{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:51:40Z","timestamp":1773265900352,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"34","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":758,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL082511"],"award-info":[{"award-number":["HL082511"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL082511"],"award-info":[{"award-number":["HL082511"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS095359"],"award-info":[{"award-number":["NS095359"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS077897"],"award-info":[{"award-number":["NS077897"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","award":["Sanofi Innovation Awards Program (iAwards)"],"award-info":[{"award-number":["Sanofi Innovation Awards Program (iAwards)"]}],"id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1074\/jbc.ra118.002405","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T13:35:37Z","timestamp":1529328937000},"page":"13338-13348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-Val66Met variant"],"prefix":"10.1016","volume":"293","author":[{"given":"Jiwon","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keun Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunghee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA118.002405_bib1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1590\/0004-2730000003223","article-title":"Obesity, insulin resistance and comorbidities? Mechanisms of association","volume":"58","author":"Castro","year":"2014","journal-title":"Arq. Bras. Endocrinol. Metabol"},{"key":"10.1074\/jbc.RA118.002405_bib2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI10842","article-title":"Obesity and insulin resistance","volume":"106","author":"Kahn","year":"2000","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA118.002405_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2337\/diacare.14.3.173","article-title":"Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease","volume":"14","author":"DeFronzo","year":"1991","journal-title":"Diabetes Care"},{"key":"10.1074\/jbc.RA118.002405_bib4","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1161\/hc4601.099487","article-title":"Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization","volume":"104","author":"Yusuf","year":"2001","journal-title":"Circulation"},{"key":"10.1074\/jbc.RA118.002405_bib5","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0140-6736(98)07019-6","article-title":"Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)","volume":"352","year":"1998","journal-title":"Lancet"},{"key":"10.1074\/jbc.RA118.002405_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0168-8227(95)01064-K","article-title":"Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study","volume":"28","author":"Ohkubo","year":"1995","journal-title":"Diabetes Res. Clin. Pract"},{"key":"10.1074\/jbc.RA118.002405_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study","volume":"321","author":"Stratton","year":"2000","journal-title":"BMJ"},{"key":"10.1074\/jbc.RA118.002405_bib8","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00134-015-3757-6","article-title":"Intensive versus conventional glucose control in critically ill patients with traumatic brain injury: long-term follow-up of a subgroup of patients from the NICE-SUGAR study","volume":"41","author":"Finfer","year":"2015","journal-title":"Intensive Care Med"},{"key":"10.1074\/jbc.RA118.002405_bib9","doi-asserted-by":"crossref","first-page":"23654","DOI":"10.1074\/jbc.M116.750018","article-title":"Cell surface CD36 protein in monocyte\/macrophage contributes to phagocytosis during the resolution phase of ischemic stroke in mice","volume":"291","author":"Woo","year":"2016","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.002405_bib10","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI14006","article-title":"CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism","volume":"108","author":"Febbraio","year":"2001","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA118.002405_bib11","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1172\/JCI25299","article-title":"CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions","volume":"115","author":"Laugerette","year":"2005","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA118.002405_bib12","doi-asserted-by":"crossref","first-page":"e24014","DOI":"10.1371\/journal.pone.0024014","article-title":"The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference","volume":"6","author":"Martin","year":"2011","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA118.002405_bib13","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1432-1033.1996.0368z.x","article-title":"Localization and regulation of the putative membrane fatty-acid transporter (FAT) in the small intestine: comparison with fatty acid-binding proteins (FABP)","volume":"238","author":"Poirier","year":"1996","journal-title":"Eur. J. Biochem"},{"key":"10.1074\/jbc.RA118.002405_bib14","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1038\/nutd.2013.1","article-title":"The origin of circulating CD36 in type 2 diabetes","volume":"3","author":"Alkhatatbeh","year":"2013","journal-title":"Nutr. Diabetes"},{"key":"10.1074\/jbc.RA118.002405_bib15","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1210\/jc.2009-2002","article-title":"Soluble CD36 (sCD36) clusters with markers of insulin resistance, and high sCD36 is associated with increased type 2 diabetes risk","volume":"95","author":"Handberg","year":"2010","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.RA118.002405_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fnins.2013.00037","article-title":"Molecular and neural bases underlying roles of BDNF in the control of body weight","volume":"7","author":"Vanevski","year":"2013","journal-title":"Front. Neurosci"},{"key":"10.1074\/jbc.RA118.002405_bib17","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/emboj\/19.6.1290","article-title":"BDNF regulates eating behavior and locomotor activity in mice","volume":"19","author":"Kernie","year":"2000","journal-title":"EMBO J"},{"key":"10.1074\/jbc.RA118.002405_bib18","doi-asserted-by":"crossref","first-page":"15239","DOI":"10.1073\/pnas.96.26.15239","article-title":"Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities","volume":"96","author":"Lyons","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA118.002405_bib19","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1210\/mend.15.10.0706","article-title":"Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity","volume":"15","author":"Rios","year":"2001","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.RA118.002405_bib20","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.2337\/db06-0550","article-title":"Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene","volume":"55","author":"Gray","year":"2006","journal-title":"Diabetes"},{"key":"10.1074\/jbc.RA118.002405_bib21","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nn1336","article-title":"A de novo mutation affecting human TrkB associated with severe obesity and developmental delay","volume":"7","author":"Yeo","year":"2004","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.RA118.002405_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3325\/cmj.2009.50.43","article-title":"Ethnic differences in brain-derived neurotrophic factor Val66Met polymorphism in Croatian and Korean healthy participants","volume":"50","author":"Pivac","year":"2009","journal-title":"Croat. Med. J"},{"key":"10.1074\/jbc.RA118.002405_bib23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0006-3223(03)00181-1","article-title":"Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants","volume":"54","author":"Shimizu","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1074\/jbc.RA118.002405_bib24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ymgme.2008.06.008","article-title":"Association