{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:57:08Z","timestamp":1790229428150,"version":"4.1.0"},"reference-count":111,"publisher":"Elsevier BV","issue":"38","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":718,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute (NCI)","doi-asserted-by":"publisher","award":["CA174713"],"award-info":[{"award-number":["CA174713"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["DK103645"],"award-info":[{"award-number":["DK103645"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007408","name":"Pitt | Medical Center, University of Pittsburgh (University of Pittsburgh Medical Center)","doi-asserted-by":"publisher","award":["The Clinical Scientist Training Program"],"award-info":[{"award-number":["The Clinical Scientist Training Program"]}],"id":[{"id":"10.13039\/100007408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1074\/jbc.ra118.004099","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T10:05:26Z","timestamp":1533809126000},"page":"14740-14757","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice"],"prefix":"10.1016","volume":"293","author":[{"given":"Huabo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Dolezal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sucheta","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Mandel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Alencastro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward V.","family":"Prochownik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA118.004099_bib1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1128\/MCB.01186-10","article-title":"Role of helix-loop-helix proteins during differentiation of erythroid cells","volume":"31","author":"Anantharaman","year":"2011","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA118.004099_bib2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1615\/CritRevImmunol.v32.i4.30","article-title":"The role of the proto-oncogene c-myc in B lymphocyte differentiation","volume":"32","author":"Fernandez","year":"2012","journal-title":"Crit. Rev. Immunol"},{"key":"10.1074\/jbc.RA118.004099_bib3","doi-asserted-by":"crossref","first-page":"E151","DOI":"10.3390\/genes8060151","article-title":"MYC deregulation in primary human cancers","volume":"8","author":"Kalkat","year":"2017","journal-title":"Genes"},{"key":"10.1074\/jbc.RA118.004099_bib4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.scr.2016.02.005","article-title":"The role of pluripotency factors to drive stemness in gastrointestinal cancer","volume":"16","author":"M\u00fcller","year":"2016","journal-title":"Stem Cell Res"},{"key":"10.1074\/jbc.RA118.004099_bib5","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1038\/sj.onc.1202746","article-title":"MYC oncogenes and human neoplastic disease","volume":"18","author":"Nesbit","year":"1999","journal-title":"Oncogene"},{"key":"10.1074\/jbc.RA118.004099_bib6","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3934\/biophy.2015.4.794","article-title":"The interplay of long non-coding RNAs and MYC in cancer","volume":"2","author":"Hamilton","year":"2015","journal-title":"AIMS Biophys"},{"key":"10.1074\/jbc.RA118.004099_bib7","doi-asserted-by":"crossref","first-page":"12543","DOI":"10.18632\/oncotarget.3033","article-title":"MYC regulates the non-coding transcriptome","volume":"5","author":"Hart","year":"2014","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.RA118.004099_bib8","doi-asserted-by":"crossref","first-page":"E1497","DOI":"10.3390\/ijms18071497","article-title":"lncRNAs and MYC: an intricate relationship","volume":"18","author":"Iaccarino","year":"2017","journal-title":"Int. J. Mol. Sci"},{"key":"10.1074\/jbc.RA118.004099_bib9","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bbagrm.2014.04.003","article-title":"MicroRNAs as regulators and mediators of c-MYC function","volume":"1849","author":"Jackstadt","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA118.004099_bib10","doi-asserted-by":"crossref","first-page":"a014233","DOI":"10.1101\/cshperspect.a014233","article-title":"Cellular MYCro economics: balancing MYC function with MYC expression","volume":"3","author":"Levens","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"10.1074\/jbc.RA118.004099_bib11","doi-asserted-by":"crossref","first-page":"a014233","DOI":"10.1101\/cshperspect.a014175","article-title":"MYC and the art of microRNA maintenance","volume":"4","author":"Psathas","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"10.1074\/jbc.RA118.004099_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/cas.12085","article-title":"Cancer metabolism: key players in metabolic reprogramming","volume":"104","author":"Soga","year":"2013","journal-title":"Cancer Sci"},{"key":"10.1074\/jbc.RA118.004099_bib13","doi-asserted-by":"crossref","first-page":"26241","DOI":"10.1074\/jbc.M116.754218","article-title":"Coordinated activities of multiple Myc-dependent and Myc-independent biosynthetic pathways in hepatoblastoma","volume":"291","author":"Wang","year":"2016","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004099_bib14","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/bjc.2015.360","article-title":"Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis","volume":"113","author":"Wilde","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1074\/jbc.RA118.004099_bib15","doi-asserted-by":"crossref","first-page":"E118","DOI":"10.3390\/genes8040118","article-title":"Controlling