{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:03:51Z","timestamp":1790755431092,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":552,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006315","name":"ReumaNederland","doi-asserted-by":"publisher","award":["LLP14"],"award-info":[{"award-number":["LLP14"]}],"id":[{"id":"10.13039\/501100006315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["DN 82\u2013304"],"award-info":[{"award-number":["DN 82\u2013304"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DN 82\u2013304"],"award-info":[{"award-number":["DN 82\u2013304"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["107471"],"award-info":[{"award-number":["107471"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1074\/jbc.ra119.007356","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T12:29:13Z","timestamp":1553862553000},"page":"5121-5136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion"],"prefix":"10.1016","volume":"294","author":[{"given":"Mandy M.F.","family":"Steinbusch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein M.J.","family":"Caron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don A.M.","family":"Surtel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guus G.H.","family":"van den Akker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Zabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lodewijk W.","family":"van Rhijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy J.","family":"Peffers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.M.","family":"Welting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA119.007356_bib1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.chom.2011.11.004","article-title":"Viperin: a multifunctional, interferon-inducible protein that regulates virus replication","volume":"10","author":"Seo","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1074\/jbc.RA119.007356_bib2","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1007\/s00018-010-0568-3","article-title":"Viperin mRNA is a novel target for the human RNase MRP\/RNase P endoribonuclease","volume":"68","author":"Mattijssen","year":"2011","journal-title":"Cell Mol. Life Sci"},{"key":"10.1074\/jbc.RA119.007356_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0092-8674(01)00205-7","article-title":"Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia","volume":"104","author":"Ridanp\u00e4\u00e4","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.RA119.007356_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/wrna.9","article-title":"RNase MRP and disease","volume":"1","author":"Mattijssen","year":"2010","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1074\/jbc.RA119.007356_bib5","unstructured":"Makitie, O., and Kostjukovits, S., (1993) Cartilage-hair hypoplasia: anauxetic dysplasia spectrum disorders. In GeneReviews(R) (Pagon, R. A., Adam, M. P., Ardinger, H. H., Wallace, S. E., Amemiya, A., Bean, L. J. H., Bird, T. D., Ledbetter, N., Mefford, H. C., Smith, R. J. H., and Stephens, K., eds) Seattle, WA."},{"key":"10.1074\/jbc.RA119.007356_bib6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrendo.2015.165","article-title":"Short and tall stature: a new paradigm emerges","volume":"11","author":"Baron","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"10.1074\/jbc.RA119.007356_bib7","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1128\/MCB.24.3.945-953.2004","article-title":"RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation","volume":"24","author":"Gill","year":"2004","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA119.007356_bib8","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.2434997","article-title":"A mammalian mitochondrial RNA processing activity contains nucleus-encoded RNA","volume":"235","author":"Chang","year":"1987","journal-title":"Science"},{"key":"10.1074\/jbc.RA119.007356_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1101\/gad.286963.116","article-title":"Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing","volume":"31","author":"Goldfarb","year":"2017","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.RA119.007356_bib10","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1093\/hmg\/ddi403","article-title":"Consequences of mutations in the non-coding RMRP RNA in cartilage-hair hypoplasia","volume":"14","author":"Hermanns","year":"2005","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.RA119.007356_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-06809-5","article-title":"Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation","volume":"7","author":"Steinbusch","year":"2017","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA119.007356_bib12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0922-3371(90)90079-C","article-title":"A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells","volume":"30","author":"Atsumi","year":"1990","journal-title":"Cell Differ. Dev"},{"key":"10.1074\/jbc.RA119.007356_bib13","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/jcb.24467","article-title":"ATDC5: an excellent in vitro model cell line for skeletal development","volume":"114","author":"Yao","year":"2013","journal-title":"J. Cell. Biochem"},{"key":"10.1074\/jbc.RA119.007356_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033467","article-title":"Activation