{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:01:52Z","timestamp":1790121712306,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":250,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"MEXT | Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18am0301007"],"award-info":[{"award-number":["JP18am0301007"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H05417"],"award-info":[{"award-number":["JP18H05417"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H01029"],"award-info":[{"award-number":["JP19H01029"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K16694"],"award-info":[{"award-number":["19K16694"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1074\/jbc.ra119.010379","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T01:45:24Z","timestamp":1573695924000},"page":"19896-19906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells"],"prefix":"10.1016","volume":"294","author":[{"given":"Natsumi","family":"Maeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-1611","authenticated-orcid":false,"given":"Takumi","family":"Maruhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3865-3889","authenticated-orcid":false,"given":"Daisuke","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8644-0100","authenticated-orcid":false,"given":"Il-mi","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-1925","authenticated-orcid":false,"given":"Taku","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA119.010379_bib1","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/ni.2762","article-title":"A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application","volume":"14","author":"Okazaki","year":"2013","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nri.2017.108","article-title":"The diverse functions of the PD1 inhibitory pathway","volume":"18","author":"Sharpe","year":"2018","journal-title":"Nat. Rev. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib3","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.4049\/jimmunol.1003304","article-title":"CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition","volume":"186","author":"Barber","year":"2011","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib4","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature04444","article-title":"Restoring function in exhausted CD8 T cells during chronic viral infection","volume":"439","author":"Barber","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.010379_bib5","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aar4060","article-title":"Cancer immunotherapy using checkpoint blockade","volume":"359","author":"Ribas","year":"2018","journal-title":"Science"},{"key":"10.1074\/jbc.RA119.010379_bib6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.immuni.2018.03.014","article-title":"Regulation and function of the PD-L1 checkpoint","volume":"48","author":"Sun","year":"2018","journal-title":"Immunity"},{"key":"10.1074\/jbc.RA119.010379_bib7","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41571-019-0218-0","article-title":"Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance","volume":"16","author":"Martins","year":"2019","journal-title":"Nat. Rev. Clin. Oncol"},{"key":"10.1074\/jbc.RA119.010379_bib8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMra1703481","article-title":"Immune-related adverse events associated with immune checkpoint blockade","volume":"378","author":"Postow","year":"2018","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.RA119.010379_bib9","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1056\/NEJMra033540","article-title":"Immunosuppressive drugs for kidney transplantation","volume":"351","author":"Halloran","year":"2004","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.RA119.010379_bib10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nri.2017.1","article-title":"Immune regulation by glucocorticoids","volume":"17","author":"Cain","year":"2017","journal-title":"Nat. Rev. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nrm.2016.152","article-title":"Glucocorticoid receptor control of transcription: precision and plasticity via allostery","volume":"18","author":"Weikum","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.RA119.010379_bib12","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1002\/eji.1830251016","article-title":"Glucocorticoids down-regulate dendritic cell function in vitro and in vivo","volume":"25","author":"Moser","year":"1995","journal-title":"Eur. J. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/2050-6511-15-35","article-title":"Transcriptional regulation of kinases downstream of the T cell receptor: another immunomodulatory mechanism of glucocorticoids","volume":"15","author":"Petrillo","year":"2014","journal-title":"BMC Pharmacol. Toxicol"},{"key":"10.1074\/jbc.RA119.010379_bib14","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.4049\/jimmunol.162.11.6473","article-title":"Glucocorticoids affect human dendritic cell differentiation and maturation","volume":"162","author":"Piemonti","year":"1999","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1172\/JCI200418975","article-title":"Enhancement of MEK\/ERK signaling promotes glucocorticoid resistance in CD4+ T cells","volume":"113","author":"Tsitoura","year":"2004","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA119.010379_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.imbio.2009.10.003","article-title":"Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells","volume":"215","author":"Boldizsar","year":"2010","journal-title":"Immunobiology"},{"key":"10.1074\/jbc.RA119.010379_bib17","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.4049\/jimmunol.1302138","article-title":"Chronic exposure to glucocorticoids shapes gene expression and modulates innate and adaptive activation pathways in macrophages with distinct changes in leukocyte attraction","volume":"192","author":"van de Garde","year":"2014","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.immuni.2009.10.010","article-title":"The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin","volume":"32","author":"Rao","year":"2010","journal-title":"Immunity"},{"key":"10.1074\/jbc.RA119.010379_bib19","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ni.2046","article-title":"Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection","volume":"12","author":"Kao","year":"2011","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib20","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.4049\/jimmunol.181.7.4832","article-title":"NFATc1 regulates PD-1 expression upon T cell activation","volume":"181","author":"Oestreich","year":"2008","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.bbrc.2019.02.004","article-title":"PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR","volume":"511","author":"Mizuno","year":"2019","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA119.010379_bib22","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3389\/fimmu.2019.00630","article-title":"PD-1 primarily targets TCR signal in the inhibition of functional T cell activation","volume":"10","author":"Mizuno","year":"2019","journal-title":"Front. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40425-018-0371-5","article-title":"Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy","volume":"6","author":"Giles","year":"2018","journal-title":"J. Immunother. Cancer"},{"key":"10.1074\/jbc.RA119.010379_bib24","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s000180050403","article-title":"Dexamethasone enhances CTLA-4 expression during T cell activation","volume":"55","author":"Xia","year":"1999","journal-title":"Cell Mol. Life Sci"},{"key":"10.1074\/jbc.RA119.010379_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12865-015-0103-2","article-title":"Dexamethasone enhances programmed cell death 1 (PD-1) expression during T cell activation: an insight into the optimum application of glucocorticoids in anti-cancer therapy","volume":"16","author":"Xing","year":"2015","journal-title":"BMC Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/icb.2012.53","article-title":"Notch signaling regulates PD-1 expression during CD8+ T-cell activation","volume":"91","author":"Mathieu","year":"2013","journal-title":"Immunol. Cell Biol"},{"key":"10.1074\/jbc.RA119.010379_bib27","doi-asserted-by":"crossref","first-page":"15419","DOI":"10.1073\/pnas.1206370109","article-title":"Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1","volume":"109","author":"Xiao","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.010379_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ni.1679","article-title":"Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection","volume":"10","author":"Blackburn","year":"2009","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib29","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41586-019-0985-x","article-title":"NR4A transcription factors limit CAR T cell function in solid tumours","volume":"567","author":"Chen","year":"2019","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.010379_bib30","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41586-019-0979-8","article-title":"Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction","volume":"567","author":"Liu","year":"2019","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.010379_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.immuni.2015.01.006","article-title":"The transcription factor NFAT promotes exhaustion of activated CD8+ T cells","volume":"42","author":"Martinez","year":"2015","journal-title":"Immunity"},{"key":"10.1074\/jbc.RA119.010379_bib32","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.immuni.2014.10.013","article-title":"The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8+ T cells during chronic infection","volume":"41","author":"Staron","year":"2014","journal-title":"Immunity"},{"key":"10.1074\/jbc.RA119.010379_bib33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1084\/jem.20130208","article-title":"Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection","volume":"211","author":"Lu","year":"2014","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.RA119.010379_bib34","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41590-018-0185-0","article-title":"Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells","volume":"19","author":"Quatrini","year":"2018","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib35","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fimmu.2019.00472","article-title":"Glucocorticoid receptor-deficient Foxp3+ regulatory T cells fail to control experimental inflammatory bowel disease","volume":"10","author":"Rocamora-Reverte","year":"2019","journal-title":"Front. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib36","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1074\/jbc.RA119.007455","article-title":"Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation","volume":"294","author":"Maeda","year":"2019","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.010379_bib37","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1126\/science.aav7062","article-title":"Restriction of PD-1 function by cis-PD-L1\/CD80 interactions is required for optimal T cell responses","volume":"364","author":"Sugiura","year":"2019","journal-title":"Science"},{"key":"10.1074\/jbc.RA119.010379_bib38","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41590-018-0217-9","article-title":"LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII","volume":"19","author":"Maruhashi","year":"2018","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.RA119.010379_bib39","doi-asserted-by":"crossref","first-page":"D142","DOI":"10.1093\/nar\/gkt997","article-title":"JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles","volume":"42","author":"Mathelier","year":"2014","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820300132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820300132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA119.010379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T22:36:36Z","timestamp":1695422196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820300132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":39,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0021925820300132"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra119.010379","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA119.010379","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Maeda et al.","name":"copyright","label":"Copyright"}]}}