{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:11:02Z","timestamp":1788462662067,"version":"build-2803163510"},"reference-count":81,"publisher":"Elsevier BV","issue":"30","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"vor","delay-in-days":783,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging (NIA)","doi-asserted-by":"publisher","award":["K01 AG033724"],"award-info":[{"award-number":["K01 AG033724"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","doi-asserted-by":"publisher","award":["R21 NS096603"],"award-info":[{"award-number":["R21 NS096603"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","doi-asserted-by":"publisher","award":["R01 NS094670"],"award-info":[{"award-number":["R01 NS094670"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1074\/jbc.ra117.001211","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T18:35:13Z","timestamp":1528742113000},"page":"11850-11866","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["The role of Twist1 in mutant huntingtin\u2013induced transcriptional alterations and neurotoxicity"],"prefix":"10.1016","volume":"293","author":[{"given":"Yanchun","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Tycksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaopeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Palucki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-0920","authenticated-orcid":false,"given":"Hiroko","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA117.001211_bib1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington's disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1074\/jbc.RA117.001211_bib2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","article-title":"Huntington disease: natural history, biomarkers and prospects for therapeutics","volume":"10","author":"Ross","year":"2014","journal-title":"Nat. Rev. Neurol"},{"key":"10.1074\/jbc.RA117.001211_bib3","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.RA117.001211_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0168-9525(03)00074-X","article-title":"Transcriptional abnormalities in Huntington disease","volume":"19","author":"Sugars","year":"2003","journal-title":"Trends Genet"},{"key":"10.1074\/jbc.RA117.001211_bib5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.pneurobio.2007.03.004","article-title":"Transcriptional signatures in Huntington's disease","volume":"83","author":"Cha","year":"2007","journal-title":"Prog. Neurobiol"},{"key":"10.1074\/jbc.RA117.001211_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.nbd.2011.07.001","article-title":"What have we learned from gene expression profiles in Huntington's disease?","volume":"45","author":"Seredenina","year":"2012","journal-title":"Neurobiol. Dis"},{"key":"10.1074\/jbc.RA117.001211_bib7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0166-2236(00)01609-X","article-title":"Transcriptional dysregulation in Huntington's disease","volume":"23","author":"Cha","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib8","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tig.2004.01.008","article-title":"Huntingtin-protein interactions and the pathogenesis of Huntington's disease","volume":"20","author":"Li","year":"2004","journal-title":"Trends Genet"},{"key":"10.1074\/jbc.RA117.001211_bib9","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/sj.embor.7400250","article-title":"Huntingtin and the molecular pathogenesis of Huntington's disease: fourth in molecular medicine review series","volume":"5","author":"Landles","year":"2004","journal-title":"EMBO Rep"},{"key":"10.1074\/jbc.RA117.001211_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.5607\/en.2014.23.1.36","article-title":"Therapeutic approaches for inhibition of protein aggregation in Huntington's disease","volume":"23","author":"Kim","year":"2014","journal-title":"Exp. Neurobiol"},{"key":"10.1074\/jbc.RA117.001211_bib11","doi-asserted-by":"crossref","first-page":"E3027","DOI":"10.1073\/pnas.1311323110","article-title":"Targeting H3K4 trimethylation in Huntington disease","volume":"110","author":"Vashishtha","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA117.001211_bib12","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1073\/pnas.1221292110","article-title":"Extensive changes in DNA methylation are associated with expression of mutant huntingtin","volume":"110","author":"Ng","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA117.001211_bib13","doi-asserted-by":"crossref","first-page":"e41423","DOI":"10.1371\/journal.pone.0041423","article-title":"Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease","volume":"7","author":"McFarland","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA117.001211_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3233\/JHD-130066","article-title":"Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington's disease","volume":"2","author":"McFarland","year":"2013","journal-title":"J. Huntingtons Dis"},{"key":"10.1074\/jbc.RA117.001211_bib15","doi-asserted-by":"crossref","first-page":"10471","DOI":"10.1523\/JNEUROSCI.0670-13.2013","article-title":"Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease","volume":"33","author":"Valor","year":"2013","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib16","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1093\/hmg\/ddt214","article-title":"Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease","volume":"22","author":"Wang","year":"2013","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.RA117.001211_bib17","doi-asserted-by":"crossref","first-page":"10720","DOI":"10.1523\/JNEUROSCI.2126-08.2008","article-title":"Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner","volume":"28","author":"Benn","year":"2008","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib18","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/jhg.2013.65","article-title":"DNA