{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:04:43Z","timestamp":1790676283596,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":322,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"HHS | NIH | National Cancer Institute","award":["NCI P01 CA214274"],"award-info":[{"award-number":["NCI P01 CA214274"]}]},{"name":"QF | Qatar National Research Fund","award":["National Priorities Research Program"],"award-info":[{"award-number":["National Priorities Research Program"]}]},{"DOI":"10.13039\/100000043","name":"American Association for Cancer Research","doi-asserted-by":"crossref","award":["Cancer Research Basic Cancer Research Fellowship"],"award-info":[{"award-number":["Cancer Research Basic Cancer Research Fellowship"]}],"id":[{"id":"10.13039\/100000043","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"crossref","award":["Mantle Cell Lymphoma Research Initiative (MCL7001\u201318)"],"award-info":[{"award-number":["Mantle Cell Lymphoma Research Initiative (MCL7001\u201318)"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/s0021-9258(17)49877-2","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:47:54Z","timestamp":1609793274000},"page":"1165-1180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma"],"prefix":"10.1016","volume":"295","author":[{"given":"Vrajesh","family":"Karkhanis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lapo","family":"Alinari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Gulcin","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-1145","authenticated-orcid":false,"given":"Sa\u00efd","family":"Sif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Baiocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0021-9258(17)49877-2_bib1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/jcb.20005","article-title":"ATP-dependent nucleosome remodeling complexes: enzymes tailored to deal with chromatin","volume":"91","author":"Sif","year":"2004","journal-title":"J. Cell. Biochem"},{"key":"10.1016\/S0021-9258(17)49877-2_bib2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nrm1761","article-title":"The diverse functions of histone lysine methylation","volume":"6","author":"Martin","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1016\/S0021-9258(17)49877-2_bib3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0955-0674(03)00013-9","article-title":"Histone and chromatin cross-talk","volume":"15","author":"Fischle","year":"2003","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1016\/S0021-9258(17)49877-2_bib4","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/sj.bjc.6601575","article-title":"Linking the epigenetic language\u2032 of covalent histone modifications to cancer","volume":"90","author":"Hake","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S0021-9258(17)49877-2_bib5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/jcp.21180","article-title":"Interplay between chromatin remodelers and protein arginine methyltransferases","volume":"213","author":"Pal","year":"2007","journal-title":"J. Cell. Physiol"},{"key":"10.1016\/S0021-9258(17)49877-2_bib6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.molcel.2005.04.003","article-title":"Arginine methylation an emerging regulator of protein function","volume":"18","author":"Bedford","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/S0021-9258(17)49877-2_bib7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.tibs.2011.09.001","article-title":"Versatility of PRMT5-induced methylation in growth control and development","volume":"36","author":"Karkhanis","year":"2011","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/S0021-9258(17)49877-2_bib8","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.1074\/jbc.M111.336271","article-title":"Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming \u03c9-NG-monomethylated arginine residues","volume":"287","author":"Zurita-Lopez","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0021-9258(17)49877-2_bib9","doi-asserted-by":"crossref","first-page":"9630","DOI":"10.1128\/MCB.24.21.9630-9645.2004","article-title":"Human SWI\/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes","volume":"24","author":"Pal","year":"2004","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S0021-9258(17)49877-2_bib10","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1038\/sj.emboj.7601794","article-title":"Low levels of miR-92b\/96 induce PRMT5 translation and H3R8\/H4R3 methylation in mantle cell lymphoma","volume":"26","author":"Pal","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/S0021-9258(17)49877-2_bib11","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.1128\/MCB.00923-08","article-title":"Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells","volume":"28","author":"Wang","year":"2008","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S0021-9258(17)49877-2_bib12","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1182\/blood-2014-12-619783","article-title":"Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation","volume":"125","author":"Alinari","year":"2015","journal-title":"Blood"},{"key":"10.1016\/S0021-9258(17)49877-2_bib13","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1128\/MCB.00742-08","article-title":"Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation","volume":"29","author":"Dacwag","year":"2009","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/S0021-9258(17)49877-2_bib14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1182\/blood-2014-05-521898","article-title":"Mantle