{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:54:22Z","timestamp":1792518862233,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":250,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19PRE34380628"],"award-info":[{"award-number":["19PRE34380628"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL128683"],"award-info":[{"award-number":["HL128683"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1074\/jbc.ra119.011177","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:45:12Z","timestamp":1574297112000},"page":"20054-20069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation"],"prefix":"10.1016","volume":"294","author":[{"given":"Jamie R.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maicon","family":"Landim-Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra A.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-5888","authenticated-orcid":false,"given":"Guilherme A.P.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gonzalez-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo H.","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Wilnai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einat","family":"Birk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nili","family":"Zucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerson L.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-561X","authenticated-orcid":false,"given":"P. Bryant","family":"Chase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Renato","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA119.011177_bib1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.healun.2018.07.022","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 35th adult heart transplantation report\u20132018; focus theme: multiorgan transplantation","volume":"37","author":"Khush","year":"2018","journal-title":"J. Heart Lung Transplant"},{"key":"10.1074\/jbc.RA119.011177_bib2","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.healun.2018.07.018","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 21st Pediatric Heart Transplantation Report\u20132018; Focus Theme: Multiorgan Transplantation","volume":"37","author":"Rossano","year":"2018","journal-title":"J. Heart Lung Transplant"},{"key":"10.1074\/jbc.RA119.011177_bib3","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart Disease and Stroke Statistics\u20132019 Update: A Report From the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"10.1074\/jbc.RA119.011177_bib4","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCRESAHA.116.309396","article-title":"Dilated cardiomyopathy: genetic determinants and mechanisms","volume":"121","author":"McNally","year":"2017","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.RA119.011177_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI62862","article-title":"Genetic mutations and mechanisms in dilated cardiomyopathy","volume":"123","author":"McNally","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA119.011177_bib6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41572-019-0084-1","article-title":"Dilated cardiomyopathy","volume":"5","author":"Schultheiss","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1074\/jbc.RA119.011177_bib7","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/j.jacc.2016.08.079","article-title":"Clinical and mechanistic insights into the genetics of cardiomyopathy","volume":"68","author":"Burke","year":"2016","journal-title":"J. Am. Coll. Cardiol"},{"key":"10.1074\/jbc.RA119.011177_bib8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/physrev.00040.2017","article-title":"Cardiac disorders and pathophysiology of sarcomeric proteins","volume":"99","author":"van der Velden","year":"2019","journal-title":"Physiol. Rev"},{"key":"10.1074\/jbc.RA119.011177_bib9","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIR.0000000000000682","article-title":"Cardiomyopathy in children: classification and diagnosis: a scientific statement from the American Heart Association","volume":"140","author":"Lipshultz","year":"2019","journal-title":"Circulation"},{"key":"10.1074\/jbc.RA119.011177_bib10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/gim.2016.90","article-title":"Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples","volume":"19","author":"Walsh","year":"2017","journal-title":"Genet. Med"},{"key":"10.1074\/jbc.RA119.011177_bib11","doi-asserted-by":"crossref","first-page":"34404","DOI":"10.1074\/jbc.M111.267211","article-title":"Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy","volume":"286","author":"Pinto","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1161\/CIRCGENETICS.111.961805","article-title":"Evaluating pathogenicity of rare variants from dilated cardiomyopathy in the exome era","volume":"5","author":"Norton","year":"2012","journal-title":"Circ. Cardiovasc. Genet"},{"key":"10.1074\/jbc.RA119.011177_bib13","doi-asserted-by":"crossref","first-page":"17371","DOI":"10.1074\/jbc.M109.064105","article-title":"A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding","volume":"285","author":"Dweck","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib14","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.yjmcc.2009.10.031","article-title":"Mutations in troponin that cause HCM, DCM, and RCM: what can we learn about thin filament