{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:49:00Z","timestamp":1785437340623,"version":"3.56.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:00:00Z","timestamp":1598659200000},"content-version":"vor","delay-in-days":606,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS National Institutes of Health","doi-asserted-by":"publisher","award":["CA153702"],"award-info":[{"award-number":["CA153702"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS National Institutes of Health","doi-asserted-by":"publisher","award":["HD076248"],"award-info":[{"award-number":["HD076248"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1074\/jbc.ra118.004143","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T09:43:47Z","timestamp":1542879827000},"page":"887-901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Inhibition of ezrin causes PKC\u03b1-mediated internalization of erbb2\/HER2 tyrosine kinase in breast cancer cells"],"prefix":"10.1016","volume":"294","author":[{"given":"Jaekwang","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungmin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonnam","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Dann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzin","family":"Takyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia V.","family":"Gefter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1905-1468","authenticated-orcid":false,"given":"Peter A.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Wysolmerski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA118.004143_bib1","series-title":"Incidence and Mortality Web-based Report. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute","article-title":"United States Cancer Statistics: 1999\u20132014","author":"U.S. Cancer Statistics Working Group","year":"2017"},{"key":"10.1074\/jbc.RA118.004143_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/nrclinonc.2011.177","article-title":"Treatment of HER2-positive breast cancer: current status and future perspectives","volume":"9","author":"Arteaga","year":"2011","journal-title":"Nat. Rev. Clin. Oncol"},{"key":"10.1074\/jbc.RA118.004143_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrc2127","article-title":"Insights from transgenic mouse models of ERBB2-induced breast cancer","volume":"7","author":"Ursini-Siegel","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.RA118.004143_bib4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ccr.2014.02.025","article-title":"ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics","volume":"25","author":"Arteaga","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.RA118.004143_bib5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ceb.2008.12.010","article-title":"ErbB receptors and signaling pathways in cancer","volume":"21","author":"Hynes","year":"2009","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1074\/jbc.RA118.004143_bib6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3390\/membranes4030424","article-title":"The mysterious ways of ErbB2\/HER2 trafficking","volume":"4","author":"Bertelsen","year":"2014","journal-title":"Membranes"},{"key":"10.1074\/jbc.RA118.004143_bib7","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1091\/mbc.e03-08-0596","article-title":"Association with membrane protrusions makes ErbB2 an internalization-resistant receptor","volume":"15","author":"Hommelgaard","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.RA118.004143_bib8","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.yexcr.2008.07.029","article-title":"Endocytosis and intracellular trafficking of ErbBs","volume":"315","author":"Sorkin","year":"2009","journal-title":"Exp. Cell Res"},{"key":"10.1074\/jbc.RA118.004143_bib9","first-page":"1729","article-title":"p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity","volume":"6","author":"Stern","year":"1986","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA118.004143_bib10","doi-asserted-by":"crossref","first-page":"E282","DOI":"10.1073\/pnas.1516138113","article-title":"PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer","volume":"113","author":"Jeong","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA118.004143_bib11","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.1074\/jbc.M116.770883","article-title":"The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2","volume":"292","author":"Jeong","year":"2017","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004143_bib12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.breast.2013.06.003","article-title":"Hsp90 inhibitors in breast cancer: a systematic review","volume":"22","author":"Zagouri","year":"2013","journal-title":"Breast"},{"key":"10.1074\/jbc.RA118.004143_bib13","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1124\/pr.110.004176","article-title":"Regulation of G protein-coupled receptor function by Na+\/H+ exchange regulatory factors","volume":"63","author":"Ardura","year":"2011","journal-title":"Pharmacol. Rev"},{"key":"10.1074\/jbc.RA118.004143_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev.cellbio.16.1.113","article-title":"ERM-Merlin and EBP50 protein families in plasma membrane organization and function","volume":"16","author":"Bretscher","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol"},{"key":"10.1074\/jbc.RA118.004143_bib15","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1038\/onc.2016.462","article-title":"Role of the PDZ-scaffold protein NHERF1\/EBP50 in cancer biology: from signaling regulation to clinical relevance","volume":"36","author":"Vaquero","year":"2017","journal-title":"Oncogene"},{"key":"10.1074\/jbc.RA118.004143_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.physiol.68.040104.131050","article-title":"The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases","volume":"68","author":"Weinman","year":"2006","journal-title":"Annu. Rev. Physiol"},{"key":"10.1074\/jbc.RA118.004143_bib17","doi-asserted-by":"crossref","first-page":"RE7","DOI":"10.1126\/stke.2003.179.re7","article-title":"PDZ domain proteins: plug and play!","volume":"2003","author":"Nourry","year":"2003","journal-title":"Sci. STKE"},{"key":"10.1074\/jbc.RA118.004143_bib18","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1091\/mbc.e06-07-0617","article-title":"The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells","volume":"18","author":"Cardone","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.RA118.004143_bib19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/bcr1992","article-title":"NHERF1: molecular brake on the PI3K pathway in breast cancer","volume":"10","author":"Georgescu","year":"2008","journal-title":"Breast Cancer Res"},{"key":"10.1074\/jbc.RA118.004143_bib20","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2174\/156652408785748031","article-title":"Roles of NHERF1\/EBP50 in cancer","volume":"8","author":"Georgescu","year":"2008","journal-title":"Curr. Mol. Med"},{"key":"10.1074\/jbc.RA118.004143_bib21","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.1091\/mbc.e04-03-0239","article-title":"The Na+\/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface","volume":"15","author":"Lazar","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.RA118.004143_bib22","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.1128\/MCB.20.22.8352-8363.2000","article-title":"Platelet-derived growth factor receptor association with Na+\/H+ exchanger regulatory factor potentiates receptor activity","volume":"20","author":"Maudsley","year":"2000","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA118.004143_bib23","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/bcr1846","article-title":"Na+\/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells","volume":"10","author":"Pan","year":"2008","journal-title":"Breast Cancer Res"},{"key":"10.1074\/jbc.RA118.004143_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000298962","article-title":"NHERF1\/EBP50 in breast cancer: clinical perspectives","volume":"5","author":"Bellizzi","year":"2010","journal-title":"Breast Care"},{"key":"10.1074\/jbc.RA118.004143_bib25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10549-010-1333-x","article-title":"Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance","volume":"130","author":"Karn","year":"2011","journal-title":"Breast Cancer Res. Treat"},{"key":"10.1074\/jbc.RA118.004143_bib26","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1365-2559.2009.03424.x","article-title":"Biological role of NHERF1 protein expression in breast cancer","volume":"55","author":"Mangia","year":"2009","journal-title":"Histopathology"},{"key":"10.1074\/jbc.RA118.004143_bib27","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/jcs.170027","article-title":"ERM proteins in cancer progression","volume":"128","author":"Clucas","year":"2015","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.RA118.004143_bib28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1248\/bpb.b16-01011","article-title":"Pathophysiological roles of Ezrin\/radixin\/moesin proteins","volume":"40","author":"Kawaguchi","year":"2017","journal-title":"Biol. Pharm. Bull"},{"key":"10.1074\/jbc.RA118.004143_bib29","doi-asserted-by":"crossref","first-page":"17903","DOI":"10.1038\/srep17903","article-title":"Prognostic value of ezrin in various cancers: a systematic review and updated meta-analysis","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA118.004143_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12929-016-0246-3","article-title":"A glimpse of the ERM proteins","volume":"23","author":"Ponuwei","year":"2016","journal-title":"J. Biomed. Sci"},{"key":"10.1074\/jbc.RA118.004143_bib31","doi-asserted-by":"crossref","first-page":"e75113","DOI":"10.1371\/journal.pone.0075113","article-title":"ss1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion","volume":"8","author":"Antelmi","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA118.004143_bib32","doi-asserted-by":"crossref","first-page":"25443","DOI":"10.18632\/oncotarget.8327","article-title":"Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins","volume":"7","author":"Asp","year":"2016","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.RA118.004143_bib33","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.3892\/or.2013.2641","article-title":"Clinical implications of Ezrin and CD44 coexpression in breast cancer","volume":"30","author":"Ma","year":"2013","journal-title":"Oncol. Rep"},{"key":"10.1074\/jbc.RA118.004143_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10549-005-9133-4","article-title":"Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas","volume":"98","author":"Sarri\u00f3","year":"2006","journal-title":"Breast Cancer Res. Treat"},{"key":"10.1074\/jbc.RA118.004143_bib35","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1074\/jbc.RA118.004143_bib36","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10983","article-title":"The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups","volume":"486","author":"Curtis","year":"2012","journal-title":"Nature"},{"key":"10.1074\/jbc.RA118.004143_bib37","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal"},{"key":"10.1074\/jbc.RA118.004143_bib38","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0960-9822(98)70135-6","article-title":"Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells","volume":"8","author":"Stauffer","year":"1998","journal-title":"Curr. Biol"},{"key":"10.1074\/jbc.RA118.004143_bib39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2144\/000114164","article-title":"Sensitive ligand-based protein quantification using immuno-PCR: a critical review of single-probe and proximity ligation