{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:33:16Z","timestamp":1768969996262,"version":"3.49.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"HHS NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR068160"],"award-info":[{"award-number":["AR068160"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS NIH National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK045227"],"award-info":[{"award-number":["DK045227"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1074\/jbc.ra119.009824","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:44:24Z","timestamp":1564706664000},"page":"14203-14214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor \u03b1"],"prefix":"10.1016","volume":"294","author":[{"given":"Jungeun","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9154-952X","authenticated-orcid":false,"given":"Ernesto","family":"Canalis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA119.009824_bib1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/physrev.00005.2017","article-title":"Notch signaling in development, tissue homeostasis, and disease","volume":"97","author":"Siebel","year":"2017","journal-title":"Physiol. Rev"},{"key":"10.1074\/jbc.RA119.009824_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1210\/er.2016-1002","article-title":"Notch signaling and the skeleton","volume":"37","author":"Zanotti","year":"2016","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.RA119.009824_bib3","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1074\/jbc.M707000200","article-title":"NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells","volume":"283","author":"Bai","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.009824_bib4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1210\/en.2012-1732","article-title":"Osteoblast lineage-specific effects of notch activation in the skeleton","volume":"154","author":"Canalis","year":"2013","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.RA119.009824_bib5","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1074\/jbc.M115.685453","article-title":"Hajdu Cheney mouse mutants exhibit osteopenia, increased osteoclastogenesis and bone resorption","volume":"291","author":"Canalis","year":"2016","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.009824_bib6","doi-asserted-by":"crossref","first-page":"14165","DOI":"10.1074\/jbc.RA118.004242","article-title":"The lateral meningocele syndrome mutation causes marked osteopenia in mice","volume":"293","author":"Canalis","year":"2018","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.009824_bib7","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1128\/MCB.00299-08","article-title":"The association of Notch2 and NF-\u03baB accelerates RANKL-induced osteoclastogenesis","volume":"28","author":"Fukushima","year":"2008","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA119.009824_bib8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm1716","article-title":"Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation","volume":"14","author":"Hilton","year":"2008","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.009824_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bone.2017.06.027","article-title":"Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes","volume":"103","author":"Zanotti","year":"2017","journal-title":"Bone"},{"key":"10.1074\/jbc.RA119.009824_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/mcne.1996.0040","article-title":"Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development","volume":"8","author":"Lindsell","year":"1996","journal-title":"Mol. Cell. Neurosci"},{"key":"10.1074\/jbc.RA119.009824_bib11","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1007\/s00198-018-4694-3","article-title":"Notch in skeletal physiology and disease","volume":"29","author":"Canalis","year":"2018","journal-title":"Osteoporos. Int"},{"key":"10.1074\/jbc.RA119.009824_bib12","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1128\/MCB.24.21.9265-9273.2004","article-title":"Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats","volume":"24","author":"Sanchez-Irizarry","year":"2004","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA119.009824_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jcp.10208","article-title":"HES and HERP families: multiple effectors of the Notch signaling pathway","volume":"194","author":"Iso","year":"2003","journal-title":"J. Cell. Physiol"},{"key":"10.1074\/jbc.RA119.009824_bib14","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1128\/MCB.21.17.6080-6089.2001","article-title":"HERP, a novel heterodimer partner of HES\/E(spl) in Notch signaling","volume":"21","author":"Iso","year":"2001","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.RA119.009824_bib15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1259\/0007-1285-21-241-42","article-title":"Cranio-skeletal dysplasia","volume":"21","author":"Hajdu","year":"1948","journal-title":"Br. J. Radiol"},{"key":"10.1074\/jbc.RA119.009824_bib16","first-page":"595","article-title":"Acro-Osteolysis","volume":"94","author":"Cheney","year":"1965","journal-title":"Am. J. Roentgenol. Radium. Ther. Nucl. Med"},{"key":"10.1074\/jbc.RA119.009824_bib17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s13023-014-0200-y","article-title":"Hajdu-Cheney syndrome: a review","volume":"9","author":"Canalis","year":"2014","journal-title":"Orphanet J. Rare Dis"},{"key":"10.1074\/jbc.RA119.009824_bib18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/ejhg.2011.125","article-title":"Serpentine fibula polycystic kidney syndrome is part of the phenotypic spectrum of Hajdu-Cheney syndrome","volume":"20","author":"Gray","year":"2012","journal-title":"Eur. J. Hum. Genet"},{"key":"10.1074\/jbc.RA119.009824_bib19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng.778","article-title":"Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis","volume":"43","author":"Isidor","year":"2011","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.RA119.009824_bib20","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/humu.21546","article-title":"Mutations in NOTCH2 in families with Hajdu-Cheney syndrome","volume":"32","author":"Majewski","year":"2011","journal-title":"Hum. Mutat"},{"key":"10.1074\/jbc.RA119.009824_bib21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng.779","article-title":"Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss","volume":"43","author":"Simpson","year":"2011","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.RA119.009824_bib22","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00198-013-2298-5","article-title":"Mutations