{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:42:29Z","timestamp":1790502149181,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T00:00:00Z","timestamp":1605312000000},"content-version":"vor","delay-in-days":227,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1074\/jbc.ra119.011251","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T19:45:15Z","timestamp":1583351115000},"page":"5136-5151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function"],"prefix":"10.1016","volume":"295","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-2429","authenticated-orcid":false,"given":"Jenny","family":"Sandmark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tigerstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Akerud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-943X","authenticated-orcid":false,"given":"Magnus","family":"Althage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Antonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blaho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Bodin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9719-9137","authenticated-orcid":false,"given":"Jonas","family":"Bostr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Dahl\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Olof","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Evertsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Fex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Fjellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareta","family":"Hersl\u00f6f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelie","family":"Jarkvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Kalies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Karlsson Svalstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Kartberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Legnehed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Martinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Moberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Ridderstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Rosengren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Sabirsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Thelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Vinblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika U.","family":"Wellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5341-1722","authenticated-orcid":false,"given":"Bingze","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Margret","family":"\u00d6stlund-Lindqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Knecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA119.011251_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2796.2012.02592.x","article-title":"Lipoprotein(a): resurrected by genetics","volume":"273","author":"Kronenberg","year":"2013","journal-title":"J. Intern. Med"},{"key":"10.1074\/jbc.RA119.011251_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1699-0463.1963.tb01808.x","article-title":"A new serum type system in man\u2013the LP system","volume":"59","author":"Berg","year":"1963","journal-title":"Acta Pathol. Microbiol. Scand"},{"key":"10.1074\/jbc.RA119.011251_bib3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jacc.2012.04.038","article-title":"Lipoprotein(a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop targeted therapies","volume":"60","author":"Tsimikas","year":"2012","journal-title":"J. Am. Coll. Cardiol"},{"key":"10.1074\/jbc.RA119.011251_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/00365513.2010.550311","article-title":"Lipoprotein(a) and risk of myocardial infarction\u2013genetic epidemiologic evidence of causality","volume":"71","author":"Kamstrup","year":"2011","journal-title":"Scand. J. Clin. Lab. Invest"},{"key":"10.1074\/jbc.RA119.011251_bib5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/MOL.0b013e32834477d2","article-title":"Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk","volume":"22","author":"Nordestgaard","year":"2011","journal-title":"Curr. Opin. Lipidol"},{"key":"10.1074\/jbc.RA119.011251_bib6","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1093\/eurheartj\/ehq386","article-title":"Lipoprotein(a) as a cardiovascular risk factor: current status","volume":"31","author":"Nordestgaard","year":"2010","journal-title":"Eur. Heart. J"},{"key":"10.1074\/jbc.RA119.011251_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/CIRCULATIONAHA.111.045120","article-title":"Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"125","author":"Virani","year":"2012","journal-title":"Circulation"},{"key":"10.1074\/jbc.RA119.011251_bib8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1001\/jamacardio.2018.1470","article-title":"Association of LPA variants with risk of coronary disease and the implications for lipoprotein(a)-lowering therapies: a Mendelian randomization analysis","volume":"3","author":"Burgess","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1074\/jbc.RA119.011251_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/joim.12013","article-title":"Fifty years of lipoprotein(a)\u2013the magical mystery tour continues","volume":"273","author":"Angelin","year":"2013","journal-title":"J. Intern. Med"},{"key":"10.1074\/jbc.RA119.011251_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.atherosclerosis.2018.04.032","article-title":"Is Lp(a) ready for prime time use in the clinic? A pros-and-cons debate","volume":"274","author":"Kostner","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.RA119.011251_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/00041433-200308000-00004","article-title":"Evaluation of lipoprotein(a) as a prothrombotic factor: progress from bench to bedside","volume":"14","author":"Marcovina","year":"2003","journal-title":"Curr. Opin. Lipidol"},{"key":"10.1074\/jbc.RA119.011251_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2174\/187152906779010764","article-title":"Novel insights into Lp(a) physiology and pathogenicity: more questions than