methylation of the BDNF gene and its relevance to psychiatric disorders","volume":"58","author":"Ikegame","year":"2013","journal-title":"J. Hum. Genet"},{"key":"10.1074\/jbc.RA117.001211_bib19","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/nn.2666","article-title":"DNA methylation and memory formation","volume":"13","author":"Day","year":"2010","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.RA117.001211_bib21","doi-asserted-by":"crossref","first-page":"31022","DOI":"10.1038\/srep31022","article-title":"Inhibition of DNA methyltransferases blocks mutant huntingtin-induced neurotoxicity","volume":"6","author":"Pan","year":"2016","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA117.001211_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12017-013-8219-0","article-title":"Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease","volume":"15","author":"Villar-Men\u00e9ndez","year":"2013","journal-title":"Neuromolecular Med"},{"key":"10.1074\/jbc.RA117.001211_bib23","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","article-title":"Role of brain-derived neurotrophic factor in Huntington's disease","volume":"81","author":"Zuccato","year":"2007","journal-title":"Prog. Neurobiol"},{"key":"10.1074\/jbc.RA117.001211_bib24","doi-asserted-by":"crossref","first-page":"12764","DOI":"10.1523\/JNEUROSCI.3566-09.2009","article-title":"New insights in the biology of BDNF synthesis and release: implications in CNS function","volume":"29","author":"Greenberg","year":"2009","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrneurol.2009.54","article-title":"Brain-derived neurotrophic factor in neurodegenerative diseases","volume":"5","author":"Zuccato","year":"2009","journal-title":"Nat. Rev. Neurol"},{"key":"10.1074\/jbc.RA117.001211_bib26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease","volume":"293","author":"Zuccato","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.RA117.001211_bib27","doi-asserted-by":"crossref","first-page":"11758","DOI":"10.1523\/JNEUROSCI.2461-07.2007","article-title":"Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration","volume":"27","author":"Strand","year":"2007","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib28","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1471-4159.2007.05137.x","article-title":"Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice","volume":"105","author":"Gharami","year":"2008","journal-title":"J. Neurochem"},{"key":"10.1074\/jbc.RA117.001211_bib29","doi-asserted-by":"crossref","first-page":"14708","DOI":"10.1523\/JNEUROSCI.1637-10.2010","article-title":"BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice","volume":"30","author":"Xie","year":"2010","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mcn.2008.04.007","article-title":"CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6\/2 mice","volume":"39","author":"Apostol","year":"2008","journal-title":"Mol. Cell. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib31","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nbd.2008.01.015","article-title":"Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease","volume":"30","author":"Duan","year":"2008","journal-title":"Neurobiol. Dis"},{"key":"10.1074\/jbc.RA117.001211_bib32","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1073\/pnas.1221891110","article-title":"Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease","volume":"110","author":"Sathasivam","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA117.001211_bib33","doi-asserted-by":"crossref","first-page":"8808","DOI":"10.1074\/jbc.M109.075028","article-title":"Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease","volume":"285","author":"Landles","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA117.001211_bib34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/nen.0b013e318040b2c8","article-title":"Characterization of huntingtin pathologic fragments in human Huntington disease, transgenic mice, and cell models","volume":"66","author":"Schilling","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"10.1074\/jbc.RA117.001211_bib35","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.RA117.001211_bib36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington's disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1074\/jbc.RA117.001211_bib37","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/78054","article-title":"Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity","volume":"25","author":"Li","year":"2000","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.RA117.001211_bib38","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.cell.2006.04.026","article-title":"Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin","volume":"125","author":"Graham","year":"2006","journal-title":"Cell"},{"key":"10.1074\/jbc.RA117.001211_bib39","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1038\/onc.2010.92","article-title":"TWISTing an embryonic transcription factor into an oncoprotein","volume":"29","author":"Ansieau","year":"2010","journal-title":"Oncogene"},{"key":"10.1074\/jbc.RA117.001211_bib40","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/cr.2011.144","article-title":"Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms","volume":"22","author":"Qin","year":"2012","journal-title":"Cell Res"},{"key":"10.1074\/jbc.RA117.001211_bib41","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1523\/JNEUROSCI.23-03-00961.2003","article-title":"Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease","volume":"23","author":"Cepeda","year":"2003","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib42","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pneurobio.2006.11.001","article-title":"The