genes in mouse embryonic stem cell cultures treated with all-trans retinoic acid and testosterone","volume":"76","author":"Silva","year":"2009","journal-title":"Mol. Reprod. Dev"},{"key":"10.1074\/jbc.RA117.000113_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.yexcr.2004.03.008","article-title":"The XY body: a specialized meiotic chromatin domain","volume":"296","author":"Handel","year":"2004","journal-title":"Exp. Cell Res"},{"key":"10.1074\/jbc.RA117.000113_bib23","first-page":"1137","article-title":"The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes","volume":"14","author":"Lammers","year":"1994","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA117.000113_bib24","first-page":"E257","article-title":"Luteinizing hormone and testosterone secretion in young and old male mice","volume":"243","author":"Coquelin","year":"1982","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.RA117.000113_bib25","doi-asserted-by":"crossref","first-page":"16696","DOI":"10.1073\/pnas.0506084102","article-title":"Androgens regulate the permeability of the blood\u2013testis barrier","volume":"102","author":"Meng","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA117.000113_bib26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1124\/pr.110.002790","article-title":"The blood\u2013testis barrier and its implications for male contraception","volume":"64","author":"Cheng","year":"2012","journal-title":"Pharmacol. Rev"},{"key":"10.1074\/jbc.RA117.000113_bib27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/jcp.21201","article-title":"Expression of CLMP, a novel tight junction protein, is mediated via the interaction of GATA with the Kruppel family proteins, KLF4 and Sp1, in mouse TM4 Sertoli cells","volume":"214","author":"Sze","year":"2008","journal-title":"J. Cell. Physiol"},{"key":"10.1074\/jbc.RA117.000113_bib28","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.yexcr.2007.01.017","article-title":"Coxsackie and adenovirus receptor (CAR) is a product of Sertoli and germ cells in rat testes which is localized at the Sertoli-Sertoli and Sertoli-germ cell interface","volume":"313","author":"Wang","year":"2007","journal-title":"Exp. Cell Res"},{"key":"10.1074\/jbc.RA117.000113_bib29","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1530\/REP-13-0653","article-title":"Mice depleted of CAR display normal spermatogenesis and an intact blood\u2013testis Barrier","volume":"147","author":"Sultana","year":"2014","journal-title":"Reproduction"},{"key":"10.1074\/jbc.RA117.000113_bib30","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nature02877","article-title":"Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C","volume":"431","author":"Gliki","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.RA117.000113_bib31","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/gene.10100","article-title":"Sertoli and granulosa cell-specific Cre recombinase activity in transgenic mice","volume":"33","author":"L\u00e9cureuil","year":"2002","journal-title":"Genesis"},{"key":"10.1074\/jbc.RA117.000113_bib32","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/er.2014-1101","article-title":"The mammalian blood\u2013testis barrier: its biology and regulation","volume":"36","author":"Mruk","year":"2015","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.RA117.000113_bib33","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1083\/jcb.201306066","article-title":"TAp73 is essential for germ cell adhesion and maturation in testis","volume":"204","author":"Holembowski","year":"2014","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.RA117.000113_bib34","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/emboj.2008.156","article-title":"Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids","volume":"27","author":"Stoffel","year":"2008","journal-title":"EMBO J"},{"key":"10.1074\/jbc.RA117.000113_bib35","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1095\/biolreprod60.5.1263","article-title":"Defects in the germ line and gonads of mice lacking connexin43","volume":"60","author":"Juneja","year":"1999","journal-title":"Biol. Reprod"},{"key":"10.1074\/jbc.RA117.000113_bib36","first-page":"935","article-title":"Loss of connexin43 (Cx43) in Sertoli cells leads to spatio-temporal alterations in occludin expression","volume":"29","author":"Gerber","year":"2014","journal-title":"Histol. Histopathol"},{"key":"10.1074\/jbc.RA117.000113_bib37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ydbio.2010.07.014","article-title":"Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility","volume":"346","author":"Carette","year":"2010","journal-title":"Dev. Biol"},{"key":"10.1074\/jbc.RA117.000113_bib38","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1095\/biolreprod.109.078907","article-title":"Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis","volume":"82","author":"Mazaud-Guittot","year":"2010","journal-title":"Biol. Reprod"},{"key":"10.1074\/jbc.RA117.000113_bib39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/(SICI)1098-2744(199608)16:4<203::AID-MC4>3.0.CO;2-G","article-title":"Localization and function of the connexin 43 gap-junction protein in normal and various oncogene-expressing rat liver epithelial cells","volume":"16","author":"de Feijter","year":"1996","journal-title":"Mol. Carcinog"},{"key":"10.1074\/jbc.RA117.000113_bib40","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0928-4257(02)00012-8","article-title":"Formation of the gap junction nexus: binding partners for connexins","volume":"96","author":"Duffy","year":"2002","journal-title":"J. Physiol. Paris"},{"key":"10.1074\/jbc.RA117.000113_bib41","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1074\/jbc.M308249200","article-title":"CLMP, a novel member of the CTX family and a new component of epithelial tight junctions","volume":"279","author":"Raschperger","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA117.000113_bib42","doi-asserted-by":"crossref","first-page":"15191","DOI":"10.1073\/pnas.261452898","article-title":"The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction","volume":"98","author":"Cohen","year":"2001","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1074\/jbc.RA117.000113_bib43","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/01.LAB.0000059928.82702.6D","article-title":"Impaired gap junction connexin43 in Sertoli cells of patients with secretory azoospermia: a marker of undifferentiated Sertoli cells","volume":"83","author":"Defamie","year":"2003","journal-title":"Lab. Investig"},{"key":"10.1074\/jbc.RA117.000113_bib44","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1093\/nar\/23.24.5080","article-title":"A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells","volume":"23","author":"Schwenk","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA117.000113_bib45","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1073\/pnas.93.12.6191","article-title":"Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice","volume":"93","author":"Dymecki","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820327125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820327125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA117.000113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T05:12:48Z","timestamp":1641273168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820327125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":45,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0021925820327125"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra117.000113","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The cell adhesion molecule BT-IgSF is essential for a functional blood\u2013testis barrier and male fertility in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA117.000113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}