{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:40:44Z","timestamp":1774654844735,"version":"3.50.1"},"reference-count":85,"publisher":"Elsevier BV","issue":"36","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":347,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS) KAKENHI Grants-in-aid for Scientific Research","doi-asserted-by":"publisher","award":["JP15H04999"],"award-info":[{"award-number":["JP15H04999"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS) KAKENHI Grants-in-aid for Scientific Research","doi-asserted-by":"publisher","award":["JP18K19625"],"award-info":[{"award-number":["JP18K19625"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS) KAKENHI Grants-in-aid for Scientific Research","doi-asserted-by":"publisher","award":["JP16K08635"],"award-info":[{"award-number":["JP16K08635"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS) KAKENHI Grants-in-aid for Scientific Research","doi-asserted-by":"publisher","award":["JP16K07076"],"award-info":[{"award-number":["JP16K07076"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS) KAKENHI Grants-in-aid for Scientific Research","doi-asserted-by":"publisher","award":["JP17K07123"],"award-info":[{"award-number":["JP17K07123"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS) KAKENHI Grants-in-aid for Scientific Research","doi-asserted-by":"publisher","award":["JP19K09943"],"award-info":[{"award-number":["JP19K09943"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1074\/jbc.ra119.007645","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T18:45:13Z","timestamp":1563907513000},"page":"13421-13433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["DOCK8 is expressed in microglia, and it regulates microglial activity during neurodegeneration in murine disease models"],"prefix":"10.1016","volume":"294","author":[{"given":"Kazuhiko","family":"Namekata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-0997","authenticated-orcid":false,"given":"Takayuki","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA119.007645_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.febslet.2004.06.095","article-title":"Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology","volume":"572","author":"Ruusala","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.RA119.007645_bib2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.tcb.2007.05.001","article-title":"GEF what? Dock180 and related proteins help Rac to polarize cells in new ways","volume":"17","author":"C\u00f4t\u00e9","year":"2007","journal-title":"Trends Cell Biol"},{"key":"10.1074\/jbc.RA119.007645_bib3","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1042\/BST20120103","article-title":"Rho family GTPases","volume":"40","author":"Hall","year":"2012","journal-title":"Biochem. Soc. Trans"},{"key":"10.1074\/jbc.RA119.007645_bib4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1101\/gad.236349.113","article-title":"Insights into the biological functions of Dock family guanine nucleotide exchange factors","volume":"28","author":"Laurin","year":"2014","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.RA119.007645_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2014.06.005","article-title":"Dock GEFs and their therapeutic potential: neuroprotection and axon regeneration","volume":"43","author":"Namekata","year":"2014","journal-title":"Prog. Retin. Eye Res"},{"key":"10.1074\/jbc.RA119.007645_bib6","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","article-title":"Combined immunodeficiency associated with DOCK8 mutations","volume":"361","author":"Zhang","year":"2009","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.RA119.007645_bib7","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.jaci.2009.10.038","article-title":"Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome","volume":"124","author":"Engelhardt","year":"2009","journal-title":"J. Allergy Clin. Immunol"},{"key":"10.1074\/jbc.RA119.007645_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1749-6632.2011.06295.x","article-title":"DOCK8 deficiency","volume":"1246","author":"Su","year":"2011","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1074\/jbc.RA119.007645_bib9","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1038\/s41591-018-0211-7","article-title":"Expanded skin virome in DOCK8-deficient patients","volume":"24","author":"Tirosh","year":"2018","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.007645_bib10","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/ni.1820","article-title":"Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production","volume":"10","author":"Randall","year":"2009","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.RA119.007645_bib11","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/ni.2305","article-title":"DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation","volume":"13","author":"Jabara","year":"2012","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.RA119.007645_bib12","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1084\/jem.20110345","article-title":"DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice","volume":"208","author":"Randall","year":"2011","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.RA119.007645_bib13","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1182\/blood-2013-02-482331","article-title":"DOCK8 is critical for the survival and function of NKT cells","volume":"122","author":"Crawford","year":"2013","journal-title":"Blood"},{"key":"10.1074\/jbc.RA119.007645_bib14","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1084\/jem.20141307","article-title":"DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity","volume":"211","author":"Zhang","year":"2014","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.RA119.007645_bib15","doi-asserted-by":"crossref","first-page":"13946","DOI":"10.1038\/ncomms13946","article-title":"The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction","volume":"8","author":"Yamamura","year":"2017","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.RA119.007645_bib16","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1172\/JCI85774","article-title":"A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton","volume":"126","author":"Janssen","year":"2016","journal-title":"J. Clin. Investig"},{"key":"10.1074\/jbc.RA119.007645_bib17","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1182\/blood-2012-01-407098","article-title":"DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses","volume":"119","author":"Harada","year":"2012","journal-title":"Blood"},{"key":"10.1074\/jbc.RA119.007645_bib18","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1073\/pnas.1501554112","article-title":"Coincidental