answers?","volume":"6","author":"Koschinsky","year":"2006","journal-title":"Cardiovasc. Hematol. Disord. Drug Targets"},{"key":"10.1074\/jbc.RA119.011251_bib13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0009-3084(94)90159-7","article-title":"Effects of lipoprotein(a) on the binding of plasminogen to fibrin and its activation by fibrin-bound tissue-type plasminogen activator","volume":"67\u201368","author":"Angles-Cano","year":"1994","journal-title":"Chem. Phys. Lipids"},{"key":"10.1074\/jbc.RA119.011251_bib14","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1021\/bi00175a026","article-title":"Fibrin-bound lipoprotein(a) promotes plasminogen binding but inhibits fibrin degradation by plasmin","volume":"33","author":"Liu","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011251_bib15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nm0395-256","article-title":"Antifibrinolytic activity of apolipoprotein(a) in vivo: human apolipoprotein(a) transgenic mice are resistant to tissue plasminogen activator-mediated thrombolysis","volume":"1","author":"Palabrica","year":"1995","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA119.011251_bib16","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1038\/srep05318","article-title":"Lp(a) is not associated with diabetes but affects fibrinolysis and clot structure ex vivo","volume":"4","author":"M\u00e5nsson","year":"2014","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA119.011251_bib17","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1074\/jbc.M113.517904","article-title":"Coagulation factor XIIIa substrates in human plasma: identification and incorporation into the clot","volume":"289","author":"Nikolajsen","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011251_bib18","doi-asserted-by":"crossref","first-page":"55187","DOI":"10.1074\/jbc.M409860200","article-title":"Stimulation of vascular smooth muscle cell proliferation and migration by apolipoprotein(a) is dependent on inhibition of transforming growth factor-\u03b2 activation and on the presence of kringle IV type 9","volume":"279","author":"O'Neil","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011251_bib19","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1074\/jbc.M309705200","article-title":"The apolipoprotein(a) component of lipoprotein(a) stimulates actin stress fiber formation and loss of cell-cell contact in cultured endothelial cells","volume":"279","author":"Pellegrino","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011251_bib20","doi-asserted-by":"crossref","first-page":"30503","DOI":"10.1074\/jbc.M802648200","article-title":"Apolipoprotein(a), through its strong lysine-binding site in KIV(10\u2032), mediates increased endothelial cell contraction and permeability via a Rho\/Rho kinase\/MYPT1-dependent pathway","volume":"283","author":"Cho","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011251_bib21","doi-asserted-by":"crossref","first-page":"46864","DOI":"10.1074\/jbc.M107943200","article-title":"Stimulation of interleukin-8 production in human THP-1 macrophages by apolipoprotein(a). Evidence for a critical involvement of elements in its C-terminal domain","volume":"276","author":"Klezovitch","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011251_bib22","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1172\/JCI119565","article-title":"Modification of apolipoprotein(a) lysine binding site reduces atherosclerosis in transgenic mice","volume":"100","author":"Boonmark","year":"1997","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA119.011251_bib23","first-page":"229","article-title":"Longitudinal cohort study on the effectiveness of lipid apheresis treatment to reduce high lipoprotein(a) levels and prevent major adverse coronary events","volume":"6","author":"Jaeger","year":"2009","journal-title":"Nat. Clin. Pract. Cardiovasc. Med"},{"key":"10.1074\/jbc.RA119.011251_bib24","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1161\/ATVBAHA.116.307983","article-title":"Lipoprotein apheresis for lipoprotein(a)-associated cardiovascular disease: prospective 5 years of follow-up and apolipoprotein(a) characterization","volume":"36","author":"Roeseler","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.RA119.011251_bib25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(14)61374-X","article-title":"Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial","volume":"385","author":"Raal","year":"2015","journal-title":"Lancet"},{"key":"10.1074\/jbc.RA119.011251_bib26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41598-017-00316-3","article-title":"Therapeutic efficacy and safety of PCSK9-monoclonal antibodies on familial hypercholesterolemia and statin-intolerant patients: A meta-analysis of 15 randomized controlled trials","volume":"7","author":"Qian","year":"2017","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA119.011251_bib27","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.118.034710","article-title":"Effect of an siRNA therapeutic targeting PCSK9 on atherogenic lipoproteins: pre-specified secondary end points in ORION 1","volume":"138","author":"Ray","year":"2018","journal-title":"Circulation"},{"key":"10.1074\/jbc.RA119.011251_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1056\/NEJMoa1609243","article-title":"A highly durable RNAi therapeutic inhibitor of PCSK9","volume":"376","author":"Fitzgerald","year":"2017","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.RA119.011251_bib29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.atherosclerosis.2017.02.019","article-title":"Effect of mipomersen on LDL-cholesterol in patients with severe LDL-hypercholesterolaemia and atherosclerosis treated by lipoprotein apheresis (The