of NF-\u03baB\/p65 facilitates early chondrogenic differentiation during endochondral ossification","volume":"7","author":"Caron","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA119.007356_bib15","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1074\/jbc.M807261200","article-title":"The N-terminal amphipathic \u03b1-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion","volume":"284","author":"Hinson","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.007356_bib16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature01657","article-title":"Developmental regulation of the growth plate","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.007356_bib17","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.4049\/jimmunol.179.5.2722","article-title":"PDGF synergistically enhances IFN-\u03b3\u2013induced expression of CXCL10 in blood-derived macrophages: implications for HIV dementia","volume":"179","author":"Dhillon","year":"2007","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.RA119.007356_bib18","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1093\/emboj\/17.11.3091","article-title":"Direct binding of Smad3 and Smad4 to critical TGF \u03b2-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene","volume":"17","author":"Dennler","year":"1998","journal-title":"EMBO J"},{"key":"10.1074\/jbc.RA119.007356_bib19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1261\/rna.1701210","article-title":"Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level","volume":"16","author":"Pais","year":"2010","journal-title":"RNA"},{"key":"10.1074\/jbc.RA119.007356_bib20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/39369","article-title":"Identification of Smad7, a TGF\u03b2-inducible antagonist of TGF-\u03b2 signalling","volume":"389","author":"Nakao","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.007356_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1023\/B:ABME.0000007790.65773.e0","article-title":"Chondrogenic differentiation of adult dermal fibroblasts","volume":"32","author":"French","year":"2004","journal-title":"Ann. Biomed. Eng"},{"key":"10.1074\/jbc.RA119.007356_bib22","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1007\/s00018-008-8342-5","article-title":"Mediation of chondrogenic and osteogenic differentiation by an interferon-inducible p202 protein","volume":"65","author":"Kong","year":"2008","journal-title":"Cell Mol. Life Sci"},{"key":"10.1074\/jbc.RA119.007356_bib23","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1038\/cdd.2008.112","article-title":"Cbfa1-dependent expression of an interferon-inducible p204 protein is required for chondrocyte differentiation","volume":"15","author":"Zhang","year":"2008","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.RA119.007356_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00441-012-1521-6","article-title":"Double-stranded RNA-dependent protein kinase regulates insulin-stimulated chondrogenesis in mouse clonal chondrogenic cells, ATDC-5","volume":"351","author":"Morimoto","year":"2013","journal-title":"Cell Tissue Res"},{"key":"10.1074\/jbc.RA119.007356_bib25","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1089\/ten.tea.2013.0553","article-title":"Inhibition of TAK1 and\/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions","volume":"20","author":"van Beuningen","year":"2014","journal-title":"Tissue Eng. Part A"},{"key":"10.1074\/jbc.RA119.007356_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/bj20020928","article-title":"The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-\u03b3\u2013mediated inhibition in human chondrocytes: requirement for Stat1\u03b1, Jak1 and Jak2","volume":"369","author":"Osaki","year":"2003","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.RA119.007356_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/jcb.240540110","article-title":"Transcriptional suppression by interleukin-1 and interferon-\u03b3 of type II collagen gene expression in human chondrocytes","volume":"54","author":"Goldring","year":"1994","journal-title":"J. Cell. Biochem"},{"key":"10.1074\/jbc.RA119.007356_bib28","doi-asserted-by":"crossref","first-page":"20452","DOI":"10.1073\/pnas.0911679106","article-title":"The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic \u03b1-helix","volume":"106","author":"Hinson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.007356_bib29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.chom.2007.06.009","article-title":"The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts","volume":"2","author":"Wang","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1074\/jbc.RA119.007356_bib30","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.immuni.2011.03.010","article-title":"Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells","volume":"34","author":"Saitoh","year":"2011","journal-title":"Immunity"},{"key":"10.1074\/jbc.RA119.007356_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12920-015-0119-8","article-title":"Expression analysis of human adipose-derived stem cells during in vitro differentiation to an adipocyte lineage","volume":"8","author":"Satish","year":"2015","journal-title":"BMC Med. Genomics"},{"key":"10.1074\/jbc.RA119.007356_bib32","article-title":"miR-200 family promotes podocyte differentiation through repression