{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:13:37Z","timestamp":1790662417828,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"42","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":339,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21658052"],"award-info":[{"award-number":["21658052"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25292069"],"award-info":[{"award-number":["25292069"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H04922"],"award-info":[{"award-number":["16H04922"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1074\/jbc.ra119.010328","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T03:45:12Z","timestamp":1567568712000},"page":"15206-15217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Circadian rhythm\u2013dependent induction of hepatic lipogenic gene expression in rats fed a high-sucrose diet"],"prefix":"10.1016","volume":"294","author":[{"given":"Shumin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Hanzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Umeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syunsuke","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-9076","authenticated-orcid":false,"given":"Hiroaki","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA119.010328_bib1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dmm.001180","article-title":"A comprehensive definition for metabolic syndrome","volume":"2","author":"Huang","year":"2009","journal-title":"Dis. Model Mech"},{"key":"10.1074\/jbc.RA119.010328_bib2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation","volume":"15","author":"Alberti","year":"1998","journal-title":"Diabet. Med"},{"key":"10.1074\/jbc.RA119.010328_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/482027a","article-title":"Public health: the toxic truth about sugar","volume":"482","author":"Lustig","year":"2012","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.010328_bib4","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.metabol.2011.01.008","article-title":"Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake","volume":"60","author":"Roncal-Jimenez","year":"2011","journal-title":"Metab. Clin. Exp"},{"key":"10.1074\/jbc.RA119.010328_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00394-016-1340-8","article-title":"A review of recent evidence relating to sugars, insulin resistance and diabetes","volume":"55","author":"Macdonald","year":"2016","journal-title":"Eur. J. Nutr"},{"key":"10.1074\/jbc.RA119.010328_bib6","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.nut.2010.02.014","article-title":"Fructose and metabolic diseases: new findings, new questions","volume":"26","author":"Tappy","year":"2010","journal-title":"Nutrition"},{"key":"10.1074\/jbc.RA119.010328_bib7","doi-asserted-by":"crossref","first-page":"E395","DOI":"10.3390\/nu9040395","article-title":"Fructose intake, serum uric acid, and cardiometabolic disorders: a critical review","volume":"9","author":"Caliceti","year":"2017","journal-title":"Nutrients"},{"key":"10.1074\/jbc.RA119.010328_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1743-7075-9-89","article-title":"Fructose metabolism in humans: what isotopic tracer studies tell us","volume":"9","author":"Sun","year":"2012","journal-title":"Nutr. Metab"},{"key":"10.1074\/jbc.RA119.010328_bib9","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1007\/s10620-016-4054-0","article-title":"Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease","volume":"61","author":"Softic","year":"2016","journal-title":"Dig. Dis. Sci"},{"key":"10.1074\/jbc.RA119.010328_bib10","series-title":"Biochemistry","first-page":"232","author":"Berg","year":"2015"},{"key":"10.1074\/jbc.RA119.010328_bib11","series-title":"Harpers Illustrated Biochemistry 30th Edition","first-page":"465","author":"Rodwell","year":"2015"},{"key":"10.1074\/jbc.RA119.010328_bib12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0005-2760(67)90154-3","article-title":"Mechanism for the differential effects of high carbohydrate diets on lipogenesis in rat liver","volume":"144","author":"Zakim","year":"1967","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA119.010328_bib13","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0021-9258(19)67903-2","article-title":"Extent and patterns of adaptation of enzyme activities in livers of normal rats fed diets high in glucose and fructose","volume":"235","author":"Fitch","year":"1960","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.010328_bib14","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1042\/bj0950832","article-title":"Citrate and the conversion of carbohydrate into fat: activities of citrate-clevage enzyme and acetate thiokinase in livers of normal and diabetic rats","volume":"95","author":"Kornacker","year":"1965","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.RA119.010328_bib15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1042\/bj1290439","article-title":"Fatty acid synthetase activity in the liver and adipose tissue of rats fed with various carbohydrates","volume":"129","author":"Bruckdorfer","year":"1972","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.RA119.010328_bib16","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nature11704","article-title":"Circadian topology of