{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:31:58Z","timestamp":1784248318676,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":83,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700709 81502284"],"award-info":[{"award-number":["81700709 81502284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"MOE | Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["111498001"],"award-info":[{"award-number":["111498001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grant of Jilin Provincial Science & Technology Committee","award":["20170520031JH 20170414028GH 20180520105JH 20190304026YY"],"award-info":[{"award-number":["20170520031JH 20170414028GH 20180520105JH 20190304026YY"]}]},{"name":"Grant of Jilin Province Development and Reform Commission","award":["2018C051"],"award-info":[{"award-number":["2018C051"]}]},{"name":"Grant of Changchun Science and Technology Bureau","award":["17YJ003"],"award-info":[{"award-number":["17YJ003"]}]},{"name":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University","award":["13002890"],"award-info":[{"award-number":["13002890"]}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1074\/jbc.ra120.012849","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T22:47:41Z","timestamp":1595285261000},"page":"12975-12992","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Tectorigenin enhances PDX1 expression and protects pancreatic \u03b2-cells by activating ERK and reducing ER stress"],"prefix":"10.1016","volume":"295","author":[{"given":"Xinlei","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Lei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Bo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Li","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guannan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luguo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA120.012849_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/jcm7030054","article-title":"The cells of the islets of Langerhans","volume":"7","author":"Da Silva Xavier","year":"2018","journal-title":"J. Clin. Med"},{"issue":"Suppl. 1","key":"10.1074\/jbc.RA120.012849_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/dom.12732","article-title":"\u03b2-Cell dysfunction in diabetes: a crisis of identity?","volume":"18","author":"Brereton","year":"2016","journal-title":"Diabetes Obes. Metab"},{"key":"10.1074\/jbc.RA120.012849_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.molmed.2016.12.005","article-title":"\u03b2-Cell fragility as a common underlying risk factor in Type 1 and Type 2 diabetes","volume":"23","author":"Liston","year":"2017","journal-title":"Trends Mol. Med"},{"key":"10.1074\/jbc.RA120.012849_bib4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1573399811666141216160217","article-title":"Pancreatic \u03b2-cell glucose toxicity in type 2 diabetes mellitus","volume":"11","author":"Kaneto","year":"2015","journal-title":"Curr. Diabetes Rev"},{"key":"10.1074\/jbc.RA120.012849_bib5","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1194\/jlr.R066514","article-title":"Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment","volume":"57","author":"Ertunc","year":"2016","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.RA120.012849_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1530\/JME-17-0262","article-title":"Glucolipotoxic conditions induce \u03b2-cell iron import, cytosolic ROS formation and apoptosis","volume":"61","author":"Hansen","year":"2018","journal-title":"J. Mol. Endocrinol"},{"key":"10.1074\/jbc.RA120.012849_bib7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13287-017-0694-z","article-title":"PDX1, Neurogenin-3, and MAFA: critical transcription regulators for \u03b2 cell development and regeneration","volume":"8","author":"Zhu","year":"2017","journal-title":"Stem Cell Res. Ther"},{"key":"10.1074\/jbc.RA120.012849_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cmet.2013.12.002","article-title":"Pdx1 maintains \u03b2 cell identity and function by repressing an \u03b1 cell program","volume":"19","author":"Gao","year":"2014","journal-title":"Cell Metab"},{"issue":"Suppl. 3","key":"10.1074\/jbc.RA120.012849_bib9","doi-asserted-by":"crossref","first-page":"S320","DOI":"10.2337\/diabetes.51.2007.S320","article-title":"Regulation of pdx-1 gene expression","volume":"51","author":"Melloul","year":"2002","journal-title":"Diabetes"},{"issue":"Suppl. 