{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:45:56Z","timestamp":1790801156056,"version":"4.1.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":787,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"MCTI | Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["456997\/2014\u20138"],"award-info":[{"award-number":["456997\/2014\u20138"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ)","doi-asserted-by":"publisher","award":["E-26\/110.085\/2014"],"award-info":[{"award-number":["E-26\/110.085\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ)","doi-asserted-by":"publisher","award":["E-26\/201.197\/2014"],"award-info":[{"award-number":["E-26\/201.197\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ)","doi-asserted-by":"publisher","award":["E-26\/202.950\/2016"],"award-info":[{"award-number":["E-26\/202.950\/2016"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1074\/jbc.ra117.001337","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T19:45:11Z","timestamp":1528227911000},"page":"11388-11400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation"],"prefix":"10.1016","volume":"293","author":[{"given":"Diogo de Barros","family":"Peruchetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Pacheco","family":"Silva-Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Marques","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner Barbosa","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso","family":"Caruso-Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA117.001337_bib1","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.2215\/CJN.11111016","article-title":"Diagnosis and management of type 2 diabetic kidney disease","volume":"12","author":"Doshi","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib2","doi-asserted-by":"crossref","DOI":"10.1177\/2054358117705371","article-title":"Potential role of serum and urinary biomarkers in diagnosis and prognosis of diabetic nephropathy","volume":"4","author":"Campion","year":"2017","journal-title":"Can. J. Kidney Health Dis"},{"key":"10.1074\/jbc.RA117.001337_bib3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nrneph.2013.58-c1","article-title":"Albuminuria is controlled primarily by proximal tubules","volume":"10","author":"Comper","year":"2014","journal-title":"Nat. Rev. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nrneph.2013.58-c2","article-title":"Reply: podocytes are key-although albumin never reaches the slit diaphragm","volume":"10","author":"Moeller","year":"2014","journal-title":"Nat. Rev. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1681\/ASN.2008050503","article-title":"Impaired tubular uptake explains albuminuria in early diabetic nephropathy. J","volume":"20","author":"Russo","year":"2009","journal-title":"Am. Soc. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1681\/ASN.2013090950","article-title":"The proximal tubule and albuminuria: really! J","volume":"25","author":"Dickson","year":"2014","journal-title":"Am. Soc. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib7","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrneph.2013.212","article-title":"Proteinuria: tubular handling of albumin-degradation or salvation? Nat","volume":"9","author":"Christensen","year":"2013","journal-title":"Rev. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s004180100317","article-title":"Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats","volume":"116","author":"Tojo","year":"2001","journal-title":"Histochem. Cell Biol"},{"key":"10.1074\/jbc.RA117.001337_bib9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1291\/hypres.26.413","article-title":"Angiotensin II blockade restores albumin reabsorption in the proximal tubules of diabetic rats","volume":"26","author":"Tojo","year":"2003","journal-title":"Hypertens. Res"},{"key":"10.1074\/jbc.RA117.001337_bib10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1159\/000332040","article-title":"Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease","volume":"34","author":"Zhou","year":"2011","journal-title":"Am. J. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib11","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jdiacomp.2015.04.014","article-title":"Renal tubular damage may contribute more to acute hyperglycemia induced kidney injury in non-diabetic conscious rats","volume":"29","author":"Wang","year":"2015","journal-title":"J. Diabetes Complications"},{"key":"10.1074\/jbc.RA117.001337_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.kint.2015.11.007","article-title":"Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease","volume":"89","author":"Nielsen","year":"2016","journal-title":"Kidney Int"},{"key":"10.1074\/jbc.RA117.001337_bib13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev.physiol.67.031103.154845","article-title":"Renal tubule albumin transport","volume":"67","author":"Gekle","year":"2005","journal-title":"Annu. Rev. Physiol"},{"key":"10.1074\/jbc.RA117.001337_bib14","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1172\/JCI1923","article-title":"Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase","volume":"101","author":"Brunskill","year":"1998","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA117.001337_bib15","doi-asserted-by":"crossref","first-page":"17513","DOI":"10.1073\/pnas.0507255102","article-title":"Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation","volume":"102","author":"Caruso-Neves","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA117.001337_bib16","doi-asserted-by":"crossref","first-page":"18810","DOI":"10.1073\/pnas.0605029103","article-title":"PKB and megalin determine the survival or death of renal proximal tubule cells","volume":"103","author":"Caruso-Neves","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA117.001337_bib17","doi-asserted-by":"crossref","first-page":"F1013","DOI":"10.1152\/ajprenal.00289.2011","article-title":"PKB\/Akt partners with Dab2 in albumin endocytosis","volume":"302","author":"Koral","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.RA117.001337_bib18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"key":"10.1074\/jbc.RA117.001337_bib19","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.bbagen.2016.04.012","article-title":"Uroguanylin modulates (Na2+K+)ATPase in a proximal tubule cell line: interactions among the cGMP\/protein kinase G, cAMP\/protein kinase A, and mTOR pathways","volume":"1860","author":"Arnaud-Batista","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA117.001337_bib20","doi-asserted-by":"crossref","first-page":"16790","DOI":"10.1074\/jbc.M114.549717","article-title":"Mis-regulation of mammalian target of rapamycin (mTOR) complexes induced by albuminuria in proximal tubules","volume":"289","author":"Peruchetti","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA117.001337_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1681\/ASN.2015111224","article-title":"mTOR regulates endocytosis and nutrient transport in proximal tubular cells","volume":"28","author":"Grahammer","year":"2017","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib22","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrneph.2016.108","article-title":"Roles of mTOR complexes in the kidney: implications for renal disease and transplantation","volume":"12","author":"Fantus","year":"2016","journal-title":"Nat. Rev. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib23","doi-asserted-by":"crossref","first-page":"F180","DOI":"10.1152\/ajprenal.00015.2012","article-title":"Mammalian target of rapamycin and the kidney: II. pathophysiology and therapeutic implications. Am. J. Physiol","volume":"303","author":"Lieberthal","year":"2012","journal-title":"Renal Physiol"},{"key":"10.1074\/jbc.RA117.001337_bib24","doi-asserted-by":"crossref","first-page":"35363","DOI":"10.1074\/jbc.M114.587840","article-title":"Activation of glycogen synthase kinase 3\u03b2 ameliorates diabetes-induced kidney injury","volume":"289","author":"Mariappan","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA117.001337_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbrc.2015.11.092","article-title":"Silencing of angiotensin II type-1 receptor inhibits high glucose-induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells via inactivation of mTOR\/p70S6K signaling pathway","volume":"469","author":"Gong","year":"2016","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA117.001337_bib26","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1016\/j.jmb.2016.05.028","article-title":"O-GlcNAcylation in cancer biology: linking metabolism and signaling","volume":"428","author":"Ferrer","year":"2016","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.RA117.001337_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/BJ20150041","article-title":"Akt\/PKB: one kinase, many modifications","volume":"468","author":"Risso","year":"2015","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.RA117.001337_bib28","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1074\/mcp.M600453-MCP200","article-title":"Dynamic interplay between O-linked N-acetylglucosaminylation and glycogen synthase kinase-3-dependent phosphorylation","volume":"6","author":"Wang","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/jbc.RA117.001337_bib29","doi-asserted-by":"crossref","first-page":"5204","DOI":"10.1074\/jbc.M109.077818","article-title":"Regulation of insulin receptor substrate 1 (IRS-1)\/AKT kinase-mediated insulin signaling by O-linked \u03b2-N-acetylglucosamine in 3T3-L1 