{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:11:50Z","timestamp":1790730710135,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG)","doi-asserted-by":"publisher","award":["SFB 829"],"award-info":[{"award-number":["SFB 829"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG)","doi-asserted-by":"publisher","award":["FOR 2722"],"award-info":[{"award-number":["FOR 2722"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010115","name":"R\u00e9gion Auvergne-Rh\u00f4ne-Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010115","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011074","name":"Universit\u00e9 de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1074\/jbc.ra119.008641","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T20:45:18Z","timestamp":1564087518000},"page":"13769-13780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["C-terminal proteolysis of the collagen VI \u03b13 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes"],"prefix":"10.1016","volume":"294","author":[{"given":"Stefanie Elisabeth","family":"Heum\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Talantikite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Napoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-445X","authenticated-orcid":false,"given":"Jean","family":"Armengaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"M\u00f6rgelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Sengle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Paulsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Moali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Wagener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA119.008641_bib1","first-page":"3525","article-title":"Collagen VI at a glance","volume":"128","author":"Cescon","year":"2015","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.RA119.008641_bib2","doi-asserted-by":"crossref","first-page":"10658","DOI":"10.1074\/jbc.M709540200","article-title":"Three novel collagen VI chains with high homology to the \u03b13 chain","volume":"283","author":"Gara","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib3","doi-asserted-by":"crossref","first-page":"20170","DOI":"10.1074\/jbc.M710139200","article-title":"Three novel collagen VI chains, \u03b14(VI), \u03b15(VI), and \u03b16(VI)","volume":"283","author":"Fitzgerald","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib4","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1074\/jbc.M115.705160","article-title":"Heterogeneity of collagen VI microfibrils: structural analysis of non-collagenous regions","volume":"291","author":"Maass","year":"2016","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.matbio.2011.03.006","article-title":"Differential and restricted expression of novel collagen VI chains in mouse","volume":"30","author":"Gara","year":"2011","journal-title":"Matrix Biol"},{"key":"10.1074\/jbc.RA119.008641_bib6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.matbio.2009.05.003","article-title":"The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5\u2032 part of the split COL6A4 gene","volume":"28","author":"Wagener","year":"2009","journal-title":"Matrix Biol"},{"key":"10.1074\/jbc.RA119.008641_bib7","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1093\/hmg\/7.13.2135","article-title":"Collagen VI deficiency induces early onset myopathy in the mouse: an animal model for Bethlem myopathy","volume":"7","author":"Bonaldo","year":"1998","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.RA119.008641_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/ng1270","article-title":"Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency","volume":"35","author":"Irwin","year":"2003","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.RA119.008641_bib9","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/nm.2247","article-title":"Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration","volume":"16","author":"Grumati","year":"2010","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.008641_bib10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00401-018-1860-9","article-title":"Collagen VI is required for the structural and functional integrity of the neuromuscular junction","volume":"136","author":"Cescon","year":"2018","journal-title":"Acta Neuropathol"},{"key":"10.1074\/jbc.RA119.008641_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nn.2240","article-title":"Collagen VI protects neurons against A\u03b2 toxicity","volume":"12","author":"Cheng","year":"2009","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.RA119.008641_bib12","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1096\/fj.13-239533","article-title":"Collagen VI regulates peripheral nerve myelination and function","volume":"28","author":"Chen","year":"2014","journal-title":"FASEB J"},{"key":"10.1074\/jbc.RA119.008641_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-014-1369-9","article-title":"Collagen VI regulates peripheral nerve regeneration by modulating macrophage recruitment and polarization","volume":"129","author":"Chen","year":"2015","journal-title":"Acta Neuropathol"},{"key":"10.1074\/jbc.RA119.008641_bib14","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/art.24293","article-title":"Developmental and osteoarthritic changes in Col6a1-knockout mice: biomechanics of type VI collagen in the cartilage pericellular matrix","volume":"60","author":"Alexopoulos","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1074\/jbc.RA119.008641_bib15","doi-asserted-by":"crossref","first-page":"e33397","DOI":"10.1371\/journal.pone.0033397","article-title":"Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice","volume":"7","author":"Christensen","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA119.008641_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tice.2011.08.002","article-title":"Type VI collagen deficiency