corticostriatal pathway in Huntington's disease","volume":"81","author":"Cepeda","year":"2007","journal-title":"Prog. Neurobiol"},{"key":"10.1074\/jbc.RA117.001211_bib43","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1113\/jphysiol.2007.142448","article-title":"Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load","volume":"585","author":"Milnerwood","year":"2007","journal-title":"J. Physiol"},{"key":"10.1074\/jbc.RA117.001211_bib44","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrn1806","article-title":"Normal huntingtin function: an alternative approach to Huntington's disease","volume":"6","author":"Cattaneo","year":"2005","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib45","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nn.3721","article-title":"Inhibition of mitochondrial protein import by mutant huntingtin","volume":"17","author":"Yano","year":"2014","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib46","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1186\/gb-2007-8-9-r183","article-title":"The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists","volume":"8","author":"Huang","year":"2007","journal-title":"Genome Biol"},{"key":"10.1074\/jbc.RA117.001211_bib47","doi-asserted-by":"crossref","first-page":"e0143563","DOI":"10.1371\/journal.pone.0143563","article-title":"RNA sequence analysis of human huntington disease brain reveals an extensive increase in inflammatory and developmental gene expression","volume":"10","author":"Labadorf","year":"2015","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA117.001211_bib48","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington's disease brain","volume":"15","author":"Hodges","year":"2006","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.RA117.001211_bib49","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1101\/gad.11.10.1207","article-title":"POU domain family values: flexibility, partnerships, and developmental codes","volume":"11","author":"Ryan","year":"1997","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.RA117.001211_bib50","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1182\/blood-2016-12-754051","article-title":"SCL\/TAL1: a multifaceted regulator from blood development to disease","volume":"129","author":"Porcher","year":"2017","journal-title":"Blood"},{"key":"10.1074\/jbc.RA117.001211_bib51","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1126\/science.278.5344.1809","article-title":"Multistep control of pituitary organogenesis","volume":"278","author":"Sheng","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.RA117.001211_bib52","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1242\/dev.068346","article-title":"The regulation of Hox gene expression during animal development","volume":"140","author":"Mallo","year":"2013","journal-title":"Development"},{"key":"10.1074\/jbc.RA117.001211_bib53","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1242\/dev.112672","article-title":"Fox transcription factors: from development to disease","volume":"143","author":"Golson","year":"2016","journal-title":"Development"},{"key":"10.1074\/jbc.RA117.001211_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1755-8794-4-57","article-title":"Identification of transcriptional regulatory networks specific to pilocytic astrocytoma","volume":"4","author":"Deshmukh","year":"2011","journal-title":"BMC Med. Genomics"},{"key":"10.1074\/jbc.RA117.001211_bib55","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.RA117.001211_bib56","doi-asserted-by":"crossref","first-page":"e49838","DOI":"10.1371\/journal.pone.0049838","article-title":"Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175","volume":"7","author":"Menalled","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA117.001211_bib57","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nn.4256","article-title":"Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice","volume":"19","author":"Langfelder","year":"2016","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib58","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nm.2559","article-title":"Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway","volume":"18","author":"Jeong","year":"2011","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA117.001211_bib59","first-page":"401","article-title":"Twist functions in mouse development","volume":"46","author":"O'Rourke","year":"2002","journal-title":"Int. J. Dev. Biol"},{"key":"10.1074\/jbc.RA117.001211_bib60","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1242\/dev.128.16.3145","article-title":"Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development","volume":"128","author":"Castanon","year":"2001","journal-title":"Development"},{"key":"10.1074\/jbc.RA117.001211_bib61","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.1093\/nar\/gkw334","article-title":"Deciphering the molecular mechanisms underlying the binding of the TWIST1\/E12 complex to regulatory E-box sequences","volume":"44","author":"Bouard","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA117.001211_bib62","doi-asserted-by":"crossref","first-page":"D110","DOI":"10.1093\/nar\/gkv1176","article-title":"JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles","volume":"44","author":"Mathelier","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA117.001211_bib63","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/bioinformatics\/btr064","article-title":"FIMO: scanning for occurrences of a given motif","volume":"27","author":"Grant","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.RA117.001211_bib64","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1128\/MCB.06315-11","article-title":"Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A\/Arf