{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T01:42:49Z","timestamp":1777167769560,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":414,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation (SNF))","doi-asserted-by":"publisher","award":["310030B 176403\/1"],"award-info":[{"award-number":["310030B 176403\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation (SNF))","doi-asserted-by":"publisher","award":["31003A 156304"],"award-info":[{"award-number":["31003A 156304"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1074\/jbc.ra119.008610","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T21:35:22Z","timestamp":1558733722000},"page":"10553-10563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria"],"prefix":"10.1016","volume":"294","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8471-469X","authenticated-orcid":false,"given":"Dawid S.","family":"\u017by\u0142a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-5339","authenticated-orcid":false,"given":"Andrea E.","family":"Prota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Capitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3320-3843","authenticated-orcid":false,"given":"Rudi","family":"Glockshuber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA119.008610_bib1","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1086\/318855","article-title":"Structure and function of Escherichia coli type 1 Pili: new insight into the pathogenesis of urinary tract infections","volume":"183","author":"Schilling","year":"2001","journal-title":"J. Infect. Dis"},{"key":"10.1074\/jbc.RA119.008610_bib2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.cell.2006.02.012","article-title":"Bacterial adhesion and entry into host cells","volume":"124","author":"Pizarro-Cerd\u00e1","year":"2006","journal-title":"Cell"},{"key":"10.1074\/jbc.RA119.008610_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nrmicro.2017.40","article-title":"A comprehensive guide to pilus biogenesis in Gram-negative bacteria","volume":"15","author":"Hospenthal","year":"2017","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1074\/jbc.RA119.008610_bib4","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/j.1574-6976.2012.00342.x","article-title":"Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function","volume":"36","author":"Thanassi","year":"2012","journal-title":"FEMS Microbiol. Rev"},{"key":"10.1074\/jbc.RA119.008610_bib5","doi-asserted-by":"crossref","first-page":"9827","DOI":"10.1073\/pnas.93.18.9827","article-title":"Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract","volume":"93","author":"Connell","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.008610_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1172\/JCI111707","article-title":"Molecular basis of Escherichia coli colonization of the upper urinary tract in BALB\/c mice; Gal-Gal pili immunization prevents Escherichia coli pyelonephritis in the BALB\/c mouse model of human pyelonephritis","volume":"75","author":"O'Hanley","year":"1985","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA119.008610_bib7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1128\/IAI.01000-09","article-title":"Waging war against uropathogenic Escherichia coli: winning back the urinary tract","volume":"78","author":"Sivick","year":"2010","journal-title":"Infect. Immun"},{"key":"10.1074\/jbc.RA119.008610_bib8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0092-8674(01)00388-9","article-title":"Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor","volume":"105","author":"Dodson","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.RA119.008610_bib9","doi-asserted-by":"crossref","first-page":"10738","DOI":"10.1038\/ncomms10738","article-title":"Catch-bond mechanism of the bacterial adhesin FimH","volume":"7","author":"Sauer","year":"2016","journal-title":"Nat Commun"},{"key":"10.1074\/jbc.RA119.008610_bib10","doi-asserted-by":"crossref","first-page":"20130153","DOI":"10.1098\/rsta.2013.0153","article-title":"Molecular mechanism of bacterial type 1 and P pili assembly","volume":"373","author":"Busch","year":"2015","journal-title":"Philos. Trans. R. Soc. A Math. Phys. Eng. Sci"},{"key":"10.1074\/jbc.RA119.008610_bib11","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.str.2017.10.004","article-title":"The cryoelectron microscopy structure of the type 1 chaperone-usher pilus rod","volume":"25","author":"Hospenthal","year":"2017","journal-title":"Structure"},{"key":"10.1074\/jbc.RA119.008610_bib12","doi-asserted-by":"crossref","first-page":"e31662","DOI":"10.7554\/eLife.31662","article-title":"Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions","volume":"7","author":"Spaulding","year":"2018","journal-title":"Elife"},{"key":"10.1074\/jbc.RA119.008610_bib13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jmb.2013.10.029","article-title":"Intramolecular donor strand complementation in the E. coli type 1 pilus subunit fima explains the existence of fima monomers as off-pathway products of pilus assembly that inhibit host cell apoptosis","volume":"426","author":"Walczak","year":"2014","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.RA119.008610_bib14","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jmb.2011.07.044","article-title":"Structure, folding and stability of FimA, the main structural subunit of type 1 Pili from uropathogenic Escherichia coli