induces osteopenia with distortion of osteoblastic cell morphology","volume":"44","author":"Izu","year":"2012","journal-title":"Tissue Cell"},{"key":"10.1074\/jbc.RA119.008641_bib17","doi-asserted-by":"crossref","first-page":"e105686","DOI":"10.1371\/journal.pone.0105686","article-title":"Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies: expression of classical and novel collagen VI variants during wound healing","volume":"9","author":"Lettmann","year":"2014","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA119.008641_bib18","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1038\/jid.2015.187","article-title":"Lack of collagen VI promotes wound-induced hair growth","volume":"135","author":"Chen","year":"2015","journal-title":"J. Invest. Dermatol"},{"key":"10.1074\/jbc.RA119.008641_bib19","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1161\/CIRCRESAHA.111.252734","article-title":"Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction","volume":"110","author":"Luther","year":"2012","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.RA119.008641_bib20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.matbio.2010.10.001","article-title":"Dysfunctional tendon collagen fibrillogenesis in collagen VI null mice","volume":"30","author":"Izu","year":"2011","journal-title":"Matrix Biol"},{"key":"10.1074\/jbc.RA119.008641_bib21","first-page":"828","article-title":"Annexin A2 mediates secretion of collagen VI, pulmonary elasticity and apoptosis of bronchial epithelial cells","volume":"127","author":"Dassah","year":"2014","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.RA119.008641_bib22","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1172\/JCI63930","article-title":"Adipocyte-derived endotrophin promotes malignant tumor progression","volume":"122","author":"Park","year":"2012","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA119.008641_bib23","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1006\/bbrc.2001.6227","article-title":"The C5 domain of Col6A3 is cleaved off from the Col6 fibrils immediately after secretion","volume":"290","author":"Aigner","year":"2002","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA119.008641_bib24","doi-asserted-by":"crossref","first-page":"40266","DOI":"10.1074\/jbc.M111.265595","article-title":"Collagen VI, conformation of A-domain arrays and microfibril architecture","volume":"286","author":"Beecher","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1074\/jbc.M008173200","article-title":"The N-terminal N5 subdomain of the \u03b13(VI) chain is important for collagen VI microfibril formation","volume":"276","author":"Fitzgerald","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib26","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1038\/ncomms4485","article-title":"Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction","volume":"5","author":"Sun","year":"2014","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.RA119.008641_bib27","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/emmm.201202006","article-title":"Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours","volume":"5","author":"Park","year":"2013","journal-title":"EMBO Mol. Med"},{"key":"10.1074\/jbc.RA119.008641_bib28","doi-asserted-by":"crossref","first-page":"16607","DOI":"10.1074\/jbc.M510192200","article-title":"The C5 domain of the collagen VI \u03b13(VI) chain is critical for extracellular microfibril formation and is present in the extracellular matrix of cultured cells","volume":"281","author":"Lamand\u00e9","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib29","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1158\/0008-5472.CAN-03-2408","article-title":"TEM8 interacts with the cleaved C5 domain of collagen \u03b13(VI)","volume":"64","author":"Nanda","year":"2004","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.RA119.008641_bib30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nbt.1611","article-title":"Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products","volume":"28","author":"Kleifeld","year":"2010","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/jbc.RA119.008641_bib31","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00018-014-1733-x","article-title":"Proteolytic control of TGF-\u03b2 co-receptor activity by BMP-1\/tolloid-like proteases revealed by quantitative iTRAQ proteomics","volume":"72","author":"Delolme","year":"2015","journal-title":"Cell Mol. Life Sci"},{"key":"10.1074\/jbc.RA119.008641_bib32","doi-asserted-by":"crossref","first-page":"M110","DOI":"10.1074\/mcp.M110.003533","article-title":"Broad coverage identification of multiple proteolytic cleavage site sequences in complex high molecular weight proteins using quantitative proteomics as a complement to edman sequencing","volume":"10","author":"Doucet","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/jbc.RA119.008641_bib33","doi-asserted-by":"crossref","first-page":"27511","DOI":"10.1074\/jbc.273.42.27511","article-title":"Bone morphogenetic protein-1 processes the NH2-terminal propeptide, and a furin-like proprotein convertase processes the COOH-terminal propeptide of pro-\u03b11(V) collagen","volume":"273","author":"Imamura","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib34","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1128\/MCB.23.13.4428-4438.2003","article-title":"Use of Bmp1\/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1\/tolloid-like metalloproteinases","volume":"23","author":"Pappano","year":"2003","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA119.008641_bib35","doi-asserted-by":"crossref","first-page":"29014","DOI":"10.1074\/jbc.M111.252585","article-title":"Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3","volume":"286","author":"Kim","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib36","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1432-1033.1994.00573.x","article-title":"Recombinant