loss of DOCK8 function in NLRP10-deficient and C3H\/HeJ mice results in defective dendritic cell migration","volume":"112","author":"Krishnaswamy","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.007645_bib19","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/molehr\/gam045","article-title":"Association of deletion 9p, 46, XY gonadal dysgenesis and autistic spectrum disorder","volume":"13","author":"Vinci","year":"2007","journal-title":"Mol. Hum. Reprod"},{"key":"10.1074\/jbc.RA119.007645_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ygeno.2007.10.011","article-title":"Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities","volume":"91","author":"Griggs","year":"2008","journal-title":"Genomics"},{"key":"10.1074\/jbc.RA119.007645_bib21","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ng.3349","article-title":"Mutational dynamics between primary and relapse neuroblastomas","volume":"47","author":"Schramm","year":"2015","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.RA119.007645_bib22","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2174\/092986707780597961","article-title":"Microglial activation and its implications in the brain diseases","volume":"14","author":"Dheen","year":"2007","journal-title":"Curr. Med. Chem"},{"key":"10.1074\/jbc.RA119.007645_bib23","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm.4397","article-title":"Microglia emerge as central players in brain disease","volume":"23","author":"Salter","year":"2017","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.007645_bib24","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1074\/jbc.RA119.007645_bib25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrn.2018.2","article-title":"Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential","volume":"19","author":"Inoue","year":"2018","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1074\/jbc.RA119.007645_bib26","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","article-title":"Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)","volume":"164","author":"Constantinescu","year":"2011","journal-title":"Br. J. Pharmacol"},{"key":"10.1074\/jbc.RA119.007645_bib27","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/nn.3168","article-title":"Animal models of multiple sclerosis: the good, the bad and the bottom line","volume":"15","author":"Ransohoff","year":"2012","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.RA119.007645_bib28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0092-8674(00)81107-1","article-title":"Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system","volume":"85","author":"Steinman","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.RA119.007645_bib29","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1001\/archneur.61.10.1613","article-title":"Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease","volume":"61","author":"Weiner","year":"2004","journal-title":"Arch. Neurol"},{"issue":"Suppl. 6","key":"10.1074\/jbc.RA119.007645_bib30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00415-008-6001-2","article-title":"Pathophysiology of multiple sclerosis","volume":"255","author":"Korn","year":"2008","journal-title":"J. Neurol"},{"key":"10.1074\/jbc.RA119.007645_bib31","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nm.3268","article-title":"How cytokine networks fuel inflammation: interleukin-17 and a tale of two autoimmune diseases","volume":"19","author":"Baeten","year":"2013","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.007645_bib32","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nm.2321","article-title":"RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis","volume":"17","author":"Muramatsu","year":"2011","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.007645_bib33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.neures.2007.08.014","article-title":"Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis","volume":"59","author":"Guo","year":"2007","journal-title":"Neurosci. Res"},{"key":"10.1074\/jbc.RA119.007645_bib34","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/emmm.201000103","article-title":"Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway","volume":"2","author":"Guo","year":"2010","journal-title":"EMBO Mol. Med"},{"key":"10.1074\/jbc.RA119.007645_bib35","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1093\/brain\/awm219","article-title":"Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing\u2013remitting experimental autoimmune encephalomyelitis","volume":"130","author":"Rasmussen","year":"2007","journal-title":"Brain"},{"key":"10.1074\/jbc.RA119.007645_bib36","doi-asserted-by":"crossref","first-page":"208093","DOI":"10.1155\/2013\/208093","article-title":"Role of microglia in CNS autoimmunity","volume":"2013","author":"Goldmann","year":"2013","journal-title":"Clin. Dev. Immunol"},{"key":"10.1074\/jbc.RA119.007645_bib37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ana.1123","article-title":"Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions","volume":"50","author":"Peterson","year":"2001","journal-title":"Ann. Neurol"},{"key":"10.1074\/jbc.RA119.007645_bib38","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1056\/NEJMoa1608889","article-title":"Trial of minocycline in a clinically isolated syndrome of multiple sclerosis","volume":"376","author":"Metz","year":"2017","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.RA119.007645_bib39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.preteyeres.2014.11.004","article-title":"Retinal microglia: just bystander or target for therapy?","volume":"45","author":"Karlstetter","year":"2015","journal-title":"Prog. Retin. Eye Res"},{"key":"10.1074\/jbc.RA119.007645_bib40","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/j.1460-9568.1991.tb00054.x","article-title":"The relationship of microglial cells to dying neurons during natural neuronal cell death and axotomy-induced degeneration of the rat retina","volume":"3","author":"Thanos","year":"1991","journal-title":"Eur. J. Neurosci"},{"key":"10.1074\/jbc.RA119.007645_bib41","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/cne.21279","article-title":"Rat retinal microglial cells under normal conditions, after optic nerve