4","key":"10.1074\/jbc.RA120.012849_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1463-1326.2009.01121.x","article-title":"Pdx1 and other factors that regulate pancreatic beta-cell survival","volume":"11","author":"Fujimoto","year":"2009","journal-title":"Diabetes Obes. Metab"},{"key":"10.1074\/jbc.RA120.012849_bib11","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.bbrc.2015.10.038","article-title":"Short-term selective alleviation of glucotoxicity and lipotoxicity ameliorates the suppressed expression of key \u03b2-cell factors under diabetic conditions","volume":"467","author":"Shimo","year":"2015","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA120.012849_bib12","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.molmet.2017.06.001","article-title":"Endoplasmic reticulum stress and eIF2\u03b1 phosphorylation: the Achilles heel of pancreatic \u03b2 cells","volume":"6","author":"Cnop","year":"2017","journal-title":"Mol. Metab"},{"key":"10.1074\/jbc.RA120.012849_bib13","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1172\/JCI40440","article-title":"Pcif1 modulates Pdx1 protein stability and pancreatic \u03b2 cell function and survival in mice","volume":"120","author":"Claiborn","year":"2010","journal-title":"J. Clin. Investig"},{"key":"10.1074\/jbc.RA120.012849_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.peptides.2013.08.021","article-title":"The DPP-4 inhibitor MK0626 and exercise protect islet function in early pre-diabetic kkay mice","volume":"49","author":"Li","year":"2013","journal-title":"Peptides"},{"key":"10.1074\/jbc.RA120.012849_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.peptides.2017.12.013","article-title":"Control of insulin secretion by GLP-1","volume":"100","author":"Jones","year":"2018","journal-title":"Peptides"},{"key":"10.1074\/jbc.RA120.012849_bib16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.diabres.2019.04.006","article-title":"The direct effect of lobeglitazone, a new thiazolidinedione, on pancreatic \u03b2 cells: a comparison with other thiazolidinediones","volume":"151","author":"Kwon","year":"2019","journal-title":"Diabetes Res. Clin. Pract"},{"key":"10.1074\/jbc.RA120.012849_bib17","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1111\/febs.15020","article-title":"Dracorhodin perchlorate protects pancreatic \u03b2-cells against glucotoxicity- or lipotoxicity-induced dysfunction and apoptosis in vitro in vivo","volume":"286","author":"Liu","year":"2019","journal-title":"FEBS J"},{"key":"10.1074\/jbc.RA120.012849_bib18","doi-asserted-by":"crossref","first-page":"e66417","DOI":"10.1371\/journal.pone.0066417","article-title":"Tectorigenin attenuates palmitate-induced endothelial insulin resistance via targeting ROS-associated inflammation and IRS-1 pathway","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA120.012849_bib19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF02976573","article-title":"Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro","volume":"23","author":"Lee","year":"2000","journal-title":"Arch. Pharmacal. Res"},{"key":"10.1074\/jbc.RA120.012849_bib20","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.3109\/13880209.2014.993038","article-title":"Tectorigenin regulates adipogenic differentiation and adipocytokines secretion via PPAR\u03b3 and IKK\/NF-\u03baB signaling","volume":"53","author":"Li","year":"2015","journal-title":"Pharm. Biol"},{"key":"10.1074\/jbc.RA120.012849_bib21","doi-asserted-by":"crossref","first-page":"104678","DOI":"10.1016\/j.phrs.2020.104678","article-title":"Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1\/2 pathway","volume":"153","author":"Yang","year":"2020","journal-title":"Pharmacol. Res"},{"key":"10.1074\/jbc.RA120.012849_bib22","doi-asserted-by":"crossref","first-page":"7592","DOI":"10.1016\/j.bmc.2006.07.002","article-title":"Aldose reductase inhibitory effect by tectorigenin derivatives from Viola hondoensis","volume":"14","author":"Moon","year":"2006","journal-title":"Bioorg. Med. Chem"},{"key":"10.1074\/jbc.RA120.012849_bib23","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/ptr.6299","article-title":"Tectorigenin protects against experimental fulminant hepatic failure by regulating the TLR4\/mitogen-activated protein kinase and TLR4\/nuclear factor-\u03baB pathways and autophagy","volume":"33","author":"Zhang","year":"2019","journal-title":"Phytother. Res"},{"key":"10.1074\/jbc.RA120.012849_bib24","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3109\/08923973.2013.770521","article-title":"Toxicity, analgesic and anti-inflammatory activities of tectorigenin","volume":"35","author":"Ha Le","year":"2013","journal-title":"Immunopharmacol. Immunotoxicol"},{"key":"10.1074\/jbc.RA120.012849_bib25","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1471-4159.2011.07395.x","article-title":"Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression","volume":"119","author":"Park","year":"2011","journal-title":"J. Neurochem"},{"key":"10.1074\/jbc.RA120.012849_bib26","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1158\/1535-7163.MCT-07-0197","article-title":"The