in NOTCH2 in patients with Hajdu-Cheney syndrome","volume":"24","author":"Zhao","year":"2013","journal-title":"Osteoporos. Int"},{"key":"10.1074\/jbc.RA119.009824_bib23","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molcel.2017.10.018","article-title":"NOTCH2 Hajdu-Cheney mutations Escape SCF(FBW7)-dependent proteolysis to promote osteoporosis","volume":"68","author":"Fukushima","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA119.009824_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bone.2018.06.020","article-title":"Mice harboring a Hajdu Cheney syndrome mutation are sensitized to osteoarthritis","volume":"114","author":"Zanotti","year":"2018","journal-title":"Bone"},{"key":"10.1074\/jbc.RA119.009824_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ajpath.2017.09.010","article-title":"The Hajdu Cheney mutation is a determinant of B-cell allocation of the splenic marginal zone","volume":"188","author":"Yu","year":"2018","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.RA119.009824_bib26","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1210\/jc.2017-01102","article-title":"Bone structural characteristics and response to bisphosphonate treatment in children with Hajdu-Cheney syndrome","volume":"102","author":"Sakka","year":"2017","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.RA119.009824_bib27","first-page":"574","article-title":"Acro-osteolysis and osteoporosis as manifestations of the Hajdu-Cheney syndrome","volume":"20","author":"Blumenauer","year":"2002","journal-title":"Clin. Exp. Rheumatol"},{"key":"10.1074\/jbc.RA119.009824_bib28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0022-3476(76)80009-1","article-title":"The acro-osteolysis syndrome: morphologic and biochemical studies","volume":"88","author":"Brown","year":"1976","journal-title":"J. Pediatr"},{"key":"10.1074\/jbc.RA119.009824_bib29","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/art.1780290815","article-title":"Idiopathic familial acroosteolysis: histomorphometric study of bone and literature review of the Hajdu-Cheney syndrome","volume":"29","author":"Udell","year":"1986","journal-title":"Arthritis Rheum"},{"key":"10.1074\/jbc.RA119.009824_bib30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jot.2017.05.002","article-title":"Macrophages and bone inflammation","volume":"10","author":"Gu","year":"2017","journal-title":"J. Orthop. Translat"},{"key":"10.1074\/jbc.RA119.009824_bib31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cytogfr.2003.10.005","article-title":"IL-6, RANKL, TNF-\u03b1\/IL-1: interrelations in bone resorption pathophysiology","volume":"15","author":"Kwan Tat","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1074\/jbc.RA119.009824_bib32","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1074\/jbc.275.7.4858","article-title":"Tumor necrosis factor-\u03b1 induces differentiation of and bone resorption by osteoclasts","volume":"275","author":"Azuma","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.009824_bib33","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S8756-3282(01)00420-3","article-title":"Tumor necrosis factor-\u03b1 cooperates with receptor activator of nuclear factor \u03baB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture","volume":"28","author":"Komine","year":"2001","journal-title":"Bone"},{"key":"10.1074\/jbc.RA119.009824_bib34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor \u03b1 stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.RA119.009824_bib35","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1172\/JCI200523394","article-title":"IL-1 mediates TNF-induced osteoclastogenesis","volume":"115","author":"Wei","year":"2005","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA119.009824_bib36","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/intimm\/dxq431","article-title":"IL-1 plays an important role in the bone metabolism under physiological conditions","volume":"22","author":"Lee","year":"2010","journal-title":"Int. Immunol"},{"key":"10.1074\/jbc.RA119.009824_bib37","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4049\/jimmunol.1602035","article-title":"IL-1\u03b2 induces pathologically activated osteoclasts bearing extremely high levels of resorbing activity: a possible pathological subpopulation of osteoclasts, accompanied by suppressed expression of Kindlin-3 and Talin-1","volume":"200","author":"Shiratori","year":"2018","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.RA119.009824_bib38","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/art.24781","article-title":"Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo","volume":"60","author":"Axmann","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1074\/jbc.RA119.009824_bib39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jbmr.5650110113","article-title":"Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation","volume":"11","author":"Kotake","year":"1996","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.RA119.009824_bib40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fimmu.2014.00048","article-title":"Classical and paradoxical effects of TNF-\u03b1 on bone homeostasis","volume":"5","author":"Osta","year":"2014","journal-title":"Front. Immunol"},{"key":"10.1074\/jbc.RA119.009824_bib41","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1172\/JCI93356","article-title":"Inflammatory osteolysis: a conspiracy against bone","volume":"127","author":"Mbalaviele","year":"2017","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA119.009824_bib42","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11914-017-0358-z","article-title":"TNF and bone remodeling","volume":"15","author":"Zhao","year":"2017","journal-title":"Curr. Osteoporos. Rep"},{"key":"10.1074\/jbc.RA119.009824_bib43","doi-asserted-by":"crossref","first-page":"e0189702","DOI":"10.1371\/journal.pone.0189702","article-title":"Tumor necrosis factor-\u03b1 antagonist diminishes osteocytic RANKL and sclerostin expression in diabetes rats with periodontitis","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA119.009824_bib44","doi-asserted-by":"crossref","first-page":"E495","DOI":"10.3390\/ijms18030495","article-title":"TNFalpha increases RANKL expression via PGE(2)-induced activation of NFATc1","volume":"18","author":"Park","year":"2017","journal-title":"Int. J. Mol. Sci"},{"key":"10.1074\/jbc.RA119.009824_bib45","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/nature08878","article-title":"Therapeutic