the master: chromatin dynamics at the MYC promoter integrate developmental signaling","volume":"8","author":"Zaytseva","year":"2017","journal-title":"Genes"},{"key":"10.1074\/jbc.RA118.004099_bib16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1101\/gad.7.4.671","article-title":"A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice","volume":"7","author":"Davis","year":"1993","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.RA118.004099_bib17","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1242\/dev.022707","article-title":"Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function","volume":"135","author":"Dubois","year":"2008","journal-title":"Development"},{"key":"10.1074\/jbc.RA118.004099_bib18","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/414768a","article-title":"c-Myc regulates mammalian body size by controlling cell number but not cell size","volume":"414","author":"Trumpp","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.RA118.004099_bib19","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nature07260","article-title":"Modelling Myc inhibition as a cancer therapy","volume":"455","author":"Soucek","year":"2008","journal-title":"Nature"},{"key":"10.1074\/jbc.RA118.004099_bib20","doi-asserted-by":"crossref","first-page":"7286","DOI":"10.1073\/pnas.0409260102","article-title":"c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver","volume":"102","author":"Baena","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA118.004099_bib21","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1158\/0008-5472.CAN-05-4242","article-title":"Conditional deletion of c-myc does not impair liver regeneration","volume":"66","author":"Li","year":"2006","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.RA118.004099_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jhep.2013.09.024","article-title":"Role of Myc in hepatocellular proliferation and hepatocarcinogenesis","volume":"60","author":"Qu","year":"2014","journal-title":"J. Hepatol"},{"key":"10.1074\/jbc.RA118.004099_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6793-12-1","article-title":"Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion","volume":"12","author":"Sanders","year":"2012","journal-title":"BMC Physiol"},{"key":"10.1074\/jbc.RA118.004099_bib24","doi-asserted-by":"crossref","first-page":"e1000385","DOI":"10.1371\/journal.pgen.1000385","article-title":"Ploidy reductions in murine fusion-derived hepatocytes","volume":"5","author":"Duncan","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA118.004099_bib25","doi-asserted-by":"crossref","first-page":"30379","DOI":"10.18632\/oncotarget.8856","article-title":"Abnormal lipid processing but normal long-term repopulation potential of myc\u2212\/\u2212 hepatocytes","volume":"7","author":"Edmunds","year":"2016","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.RA118.004099_bib26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ng0895-453","article-title":"Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I","volume":"10","author":"Grompe","year":"1995","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.RA118.004099_bib27","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1053\/j.gastro.2014.05.004","article-title":"Activation of \u03b2-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice","volume":"147","author":"Tao","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.RA118.004099_bib28","first-page":"2668","article-title":"L-Myc cooperates with Ras to transform primary rat embryo fibroblasts","volume":"8","author":"Birrer","year":"1988","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA118.004099_bib29","first-page":"3130","article-title":"Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells","volume":"12","author":"Barrett","year":"1992","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA118.004099_bib30","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1128\/MCB.21.3.691-702.2001","article-title":"The Max network gone mad","volume":"21","author":"Baudino","year":"2001","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA118.004099_bib31","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1146\/annurev.cellbio.16.1.653","article-title":"The Myc\/Max\/Mad network and the transcriptional control of cell behavior","volume":"16","author":"Grandori","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol"},{"key":"10.1074\/jbc.RA118.004099_bib32","first-page":"255","article-title":"The Mlx network: evidence for a parallel Max-like transcriptional network that regulates energy metabolism","volume":"302","author":"Billin","year":"2006","journal-title":"Curr. Top. Microbiol. Immunol"},{"key":"10.1074\/jbc.RA118.004099_bib33","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/gbe\/evr082","article-title":"Evolution of the Max and Mlx networks in animals","volume":"3","author":"McFerrin","year":"2011","journal-title":"Genome Biol. Evol"},{"key":"10.1074\/jbc.RA118.004099_bib34","doi-asserted-by":"crossref","first-page":"a014258","DOI":"10.1101\/cshperspect.a014258","article-title":"Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks","volume":"3","author":"O'Shea","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"10.1074\/jbc.RA118.004099_bib35","doi-asserted-by":"crossref","first-page":"14878","DOI":"10.1073\/pnas.0901221106","article-title":"Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity","volume":"106","author":"Kaadige","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA118.004099_bib36","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.2741\/3848","article-title":"An