MICA-Study)","volume":"259","author":"Waldmann","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.RA119.011251_bib30","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1161\/ATVBAHA.114.304549","article-title":"Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials","volume":"35","author":"Santos","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.RA119.011251_bib31","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/S0140-6736(15)61252-1","article-title":"Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study","volume":"386","author":"Tsimikas","year":"2015","journal-title":"Lancet"},{"key":"10.1074\/jbc.RA119.011251_bib32","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/S0140-6736(16)31009-1","article-title":"Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials","volume":"388","author":"Viney","year":"2016","journal-title":"Lancet"},{"key":"10.1074\/jbc.RA119.011251_bib33","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1161\/01.ATV.15.10.1774","article-title":"Inhibitors for the in vitro assembly of Lp(a)","volume":"15","author":"Frank","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.RA119.011251_bib34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0014-5793(76)80161-5","article-title":"Multiple gene duplication in the evolution of plasminogen. Five regions of sequence homology with the two internally homologous structures in prothrombin","volume":"61","author":"Claeys","year":"1976","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.RA119.011251_bib35","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/330132a0","article-title":"cDNA sequence of human apolipoprotein(a) is homologous to plasminogen","volume":"330","author":"McLean","year":"1987","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.011251_bib36","doi-asserted-by":"crossref","first-page":"11643","DOI":"10.1073\/pnas.90.24.11643","article-title":"Cys4057 of apolipoprotein(a) is essential for lipoprotein(a) assembly","volume":"90","author":"Brunner","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA119.011251_bib37","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/protein\/10.3.291","article-title":"The role of apo-(a) kringle-IVs in the assembly of lipoprotein-(a)","volume":"10","author":"Frank","year":"1997","journal-title":"Protein Eng"},{"key":"10.1074\/jbc.RA119.011251_bib38","first-page":"36","article-title":"Molecular basis of the interaction between LDL and recombinant apo(a)","volume":"34","author":"Helmhold","year":"1996","journal-title":"Z. Gastroenterol"},{"key":"10.1074\/jbc.RA119.011251_bib39","doi-asserted-by":"crossref","first-page":"7892","DOI":"10.1021\/bi973186w","article-title":"Sequences within apolipoprotein(a) kringle IV types 6\u20138 bind directly to low-density lipoprotein and mediate noncovalent association of apolipoprotein(a) with apolipoprotein B-100","volume":"37","author":"Gabel","year":"1998","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011251_bib40","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1021\/bi010964i","article-title":"Comparative analyses of the lysine binding site properties of apolipoprotein(a) kringle IV types 7 and 10","volume":"41","author":"Rahman","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011251_bib41","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0140-6736(11)60278-X","article-title":"The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial","volume":"377","author":"CRASH-2 collaborators","year":"2011","journal-title":"Lancet"},{"key":"10.1074\/jbc.RA119.011251_bib42","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1021\/jm301818g","article-title":"Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid","volume":"56","author":"Bostr\u00f6m","year":"2013","journal-title":"J. Med. Chem"},{"key":"10.1074\/jbc.RA119.011251_bib43","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1021\/ml400526d","article-title":"Discovery of the fibrinolysis inhibitor AZD6564, acting via interference of a protein\u2013protein interaction","volume":"5","author":"Cheng","year":"2014","journal-title":"ACS Med. Chem. Lett"},{"key":"10.1074\/jbc.RA119.011251_bib44","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1021\/ci0504723","article-title":"Multifingerprint based similarity searches for targeted class compound selection","volume":"46","author":"Kogej","year":"2006","journal-title":"J. Chem. Inf. Model"},{"key":"10.1074\/jbc.RA119.011251_bib45","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1021\/bi9820558","article-title":"Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance","volume":"38","author":"Mochalkin","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011251_bib46","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1110\/ps.01701","article-title":"High-resolution crystal structure of apolipoprotein(a) kringle IV type 7: insights into ligand binding","volume":"10","author":"Ye","year":"2001","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.RA119.011251_bib47","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1021\/bi9521351","article-title":"Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands \u025b-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic acid","volume":"35","author":"Mathews","year":"1996","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011251_bib48","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1021\/bi972284e","article-title":"Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen","volume":"37","author":"Chang","year":"1998","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011251_bib49","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1749-6632.2001.tb03514.x","article-title":"Inhibition of fibrinolysis by lipoprotein(a)","volume":"936","author":"Angl\u00e9s-Cano","year":"2001","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1074\/jbc.RA119.011251_bib50","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1074\/jbc.M212855200","article-title":"A ligand-induced conformational change in apolipoprotein(a) enhances covalent Lp(a) formation","volume":"278","author":"Becker","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA119.011251_bib51","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1021\/bi951792q","article-title":"Ligand-induced conformational change of