{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:19:10Z","timestamp":1790299150155,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":639,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271291"],"award-info":[{"award-number":["81271291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1074\/jbc.ra118.001858","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T19:45:13Z","timestamp":1539891913000},"page":"20041-20050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"title":["miR-27a-3p protects against blood\u2013brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11"],"prefix":"10.1016","volume":"293","author":[{"given":"Tianyang","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Liebeskind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-8104","authenticated-orcid":false,"given":"Fabien","family":"Scalzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA118.001858_bib1","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJM200105103441907","article-title":"Spontaneous intracerebral hemorrhage","volume":"344","author":"Qureshi","year":"2001","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.RA118.001858_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1474-4422(11)70264-2","article-title":"Complications of intracerebral haemorrhage","volume":"11","author":"Balami","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1074\/jbc.RA118.001858_bib3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1042-3680(02)00007-4","article-title":"Pathophysiology of brain edema formation","volume":"13","author":"Xi","year":"2002","journal-title":"Neurosurg. Clin. N. Am"},{"key":"10.1074\/jbc.RA118.001858_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1474-4422(05)70283-0","article-title":"Mechanisms of brain injury after intracerebral haemorrhage","volume":"5","author":"Xi","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1074\/jbc.RA118.001858_bib5","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1161\/01.STR.0000145485.67827.d0","article-title":"Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits","volume":"35","author":"Gong","year":"2004","journal-title":"Stroke"},{"key":"10.1074\/jbc.RA118.001858_bib6","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1161\/01.STR.30.6.1167","article-title":"Progression of mass effect after intracerebral hemorrhage","volume":"30","author":"Zazulia","year":"1999","journal-title":"Stroke"},{"key":"10.1074\/jbc.RA118.001858_bib7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/jnnp-2012-303160","article-title":"Volume-dependent effect of perihaematomal oedema on outcome for spontaneous intracerebral haemorrhages","volume":"84","author":"Appelboom","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1074\/jbc.RA118.001858_bib8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/STROKEAHA.114.007154","article-title":"Prognostic significance of perihematomal edema in acute intracerebral hemorrhage: pooled analysis from the intensive blood pressure reduction in acute cerebral hemorrhage trial studies","volume":"46","author":"Yang","year":"2015","journal-title":"Stroke"},{"key":"10.1074\/jbc.RA118.001858_bib9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.RA118.001858_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrm2085","article-title":"Illuminating the silence: understanding the structure and function of small RNAs","volume":"8","author":"Rana","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.RA118.001858_bib11","article-title":"Circulating microRNAs as specific biomarkers for breast cancer detection","volume":"8","author":"Ng","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA118.001858_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.vph.2011.08.001","article-title":"microRNAs as peripheral blood biomarkers of cardiovascular disease","volume":"55","author":"Di Stefano","year":"2011","journal-title":"Vascul. Pharmacol"},{"key":"10.1074\/jbc.RA118.001858_bib13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/jcbfm.2009.186","article-title":"Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures","volume":"30","author":"Liu","year":"2010","journal-title":"J. Cereb. Blood Flow Metab"},{"key":"10.1074\/jbc.RA118.001858_bib14","article-title":"Association of altered serum microRNAs with perihematomal edema after acute intracerebral hemorrhage","volume":"10","author":"Zhu","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA118.001858_bib15","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3171\/2016.1.JNS151454","article-title":"miRNA expression profiling of cerebrospinal fluid in patients with aneurysmal subarachnoid hemorrhage","volume":"126","author":"Stylli","year":"2017","journal-title":"J. Neurosurg"},{"key":"10.1074\/jbc.RA118.001858_bib16","doi-asserted-by":"crossref","first-page":"E861","DOI":"10.3390\/ijms17060861","article-title":"Aquaporin-11 (AQP11) expression in the mouse brain","volume":"17","author":"Koike","year":"2016","journal-title":"Int. J. Mol. Sci"},{"key":"10.1074\/jbc.RA118.001858_bib17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.bbrc.2017.05.040","article-title":"MicroRNA-27a reduces mutant hutingtin aggregation in an in vitro model of Huntington's disease","volume":"488","author":"Ban","year":"2017","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA118.001858_bib18","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.bbrc.2016.12.001","article-title":"Neuroprotective effects of miR-27a against traumatic brain injury via suppressing FoxO3a-mediated neuronal autophagy","volume":"482","author":"Sun","year":"2017","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA118.001858_bib19","doi-asserted-by":"crossref","first-page":"10055","DOI":"10.1523\/JNEUROSCI.1260-14.2014","article-title":"Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins","volume":"34","author":"Sabirzhanov","year":"2014","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA118.001858_bib20","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/aps.2018.30","article-title":"miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges","volume":"39","author":"Zhou","year":"2018","journal-title":"Acta Pharmacol. Sin"},{"key":"10.1074\/jbc.RA118.001858_bib21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.phrs.2017.10.002","article-title":"Circulating miRNAs in nontumoral liver diseases","volume":"128","author":"do