section, and after optic nerve section and intravitreal injection of trophic factors or macrophage inhibitory factor","volume":"501","author":"Sobrado-Calvo","year":"2007","journal-title":"J. Comp. Neurol"},{"key":"10.1074\/jbc.RA119.007645_bib42","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/cdd.2012.122","article-title":"Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury","volume":"20","author":"Katome","year":"2013","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.RA119.007645_bib43","doi-asserted-by":"crossref","first-page":"e1720","DOI":"10.1038\/cddis.2015.93","article-title":"Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury","volume":"6","author":"Noro","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1074\/jbc.RA119.007645_bib44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ydbio.2003.06.003","article-title":"Cell migration: Rho GTPases lead the way","volume":"265","author":"Raftopoulou","year":"2004","journal-title":"Dev. Biol"},{"key":"10.1074\/jbc.RA119.007645_bib45","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1016\/j.neurobiolaging.2013.05.001","article-title":"Insights into TREM2 biology by network analysis of human brain gene expression data","volume":"34","author":"Forabosco","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.RA119.007645_bib46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1084\/jem.20160068","article-title":"LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis","volume":"214","author":"Xu","year":"2017","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.RA119.007645_bib47","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neulet.2009.07.028","article-title":"Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis","volume":"462","author":"Guo","year":"2009","journal-title":"Neurosci. Lett"},{"key":"10.1074\/jbc.RA119.007645_bib48","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1167\/iovs.10-6015","article-title":"Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis","volume":"52","author":"Guo","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.RA119.007645_bib49","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.007645_bib50","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1523\/JNEUROSCI.0584-17.2017","article-title":"Microglia are irrelevant for neuronal degeneration and axon regeneration after acute injury","volume":"37","author":"Hilla","year":"2017","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA119.007645_bib51","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nrm2476","article-title":"Mammalian Rho GTPases: new insights into their functions from in vivo studies","volume":"9","author":"Heasman","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.RA119.007645_bib52","doi-asserted-by":"crossref","first-page":"a001818","DOI":"10.1101\/cshperspect.a001818","article-title":"Rho and Ras GTPases in axon growth, guidance, and branching","volume":"2","author":"Hall","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"10.1074\/jbc.RA119.007645_bib53","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1038\/onc.2013.362","article-title":"Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease","volume":"33","author":"Cook","year":"2014","journal-title":"Oncogene"},{"key":"10.1074\/jbc.RA119.007645_bib54","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1091\/mbc.e06-05-0466","article-title":"Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts","volume":"17","author":"Yang","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.RA119.007645_bib55","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ceb.2015.08.005","article-title":"Rho GTPase signalling in cell migration","volume":"36","author":"Ridley","year":"2015","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1074\/jbc.RA119.007645_bib56","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ncb3292","article-title":"Locally excitable Cdc42 signals steer cells during chemotaxis","volume":"18","author":"Yang","year":"2016","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.RA119.007645_bib57","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1016\/j.febslet.2014.05.046","article-title":"Tumour necrosis factor \u03b1-induced neuronal loss is mediated by microglial phagocytosis","volume":"588","author":"Neniskyte","year":"2014","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.RA119.007645_bib58","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1016\/j.ajpath.2015.08.005","article-title":"TrkB signaling in retinal glia stimulates neuroprotection after optic nerve injury","volume":"185","author":"Harada","year":"2015","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.RA119.007645_bib59","doi-asserted-by":"crossref","first-page":"8240","DOI":"10.1523\/JNEUROSCI.1808-05.2005","article-title":"Microglial phagocytosis induced by fibrillar \u03b2-amyloid and IgGs are differentially regulated by proinflammatory cytokines","volume":"25","author":"Koenigsknecht-Talboo","year":"2005","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA119.007645_bib60","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/glia.20691","article-title":"Microglial phagocytosis is enhanced by monomeric \u03b1-synuclein, not aggregated \u03b1-synuclein: implications for Parkinson\u2019s disease","volume":"56","author":"Park","year":"2008","journal-title":"Glia"},{"key":"10.1074\/jbc.RA119.007645_bib61","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1002\/jnr.22424","article-title":"Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis","volume":"88","author":"Sanagi","year":"2010","journal-title":"J. Neurosci. Res"},{"key":"10.1074\/jbc.RA119.007645_bib62","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/brain\/awn109","article-title":"Debris clearance by microglia: an essential link between degeneration and regeneration","volume":"132","author":"Neumann","year":"2009","journal-title":"Brain"},{"key":"10.1074\/jbc.RA119.007645_bib63","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1007\/s12035-013-8620-6","article-title":"Phagocytosis of microglia in the central nervous system diseases","volume":"49","author":"Fu","year":"2014","journal-title":"Mol. Neurobiol"},{"key":"10.1074\/jbc.RA119.007645_bib64","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fphar.2012.00027","article-title":"Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration","volume":"3","author":"Neher","year":"2012","journal-title":"Front. Pharmacol"},{"key":"10.1074\/jbc.RA119.007645_bib65","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrn3710","article-title":"Microglial