cell lymphoma: evolving management strategies","volume":"125","author":"Campo","year":"2015","journal-title":"Blood"},{"key":"10.1016\/S0021-9258(17)49877-2_bib15","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","article-title":"A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project","volume":"89","author":"Non-Hodgkin's Lymphoma Classification Project","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0021-9258(17)49877-2_bib16","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1126\/science.6610211","article-title":"Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation","volume":"224","author":"Tsujimoto","year":"1984","journal-title":"Science"},{"key":"10.1016\/S0021-9258(17)49877-2_bib17","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nrc2230","article-title":"Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics","volume":"7","author":"Jares","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/S0021-9258(17)49877-2_bib18","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/S0002-9440(10)65710-0","article-title":"Differential expression of cyclin D1 in mantle cell lymphoma and other non-Hodgkin's lymphomas","volume":"153","author":"Aguilera","year":"1998","journal-title":"Am. J. Pathol"},{"key":"10.1016\/S0021-9258(17)49877-2_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-5793(01)02118-4","article-title":"Making decisions through Myc","volume":"490","author":"Nasi","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/S0021-9258(17)49877-2_bib20","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nature03677","article-title":"c-Myc-regulated microRNAs modulate E2F1 expression","volume":"435","author":"O'Donnell","year":"2005","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(17)49877-2_bib21","doi-asserted-by":"crossref","first-page":"35534","DOI":"10.1074\/jbc.M113.510669","article-title":"Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing","volume":"288","author":"Chung","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0021-9258(17)49877-2_bib22","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1182\/blood-2008-03-142182","article-title":"Truncation in CCND1 mRNA alters miR-16\u20131 regulation in mantle cell lymphoma","volume":"112","author":"Chen","year":"2008","journal-title":"Blood"},{"key":"10.1016\/S0021-9258(17)49877-2_bib23","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1182\/blood-2006-08-039859","article-title":"Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival","volume":"109","author":"Wiestner","year":"2007","journal-title":"Blood"},{"key":"10.1016\/S0021-9258(17)49877-2_bib24","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1182\/blood-2013-05-498329","article-title":"Understanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classification","volume":"122","author":"Ott","year":"2013","journal-title":"Blood"},{"key":"10.1016\/S0021-9258(17)49877-2_bib25","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/nrc2231","article-title":"Reflecting on 25 years with MYC","volume":"8","author":"Meyer","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/S0021-9258(17)49877-2_bib26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/his.12207","article-title":"Immunohistochemical evaluation of MYC expression in mantle cell lymphoma","volume":"63","author":"Oberley","year":"2013","journal-title":"Histopathology"},{"key":"10.1016\/S0021-9258(17)49877-2_bib27","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/sj.leu.2401599","article-title":"c-myc mRNA expression and genomic alterations in mantle cell lymphomas and other nodal non-Hodgkin's lymphomas","volume":"13","author":"Hern\u00e1ndez","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/S0021-9258(17)49877-2_bib28","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1182\/blood-2015-05-647602","article-title":"MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA\/LYSA study","volume":"126","author":"Copie-Bergman","year":"2015","journal-title":"Blood"},{"key":"10.1016\/S0021-9258(17)49877-2_bib29","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/PAS.0000000000000758","article-title":"Mantle cell lymphoma with MYC rearrangement: a report of 17 patients","volume":"41","author":"Hu","year":"2017","journal-title":"Am. J. Surg. Pathol"},{"key":"10.1016\/S0021-9258(17)49877-2_bib30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/blood-2016-02-636316","article-title":"Approach to the diagnosis and treatment of high-grade B-cell lymphomas with MYC and BCL2 and\/or BCL6 