antibody targeting of individual Notch receptors","volume":"464","author":"Wu","year":"2010","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.009824_bib46","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1210\/en.2016-1787","article-title":"An antibody to Notch2 reverses the osteopenic phenotype of Hajdu-Cheney mutant male mice","volume":"158","author":"Canalis","year":"2017","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.RA119.009824_bib47","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nature15715","article-title":"Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung","volume":"528","author":"Lafkas","year":"2015","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.009824_bib48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/jbmr.3283","article-title":"High bone turnover in mice carrying a pathogenic Notch2 mutation causing Hajdu-Cheney syndrome","volume":"33","author":"Vollersen","year":"2018","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.RA119.009824_bib49","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1084\/jem.20111566","article-title":"TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J","volume":"209","author":"Zhao","year":"2012","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.RA119.009824_bib50","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1074\/jbc.M110.183038","article-title":"Hairy and enhancer of split (HES)1 is a determinant of bone mass","volume":"286","author":"Zanotti","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.009824_bib51","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s13238-016-0250-0","article-title":"Role of Notch signaling in regulating innate immunity and inflammation in health and disease","volume":"7","author":"Shang","year":"2016","journal-title":"Protein Cell"},{"key":"10.1074\/jbc.RA119.009824_bib52","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0968-0004(96)10031-1","article-title":"PEST sequences and regulation by proteolysis","volume":"21","author":"Rechsteiner","year":"1996","journal-title":"Trends Biochem. Sci"},{"key":"10.1074\/jbc.RA119.009824_bib53","doi-asserted-by":"crossref","first-page":"17873","DOI":"10.18632\/oncotarget.15013","article-title":"The interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets","volume":"8","author":"Cenciarelli","year":"2017","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.RA119.009824_bib54","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/nm1636","article-title":"Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia","volume":"13","author":"Palomero","year":"2007","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.009824_bib55","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1182\/blood-2011-12-395319","article-title":"HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRbeta-selected mouse thymocytes","volume":"120","author":"Wong","year":"2012","journal-title":"Blood"},{"key":"10.1074\/jbc.RA119.009824_bib56","doi-asserted-by":"crossref","first-page":"e94496","DOI":"10.1371\/journal.pone.0094496","article-title":"Identification of a role for the PI3K\/AKT\/mTOR signaling pathway in innate immune cells","volume":"9","author":"Xie","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA119.009824_bib57","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S8756-3282(01)00657-3","article-title":"The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation","volume":"30","author":"Lee","year":"2002","journal-title":"Bone"},{"key":"10.1074\/jbc.RA119.009824_bib58","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1136\/ard.2009.120816","article-title":"Hes1, a new target for interleukin 1\u03b2 in chondrocytes","volume":"69","author":"Ottaviani","year":"2010","journal-title":"Ann. Rheum. Dis"},{"key":"10.1074\/jbc.RA119.009824_bib59","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jbmr.3092","article-title":"RANKL-independent osteoclastogenesis: a long-standing controversy","volume":"32","author":"Tanaka","year":"2017","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.RA119.009824_bib60","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1242\/dev.021535","article-title":"Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline","volume":"135","author":"Imayoshi","year":"2008","journal-title":"Development"},{"key":"10.1074\/jbc.RA119.009824_bib61","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/art.39538","article-title":"Contradictory role of CD97 in basal and tumor necrosis factor-induced osteoclastogenesis in vivo","volume":"68","author":"Yeon Won","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1074\/jbc.RA119.009824_bib62","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.RA119.009824_bib63","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/nm1514","article-title":"v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation","volume":"12","author":"Lee","year":"2006","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.009824_bib64","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1471-2164-8-127","article-title":"Housekeeping and tissue-specific genes in mouse tissues","volume":"8","author":"Kouadjo","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1074\/jbc.RA119.009824_bib65","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1074\/jbc.M112.340455","article-title":"Nuclear factor of activated T-cells (Nfat)c2 inhibits Notch signaling in osteoblasts","volume":"288","author":"Zanotti","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.009824_bib66","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/imm.12288","article-title":"Rituximab-mediated Raf kinase inhibitor protein induction modulates NF-kappaB in Sjogren syndrome","volume":"143","author":"Sisto","year":"2014","journal-title":"Immunology"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820349826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820349826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA119.009824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T19:41:07Z","timestamp":1695066067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820349826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":66,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0021925820349826"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra119.009824","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor \u03b1","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA119.009824","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Yu and Canalis.","name":"copyright","label":"Copyright"}]}}