expression and properties of the Kunitz-type protease-inhibitor module from human type VI collagen \u03b13(VI) chain","volume":"225","author":"Mayer","year":"1994","journal-title":"Eur. J. Biochem"},{"key":"10.1074\/jbc.RA119.008641_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/bip.23069","article-title":"The polypeptide biophysics of proline\/alanine-rich sequences (PAS): recombinant biopolymers with PEG-like properties","volume":"109","author":"Breibeck","year":"2018","journal-title":"Biopolymers"},{"key":"10.1074\/jbc.RA119.008641_bib38","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/protein\/gzt023","article-title":"PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins","volume":"26","author":"Schlapschy","year":"2013","journal-title":"Protein Eng. Des. Sel"},{"key":"10.1074\/jbc.RA119.008641_bib39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.matbio.2015.02.006","article-title":"BMP-1\/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling","volume":"44","author":"Vadon-Le Goff","year":"2015","journal-title":"Matrix Biol"},{"key":"10.1074\/jbc.RA119.008641_bib40","doi-asserted-by":"crossref","first-page":"26372","DOI":"10.1074\/jbc.M203247200","article-title":"Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen","volume":"277","author":"Rattenholl","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib41","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1111\/febs.13938","article-title":"Influence of WFIKKN1 on BMP1-mediated activation of latent myostatin","volume":"283","author":"Szl\u00e1ma","year":"2016","journal-title":"FEBS J"},{"key":"10.1074\/jbc.RA119.008641_bib42","doi-asserted-by":"crossref","first-page":"11434","DOI":"10.1021\/bi034925d","article-title":"Procollagen VII self-assembly depends on site-specific interactions and is promoted by cleavage of the NC2 domain with procollagen C-proteinase","volume":"42","author":"Colombo","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.008641_bib43","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrd3699","article-title":"The biology and therapeutic targeting of the proprotein convertases","volume":"11","author":"Seidah","year":"2012","journal-title":"Nat. Rev. Drug Discov"},{"key":"10.1074\/jbc.RA119.008641_bib44","doi-asserted-by":"crossref","first-page":"D655","DOI":"10.1093\/nar\/gkj040","article-title":"The PeptideAtlas project","volume":"34","author":"Desiere","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA119.008641_bib45","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1093\/emboj\/19.19.5051","article-title":"A short sequence in the N-terminal region is required for the trimerization of type XIII collagen and is conserved in other collagenous transmembrane proteins","volume":"19","author":"Snellman","year":"2000","journal-title":"EMBO J"},{"key":"10.1074\/jbc.RA119.008641_bib46","doi-asserted-by":"crossref","first-page":"25937","DOI":"10.1074\/jbc.273.40.25937","article-title":"Two forms of collagen XVII in keratinocytes: a full-length transmembrane protein and a soluble ectodomain","volume":"273","author":"Sch\u00e4cke","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib47","doi-asserted-by":"crossref","first-page":"27424","DOI":"10.1074\/jbc.M703425200","article-title":"Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment","volume":"282","author":"Veit","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib48","doi-asserted-by":"crossref","first-page":"10647","DOI":"10.1074\/jbc.M611339200","article-title":"Cleavage and oligomerization of gliomedin, a transmembrane collagen required for node of ranvier formation","volume":"282","author":"Maertens","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib49","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/path.5172","article-title":"COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease","volume":"247","author":"Lee","year":"2019","journal-title":"J. Pathol"},{"key":"10.1074\/jbc.RA119.008641_bib50","doi-asserted-by":"crossref","first-page":"14320","DOI":"10.1074\/jbc.M112.433078","article-title":"COL6A3 protein deficiency in mice leads to muscle and tendon defects similar to human collagen VI congenital muscular dystrophy","volume":"288","author":"Pan","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib51","doi-asserted-by":"crossref","first-page":"10293","DOI":"10.1074\/jbc.M114.549311","article-title":"A mouse model for dominant collagen VI disorders: heterozygous deletion of Col6a3 Exon 16","volume":"289","author":"Pan","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.008641_bib52","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1086\/340608","article-title":"Mutations in COL6A3 cause severe and mild phenotypes of Ullrich congenital muscular dystrophy","volume":"70","author":"Demir","year":"2002","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.RA119.008641_bib53","doi-asserted-by":"crossref","first-page":"e0144525","DOI":"10.1371\/journal.pone.0144525","article-title":"Collagen type III and VI turnover in response to long-term immobilization","volume":"10","author":"Sun","year":"2015","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA119.008641_bib54","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.chest.2016.08.1440","article-title":"Systemic biomarkers of collagen and elastin turnover are associated with clinically relevant outcomes in COPD","volume":"151","author":"Stolz","year":"2017","journal-title":"Chest"},{"key":"10.1074\/jbc.RA119.008641_bib55","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12931-017-0509-x","article-title":"Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD","volume":"18","author":"Bihlet","year":"2017","journal-title":"Respir. Res"},{"key":"10.1074\/jbc.RA119.008641_bib56","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.clinbiochem.2016.09.003","article-title":"Characterization