function?","volume":"48","author":"Willott","year":"2010","journal-title":"J. Mol. Cell. Cardiol"},{"key":"10.1074\/jbc.RA119.011177_bib15","doi-asserted-by":"crossref","first-page":"31845","DOI":"10.1074\/jbc.M112.377713","article-title":"A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation","volume":"287","author":"Parvatiyar","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib16","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1161\/CIRCRESAHA.119.313569","article-title":"Novel therapies for prevention and early treatment of cardiomyopathies","volume":"124","author":"Repetti","year":"2019","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.RA119.011177_bib17","first-page":"969","article-title":"Troponin: structure, properties, and mechanism of functioning","volume":"64","author":"Filatov","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011177_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.physiol.67.040403.114025","article-title":"Calcium, thin filaments, and the integrative biology of cardiac contractility","volume":"67","author":"Kobayashi","year":"2005","journal-title":"Annu. Rev. Physiol"},{"key":"10.1074\/jbc.RA119.011177_bib19","doi-asserted-by":"crossref","first-page":"11688","DOI":"10.1016\/S0021-9258(19)70187-2","article-title":"The calcium and magnesium binding sites on cardiac troponin and their role in the regulation of myofibrillar adenosine triphosphatase","volume":"255","author":"Holroyde","year":"1980","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2016.01.006","article-title":"TNNT1, TNNT2, and TNNT3: isoform genes, regulation, and structure-function relationships","volume":"582","author":"Wei","year":"2016","journal-title":"Gene"},{"key":"10.1074\/jbc.RA119.011177_bib21","doi-asserted-by":"crossref","first-page":"7790","DOI":"10.1021\/bi0341509","article-title":"Small-angle neutron scattering with contrast variation reveals spatial relationships between the three subunits in the ternary cardiac troponin complex and the effects of troponin I phosphorylation","volume":"42","author":"Heller","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011177_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nature01780","article-title":"Structure of the core domain of human cardiac troponin in the Ca2+-saturated form","volume":"424","author":"Takeda","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.011177_bib23","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1074\/jbc.270.6.2557","article-title":"A direct regulatory role for troponin T and a dual role for troponin C in the Ca2+ regulation of muscle contraction","volume":"270","author":"Potter","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib24","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0092-8674(94)90054-X","article-title":"\u03b1-Tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere","volume":"77","author":"Thierfelder","year":"1994","journal-title":"Cell"},{"key":"10.1074\/jbc.RA119.011177_bib25","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1016\/j.bpj.2012.04.037","article-title":"The C terminus of troponin T is essential for maintaining the inactive state of regulated actin","volume":"102","author":"Franklin","year":"2012","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.RA119.011177_bib26","doi-asserted-by":"crossref","first-page":"15276","DOI":"10.1021\/bi048646h","article-title":"The \u039414 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin","volume":"43","author":"Gafurov","year":"2004","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011177_bib27","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.bpj.2018.06.028","article-title":"Stepwise C-terminal truncation of cardiac troponin T alters function at low and saturating Ca2","volume":"115","author":"Johnson","year":"2018","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.RA119.011177_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.abb.2013.12.021","volume":"552","author":"Brunet","year":"2014","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.RA119.011177_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med"},{"key":"10.1074\/jbc.RA119.011177_bib30","article-title":"Variation across 141,456 human exomes and genomes reveals the spectrum of loss-of-function intolerance across human protein-coding genes","author":"Karczewski","year":"2019","journal-title":"bioRxiv"},{"key":"10.1074\/jbc.RA119.011177_bib31","doi-asserted-by":"crossref","first-page":"D980","DOI":"10.1093\/nar\/gkt1113","article-title":"ClinVar: public archive of relationships among sequence variation and human phenotype","volume":"42","author":"Landrum","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA119.011177_bib32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nmeth.2890","article-title":"MutationTaster2: mutation prediction for the deep-sequencing age","volume":"11","author":"Schwarz","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1074\/jbc.RA119.011177_bib33","article-title":"MutPred2: inferring the molecular and phenotypic impact of amino acid variants","author":"Pejaver","year":"2017","journal-title":"bioRxiv"},{"key":"10.1074\/jbc.RA119.011177_bib34","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nprot.2009.86","article-title":"Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm","volume":"4","author":"Kumar","year":"2009","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.RA119.011177_bib35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1074\/jbc.RA119.011177_bib36","first-page":"H1260","article-title":"Coupling