metabolism","volume":"491","author":"Bass","year":"2012","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.010328_bib17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2015.03.015","article-title":"Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock","volume":"161","author":"Asher","year":"2015","journal-title":"Cell"},{"key":"10.1074\/jbc.RA119.010328_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/srep00439","article-title":"Real-time monitoring in three-dimensional hepatocytes reveals that insulin acts as a synchronizer for liver clock","volume":"2","author":"Yamajuku","year":"2012","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA119.010328_bib19","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1126\/science.aah4967","article-title":"Circadian physiology of metabolism","volume":"354","author":"Panda","year":"2016","journal-title":"Science"},{"key":"10.1074\/jbc.RA119.010328_bib20","doi-asserted-by":"crossref","first-page":"e0201261","DOI":"10.1371\/journal.pone.0201261","article-title":"Time-restricted feeding suppresses excess sucrose-induced plasma and liver lipid accumulation in rats","volume":"13","author":"Sun","year":"2018","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA119.010328_bib21","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.cmet.2012.04.019","article-title":"Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet","volume":"15","author":"Hatori","year":"2012","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.RA119.010328_bib22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cmet.2018.08.004","article-title":"Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock","volume":"29","author":"Chaix","year":"2019","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.RA119.010328_bib23","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.cmet.2014.11.001","article-title":"Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges","volume":"20","author":"Chaix","year":"2014","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.RA119.010328_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biochi.2013.06.007","article-title":"Zonation of glucose and fatty acid metabolism in the liver: mechanism and metabolic consequences","volume":"96","author":"Hijmans","year":"2014","journal-title":"Biochimie"},{"key":"10.1074\/jbc.RA119.010328_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1753-4887.2005.tb00132.x","article-title":"Dietary fructose: implications for dysregulation of energy homeostasis and lipid\/carbohydrate metabolism","volume":"63","author":"Havel","year":"2005","journal-title":"Nutr. Rev"},{"key":"10.1074\/jbc.RA119.010328_bib26","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.1195027","article-title":"Circadian integration of metabolism and energetics","volume":"330","author":"Bass","year":"2010","journal-title":"Science"},{"key":"10.1074\/jbc.RA119.010328_bib27","doi-asserted-by":"crossref","first-page":"e1000181","DOI":"10.1371\/journal.pbio.1000181","article-title":"REV-ERB\u03b1 participates in circadian SREBP signaling and bile acid homeostasis","volume":"7","author":"Le Martelot","year":"2009","journal-title":"PLoS Biol"},{"key":"10.1074\/jbc.RA119.010328_bib28","doi-asserted-by":"crossref","first-page":"E181","DOI":"10.3390\/nu9020181","article-title":"The role of carbohydrate response element binding protein in intestinal and hepatic fructose metabolism","volume":"9","author":"Iizuka","year":"2017","journal-title":"Nutrients"},{"key":"10.1074\/jbc.RA119.010328_bib29","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00018-014-1574-7","article-title":"Circadian clocks and energy metabolism","volume":"71","author":"Sancar","year":"2014","journal-title":"Cell Mol. Life Sci"},{"key":"10.1074\/jbc.RA119.010328_bib30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.plipres.2013.12.001","article-title":"Regulation of energy metabolism by long-chain fatty acids","volume":"53","author":"Nakamura","year":"2014","journal-title":"Prog. Lipid Res"},{"key":"10.1074\/jbc.RA119.010328_bib31","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.1074\/jbc.273.17.10609","article-title":"Importance of glucose-6-phosphate dehydrogenase activity for cell growth","volume":"273","author":"Tian","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.010328_bib32","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ng1738","article-title":"Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions","volume":"38","author":"Ripperger","year":"2006","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.RA119.010328_bib33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0167-4889(89)90084-0","article-title":"Regulation of hepatic inorganic phosphate and ATP in response to fructose loading: an in vivo 31P-NMR study","volume":"1012","author":"Karczmar","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA119.010328_bib34","doi-asserted-by":"crossref","first-page":"E230","DOI":"10.3390\/nu9030230","article-title":"Fructose and NAFLD: the multifaceted aspects of fructose metabolism","volume":"9","author":"Jegatheesan","year":"2017","journal-title":"Nutrients"},{"key":"10.1074\/jbc.RA119.010328_bib35","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.010328_bib36","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.3748\/wjg.v18.i19.2300","article-title":"Animal models of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"18","author":"Takahashi","year":"2012","journal-title":"World J. Gastroenterol"},{"key":"10.1074\/jbc.RA119.010328_bib37","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.redox.2017.01.012","article-title":"Metabolic