relevance of estrogen receptor-\u03b2 expression to the antiproliferative effects observed with histone deacetylase inhibitors and phytoestrogens in prostate cancer treatment","volume":"6","author":"Stettner","year":"2007","journal-title":"Mol. Cancer Ther"},{"key":"10.1074\/jbc.RA120.012849_bib27","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/ptr.6599","article-title":"Tectorigenin, an isoflavone aglycone from the rhizome of Belamcanda chinensis, induces neuronal expression of erythropoietin via accumulation of hypoxia-inducible factor-1\u03b1","volume":"34","author":"Liu","year":"2019","journal-title":"Phytother. Res"},{"key":"10.1074\/jbc.RA120.012849_bib28","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1073\/pnas.0811715106","article-title":"Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic \u03b2-cells","volume":"106","author":"Zhang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA120.012849_bib29","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1074\/jbc.M111272200","article-title":"Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion","volume":"277","author":"Brissova","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.012849_bib30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/BJ20141384","article-title":"Pancreatic \u03b2-cell identity, glucose sensing and the control of insulin secretion","volume":"466","author":"Rutter","year":"2015","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.RA120.012849_bib31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jnutbio.2018.05.005","article-title":"Chronic palmitic acid-induced lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic \u03b2 cells","volume":"59","author":"Ruan","year":"2018","journal-title":"J. Nutr. Biochem"},{"key":"10.1074\/jbc.RA120.012849_bib32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.biopha.2018.02.097","article-title":"Liquiritigenin prevents palmitate-induced \u03b2-cell apoptosis via estrogen receptor-mediated AKT activation","volume":"101","author":"Bae","year":"2018","journal-title":"Biomed. Pharmacother"},{"key":"10.1074\/jbc.RA120.012849_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.abb.2013.03.011","article-title":"Protective effect of nicotinamide on high glucose\/palmitate-induced glucolipotoxicity to INS-1 \u03b2 cells is attributed to its inhibitory activity to sirtuins","volume":"535","author":"Lee","year":"2013","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.RA120.012849_bib34","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.bcp.2013.08.023","article-title":"Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic \u03b2-cells: protection by nifedipine","volume":"86","author":"Syeda","year":"2013","journal-title":"Biochem. Pharmacol"},{"key":"10.1074\/jbc.RA120.012849_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jsbmb.2013.09.018","article-title":"Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic \u03b2-cell death","volume":"139","author":"Kooptiwut","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol"},{"key":"10.1074\/jbc.RA120.012849_bib36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejps.2017.03.038","article-title":"Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells","volume":"110","author":"Guo","year":"2017","journal-title":"Eur. J. Pharmaceut. Sci"},{"key":"10.1074\/jbc.RA120.012849_bib37","doi-asserted-by":"crossref","first-page":"4973851","DOI":"10.1155\/2018\/4973851","article-title":"Polysiphonia japonica extract attenuates palmitate-induced toxicity and enhances insulin secretion in pancreatic \u03b2-cells","volume":"2018","author":"Cha","year":"2018","journal-title":"Oxid. Med. Cell. Longev"},{"key":"10.1074\/jbc.RA120.012849_bib38","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1073\/pnas.93.6.2239","article-title":"The molecular biology of apoptosis","volume":"93","author":"Vaux","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA120.012849_bib39","doi-asserted-by":"crossref","first-page":"4513051","DOI":"10.1155\/2016\/4513051","article-title":"Ghrelin protects against dexamethasone-induced INS-1 cell apoptosis via ERK and p38MAPK signaling","volume":"2016","author":"Zhang","year":"2016","journal-title":"Int. J. Endocrinol"},{"key":"10.1074\/jbc.RA120.012849_bib40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/cbf.3383","article-title":"Telmisartan protects against high glucose\/high lipid-induced apoptosis and insulin secretion by reducing the oxidative and ER stress","volume":"37","author":"Wang","year":"2019","journal-title":"Cell Biochem. Funct"},{"key":"10.1074\/jbc.RA120.012849_bib41","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/jpi.12264","article-title":"Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis","volume":"59","author":"Fernandez","year":"2015","journal-title":"J. Pineal Res"},{"issue":"Suppl. 