calcium binding to troponin C and cross-bridge cycling in skinned cardiac cells","volume":"266","author":"Landesberg","year":"1994","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.RA119.011177_bib37","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1074\/jbc.M116.765362","article-title":"Allosteric transmission along a loosely structured backbone allows a cardiac troponin C mutant to function with only one Ca2+ ion","volume":"292","author":"Marques","year":"2017","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib38","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.jacc.2004.08.027","article-title":"Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy","volume":"44","author":"Mogensen","year":"2004","journal-title":"J. Am. Coll. Cardiol"},{"key":"10.1074\/jbc.RA119.011177_bib39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.gene.2015.07.074","article-title":"Structure and function of cardiac troponin C (TNNC1): implications for heart failure, cardiomyopathies, and troponin modulating drugs","volume":"571","author":"Li","year":"2015","journal-title":"Gene"},{"key":"10.1074\/jbc.RA119.011177_bib40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s13059-016-1110-1","article-title":"New insights into the generation and role of de novo mutations in health and disease","volume":"17","author":"Acuna-Hidalgo","year":"2016","journal-title":"Genome Biol"},{"key":"10.1074\/jbc.RA119.011177_bib41","doi-asserted-by":"crossref","first-page":"33119","DOI":"10.1074\/jbc.M804070200","article-title":"Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes?","volume":"283","author":"Dweck","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib42","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation-contraction coupling","volume":"415","author":"Bers","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.011177_bib43","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/cvr\/cvx068","article-title":"Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice","volume":"113","author":"Alves","year":"2017","journal-title":"Cardiovasc. Res"},{"key":"10.1074\/jbc.RA119.011177_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10794","article-title":"Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease","volume":"7","author":"Shettigar","year":"2016","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.RA119.011177_bib45","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3389\/fphys.2016.00562","article-title":"Myofilament calcium sensitivity: role in regulation of in vivo cardiac contraction and relaxation","volume":"7","author":"Chung","year":"2016","journal-title":"Front. Physiol"},{"key":"10.1074\/jbc.RA119.011177_bib46","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.yjmcc.2009.12.020","article-title":"Kinetics of cardiac sarcomeric processes and rate-limiting steps in contraction and relaxation","volume":"48","author":"Stehle","year":"2010","journal-title":"J. Mol. Cell. Cardiol"},{"key":"10.1074\/jbc.RA119.011177_bib47","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1161\/01.RES.76.1.154","article-title":"Rate of tension development in cardiac muscle varies with level of activator calcium","volume":"76","author":"Wolff","year":"1995","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.RA119.011177_bib48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.yjmcc.2018.08.015","article-title":"Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle","volume":"123","author":"Gonzalez-Martinez","year":"2018","journal-title":"J. Mol. Cell. Cardiol"},{"key":"10.1074\/jbc.RA119.011177_bib49","first-page":"H744","article-title":"Ca2+ regulates the kinetics of tension development in intact cardiac muscle","volume":"275","author":"Baker","year":"1998","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.RA119.011177_bib50","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12195-013-0269-8","article-title":"Slowed dynamics of thin filament regulatory units reduces Ca2+-sensitivity of cardiac biomechanical function","volume":"6","author":"Loong","year":"2013","journal-title":"Cell. Mol. Bioeng"},{"key":"10.1074\/jbc.RA119.011177_bib51","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1073\/pnas.85.9.3265","article-title":"Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction","volume":"85","author":"Brenner","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.011177_bib52","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1073\/pnas.83.10.3542","article-title":"Rate of force generation in muscle: correlation with actomyosin ATPase activity in solution","volume":"83","author":"Brenner","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.011177_bib53","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/S0006-3495(99)77418-7","article-title":"Regulation of skeletal muscle tension redevelopment by troponin C constructs with different Ca2+ affinities","volume":"76","author":"Regnier","year":"1999","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.RA119.011177_bib54","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/j.bpj.2017.02.045","article-title":"Myosin rod hypophosphorylation and CB kinetics in papillary muscles from a TnC-A8V KI mouse