zonation of the liver: the oxygen gradient revisited","volume":"11","author":"Kietzmann","year":"2017","journal-title":"Redox Biol"},{"key":"10.1074\/jbc.RA119.010328_bib38","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA119.010328_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1152\/physrev.00019.2009","article-title":"Metabolic effects of fructose and the worldwide increase in obesity","volume":"90","author":"Tappy","year":"2010","journal-title":"Physiol. Rev"},{"key":"10.1074\/jbc.RA119.010328_bib40","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.metabol.2005.04.004","article-title":"Hepatic adaptations to sucrose and fructose","volume":"54","author":"Bizeau","year":"2005","journal-title":"Metab. Clin. Exp"},{"key":"10.1074\/jbc.RA119.010328_bib41","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.aah4965","article-title":"Circadian time signatures of fitness and disease","volume":"354","author":"Bass","year":"2016","journal-title":"Science"},{"key":"10.1074\/jbc.RA119.010328_bib42","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0168-9525(96)10016-0","article-title":"Control of messenger RNA stability in higher eukaryotes","volume":"12","author":"Ross","year":"1996","journal-title":"Trends Genet"},{"key":"10.1074\/jbc.RA119.010328_bib43","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1042\/bj20030661","article-title":"Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2","volume":"375","author":"Gouyon","year":"2003","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.RA119.010328_bib44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbrc.2007.03.113","article-title":"LMO4 mRNA stability is regulated by extracellular ATP in F11 cells","volume":"357","author":"Chen","year":"2007","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA119.010328_bib45","doi-asserted-by":"crossref","first-page":"39035","DOI":"10.1038\/srep39035","article-title":"Differential IL-1\u03b2 secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability","volume":"6","author":"Hadadi","year":"2016","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA119.010328_bib46","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1108750","article-title":"Obesity and metabolic syndrome in circadian Clock mutant mice","volume":"308","author":"Turek","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.RA119.010328_bib47","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1161\/CIRCRESAHA.109.199034","article-title":"Regular feeding plays an important role in cholesterol homeostasis through the liver circadian clock","volume":"105","author":"Yamajuku","year":"2009","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.RA119.010328_bib48","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1038\/nm.2979","article-title":"Obesity in mice with adipocyte-specific deletion of clock component Arntl","volume":"18","author":"Paschos","year":"2012","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.010328_bib49","doi-asserted-by":"crossref","first-page":"e0206669","DOI":"10.1371\/journal.pone.0206669","article-title":"Delayed first active-phase meal, a breakfast-skipping model, led to increased body weight and shifted the circadian oscillation of the hepatic clock and lipid metabolism-related genes in rats fed a high-fat diet","volume":"13","author":"Shimizu","year":"2018","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA119.010328_bib50","doi-asserted-by":"crossref","first-page":"838S","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 diets as improvements in the AIN-76A diet","volume":"127","author":"Reeves","year":"1997","journal-title":"J. Nutr"},{"key":"10.1074\/jbc.RA119.010328_bib51","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.010328_bib52","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem"},{"key":"10.1074\/jbc.RA119.010328_bib53","doi-asserted-by":"crossref","first-page":"17115","DOI":"10.18632\/oncotarget.15081","article-title":"Investigations in the possibility of early detection of colorectal cancer by gas chromatography\/triple-quadrupole mass spectrometry","volume":"8","author":"Nishiumi","year":"2017","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.RA119.010328_bib54","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/0748730410379711","article-title":"JTK_CYCLE: an efficient non-parametric algorithm for detecting rhythmic components in genome-scale datasets","volume":"25","author":"Hughes","year":"2010","journal-title":"J. Biol. Rhythms"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820337674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820337674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA119.010328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T14:11:17Z","timestamp":1619878277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820337674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":54,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0021925820337674"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra119.010328","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circadian rhythm\u2013dependent induction of hepatic lipogenic gene expression in rats fed a high-sucrose diet","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA119.010328","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Sun et al.","name":"copyright","label":"Copyright"}]}}