adipocytes","volume":"285","author":"Whelan","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA117.001337_bib30","doi-asserted-by":"crossref","first-page":"19248","DOI":"10.1074\/jbc.M109.005678","article-title":"O-Linked N-acetylglucosamine modification on CCAAT enhancer-binding protein \u03b2: role during adipocyte differentiation","volume":"284","author":"Li","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA117.001337_bib31","doi-asserted-by":"crossref","first-page":"14500","DOI":"10.1038\/srep14500","article-title":"O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling","volume":"5","author":"Shi","year":"2015","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA117.001337_bib32","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev-biochem-060608-102511","article-title":"Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease","volume":"80","author":"Hart","year":"2011","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.RA117.001337_bib33","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1083\/jcb.201501101","article-title":"A little sugar goes a long way: the cell biology of O-GlcNAc","volume":"208","author":"Bond","year":"2015","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.RA117.001337_bib34","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.lfs.2009.01.007","article-title":"Evidence of O-linked N-acetylglucosamine in diabetic nephropathy","volume":"84","author":"Degrell","year":"2009","journal-title":"Life Sci"},{"key":"10.1074\/jbc.RA117.001337_bib35","doi-asserted-by":"crossref","first-page":"E1083","DOI":"10.3390\/ijms18051083","article-title":"SGLT2 Inhibitors as a therapeutic option for diabetic nephropathy","volume":"18","author":"Kawanami","year":"2017","journal-title":"Int. J. Mol. Sci"},{"key":"10.1074\/jbc.RA117.001337_bib36","doi-asserted-by":"crossref","first-page":"F1006","DOI":"10.1152\/ajprenal.00021.2012","article-title":"CD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies","volume":"303","author":"Baines","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.RA117.001337_bib37","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/ndt\/gfu261","article-title":"Progression of renal injury toward interstitial inflammation and glomerular sclerosis is dependent on abnormal protein filtration","volume":"30","author":"Zoja","year":"2015","journal-title":"Nephrol. Dial. Transplant"},{"key":"10.1074\/jbc.RA117.001337_bib38","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1681\/ASN.2006040377","article-title":"How does proteinuria cause progressive renal damage? J","volume":"17","author":"Abbate","year":"2006","journal-title":"Am. Soc. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib39","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1681\/ASN.2006111266","article-title":"Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulointerstitial injury","volume":"18","author":"Theilig","year":"2007","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharmacol"},{"key":"10.1074\/jbc.RA117.001337_bib41","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/fcp.12296","article-title":"Modulation of heme oxygenase-1 expression and activity affects streptozotocin-induced diabetic nephropathy in rats","volume":"31","author":"Ali","year":"2017","journal-title":"Fundam. Clin. Pharmacol"},{"key":"10.1074\/jbc.RA117.001337_bib42","doi-asserted-by":"crossref","first-page":"21327","DOI":"10.1074\/jbc.M109.007310","article-title":"Regulation of calcium\/calmodulin-dependent kinase IV by O-GlcNAc modification","volume":"284","author":"Dias","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA117.001337_bib43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.diabres.2004.02.003","article-title":"High glucose reduces albumin uptake in cultured proximal tubular cells (LLC-PK1)","volume":"65","author":"Ishibashi","year":"2004","journal-title":"Diabetes Res. Clin. Pract"},{"key":"10.1074\/jbc.RA117.001337_bib44","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.diabres.2005.10.019","article-title":"Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1)","volume":"72","author":"Ishibashi","year":"2006","journal-title":"Diabetes Res. Clin. Pract"},{"key":"10.1074\/jbc.RA117.001337_bib45","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1096\/fj.02-0130fje","article-title":"High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases","volume":"17","author":"Allen","year":"2003","journal-title":"FASEB J"},{"key":"10.1074\/jbc.RA117.001337_bib46","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/sj.ki.5002106","article-title":"High glucose initiates calpain-induced necrosis before apoptosis in LLC-PK1 cells","volume":"71","author":"Harwood","year":"2007","journal-title":"Kidney