model","volume":"112","author":"Kawai","year":"2017","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.RA119.011177_bib55","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/bj3270335","article-title":"Troponin I and troponin T interact with troponin C to produce different Ca2+-dependent effects on actin-tropomyosin filament motility","volume":"327","author":"Bing","year":"1997","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.RA119.011177_bib56","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0006-3495(93)81110-X","article-title":"Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament","volume":"65","author":"McKillop","year":"1993","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.RA119.011177_bib57","doi-asserted-by":"crossref","first-page":"6782","DOI":"10.1073\/pnas.1700868114","article-title":"Ca2+-induced movement of tropomyosin on native cardiac thin filaments revealed by cryoelectron microscopy","volume":"114","author":"Risi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.011177_bib58","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.recesp.2015.06.028","article-title":"Clinical and prognostic profiles of cardiomyopathies caused by mutations in the troponin T gene","volume":"69","author":"Ripoll-Vera","year":"2016","journal-title":"Rev. Esp. Cardiol"},{"key":"10.1074\/jbc.RA119.011177_bib59","doi-asserted-by":"crossref","first-page":"20691","DOI":"10.1039\/C6CP02610A","article-title":"Troponin structure: its modulation by Ca2+ and phosphorylation studied by molecular dynamics simulations","volume":"18","author":"Zamora","year":"2016","journal-title":"Phys. Chem. Chem. Phys"},{"key":"10.1074\/jbc.RA119.011177_bib60","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1021\/bi981320m","article-title":"Involvement of conserved, acidic residues in the N-terminal domain of troponin C in calcium-dependent regulation","volume":"38","author":"Kobayashi","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011177_bib61","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.bpj.2018.08.033","article-title":"Ca2+ and myosin cycle states work as allosteric effectors of troponin activation","volume":"115","author":"Sol\u00eds","year":"2018","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.RA119.011177_bib62","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1006\/jmbi.1998.1654","article-title":"The muscle thin filament as a classical cooperative\/allosteric regulatory system","volume":"277","author":"Lehrer","year":"1998","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.RA119.011177_bib63","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1073\/pnas.1519541113","article-title":"Atomic resolution probe for allostery in the regulatory thin filament","volume":"113","author":"Williams","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.011177_bib64","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm1589","article-title":"Intrinsically unstructured proteins and their functions","volume":"6","author":"Dyson","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.RA119.011177_bib65","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1515\/hsz-2015-0303","article-title":"Troponins, intrinsic disorder, and cardiomyopathy","volume":"397","author":"Na","year":"2016","journal-title":"Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib66","doi-asserted-by":"crossref","first-page":"36606","DOI":"10.1074\/jbc.M105130200","article-title":"Mapping the interacting regions between troponins T and C. Binding of TnT and TnI peptides to TnC and NMR mapping of the TnT-binding site on TnC","volume":"276","author":"Blumenschein","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib67","doi-asserted-by":"crossref","first-page":"10594","DOI":"10.1074\/jbc.273.17.10594","article-title":"Regulatory properties of the NH2- and COOH-terminal domains of troponin T. ATPase activation and binding to troponin I and troponin C","volume":"273","author":"Malnic","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib68","doi-asserted-by":"crossref","first-page":"42299","DOI":"10.1074\/jbc.M112.423459","article-title":"Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy","volume":"287","author":"Kowlessur","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib69","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nature06522","article-title":"Dynamic personalities of proteins","volume":"450","author":"Henzler-Wildman","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.011177_bib70","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.abb.2018.12.026","article-title":"The missing links within troponin","volume":"663","author":"Marques","year":"2019","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.RA119.011177_bib71","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41598-017-00777-6","article-title":"Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C","volume":"7","author":"Veltri","year":"2017","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA119.011177_bib72","doi-asserted-by":"crossref","first-page":"11915","DOI":"10.1074\/jbc.M116.770776","article-title":"Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations","volume":"292","author":"Stevens","year":"2017","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib73","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbagen.2013.04.038","article-title":"Methionine oxidation and reduction in