extended Myc network contributes to glucose homeostasis in cancer and diabetes","volume":"16","author":"Peterson","year":"2011","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1074\/jbc.RA118.004099_bib37","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1210\/en.2014-1666","article-title":"Genome-wide analysis of ChREBP binding sites on male mouse liver and white adipose chromatin","volume":"156","author":"Poungvarin","year":"2015","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.RA118.004099_bib38","doi-asserted-by":"crossref","first-page":"21991","DOI":"10.1074\/jbc.270.37.21991","article-title":"Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription","volume":"270","author":"Shih","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004099_bib39","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.bbagrm.2014.05.016","article-title":"Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis","volume":"1849","author":"Diolaiti","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA118.004099_bib40","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1210\/me.2009-0437","article-title":"c-Myc is required for the CHREBP-dependent activation of glucose-responsive genes","volume":"24","author":"Zhang","year":"2010","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.RA118.004099_bib41","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ceb.2017.12.007","article-title":"Sugar sensing by ChREBP\/Mondo-Mlx-new insight into downstream regulatory networks and integration of nutrient-derived signals","volume":"51","author":"Havula","year":"2018","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1074\/jbc.RA118.004099_bib42","doi-asserted-by":"crossref","first-page":"15597","DOI":"10.1073\/pnas.0405238101","article-title":"Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription","volume":"101","author":"Ishii","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA118.004099_bib43","doi-asserted-by":"crossref","first-page":"e22544","DOI":"10.1371\/journal.pone.0022544","article-title":"Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression","volume":"6","author":"Jeong","year":"2011","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA118.004099_bib44","doi-asserted-by":"crossref","first-page":"12019","DOI":"10.1074\/jbc.M413063200","article-title":"Direct role of ChREBP: Mlx in regulating hepatic glucose-responsive genes","volume":"280","author":"Ma","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004099_bib45","doi-asserted-by":"crossref","first-page":"28721","DOI":"10.1074\/jbc.M601576200","article-title":"ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver","volume":"281","author":"Ma","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004099_bib46","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1128\/MCB.00657-05","article-title":"MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis","volume":"26","author":"Sans","year":"2006","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA118.004099_bib47","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1073\/pnas.0712199105","article-title":"Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression","volume":"105","author":"Stoltzman","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA118.004099_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.nutr.27.061406.093618","article-title":"ChREBP, a transcriptional regulator of glucose and lipid metabolism","volume":"27","author":"Postic","year":"2007","journal-title":"Annu. Rev. Nutr"},{"key":"10.1074\/jbc.RA118.004099_bib49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cmet.2006.06.008","article-title":"Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis","volume":"4","author":"Uyeda","year":"2006","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.RA118.004099_bib50","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF00710049","article-title":"Tyrosinaemia\u2013treatment and outcome","volume":"18","author":"Kvittingen","year":"1995","journal-title":"J. Inherit. Metab. Dis"},{"key":"10.1074\/jbc.RA118.004099_bib51","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1158\/0008-5472.CAN-17-1325","article-title":"Genetic dissociation of glycolysis and the TCA cycle affects neither normal nor neoplastic proliferation","volume":"77","author":"Jackson","year":"2017","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.RA118.004099_bib52","first-page":"266","article-title":"Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat","volume":"12","author":"Overturf","year":"1996","journal-title":"Genet"},{"key":"10.1074\/jbc.RA118.004099_bib53","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00441-014-1800-5","article-title":"Cell turnover in the repopulated rat liver: distinct lineages for hepatocytes and the biliary epithelium","volume":"356","author":"Marongiu","year":"2014","journal-title":"Cell Tissue Res"},{"key":"10.1074\/jbc.RA118.004099_bib54","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.cub.2012.05.016","article-title":"Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration","volume":"22","author":"Miyaoka","year":"2012","journal-title":"Curr. Biol"},{"key":"10.1074\/jbc.RA118.004099_bib55","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0304-3835(95)03790-4","article-title":"The