Int"},{"key":"10.1074\/jbc.RA117.001337_bib47","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.biopha.2017.12.112","article-title":"The protective effect of shikonin on renal tubular epithelial cell injury induced by high glucose","volume":"98","author":"Tong","year":"2018","journal-title":"Biomed. Pharmacother"},{"key":"10.1074\/jbc.RA117.001337_bib48","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbrc.2016.10.060","article-title":"Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells","volume":"480","author":"Jiao","year":"2016","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA117.001337_bib49","doi-asserted-by":"crossref","first-page":"e96236","DOI":"10.1371\/journal.pone.0096236","article-title":"Impaired insulin signaling affects renal organic anion transporter 3 (Oat3) function in streptozotocin-induced diabetic rats","volume":"9","author":"Lungkaphin","year":"2014","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA117.001337_bib50","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000325647","article-title":"Diabetic tubulopathy: an emerging entity","volume":"170","author":"Tang","year":"2011","journal-title":"Contrib. Nephrol"},{"key":"10.1074\/jbc.RA117.001337_bib51","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1093\/ndt\/gfs260","article-title":"The pathogenic role of the renal proximal tubular cell in diabetic nephropathy","volume":"27","author":"Tang","year":"2012","journal-title":"Nephrol. Dial. Transplant"},{"key":"10.1074\/jbc.RA117.001337_bib52","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/jcp.25286","article-title":"SGLT2 Inhibitors: glucotoxicity and tumorigenesis downstream the renal proximal tubule? J","volume":"231","author":"Bertinat","year":"2016","journal-title":"Cell. Physiol"},{"key":"10.1074\/jbc.RA117.001337_bib53","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00125-016-4157-3","article-title":"Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition","volume":"60","author":"Vallon","year":"2017","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.RA117.001337_bib54","doi-asserted-by":"crossref","first-page":"e12436","DOI":"10.14814\/phy2.12436","article-title":"Renoprotective effects of combined SGLT2 and ACE inhibitor therapy in diabetic Dahl S rats","volume":"3","author":"Kojima","year":"2015","journal-title":"Physiol. Rep"},{"key":"10.1074\/jbc.RA117.001337_bib55","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1055\/s-0034-1395609","article-title":"Empagliflozin, an inhibitor of sodium-glucose cotransporter 2 exerts anti-inflammatory and antifibrotic effects on experimental diabetic nephropathy partly by suppressing AGEs-receptor axis","volume":"47","author":"Ojima","year":"2015","journal-title":"Horm. Metab. Res"},{"key":"10.1074\/jbc.RA117.001337_bib56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1559-0275-8-15","article-title":"Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including \u03b1-actinin 4","volume":"8","author":"Akimoto","year":"2011","journal-title":"Clin. Proteomics"},{"key":"10.1074\/jbc.RA117.001337_bib57","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00726-010-0698-9","article-title":"O-GlcNAcylation of tubulin inhibits its polymerization","volume":"40","author":"Ji","year":"2011","journal-title":"Amino Acids"},{"key":"10.1074\/jbc.RA117.001337_bib58","doi-asserted-by":"crossref","first-page":"F1172","DOI":"10.1152\/ajprenal.00545.2015","article-title":"Role of O-linked N-acetylglucosamine modification in diabetic nephropathy","volume":"311","author":"Gellai","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.RA117.001337_bib59","doi-asserted-by":"crossref","first-page":"L807","DOI":"10.1152\/ajplung.00569.2016","article-title":"TGF-\u03b2 inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis and transcriptional downregulation of megalin","volume":"313","author":"Mazzocchi","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol"},{"key":"10.1074\/jbc.RA117.001337_bib60","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1113\/jphysiol.2003.048074","article-title":"Transforming growth factor-\u03b21 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells","volume":"552","author":"Gekle","year":"2003","journal-title":"J. Physiol"},{"key":"10.1074\/jbc.RA117.001337_bib61","doi-asserted-by":"crossref","first-page":"F689","DOI":"10.1152\/ajprenal.00502.2015","article-title":"Transforming growth factor-\u03b21 and diabetic nephropathy","volume":"310","author":"Chang","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.RA117.001337_bib62","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1371\/journal.pmed.0020045","article-title":"Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy","volume":"2","author":"Susztak","year":"2005","journal-title":"PLoS