Amaral","year":"2018","journal-title":"Pharmacol. Res"},{"key":"10.1074\/jbc.RA118.001858_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/CIRCGENETICS.110.957415","article-title":"Circulating microRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease","volume":"3","author":"Corsten","year":"2010","journal-title":"Circ. Cardiovasc. Genet"},{"key":"10.1074\/jbc.RA118.001858_bib23","first-page":"133","article-title":"Brain edema: a classification based on blood-brain barrier integrity","volume":"1","author":"Betz","year":"1989","journal-title":"Cerebrovasc. Brain Metab. Rev"},{"key":"10.1074\/jbc.RA118.001858_bib24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3171\/jns.1994.81.1.0093","article-title":"Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats","volume":"81","author":"Yang","year":"1994","journal-title":"J. Neurosurg"},{"key":"10.1074\/jbc.RA118.001858_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0006-8993(00)02427-6","article-title":"Acute inflammatory reaction following experimental intracerebral hemorrhage in rat","volume":"871","author":"Gong","year":"2000","journal-title":"Brain Res"},{"key":"10.1074\/jbc.RA118.001858_bib26","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/ana.10750","article-title":"Protective role of tuftsin fragment 1\u20133 in an animal model of intracerebral hemorrhage","volume":"54","author":"Wang","year":"2003","journal-title":"Ann. Neurol"},{"key":"10.1074\/jbc.RA118.001858_bib27","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/cdd.2014.198","article-title":"miR-23a, miR-24 and miR-27a protect differentiating ESCs from BMP4-induced apoptosis","volume":"22","author":"Musto","year":"2015","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.RA118.001858_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.92","article-title":"MicroRNA-23a\/b and microRNA-27a\/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis","volume":"5","author":"Chen","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1074\/jbc.RA118.001858_bib29","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/cvr\/cvn156","article-title":"Role of microRNAs in vascular diseases, inflammation, and angiogenesis","volume":"79","author":"Urbich","year":"2008","journal-title":"Cardiovasc. Res"},{"key":"10.1074\/jbc.RA118.001858_bib30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","article-title":"The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis","volume":"15","author":"Wang","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.RA118.001858_bib31","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1182\/blood-2010-01-264812","article-title":"Members of the microRNA-17\u201392 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells","volume":"115","author":"Doebele","year":"2010","journal-title":"Blood"},{"key":"10.1074\/jbc.RA118.001858_bib32","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood-2011-08-373886","article-title":"MicroRNA-27a\/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A","volume":"119","author":"Urbich","year":"2012","journal-title":"Blood"},{"key":"10.1074\/jbc.RA118.001858_bib33","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1182\/blood-2012-12-473017","article-title":"Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27","volume":"122","author":"Young","year":"2013","journal-title":"Blood"},{"key":"10.1074\/jbc.RA118.001858_bib34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13578-018-0211-9","article-title":"Function of aquaporins in sepsis: a systematic review","volume":"8","author":"Rump","year":"2018","journal-title":"Cell Biosci"},{"key":"10.1074\/jbc.RA118.001858_bib35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jsb.2011.01.003","article-title":"Water permeability and characterization of aquaporin-11","volume":"174","author":"Yakata","year":"2011","journal-title":"J. Struct. Biol"},{"key":"10.1074\/jbc.RA118.001858_bib36","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1074\/jbc.M110.180968","article-title":"The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function","volume":"286","author":"Ikeda","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.001858_bib37","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1002\/oby.20792","article-title":"Human aquaporin-11 is a water and glycerol channel and localizes in the vicinity of lipid droplets in human adipocytes","volume":"22","author":"Madeira","year":"2014","journal-title":"Obesity"},{"key":"10.1074\/jbc.RA118.001858_bib38","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/01.STR.21.5.801","article-title":"Collagenase-induced intracerebral hemorrhage in rats","volume":"21","author":"Rosenberg","year":"1990","journal-title":"Stroke"},{"key":"10.1074\/jbc.RA118.001858_bib39","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbrc.2017.10.064","article-title":"MicroRNA-126\u20133p attenuates blood-brain barrier disruption, cerebral edema and neuronal injury following intracerebral hemorrhage by regulating PIK3R2 and Akt","volume":"494","author":"Xi","year":"2017","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA118.001858_bib40","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1161\/01.STR.26.4.644","article-title":"Environment influences functional outcome of cerebral infarction in rats","volume":"26","author":"Ohlsson","year":"1995","journal-title":"Stroke"},{"key":"10.1074\/jbc.RA118.001858_bib41","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s12035-013-8396-8","article-title":"Astrocyte-derived sonic hedgehog contributes to angiogenesis in brain microvascular endothelial cells via RhoA\/ROCK pathway after oxygen-glucose deprivation","volume":"47","author":"He","year":"2013","journal-title":"Mol. Neurobiol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820318810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820318810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA118.001858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T04:39:58Z","timestamp":1641271198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820318810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":41,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0021925820318810"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra118.001858","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-27a-3p protects against blood\u2013brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA118.001858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Xi et al.","name":"copyright","label":"Copyright"}]}}