{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:47:23Z","timestamp":1761709643980},"reference-count":39,"publisher":"Elsevier BV","issue":"45","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA207772","1R01CA215095"],"award-info":[{"award-number":["1R01CA207772","1R01CA215095"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-15\u20131-0052"],"award-info":[{"award-number":["W81XWH-15\u20131-0052"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1074\/jbc.ra119.009312","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T22:09:00Z","timestamp":1569881340000},"page":"16846-16854","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Heat shock protein 47 (HSP47) binds to discoidin domain\u2013containing receptor 2 (DDR2) and regulates its protein stability"],"prefix":"10.1016","volume":"294","author":[{"given":"Jie","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shike","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher I.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA119.009312_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10555-008-9178-z","article-title":"Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices","volume":"28","author":"Xu","year":"2009","journal-title":"Cancer Metastasis Rev"},{"key":"10.1074\/jbc.RA119.009312_bib2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","article-title":"Collagen structure and stability","volume":"78","author":"Shoulders","year":"2009","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.RA119.009312_bib3","doi-asserted-by":"crossref","first-page":"R912","DOI":"10.1016\/S0960-9822(00)00850-2","article-title":"Protein-specific chaperones: the role of hsp47 begins to gel","volume":"10","author":"Hendershot","year":"2000","journal-title":"Curr. Biol"},{"key":"10.1074\/jbc.RA119.009312_bib4","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1074\/jbc.TM118.002812","article-title":"Roles of the endoplasmic reticulum-resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease","volume":"294","author":"Ito","year":"2019","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.009312_bib5","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1046\/j.1523-1747.1998.00437.x","article-title":"Increased expression of heat-shock protein 47 is associated with overproduction of type I procollagen in systemic sclerosis skin fibroblasts","volume":"111","author":"Kuroda","year":"1998","journal-title":"J. Invest. Dermatol"},{"key":"10.1074\/jbc.RA119.009312_bib6","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/j.1365-2133.2007.07898.x","article-title":"Effect of heat shock protein 47 on collagen accumulation in keloid fibroblast cells","volume":"156","author":"Chen","year":"2007","journal-title":"Br. J. Dermatol"},{"key":"10.1074\/jbc.RA119.009312_bib7","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1158\/0008-5472.CAN-14-1027","article-title":"Chaperone Hsp47 drives malignant growth and invasion by modulating an ECM gene network","volume":"75","author":"Zhu","year":"2015","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.RA119.009312_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/(SICI)1097-4644(19990501)73:2<248::AID-JCB11>3.0.CO;2-A","article-title":"Cell surface colligin\/Hsp47 associates with tetraspanin protein CD9 in epidermoid carcinoma cell lines","volume":"73","author":"Hebert","year":"1999","journal-title":"J. Cell Biochem"},{"key":"10.1074\/jbc.RA119.009312_bib9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1021\/acschemneuro.6b00253","article-title":"HSP47 promotes glioblastoma stemlike cell survival by modulating tumor microenvironment extracellular matrix through TGF-\u03b2 pathway","volume":"8","author":"Jiang","year":"2017","journal-title":"ACS Chem. Neurosci"},{"key":"10.1074\/jbc.RA119.009312_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/bpa.12256","article-title":"Heat shock protein 47 promotes glioma angiogenesis","volume":"26","author":"Wu","year":"2016","journal-title":"Brain Pathol"},{"key":"10.1074\/jbc.RA119.009312_bib11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1083\/jcb.103.1.223","article-title":"A major collagen-binding protein of chick embryo fibroblasts is a novel heat shock protein","volume":"103","author":"Nagata","year":"1986","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.RA119.009312_bib12","first-page":"4036","article-title":"HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts","volume":"11","author":"Hirayoshi","year":"1991","journal-title":"Mol. Cell Biol"},{"key":"10.1074\/jbc.RA119.009312_bib13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1432-1033.1992.tb16930.x","article-title":"Molecular cloning of a mouse 47-kDa heat-shock protein (HSP47), a collagen-binding stress protein, and its expression during the differentiation of F9 teratocarcinoma cells","volume":"206","author":"Takechi","year":"1992","journal-title":"Eur. J. Biochem"},{"key":"10.1074\/jbc.RA119.009312_bib14","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1158\/2159-8274.CD-11-0005","article-title":"Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer","volume":"1","author":"Hammerman","year":"2011","journal-title":"Cancer Discovery"},{"key":"10.1074\/jbc.RA119.009312_bib15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ncb2743","article-title":"The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis","volume":"15","author":"Zhang","year":"2013","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.RA119.009312_bib16","first-page":"378","article-title":"Discoidin domain receptors: Microenvironment sensors that promote cellular migration and invasion","volume":"12","author":"Itoh","year":"2018","journal-title":"Cell Adh. Migr"},{"key":"10.1074\/jbc.RA119.009312_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-12-800180-6.00002-5","article-title":"Discoidin domain receptor functions in physiological and pathological conditions","volume":"310","author":"Leitinger","year":"2014","journal-title":"Int. Rev. Cell Mol. Biol"},{"key":"10.1074\/jbc.RA119.009312_bib18","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.celrep.2016.12.079","article-title":"Mesenchymal stem cell-induced DDR2 mediates stromal\u2013breast cancer interactions and metastasis growth","volume":"18","author":"Gonzalez","year":"2017","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.RA119.009312_bib19","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1002\/cncr.23900","article-title":"Switching in discoid domain receptor expressions in SLUG-induced epithelial\u2013mesenchymal transition","volume":"113","author":"Maeyama","year":"2008","journal-title":"Cancer"},{"key":"10.1074\/jbc.RA119.009312_bib20","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/path.4415","article-title":"Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial\u2013mesenchymal