lipoprotein(a)","volume":"35","author":"Fless","year":"1996","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011251_bib52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.RA119.011251_bib53","doi-asserted-by":"crossref","first-page":"9284","DOI":"10.1021\/bi9729662","article-title":"Apolipoprotein(a) binds to low-density lipoprotein at two distant sites in lipoprotein(a)","volume":"37","author":"Xu","year":"1998","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011251_bib54","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1161\/01.ATV.8.4.348","article-title":"Enhanced macrophage uptake of low density lipoprotein after self-aggregation","volume":"8","author":"Khoo","year":"1988","journal-title":"Arteriosclerosis"},{"key":"10.1074\/jbc.RA119.011251_bib55","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11745-998-0219-5","article-title":"Enhanced macrophage uptake of lipoprotein(a) after Ca2+-induced aggregate-formation","volume":"33","author":"Tanaka","year":"1998","journal-title":"Lipids"},{"key":"10.1074\/jbc.RA119.011251_bib56","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/protein\/14.6.427","article-title":"Antifibrinolytic effect of single apo(a) kringle domains: relationship to fibrinogen binding","volume":"14","author":"Rahman","year":"2001","journal-title":"Protein Eng"},{"key":"10.1074\/jbc.RA119.011251_bib57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.celrep.2012.02.012","article-title":"The X-ray crystal structure of full-length human plasminogen","volume":"1","author":"Law","year":"2012","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.RA119.011251_bib58","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1538-7836.2012.04765.x","article-title":"Crystal structure of the native plasminogen reveals an activation-resistant compact conformation","volume":"10","author":"Xue","year":"2012","journal-title":"J. Thromb. Haemost"},{"key":"10.1074\/jbc.RA119.011251_bib59","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1194\/jlr.M040733","article-title":"Determinants of binding of oxidized phospholipids on apolipoprotein(a) and lipoprotein(a)","volume":"54","author":"Leibundgut","year":"2013","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.RA119.011251_bib60","first-page":"721","article-title":"Effects of wild-type (Trp-72) and mutant (Arg-72) apolipoprotein(a) kringle IV-10 on the proliferation of human arterial smooth muscle cells","volume":"116","author":"Yu","year":"2003","journal-title":"Chin. Med. J"},{"key":"10.1074\/jbc.RA119.011251_bib61","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1021\/bi00065a026","article-title":"Physical properties of recombinant apolipoprotein(a) and its association with LDL to form an LP (a)-like complex","volume":"32","author":"Phillips","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011251_bib62","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0021-9150(94)05445-O","article-title":"Extraction of lipoprotein(a), apo B, and apo E from fresh human arterial wall and atherosclerotic plaques","volume":"113","author":"Reblin","year":"1995","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.RA119.011251_bib63","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1388-1981(99)00044-X","article-title":"Effect of tranexamic acid and \u03b4-aminovaleric acid on lipoprotein(a) metabolism in transgenic mice","volume":"1438","author":"Frank","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA119.011251_bib64","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1021\/bi00234a029","article-title":"Apolipoprotein(a): expression and characterization of a recombinant form of the protein in mammalian cells","volume":"30","author":"Koschinsky","year":"1991","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA119.011251_bib65","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1107\/S0907444910045749","article-title":"Overview of the CCP4 suite and current developments","volume":"67","author":"Winn","year":"2011","journal-title":"Acta Crystallogr. D Biol. Crystallogr"},{"key":"10.1074\/jbc.RA119.011251_bib66","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1021\/jm011122k","article-title":"NMR-based screening with competition water-ligand observed via gradient spectroscopy experiments: detection of high-affinity ligands","volume":"45","author":"Dalvit","year":"2002","journal-title":"J. Med. Chem"},{"key":"10.1074\/jbc.RA119.011251_bib67","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/jmra.1995.1047","article-title":"Water suppression that works. Excitation sculpting using arbitrary wave-forms and pulsed-field gradients","volume":"112","author":"Hwang","year":"1995","journal-title":"J. Magnetic Resonance Series A"},{"key":"10.1074\/jbc.RA119.011251_bib68","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/cmr.a.20121","article-title":"Theoretical analysis of the competition ligand-based NMR experiments and selected applications to fragment screening and binding constant measurements","volume":"32A","author":"Dalvit","year":"2008","journal-title":"Concepts in Magnetic Resonance Part A"},{"key":"10.1074\/jbc.RA119.011251_bib69","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/abio.1994.1390","article-title":"Real-time competitive kinetic analysis of interactions between low-molecular-weight ligands in solution and surface-immobilized receptors","volume":"221","author":"Karlsson","year":"1994","journal-title":"Anal. Biochem"},{"key":"10.1074\/jbc.RA119.011251_bib70","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817486042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817486042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA119.011251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T11:38:23Z","timestamp":1639654703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817486042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":70,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0021925817486042"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra119.011251","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA119.011251","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Sandmark et al.","name":"copyright","label":"Copyright"}]}}