strains","volume":"412","author":"Puorger","year":"2011","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.RA119.008610_bib15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.sbi.2012.02.001","article-title":"Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens","volume":"22","author":"Allen","year":"2012","journal-title":"Curr. Opin. Struct. Biol"},{"key":"10.1074\/jbc.RA119.008610_bib16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1126\/science.1154994","article-title":"Reconstitution of pilus assembly reveals a bacterial outer membrane catalyst","volume":"320","author":"Nishiyama","year":"2008","journal-title":"Science"},{"key":"10.1074\/jbc.RA119.008610_bib17","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.str.2008.01.013","article-title":"Infinite kinetic stability against dissociation of supramolecular protein complexes through donor strand complementation","volume":"16","author":"Puorger","year":"2008","journal-title":"Structure"},{"key":"10.1074\/jbc.RA119.008610_bib18","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0022-2836(02)00845-8","article-title":"Chaperone-independent folding of type 1 pilus domains","volume":"322","author":"Vetsch","year":"2002","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.RA119.008610_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature02891","article-title":"Pilus chaperones represent a new type of protein-folding catalyst","volume":"431","author":"Vetsch","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.008610_bib20","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nchembio.1019","article-title":"Quality control of disulfide bond formation in pilus subunits by the chaperone FimC","volume":"8","author":"Crespo","year":"2012","journal-title":"Nat. Chem. Biol"},{"key":"10.1074\/jbc.RA119.008610_bib21","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.molcel.2010.02.015","article-title":"A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis","volume":"37","author":"Sukumaran","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA119.008610_bib22","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1002\/pro.5560061215","article-title":"OLDERADO: On-line database of ensemble representatives and domains","volume":"6","author":"Kelley","year":"1997","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.RA119.008610_bib23","doi-asserted-by":"crossref","first-page":"8938","DOI":"10.1021\/ja0718927","article-title":"Quantitative analysis of nonequilibrium, denaturant-dependent protein folding transitions","volume":"129","author":"Erilov","year":"2007","journal-title":"J. Am. Chem. Soc"},{"key":"10.1074\/jbc.RA119.008610_bib24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1128\/jb.148.1.308-314.1981","article-title":"Dissociation and reassembly of Escherichia coli type 1 pili","volume":"148","author":"Eshdat","year":"1981","journal-title":"J. Bacteriol"},{"key":"10.1074\/jbc.RA119.008610_bib25","series-title":"Structure and mechanism in protein science: a guide to enzyme catalysis and protein folding","author":"Fersht","year":"1998"},{"key":"10.1074\/jbc.RA119.008610_bib26","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/sj.embor.7400722","article-title":"Mechanism of fibre assembly through the chaperone-usher pathway","volume":"7","author":"Vetsch","year":"2006","journal-title":"EMBO Rep"},{"key":"10.1074\/jbc.RA119.008610_bib27","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr"},{"key":"10.1074\/jbc.RA119.008610_bib28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1074\/jbc.RA119.008610_bib29","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1073\/pnas.130183897","article-title":"PapD-like chaperones provide the missing information for folding of pilin proteins","volume":"97","author":"Barnhart","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.008610_bib30","series-title":"The Proteomics Protocols Handbook","author":"Gasteiger","year":"2005"},{"key":"10.1074\/jbc.RA119.008610_bib31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0076-6879(72)26005-0","article-title":"The preparation of guanidine hydrochloride","volume":"26","author":"Nozaki","year":"1972","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.RA119.008610_bib32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","volume":"66","author":"Kabsch","year":"2010","journal-title":"XDS Acta Crystallogr. Sect. D Biol. Crystallogr"},{"key":"10.1074\/jbc.RA119.008610_bib33","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J. Appl. Crystallogr"},{"key":"10.1074\/jbc.RA119.008610_bib34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: A comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820318469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820318469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA119.008610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T23:39:28Z","timestamp":1641253168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820318469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":34,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0021925820318469"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra119.008610","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735836418.793560851","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA119.008610","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 ?y?a et al.","name":"copyright","label":"Copyright"}]}}