potential for the use of cell proliferation and oncogene expression as intermediate markers during liver carcinogenesis","volume":"93","author":"Mehta","year":"1995","journal-title":"Cancer Lett"},{"key":"10.1074\/jbc.RA118.004099_bib56","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/01.pas.0000183572.94140.43","article-title":"Two mitosis-specific antibodies, MPM-2 and phospho-histone H3 (Ser28), allow rapid and precise determination of mitotic activity","volume":"30","author":"Tapia","year":"2006","journal-title":"Am. J. Surg. Pathol"},{"key":"10.1074\/jbc.RA118.004099_bib57","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1128\/MCB.22.16.5793-5800.2002","article-title":"A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism","volume":"22","author":"Nikiforov","year":"2002","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA118.004099_bib58","doi-asserted-by":"crossref","first-page":"18968","DOI":"10.1073\/pnas.0507902102","article-title":"Deregulation of common genes by c-Myc and its direct target, MT-MC1","volume":"102","author":"Rogulski","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA118.004099_bib59","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1158\/0008-5472.CAN-04-2928","article-title":"C-Myc-independent restoration of multiple phenotypes by two C-Myc target genes with overlapping functions","volume":"65","author":"Rothermund","year":"2005","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.RA118.004099_bib60","doi-asserted-by":"crossref","first-page":"19998","DOI":"10.1074\/jbc.M200860200","article-title":"Myc target in myeloid cells-1, a novel c-Myc target, recapitulates multiple c-Myc phenotypes","volume":"277","author":"Yin","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004099_bib61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybidization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA118.004099_bib62","first-page":"2734","article-title":"A transfected L-myc gene can substitute for c-myc in blocking murine erythroleukemia differentiation","volume":"9","author":"Birrer","year":"1989","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA118.004099_bib63","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ccell.2014.11.024","article-title":"Deregulated Myc requires MondoA\/Mlx for metabolic reprogramming and tumorigenesis","volume":"27","author":"Carroll","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.RA118.004099_bib64","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1038\/sj.onc.1202748","article-title":"The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation","volume":"18","author":"Cole","year":"1999","journal-title":"Oncogene"},{"key":"10.1074\/jbc.RA118.004099_bib65","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1101\/gad.14.11.1390","article-title":"N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation","volume":"14","author":"Malynn","year":"2000","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.RA118.004099_bib66","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1507\/endocrj.K07E-110","article-title":"ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome","volume":"55","author":"Iizuka","year":"2008","journal-title":"Endocr. J"},{"key":"10.1074\/jbc.RA118.004099_bib67","doi-asserted-by":"crossref","first-page":"e0147411","DOI":"10.1371\/journal.pone.0147411","article-title":"ChREBP regulates itself and metabolic genes implicated in lipid accumulation in \u03b2-cell line","volume":"11","author":"Sae-Lee","year":"2016","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA118.004099_bib68","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.nut.2015.01.005","article-title":"ChREBP binding and histone modifications modulate hepatic expression of the Fasn gene in a metabolic syndrome rat model","volume":"31","author":"Suzuki","year":"2015","journal-title":"Nutrition"},{"key":"10.1074\/jbc.RA118.004099_bib69","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1210\/EN.2015-1209","article-title":"The glucose sensor ChREBP links de novo lipogenesis to PPAR\u03b3 activity and adipocyte differentiation","volume":"156","author":"Witte","year":"2015","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.RA118.004099_bib70","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1158\/1078-0432.CCR-09-0889","article-title":"MYC-induced cancer cell energy metabolism and therapeutic opportunities","volume":"15","author":"Dang","year":"2009","journal-title":"Clin. Cancer Res"},{"key":"10.1074\/jbc.RA118.004099_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2018.00129","article-title":"The role for Myc in coordinating glycolysis, oxidative phosphorylation, glutaminolysis, and fatty acid metabolism in normal and neoplastic tissues","volume":"9","author":"Goetzman","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1074\/jbc.RA118.004099_bib72","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s00018-015-1840-3","article-title":"Dysregulated glycolysis as an oncogenic event","volume":"72","author":"Mikawa","year":"2015","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.RA118.004099_bib73","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ccr.2012.02.014","article-title":"Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate","volume":"21","author":"Ward","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.RA118.004099_bib74","doi-asserted-by":"crossref","first-page":"e10769","DOI":"10.7554\/eLife.10769","article-title":"Mitochondrial