of the BDNF Val66Met variation with obesity in women","volume":"95","author":"Beckers","year":"2008","journal-title":"Mol. Genet. Metab"},{"key":"10.1074\/jbc.RA118.002405_bib25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.pnpbp.2011.08.003","article-title":"Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents","volume":"36","author":"Skledar","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1074\/jbc.RA118.002405_bib26","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.celrep.2015.09.065","article-title":"Human obesity associated with an intronic SNP in the brain-derived neurotrophic factor locus","volume":"13","author":"Mou","year":"2015","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.RA118.002405_bib27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","article-title":"The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function","volume":"112","author":"Egan","year":"2003","journal-title":"Cell"},{"key":"10.1074\/jbc.RA118.002405_bib28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1126\/science.1129663","article-title":"Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior","volume":"314","author":"Chen","year":"2006","journal-title":"Science"},{"key":"10.1074\/jbc.RA118.002405_bib29","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1523\/JNEUROSCI.4140-13.2014","article-title":"An adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke","volume":"34","author":"Qin","year":"2014","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA118.002405_bib30","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.atherosclerosis.2012.05.006","article-title":"Salvianolic acid B inhibits macrophage uptake of modified low density lipoprotein (mLDL) in a scavenger receptor CD36-dependent manner","volume":"223","author":"Bao","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.RA118.002405_bib31","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.RA118.002405_bib32","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and insulin resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA118.002405_bib33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/1087057109359686","article-title":"Discovery of antagonists for human scavenger receptor CD36 via an ELISA-like high-throughput screening assay","volume":"15","author":"Wang","year":"2010","journal-title":"J. Biomol. Screen"},{"key":"10.1074\/jbc.RA118.002405_bib34","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/cvr\/cvq360","article-title":"A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling","volume":"89","author":"Kennedy","year":"2011","journal-title":"Cardiovasc. Res"},{"key":"10.1074\/jbc.RA118.002405_bib35","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/oby.20354","article-title":"CD36 is important for adipocyte recruitment and affects lipolysis","volume":"21","author":"Vroegrijk","year":"2013","journal-title":"Obesity"},{"key":"10.1074\/jbc.RA118.002405_bib36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12877-016-0393-0","article-title":"Potential unfavorable impacts of BDNF Val66Met polymorphisms on metabolic risks in average population in a longevous area","volume":"17","author":"Peng","year":"2017","journal-title":"BMC Geriatr"},{"key":"10.1074\/jbc.RA118.002405_bib37","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrendo.2009.166","article-title":"Influence of menopause on diabetes and diabetes risk","volume":"5","author":"Szmuilowicz","year":"2009","journal-title":"Nat. Rev. Endocrinol"},{"key":"10.1074\/jbc.RA118.002405_bib38","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1530\/EJE-09-0151","article-title":"Hormone therapy protects from diabetes: the Kuopio osteoporosis risk factor and prevention study","volume":"160","author":"Pentti","year":"2009","journal-title":"Eur. J. Endocrinol"},{"key":"10.1074\/jbc.RA118.002405_bib39","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1172\/JCI118173","article-title":"Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet","volume":"96","author":"Greenwalt","year":"1995","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA118.002405_bib40","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/89969","article-title":"A link between diabetes and atherosclerosis: glucose regulates expression of CD36 at the level of translation","volume":"7","author":"Griffin","year":"2001","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA118.002405_bib41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0021-9150(02)00421-5","article-title":"Increased expression of a scavenger receptor (CD36) in monocytes from subjects with Type 2 diabetes","volume":"167","author":"Sampson","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.RA118.002405_bib42","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1523\/JNEUROSCI.4547-10.2011","article-title":"Genetic variant of BDNF (Val66Met) polymorphism attenuates stroke-induced angiogenic responses by enhancing anti-angiogenic mediator CD36 expression","volume":"31","author":"Qin","year":"2011","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA118.002405_bib43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0092-8674(00)81574-3","article-title":"Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR\u03b3","volume":"93","author":"Nagy","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.RA118.002405_bib44","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0092-8674(00)81575-5","article-title":"PPAR\u03b3 promotes monocyte\/macrophage differentiation and uptake of oxidized LDL","volume":"93","author":"Tontonoz","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.RA118.002405_bib45","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2337\/dc12-0210","article-title":"Understanding and addressing unique needs of diabetes in Asian Americans, native Hawaiians, and Pacific Islanders","volume":"35","author":"King","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1074\/jbc.RA118.002405_bib46","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00125-003-1158-9","article-title":"Age, body mass index and Type 2 diabetes-associations modified by ethnicity","volume":"46","author":"Nakagami","year":"2003","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.RA118.002405_bib47","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0140-6736(09)60937-5","article-title":"Diabetes in Asia","volume":"375","author":"Ramachandran","year":"2010","journal-title":"Lancet"},{"key":"10.1074\/jbc.RA118.002405_bib48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2337\/dc14-2391","article-title":"BMI cut points to identify at-risk Asian Americans for type 2 diabetes screening","volume":"38","author":"Hsu","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1074\/jbc.RA118.002405_bib49","doi-asserted-by":"crossref","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820310395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820310395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA118.002405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T13:45:02Z","timestamp":1619876702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820310395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":49,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0021925820310395"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra118.002405","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-Val66Met variant","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA118.002405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Yang et al.","name":"copyright","label":"Copyright"}]}}