phagocytosis of live neurons","volume":"15","author":"Brown","year":"2014","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1074\/jbc.RA119.007645_bib66","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.brainres.2005.06.053","article-title":"Neuroprotective effects of minocycline against in vitro and in vivo retinal ganglion cell damage","volume":"1053","author":"Shimazawa","year":"2005","journal-title":"Brain Res"},{"key":"10.1074\/jbc.RA119.007645_bib67","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuroscience.2005.04.011","article-title":"Effects of minocycline and tetracycline on retinal ganglion cell survival after axotomy","volume":"134","author":"Baptiste","year":"2005","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.RA119.007645_bib68","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1167\/iovs.07-1337","article-title":"Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA\/2J mouse model of glaucoma","volume":"49","author":"Bosco","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.RA119.007645_bib69","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1523\/JNEUROSCI.22-21-09228.2002","article-title":"Microglia-M\u00fcller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration","volume":"22","author":"Harada","year":"2002","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA119.007645_bib70","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ncomms1190","article-title":"Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration","volume":"2","author":"Harada","year":"2011","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.RA119.007645_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","article-title":"Glia-neuron interactions in the mammalian retina","volume":"51","author":"Vecino","year":"2016","journal-title":"Prog. Retin. Eye Res"},{"key":"10.1074\/jbc.RA119.007645_bib72","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1172\/JCI30178","article-title":"The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma","volume":"117","author":"Harada","year":"2007","journal-title":"J. Clin. Investig"},{"key":"10.1074\/jbc.RA119.007645_bib73","doi-asserted-by":"crossref","first-page":"e91742","DOI":"10.1371\/journal.pone.0091742","article-title":"Over-expression of either MECP2_e1 or MECP2_e2 in neuronally differentiated cells results in different patterns of gene expression","volume":"9","author":"Orlic-Milacic","year":"2014","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA119.007645_bib74","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1523\/JNEUROSCI.5966-09.2010","article-title":"Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate","volume":"30","author":"Maezawa","year":"2010","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA119.007645_bib75","doi-asserted-by":"crossref","first-page":"7586","DOI":"10.1073\/pnas.0914514107","article-title":"Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex","volume":"107","author":"Namekata","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.007645_bib76","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1523\/JNEUROSCI.4884-11.2012","article-title":"Dock3 stimulates axonal outgrowth via GSK-3\u03b2-mediated microtubule assembly","volume":"32","author":"Namekata","year":"2012","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.RA119.007645_bib77","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/eji.1830250723","article-title":"A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V \u03b2 expression of encephalitogenic T cells","volume":"25","author":"Mendel","year":"1995","journal-title":"Eur. J. Immunol"},{"key":"10.1074\/jbc.RA119.007645_bib78","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1016\/j.ajpath.2017.08.012","article-title":"The renin-angiotensin system regulates neurodegeneration in a mouse model of optic neuritis","volume":"187","author":"Guo","year":"2017","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.RA119.007645_bib79","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"key":"10.1074\/jbc.RA119.007645_bib80","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1440-1711.1998.00709.x","article-title":"Defective TCR expression in transgenic mice constructed using cDNA-based \u03b1- and \u03b2-chain genes under the control of heterologous regulatory elements","volume":"76","author":"Barnden","year":"1998","journal-title":"Immunol. Cell Biol"},{"key":"10.1074\/jbc.RA119.007645_bib81","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0042-6989(98)00161-8","article-title":"The optic nerve head component of the human ERG","volume":"39","author":"Sutter","year":"1999","journal-title":"Vision Res"},{"key":"10.1074\/jbc.RA119.007645_bib82","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2353\/ajpath.2006.050765","article-title":"Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo","volume":"168","author":"Harada","year":"2006","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.RA119.007645_bib83","doi-asserted-by":"crossref","first-page":"e2934","DOI":"10.1038\/cddis.2017.341","article-title":"Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma","volume":"8","author":"Akaiwa","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1074\/jbc.RA119.007645_bib84","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1074\/jbc.M311275200","article-title":"MOCA induces membrane spreading by activating Rac1","volume":"279","author":"Namekata","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.007645_bib85","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820303951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820303951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA119.007645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T08:31:23Z","timestamp":1721550683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820303951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":85,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0021925820303951"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra119.007645","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DOCK8 is expressed in microglia, and it regulates microglial activity during neurodegeneration in murine disease models","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA119.007645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Namekata et al.","name":"copyright","label":"Copyright"}]}}