DNA copy number variation across human cancers","volume":"5","author":"Reznik","year":"2016","journal-title":"ELife"},{"key":"10.1074\/jbc.RA118.004099_bib75","doi-asserted-by":"crossref","first-page":"10068","DOI":"10.1074\/jbc.M117.782052","article-title":"Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma","volume":"292","author":"Dolezal","year":"2017","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004099_bib76","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/MCO.0b013e328042ba90","article-title":"Free fatty acids and insulin resistance","volume":"10","author":"Delarue","year":"2007","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1074\/jbc.RA118.004099_bib77","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bbrc.2016.08.061","article-title":"Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c","volume":"478","author":"Bae","year":"2016","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA118.004099_bib78","doi-asserted-by":"crossref","first-page":"10028","DOI":"10.1074\/jbc.M208312200","article-title":"Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding","volume":"278","author":"Kassam","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004099_bib79","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbadis.2017.10.003","article-title":"Farnesoid X receptor: a \u201chomeostat\u201d for hepatic nutrient metabolism","volume":"1864","author":"Massafra","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA118.004099_bib80","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1677\/JOE-09-0271","article-title":"Liver X receptor in cholesterol metabolism","volume":"204","author":"Zhao","year":"2010","journal-title":"J. Endocrinol"},{"key":"10.1074\/jbc.RA118.004099_bib81","doi-asserted-by":"crossref","first-page":"16615","DOI":"10.1074\/jbc.R114.563148","article-title":"The pyruvate dehydrogenase complexes: structure-based function and regulation","volume":"289","author":"Patel","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004099_bib82","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0098-2997(98)00003-X","article-title":"Lipid metabolism in peroxisomes in relation to human disease","volume":"19","author":"Wanders","year":"1998","journal-title":"Mol. Aspects Med"},{"key":"10.1074\/jbc.RA118.004099_bib83","doi-asserted-by":"crossref","first-page":"44876","DOI":"10.1038\/srep44876","article-title":"Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma","volume":"7","author":"Arseneault","year":"2017","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA118.004099_bib84","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.1073\/pnas.1600420113","article-title":"Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression","volume":"113","author":"Komura","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA118.004099_bib85","doi-asserted-by":"crossref","first-page":"e974467","DOI":"10.4161\/23723556.2014.974467","article-title":"The PVT1-MYC duet in cancer","volume":"2","author":"Tseng","year":"2015","journal-title":"Mol. Cell. Oncol"},{"key":"10.1074\/jbc.RA118.004099_bib86","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/acel.12685","article-title":"Sirtuins at the crossroads of stemness, aging, and cancer","volume":"16","author":"O'Callaghan","year":"2017","journal-title":"Aging Cell"},{"key":"10.1074\/jbc.RA118.004099_bib87","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.molmed.2017.02.005","article-title":"Mitochondrial sirtuins and molecular mechanisms of aging","volume":"23","author":"van de Ven","year":"2017","journal-title":"Trends Mol. Med"},{"key":"10.1074\/jbc.RA118.004099_bib88","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.RA118.004099_bib89","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3390\/cancers3021605","article-title":"The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells","volume":"3","author":"Rushworth","year":"2011","journal-title":"Cancers"},{"key":"10.1074\/jbc.RA118.004099_bib90","doi-asserted-by":"crossref","first-page":"e0182705","DOI":"10.1371\/journal.pone.0182705","article-title":"Ribosomopathy-like properties of murine and human cancers","volume":"12","author":"Kulkarni","year":"2017","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA118.004099_bib91","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12885-018-4178-z","article-title":"Diagnostic and prognostic implications of ribosomal protein transcript expression patterns in human cancers","volume":"18","author":"Dolezal","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1074\/jbc.RA118.004099_bib92","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2174\/1566524033479537","article-title":"Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis","volume":"3","author":"Yu","year":"2003","journal-title":"Curr. Mol. Med"},{"key":"10.1074\/jbc.RA118.004099_bib93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00008571-199602000-00002","article-title":"P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature","volume":"6","author":"Nelson","year":"1996","journal-title":"Pharmacogenetics"},{"key":"10.1074\/jbc.RA118.004099_bib94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00008571-200401000-00001","article-title":"Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants","volume":"14","author":"Nelson","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1074\/jbc.RA118.004099_bib95","doi-asserted-by":"crossref","first-page":"20120431","DOI":"10.1098\/rstb.2012.0431","article-title":"Human