transition programme under hypoxia","volume":"234","author":"Ren","year":"2014","journal-title":"J. Pathol"},{"key":"10.1074\/jbc.RA119.009312_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13046-015-0218-6","article-title":"DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1","volume":"34","author":"Xie","year":"2015","journal-title":"J Exp Clin. Cancer Res"},{"key":"10.1074\/jbc.RA119.009312_bib22","doi-asserted-by":"crossref","first-page":"13243","DOI":"10.1073\/pnas.1208072109","article-title":"Molecular basis for the action of the collagen-specific chaperone Hsp47\/SERPINH1 and its structure-specific client recognition","volume":"109","author":"Widmer","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.009312_bib23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1083\/jcb.133.2.469","article-title":"Intracellular interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen","volume":"133","author":"Satoh","year":"1996","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.RA119.009312_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1097-2765(00)80003-9","article-title":"The discoidin domain receptor tyrosine kinases are activated by collagen","volume":"1","author":"Vogel","year":"1997","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA119.009312_bib25","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.14440\/jbm.2018.266","article-title":"High resolution measurement of membrane receptor endocytosis","volume":"5","author":"Zhang","year":"2018","journal-title":"J. Biol. Methods"},{"key":"10.1074\/jbc.RA119.009312_bib26","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1158\/0008-5472.CAN-11-2762","article-title":"ROR\u03b1 suppresses breast tumor invasion by inducing SEMA3F expression","volume":"72","author":"Xiong","year":"2012","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.RA119.009312_bib27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13058-018-1030-y","article-title":"Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance","volume":"20","author":"Zhang","year":"2018","journal-title":"Breast Cancer Res"},{"key":"10.1074\/jbc.RA119.009312_bib28","doi-asserted-by":"crossref","first-page":"13707","DOI":"10.1074\/jbc.RA117.000758","article-title":"The endoplasmic reticulum-resident collagen chaperone Hsp47 interacts with and promotes the secretion of decorin, fibromodulin, and lumican","volume":"293","author":"Ishikawa","year":"2018","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.009312_bib29","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.molcel.2017.12.028","article-title":"Interactome screening identifies the ER luminal chaperone Hsp47 as a regulator of the unfolded protein response transducer IRE1\u03b1","volume":"69","author":"Sepulveda","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA119.009312_bib30","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1042\/BCJ20170111","article-title":"Role of glycosylation in nucleating protein folding and stability","volume":"474","author":"Jayaprakash","year":"2017","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.RA119.009312_bib31","first-page":"208","article-title":"New insights into protein hydroxylation and its important role in human diseases","volume":"1866","author":"Zurlo","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA119.009312_bib32","doi-asserted-by":"crossref","first-page":"9441","DOI":"10.1093\/nar\/gkx619","article-title":"Phosphorylation regulates human poleta stability and damage bypass throughout the cell cycle","volume":"45","author":"Bertoletti","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA119.009312_bib33","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1271\/bbb.130351","article-title":"Low stability and a conserved N-glycosylation site are associated with regulation of the discoidin domain receptor family by glucose via post-translational N-glycosylation","volume":"77","author":"Phan","year":"2013","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"10.1074\/jbc.RA119.009312_bib34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.matbio.2011.03.007","article-title":"Discoidin domain receptor 2 is a critical regulator of epithelial\u2013mesenchymal transition","volume":"30","author":"Walsh","year":"2011","journal-title":"Matrix Biol"},{"key":"10.1074\/jbc.RA119.009312_bib35","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI36183","article-title":"Biomarkers for epithelial\u2013mesenchymal transitions","volume":"119","author":"Zeisberg","year":"2009","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA119.009312_bib36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40169-015-0048-3","article-title":"EMT and tumor metastasis","volume":"4","author":"Heerboth","year":"2015","journal-title":"Clin. Transl. Med"},{"key":"10.1074\/jbc.RA119.009312_bib37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.matbio.2009.12.003","article-title":"Type I collagen promotes epithelial\u2013mesenchymal transition through ILK-dependent activation of NF-\u03baB and LEF-1","volume":"29","author":"Medici","year":"2010","journal-title":"Matrix Biol"},{"key":"10.1074\/jbc.RA119.009312_bib38","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.diff.2013.03.003","article-title":"Extracellular matrix proteins regulate epithelial\u2013mesenchymal transition in mammary epithelial cells","volume":"86","author":"Chen","year":"2013","journal-title":"Differentiation"},{"key":"10.1074\/jbc.RA119.009312_bib39","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1038\/s41467-018-06893-9","article-title":"Collagen prolyl 4-hydroxylase 1 is essential for HIF-1\u03b1 stabilization and TNBC chemoresistance","volume":"9","author":"Xiong","year":"2018","journal-title":"Nat. Commun"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820305275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820305275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA119.009312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T04:06:26Z","timestamp":1641269186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820305275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":39,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0021925820305275"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra119.009312","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heat shock protein 47 (HSP47) binds to discoidin domain\u2013containing receptor 2 (DDR2) and regulates its protein stability","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA119.009312","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Chen et al.","name":"copyright","label":"Copyright"}]}}