of serological neo-epitope biomarkers reflecting collagen remodeling in clinically stable chronic obstructive pulmonary disease","volume":"49","author":"Sand","year":"2016","journal-title":"Clin. Biochem"},{"key":"10.1074\/jbc.RA119.008641_bib57","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12931-015-0225-3","article-title":"Accelerated extracellular matrix turnover during exacerbations of COPD","volume":"16","author":"Sand","year":"2015","journal-title":"Respir. Res"},{"key":"10.1074\/jbc.RA119.008641_bib58","doi-asserted-by":"crossref","first-page":"e0207324","DOI":"10.1371\/journal.pone.0207324","article-title":"Serum biomarkers of collagen turnover as potential diagnostic tools in diffuse systemic sclerosis: a cross-sectional study","volume":"13","author":"Juhl","year":"2018","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA119.008641_bib59","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/2047487318758750","article-title":"Accelerated collagen turnover in women with angina pectoris without obstructive coronary artery disease: an iPOWER substudy","volume":"25","author":"Nielsen","year":"2018","journal-title":"Eur. J. Prev. Cardiol"},{"key":"10.1074\/jbc.RA119.008641_bib60","doi-asserted-by":"crossref","first-page":"e0175200","DOI":"10.1371\/journal.pone.0175200","article-title":"Serum endotrophin, a type VI collagen cleavage product, is associated with increased mortality in chronic kidney disease","volume":"12","author":"Fenton","year":"2017","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA119.008641_bib61","doi-asserted-by":"crossref","first-page":"e0175898","DOI":"10.1371\/journal.pone.0175898","article-title":"Non-invasive quantification of collagen turnover in renal transplant recipients","volume":"12","author":"Stribos","year":"2017","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA119.008641_bib62","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2337\/dc17-2392","article-title":"Higher collagen VI formation is associated with all-cause mortality in patients with type 2 diabetes and microalbuminuria","volume":"41","author":"Rasmussen","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1074\/jbc.RA119.008641_bib63","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00125-016-4094-1","article-title":"Serum endotrophin identifies optimal responders to PPAR\u03b3 agonists in type 2 diabetes","volume":"60","author":"Karsdal","year":"2017","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.RA119.008641_bib64","doi-asserted-by":"crossref","first-page":"17328","DOI":"10.1038\/s41598-017-17470-3","article-title":"Urinary endotrophin predicts disease progression in patients with chronic kidney disease","volume":"7","author":"Rasmussen","year":"2017","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA119.008641_bib65","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jprot.2016.02.031","article-title":"Characterization of post-translational modifications in full-length human BMP-1 confirms the presence of a rare vicinal disulfide linkage in the catalytic domain and highlights novel features of the EGF domain","volume":"138","author":"Hung","year":"2016","journal-title":"J. Proteomics"},{"key":"10.1074\/jbc.RA119.008641_bib66","first-page":"S95","article-title":"Development of an optimised culture medium for keratocytes in monolayer","volume":"16","author":"Builles","year":"2006","journal-title":"Biomed. Mater. Eng"},{"key":"10.1074\/jbc.RA119.008641_bib67","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1002\/2211-5463.12540","article-title":"Inhibitors of BMP-1\/tolloid-like proteinases: efficacy, selectivity and cellular toxicity","volume":"8","author":"Talantikite","year":"2018","journal-title":"FEBS Open Bio"},{"key":"10.1074\/jbc.RA119.008641_bib68","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1096\/fj.15-279869","article-title":"Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-\u03b2 signaling as primary targets","volume":"30","author":"Bekhouche","year":"2016","journal-title":"FASEB J"},{"key":"10.1074\/jbc.RA119.008641_bib69","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/pmic.200900375","article-title":"A guided tour of the Trans-Proteomic Pipeline","volume":"10","author":"Deutsch","year":"2010","journal-title":"Proteomics"},{"key":"10.1074\/jbc.RA119.008641_bib70","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jemt.1060140405","article-title":"Small colloidal gold conjugated to Fab fragments or to immunoglobulin G as high-resolution labels for electron microscopy: a technical overview","volume":"14","author":"Baschong","year":"1990","journal-title":"J. Electron Microsc. Tech"},{"key":"10.1074\/jbc.RA119.008641_bib71","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/28.1.6153194","article-title":"FITC-protein A-gold complex for light and electron microscopic immunocytochemistry","volume":"28","author":"Roth","year":"1980","journal-title":"J. Histochem. Cytochem"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820332099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820332099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA119.008641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:32:27Z","timestamp":1641256347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820332099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":71,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0021925820332099"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra119.008641","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736274411.793563686","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"C-terminal proteolysis of the collagen VI \u03b13 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA119.008641","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Heum\u00fcller et al.","name":"copyright","label":"Copyright"}]}}