cytochromes P450 in health and disease","volume":"368","author":"Nebert","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci"},{"key":"10.1074\/jbc.RA118.004099_bib96","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cell.2012.08.033","article-title":"c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells","volume":"151","author":"Nie","year":"2012","journal-title":"Cell"},{"key":"10.1074\/jbc.RA118.004099_bib97","doi-asserted-by":"crossref","first-page":"e97285","DOI":"10.1371\/journal.pone.0097285","article-title":"Targeting of the MYCN protein with small molecule c-MYC inhibitors","volume":"9","author":"M\u00fcller","year":"2014","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA118.004099_bib98","doi-asserted-by":"crossref","first-page":"15857","DOI":"10.18632\/oncotarget.4327","article-title":"Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.RA118.004099_bib99","doi-asserted-by":"crossref","first-page":"10258","DOI":"10.1073\/pnas.1222404110","article-title":"MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells","volume":"110","author":"Zirath","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA118.004099_bib100","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrg.2017.47","article-title":"Synthetic lethality and cancer","volume":"18","author":"O'Neil","year":"2017","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/jbc.RA118.004099_bib101","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/sj.cdd.4400701","article-title":"Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family","volume":"7","author":"Landay","year":"2000","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.RA118.004099_bib102","doi-asserted-by":"crossref","first-page":"fow081","DOI":"10.1093\/femsyr\/fow081","article-title":"Rethinking cell growth models","volume":"16","author":"Kafri","year":"2016","journal-title":"FEMS Yeast Res"},{"key":"10.1074\/jbc.RA118.004099_bib103","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.cell.2014.02.033","article-title":"Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources","volume":"157","author":"Li","year":"2014","journal-title":"Cell"},{"key":"10.1074\/jbc.RA118.004099_bib104","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.tig.2012.07.003","article-title":"Coordinating genome expression with cell size","volume":"28","author":"Marguerat","year":"2012","journal-title":"Trends Genet"},{"key":"10.1074\/jbc.RA118.004099_bib105","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1073\/pnas.90.3.960","article-title":"Differential patterns of DNA binding by myc and max proteins","volume":"90","author":"Prochownik","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA118.004099_bib106","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1101\/gad.10.4.447","article-title":"Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc","volume":"10","author":"Desbarats","year":"1996","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.RA118.004099_bib107","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1101\/gad.1067003","article-title":"Genomic targets of the human c-Myc protein","volume":"17","author":"Fernandez","year":"2003","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.RA118.004099_bib108","doi-asserted-by":"crossref","first-page":"e0180147","DOI":"10.1371\/journal.pone.0180147","article-title":"Sequence-specific DNA binding by MYC\/MAX to low-affinity non-E-box motifs","volume":"12","author":"Allevato","year":"2017","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA118.004099_bib109","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev-cellbio-100814-125346","article-title":"Translating the genome in time and space: specialized ribosomes, RNA regulons, and RNA-binding proteins","volume":"31","author":"Shi","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol"},{"key":"10.1074\/jbc.RA118.004099_bib110","doi-asserted-by":"crossref","first-page":"e223","DOI":"10.21769\/BioProtoc.223","article-title":"Measurement of liver triglyceride content","volume":"2","author":"Jouihan","year":"2012","journal-title":"Bio-protocol"},{"key":"10.1074\/jbc.RA118.004099_bib111","doi-asserted-by":"crossref","first-page":"e13717","DOI":"10.1371\/journal.pone.0013717","article-title":"Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts","volume":"5","author":"Graves","year":"2010","journal-title":"PLoS One"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820308711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820308711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA118.004099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T04:16:34Z","timestamp":1641269794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820308711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":111,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0021925820308711"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra118.004099","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA118.004099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Wang et al.","name":"copyright","label":"Copyright"}]}}