assays","volume":"56","author":"Hansen","year":"2014","journal-title":"BioTechniques"},{"key":"10.1074\/jbc.RA118.004143_bib40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/onc.2011.245","article-title":"Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells","volume":"31","author":"Bulut","year":"2012","journal-title":"Oncogene"},{"key":"10.1074\/jbc.RA118.004143_bib41","doi-asserted-by":"crossref","first-page":"30443","DOI":"10.1074\/jbc.M114.608992","article-title":"A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells","volume":"289","author":"Bailey","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004143_bib42","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.semcancer.2017.04.012","article-title":"Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression","volume":"48","author":"Isakov","year":"2018","journal-title":"Semin. Cancer Biol"},{"key":"10.1074\/jbc.RA118.004143_bib43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000477329","article-title":"PKC-\u03b1 triggers EGFR ubiquitination, endocytosis and ERK activation in podocytes stimulated with high glucose","volume":"42","author":"Lei","year":"2017","journal-title":"Cell Physiol. Biochem"},{"key":"10.1074\/jbc.RA118.004143_bib44","doi-asserted-by":"crossref","first-page":"e80721","DOI":"10.1371\/journal.pone.0080721","article-title":"Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA118.004143_bib45","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1158\/0008-5472.CAN-06-3936","article-title":"Protein kinase C\u03b1 determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification","volume":"67","author":"Magnifico","year":"2007","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.RA118.004143_bib46","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.semcancer.2017.04.017","article-title":"Protein kinase C as a tumor suppressor","volume":"48","author":"Newton","year":"2018","journal-title":"Semin. Cancer Biol"},{"key":"10.1074\/jbc.RA118.004143_bib47","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1056\/NEJMoa064320","article-title":"Lapatinib plus capecitabine for HER2-positive advanced breast cancer","volume":"355","author":"Geyer","year":"2006","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.RA118.004143_bib48","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/onc.2008.432","article-title":"Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity","volume":"28","author":"Scaltriti","year":"2009","journal-title":"Oncogene"},{"key":"10.1074\/jbc.RA118.004143_bib49","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.1016\/S0021-9258(18)53360-3","article-title":"Association of p185neu with microfilaments via a large glycoprotein complex in mammary carcinoma microvilli: evidence for a microfilament-associated signal transduction particle","volume":"268","author":"Carraway","year":"1993","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004143_bib50","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.biochi.2012.04.011","article-title":"Application of fusion protein 4D5 scFv-dibarnase:barstar-gold complex for studying P185HER2 receptor distribution in human cancer cells","volume":"94","author":"Ivanova","year":"2012","journal-title":"Biochimie"},{"key":"10.1074\/jbc.RA118.004143_bib51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF02899192","article-title":"Light and electron microscopical demonstration of c-erB-2 gene product-like immunoreactivity in human malignant tumors","volume":"54","author":"Mori","year":"1987","journal-title":"Virchows Arch. B Cell Pathol. Incl. Mol. Pathol"},{"key":"10.1074\/jbc.RA118.004143_bib52","doi-asserted-by":"crossref","first-page":"e0174849","DOI":"10.1371\/journal.pone.0174849","article-title":"HER2 signaling regulates HER2 localization and membrane retention","volume":"12","author":"Jeong","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA118.004143_bib53","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/35017038","article-title":"ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2\/HER2 receptor","volume":"2","author":"Borg","year":"2000","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.RA118.004143_bib54","doi-asserted-by":"crossref","first-page":"15256","DOI":"10.1074\/jbc.M010032200","article-title":"The ERBB2\/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95\/DLG\/ZO-1 domain proteins","volume":"276","author":"Jaulin-Bastard","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA118.004143_bib55","first-page":"705","article-title":"TPA inhibits the tyrosine kinase activity of the neu protein in vivo and in vitro","volume":"6","author":"Cao","year":"1991","journal-title":"Oncogene"},{"key":"10.1074\/jbc.RA118.004143_bib56","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1089\/dna.1989.8.723","article-title":"Differential regulation of oncogenic and cellular p185 by serine\/threonine kinases","volume":"8","author":"Dobashi","year":"1989","journal-title":"DNA"},{"key":"10.1074\/jbc.RA118.004143_bib57","doi-asserted-by":"crossref","first-page":"85411","DOI":"10.18632\/oncotarget.13392","article-title":"Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells","volume":"7","author":"Castagnola","year":"2016","journal-title":"Oncotarget"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820400250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820400250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA118.004143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T10:18:51Z","timestamp":1641291531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820400250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0021925820400250"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra118.004143","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of ezrin causes PKC\u03b1-mediated internalization of erbb2\/HER2 tyrosine kinase in breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA118.004143","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Jeong et al.","name":"copyright","label":"Copyright"}]}}