Med"},{"key":"10.1074\/jbc.RA117.001337_bib63","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cell.2015.06.017","article-title":"The utilization of extracellular proteins as nutrients is suppressed by mTORC1","volume":"162","author":"Palm","year":"2015","journal-title":"Cell"},{"key":"10.1074\/jbc.RA117.001337_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2016.05.005","article-title":"Roles of O-GlcNAc in chronic diseases of aging","volume":"51","author":"Banerjee","year":"2016","journal-title":"Mol. Aspects Med"},{"key":"10.1074\/jbc.RA117.001337_bib65","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fonc.2014.00132","article-title":"O-GlcNAcylation: the sweet side of the cancer","volume":"4","author":"de Queiroz","year":"2014","journal-title":"Front. Oncol"},{"key":"10.1074\/jbc.RA117.001337_bib66","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/10409238.2015.1135102","article-title":"New insights: a role for O-GlcNAcylation in diabetic complications","volume":"51","author":"Peterson","year":"2016","journal-title":"Crit. Rev. Biochem. Mol. Biol"},{"key":"10.1074\/jbc.RA117.001337_bib67","article-title":"Nutrient-driven O-GlcNAc in proteostasis and neurodegeneration","author":"Akan","year":"2017","journal-title":"J. Neurochem"},{"key":"10.1074\/jbc.RA117.001337_bib68","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1042\/CS20150777","article-title":"High-fat diet increases O-GlcNAc levels in cerebral arteries: a link to vascular dysfunction associated with hyperlipidaemia\/obesity?","volume":"130","author":"Lima","year":"2016","journal-title":"Clin. Sci. (Lond)"},{"key":"10.1074\/jbc.RA117.001337_bib69","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1042\/CS20110638","article-title":"O-GlcNAcylation and oxidation of proteins: is signalling in the cardiovascular system becoming sweeter? Clin","volume":"123","author":"Lima","year":"2012","journal-title":"Sci. (Lond)"},{"key":"10.1074\/jbc.RA117.001337_bib70","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbrc.2012.04.124","article-title":"O-GlcNAcylation of kinases","volume":"422","author":"Dias","year":"2012","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA117.001337_bib71","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1289\/ehp.0901874","article-title":"Cadmium impairs albumin reabsorption by down-regulating megalin and ClC5 channels in renal proximal tubule cells","volume":"118","author":"Gena","year":"2010","journal-title":"Environ. Health Perspect"},{"key":"10.1074\/jbc.RA117.001337_bib72","doi-asserted-by":"crossref","unstructured":"Salminen, A., and Kaarniranta, K, . Insulin\/IGF-1 paradox of aging: regulation via AKT\/IKK\/NF-\u03baB signaling. Cell. Signal. 22, 573\u2013577","DOI":"10.1016\/j.cellsig.2009.10.006"},{"key":"10.1074\/jbc.RA117.001337_bib73","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2337\/db16-0796","article-title":"Proximal tubulopathy: prime mover and key therapeutic target in diabetic kidney disease","volume":"66","author":"Gilbert","year":"2017","journal-title":"Diabetes"},{"key":"10.1074\/jbc.RA117.001337_bib74","doi-asserted-by":"crossref","first-page":"45041","DOI":"10.1074\/jbc.M111.260737","article-title":"(Na2+,K+)-ATPase is a target for phosphoinositide 3-kinase\/protein kinase B and protein kinase C pathways triggered by albumin","volume":"286","author":"Peruchetti","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA117.001337_bib75","doi-asserted-by":"crossref","first-page":"e107549","DOI":"10.1371\/journal.pone.0107549","article-title":"5-Lypoxygenase products are involved in renal tubulointerstitial injury induced by albumin overload in proximal tubules in mice","volume":"9","author":"Landgraf","year":"2014","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA117.001337_bib76","doi-asserted-by":"crossref","first-page":"F499","DOI":"10.1152\/ajprenal.00384.2010","article-title":"Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats","volume":"300","author":"Landgraf","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.RA117.001337_bib77","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820315623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820315623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA117.001337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:51:48Z","timestamp":1639702308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820315623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":77,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0021925820315623"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra117.001337","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA117.001337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by The American Society for Biochemistry and Molecular Biology, Inc.","name":"copyright","label":"Copyright"}]}}