locus in mesenchymal stem cells","volume":"32","author":"Cakouros","year":"2012","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA117.001211_bib65","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1038\/onc.2011.483","article-title":"Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-\u03b1","volume":"31","author":"Vesuna","year":"2012","journal-title":"Oncogene"},{"key":"10.1074\/jbc.RA117.001211_bib66","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/ncb2099","article-title":"Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition","volume":"12","author":"Yang","year":"2010","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.RA117.001211_bib67","doi-asserted-by":"crossref","first-page":"e315","DOI":"10.1038\/oncsis.2017.16","article-title":"Twist1\/Dnmt3a and miR186 establish a regulatory circuit that controls inflammation-associated prostate cancer progression","volume":"6","author":"Zhao","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1074\/jbc.RA117.001211_bib68","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/bioinformatics\/btr625","article-title":"Expression2Kinases: mRNA profiling linked to multiple upstream regulatory layers","volume":"28","author":"Chen","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.RA117.001211_bib69","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature09784","article-title":"The Polycomb complex PRC2 and its mark in life","volume":"469","author":"Margueron","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.RA117.001211_bib70","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.tibs.2010.02.009","article-title":"Polycomb group protein-mediated repression of transcription","volume":"35","author":"Morey","year":"2010","journal-title":"Trends Biochem. Sci"},{"key":"10.1074\/jbc.RA117.001211_bib71","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jnr.21139","article-title":"Mouse and rat BDNF gene structure and expression revisited","volume":"85","author":"Aid","year":"2007","journal-title":"J. Neurosci. Res"},{"key":"10.1074\/jbc.RA117.001211_bib72","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ygeno.2007.05.004","article-title":"Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters","volume":"90","author":"Pruunsild","year":"2007","journal-title":"Genomics"},{"key":"10.1074\/jbc.RA117.001211_bib73","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1750-3639.2007.00111.x","article-title":"Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease","volume":"18","author":"Zuccato","year":"2008","journal-title":"Brain Pathol"},{"key":"10.1074\/jbc.RA117.001211_bib74","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fendo.2012.00108","article-title":"A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue","volume":"3","author":"Dobrian","year":"2012","journal-title":"Front. Endocrinol"},{"key":"10.1074\/jbc.RA117.001211_bib75","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/nar\/gkq890","article-title":"Redundant or separate entities?\u2013roles of Twist1 and Twist2 as molecular switches during gene transcription","volume":"39","author":"Franco","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA117.001211_bib76","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/nn.4360","article-title":"Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration","volume":"19","author":"von Schimmelmann","year":"2016","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.RA117.001211_bib77","doi-asserted-by":"crossref","first-page":"e29610","DOI":"10.1371\/journal.pone.0029610","article-title":"Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging","volume":"6","author":"Podtelezhnikov","year":"2011","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA117.001211_bib78","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ng0297-197","article-title":"Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation","volume":"15","author":"Mangiarini","year":"1997","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.RA117.001211_bib79","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/(SICI)1097-4547(19991115)58:4<515::AID-JNR5>3.0.CO;2-F","article-title":"Enhanced sensitivity to N-methyl-d-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease","volume":"58","author":"Levine","year":"1999","journal-title":"J. Neurosci. Res"},{"key":"10.1074\/jbc.RA117.001211_bib80","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nprot.2012.012","article-title":"Methylome analysis using MeDIP-seq with low DNA concentrations","volume":"7","author":"Taiwo","year":"2012","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.RA117.001211_bib81","doi-asserted-by":"crossref","first-page":"E8247","DOI":"10.1073\/pnas.1610921114","article-title":"An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma","volume":"113","author":"Gujar","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820317786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820317786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA117.001211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T13:00:04Z","timestamp":1639832404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820317786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":81,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0021925820317786"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra117.001211","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of Twist1 in mutant huntingtin\u2013induced transcriptional alterations and neurotoxicity","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA117.001211","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by The American Society for Biochemistry and Molecular Biology, Inc.","name":"copyright","label":"Copyright"}]}}