proteins","volume":"1840","author":"Kim","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA119.011177_bib74","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00424-019-02269-0","article-title":"Moving beyond simple answers to complex disorders in sarcomeric cardiomyopathies: the role of integrated systems","volume":"471","author":"Deranek","year":"2019","journal-title":"Pflugers Arch"},{"key":"10.1074\/jbc.RA119.011177_bib75","doi-asserted-by":"crossref","first-page":"B90","DOI":"10.1093\/eurheartj\/suz033","article-title":"Myocarditis evolving in cardiomyopathy: when genetics and offending causes work together","volume":"21","author":"Cannat\u00e1","year":"2019","journal-title":"Eur. Heart J. Suppl"},{"key":"10.1074\/jbc.RA119.011177_bib76","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.18632\/oncotarget.22879","article-title":"Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction","volume":"9","author":"Johnston","year":"2018","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.RA119.011177_bib77","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib78","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.yjmcc.2008.05.003","article-title":"Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C","volume":"45","author":"Landstrom","year":"2008","journal-title":"J. Mol. Cell. Cardiol"},{"key":"10.1074\/jbc.RA119.011177_bib79","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1074\/jbc.M707066200","article-title":"A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin","volume":"283","author":"Pinto","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011177_bib80","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ab.2005.09.025","article-title":"Expanding the range of free calcium regulation in biological solutions","volume":"347","author":"Dweck","year":"2005","journal-title":"Anal. Biochem"},{"key":"10.1074\/jbc.RA119.011177_bib81","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0006-3495(88)83174-6","article-title":"Effects of pH on contraction of rabbit fast and slow skeletal muscle fibers","volume":"53","author":"Chase","year":"1988","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.RA119.011177_bib82","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1021\/bi00185a040","article-title":"Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation","volume":"33","author":"Farrow","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011177_bib83","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/300197a0","article-title":"Protein dynamics and NMR relaxation: comparison of simulations with experiment","volume":"300","author":"Lipari","year":"1982","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.011177_bib84","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.pnmrs.2010.12.003","article-title":"A practical guide to protein dynamics from 15N spin relaxation in solution","volume":"59","author":"Morin","year":"2011","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc"},{"key":"10.1074\/jbc.RA119.011177_bib85","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10858-007-9213-3","article-title":"Optimisation of NMR dynamic models II. A new methodology for the dual optimisation of the model-free parameters and the Brownian rotational diffusion tensor","volume":"40","author":"d'Auvergne","year":"2008","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.RA119.011177_bib86","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/jmre.2000.2170","article-title":"HYDRONMR: prediction of NMR relaxation of globular proteins from atomic-level structures and hydrodynamic calculations","volume":"147","author":"Garc\u00eda de la Torre","year":"2000","journal-title":"J. Magn. Reson"},{"key":"10.1074\/jbc.RA119.011177_bib87","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1038\/nprot.2014.144","article-title":"A comparative cross-linking strategy to probe conformational changes in protein complexes","volume":"9","author":"Schmidt","year":"2014","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.RA119.011177_bib88","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/jbc.RA119.011177_bib89","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s13361-011-0261-2","article-title":"StavroX\u2013a software for analyzing crosslinked products in protein interaction studies","volume":"23","author":"G\u00f6tze","year":"2012","journal-title":"J. Am. Soc. Mass. Spectrom"},{"key":"10.1074\/jbc.RA119.011177_bib90","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1074\/jbc.M110.168583","article-title":"Strong cross-bridges potentiate the Ca2+ affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: a fast kinetic approach","volume":"286","author":"Pinto","year":"2011","journal-title":"J. Biol. Chem"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820300259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820300259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA119.011177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T14:58:53Z","timestamp":1665068333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820300259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":90,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0021925820300259"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra119.011177","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA119.011177","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Johnston et al.","name":"copyright","label":"Copyright"}]}}