rearrangements","volume":"129","author":"Sesques","year":"2017","journal-title":"Blood"},{"key":"10.1016\/S0021-9258(17)49877-2_bib31","doi-asserted-by":"crossref","first-page":"42362","DOI":"10.18632\/oncotarget.5705","article-title":"High incidence of MYC and BCL2 abnormalities in mantle cell lymphoma, although only MYC abnormality predicts poor survival","volume":"6","author":"Yi","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/S0021-9258(17)49877-2_bib32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature14351","article-title":"MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis","volume":"523","author":"Koh","year":"2015","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(17)49877-2_bib33","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/leu.2015.308","article-title":"The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation","volume":"30","author":"Tarighat","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/S0021-9258(17)49877-2_bib34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ccr.2010.03.008","article-title":"Sp1\/NF\u03baB\/HDAC\/miR-29b regulatory network in KIT-driven myeloid leukemia","volume":"17","author":"Liu","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/S0021-9258(17)49877-2_bib35","doi-asserted-by":"crossref","first-page":"38230","DOI":"10.1074\/jbc.M206064200","article-title":"Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells","volume":"277","author":"Won","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0021-9258(17)49877-2_bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrc3409","article-title":"Protein arginine methyltransferases and cancer","volume":"13","author":"Yang","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/S0021-9258(17)49877-2_bib37","doi-asserted-by":"crossref","first-page":"18824","DOI":"10.1038\/srep18824","article-title":"DNA methylation-mediated down-regulating of MicroRNA-33b and its role in gastric cancer","volume":"6","author":"Yin","year":"2016","journal-title":"Sci. Rep"},{"key":"10.1016\/S0021-9258(17)49877-2_bib38","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1182\/blood-2012-01-401794","article-title":"Investigational agent MLN9708\/2238 targets tumor-suppressor miR33b in MM cells","volume":"120","author":"Tian","year":"2012","journal-title":"Blood"},{"key":"10.1016\/S0021-9258(17)49877-2_bib39","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.3892\/mmr.2014.2591","article-title":"Role and mechanisms of microRNA503 in drug resistance reversal in HepG2\/ADM human hepatocellular carcinoma cells","volume":"10","author":"Wang","year":"2014","journal-title":"Mol. Med. Rep"},{"key":"10.1016\/S0021-9258(17)49877-2_bib40","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1158\/0008-5472.CAN-14-0389","article-title":"Metastatic heterogeneity of breast cancer cells is associated with expression of a heterogeneous TGF\u03b2-activating miR424\u2013503 gene cluster","volume":"74","author":"Li","year":"2014","journal-title":"Cancer Res"},{"key":"10.1016\/S0021-9258(17)49877-2_bib41","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/cam4.1360","article-title":"PRMT5 promotes cell proliferation by inhibiting BTG2 expression via the ERK signaling pathway in hepatocellular carcinoma","volume":"7","author":"Jiang","year":"2018","journal-title":"Cancer Med"},{"key":"10.1016\/S0021-9258(17)49877-2_bib42","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10549-017-4597-6","article-title":"PRMT5 determines the sensitivity to chemotherapy by governing stemness in breast cancer","volume":"168","author":"Wang","year":"2018","journal-title":"Breast Cancer Res. Treat"},{"key":"10.1016\/S0021-9258(17)49877-2_bib43","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1038\/leu.2008.213","article-title":"Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2","volume":"22","author":"Klier","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/S0021-9258(17)49877-2_bib44","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0021-9258(17)49877-2_bib45","doi-asserted-by":"crossref","first-page":"e1003118","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for computing and annotating genomic ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Comput. Biol"},{"key":"10.1016\/S0021-9258(17)49877-2_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(17)49877-2_bib47","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand. J. Statist"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817498772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817498772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T04:17:04Z","timestamp":1758169024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817498772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":47,"aliases":["10.1074\/jbc.ra119.008742"],"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0021925817498772"],"URL":"https:\/\/doi.org\/10.1016\/s0021-9258(17)49877-2","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0021-9258(17)49877-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}