of RSAD2","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA119.007356_bib33","first-page":"505","article-title":"Distinct patterns of gene expression in the superficial, middle and deep zones of bovine articular cartilage","volume":"8","author":"Amanatullah","year":"2014","journal-title":"J. Tissue Eng. Regen. Med"},{"key":"10.1074\/jbc.RA119.007356_bib34","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1096\/fasebj.14.3.523","article-title":"Best5: a novel interferon-inducible gene expressed during bone formation","volume":"14","author":"Grewal","year":"2000","journal-title":"FASEB J"},{"key":"10.1074\/jbc.RA119.007356_bib35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ygeno.2006.02.013","article-title":"Activation of genes for growth factor and cytokine pathways late in chondrogenic differentiation of ATDC5 cells","volume":"88","author":"Osawa","year":"2006","journal-title":"Genomics"},{"key":"10.1074\/jbc.RA119.007356_bib36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1089\/ten.a.2007.0121","article-title":"Expression of CXC chemokines and their receptors is modulated during chondrogenic differentiation of human mesenchymal stem cells grown in three-dimensional scaffold: evidence in native cartilage","volume":"14","author":"Cristino","year":"2008","journal-title":"Tissue Eng. Part A"},{"key":"10.1074\/jbc.RA119.007356_bib37","doi-asserted-by":"crossref","first-page":"C34","DOI":"10.1152\/ajpcell.00441.2005","article-title":"CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways","volume":"291","author":"Shahabuddin","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.RA119.007356_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8212","article-title":"PI3K\/mTORC2 regulates TGF-\u03b2\/activin signalling by modulating Smad2\/3 activity via linker phosphorylation","volume":"6","author":"Yu","year":"2015","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.RA119.007356_bib39","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/17826","article-title":"Inhibition of transforming growth factor-\u03b2\/SMAD signalling by the interferon-\u03b3\/STAT pathway","volume":"397","author":"Ulloa","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.007356_bib40","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1182\/blood-2008-07-171942","article-title":"Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-\u03baB and AP-1","volume":"113","author":"Qiu","year":"2009","journal-title":"Blood"},{"key":"10.1074\/jbc.RA119.007356_bib41","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.yexcr.2010.12.017","article-title":"CXCR3 in T cell function","volume":"317","author":"Groom","year":"2011","journal-title":"Exp. Cell Res"},{"key":"10.1074\/jbc.RA119.007356_bib42","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s004310050943","article-title":"Susceptibility to infections and in vitro immune functions in cartilage-hair hypoplasia","volume":"157","author":"M\u00e4kitie","year":"1998","journal-title":"Eur. J. Pediatr"},{"key":"10.1074\/jbc.RA119.007356_bib43","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1128\/MCB.00206-14","article-title":"Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins","volume":"34","author":"Groot","year":"2014","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA119.007356_bib44","doi-asserted-by":"crossref","first-page":"20658","DOI":"10.3390\/ijms141020658","article-title":"Absolute quantification of selected proteins in the human osteoarthritic secretome","volume":"14","author":"Peffers","year":"2013","journal-title":"Int. J. Mol. Sci"},{"key":"10.1074\/jbc.RA119.007356_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/srep20455","article-title":"Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition","volume":"6","author":"Thorpe","year":"2016","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA119.007356_bib46","doi-asserted-by":"crossref","first-page":"25867","DOI":"10.1074\/jbc.M114.566554","article-title":"Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation","volume":"289","author":"Peffers","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.007356_bib47","doi-asserted-by":"crossref","first-page":"D1063","DOI":"10.1093\/nar\/gks1262","article-title":"The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013","volume":"41","author":"Vizca\u00edno","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA119.007356_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-06809-5","article-title":"Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation","volume":"7","author":"Steinbusch","year":"2017","journal-title":"Sci. Rep"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820355617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820355617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA119.007356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T11:07:27Z","timestamp":1664104047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820355617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":48,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0021925820355617"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra119.007356","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA119.007356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Steinbusch et al.","name":"copyright","label":"Copyright"}]}}