2","key":"10.1074\/jbc.RA120.012849_bib42","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.2337\/diabetes.54.suppl_2.S97","article-title":"Mechanisms of pancreatic \u03b2-cell death in type 1 and type 2 diabetes: many differences, few similarities","volume":"54","author":"Cnop","year":"2005","journal-title":"Diabetes"},{"key":"10.1074\/jbc.RA120.012849_bib43","doi-asserted-by":"crossref","first-page":"2902351","DOI":"10.1155\/2016\/2902351","article-title":"An overview of murine high fat diet as a model for type 2 diabetes mellitus","volume":"2016","author":"Heydemann","year":"2016","journal-title":"J. Diabetes Res"},{"key":"10.1074\/jbc.RA120.012849_bib44","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.biopha.2016.03.038","article-title":"The inhibiting effect of the Coptis chinensis polysaccharide on the type II diabetic mice","volume":"81","author":"Cui","year":"2016","journal-title":"Biomed. Pharmacother"},{"key":"10.1074\/jbc.RA120.012849_bib45","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","article-title":"Use and abuse of HOMA modeling","volume":"27","author":"Wallace","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1074\/jbc.RA120.012849_bib46","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.bbrc.2016.12.128","article-title":"Preserving expression of Pdx1 improves \u03b2-cell failure in diabetic mice","volume":"483","author":"Yamamoto","year":"2017","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA120.012849_bib47","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.7150\/ijbs.33817","article-title":"Hypericin maintians PDX1 expression via the Erk pathway and protects islet \u03b2-cells against glucotoxicity and lipotoxicity","volume":"15","author":"Liang","year":"2019","journal-title":"Int. J. Biol. Sci"},{"key":"10.1074\/jbc.RA120.012849_bib48","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00125-004-1368-9","article-title":"Transcriptional networks controlling pancreatic development and beta cell function","volume":"47","author":"Servitja","year":"2004","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.RA120.012849_bib49","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2337\/diabetes.52.3.581","article-title":"Glucose toxicity in \u03b2-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection","volume":"52","author":"Robertson","year":"2003","journal-title":"Diabetes"},{"key":"10.1074\/jbc.RA120.012849_bib50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/CS20180836","article-title":"GPR120 protects lipotoxicity-induced pancreatic \u03b2-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation","volume":"133","author":"Wang","year":"2019","journal-title":"Clin. Sci"},{"key":"10.1074\/jbc.RA120.012849_bib51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/jb\/mvx048","article-title":"ERK signalling as a regulator of cell motility","volume":"162","author":"Tanimura","year":"2017","journal-title":"J. Biochem"},{"key":"10.1074\/jbc.RA120.012849_bib52","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/MMBR.68.2.320-344.2004","article-title":"ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions","volume":"68","author":"Roux","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev"},{"key":"10.1074\/jbc.RA120.012849_bib53","doi-asserted-by":"crossref","first-page":"e0176432","DOI":"10.1371\/journal.pone.0176432","article-title":"Baicalein protects rat insulinoma INS-1 cells from palmitate-induced lipotoxicity by inducing HO-1","volume":"12","author":"Kwak","year":"2017","journal-title":"PLoS One"},{"key":"10.1074\/jbc.RA120.012849_bib54","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cellsig.2018.03.013","article-title":"Caveolin-1 deficiency protects pancreatic \u03b2 cells against palmitate-induced dysfunction and apoptosis","volume":"47","author":"Zeng","year":"2018","journal-title":"Cell. Signal"},{"key":"10.1074\/jbc.RA120.012849_bib55","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.cellsig.2016.05.007","article-title":"Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic \u03b2 cells","volume":"28","author":"Wang","year":"2016","journal-title":"Cell. Signal"},{"key":"10.1074\/jbc.RA120.012849_bib56","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev-biochem-072909-095555","article-title":"Endoplasmic reticulum stress and type 2 diabetes","volume":"81","author":"Back","year":"2012","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.RA120.012849_bib57","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.molmet.2019.06.012","article-title":"Endoplasmic reticulum stress, degeneration of pancreatic islet \u03b2-cells, and therapeutic modulation of the unfolded protein response in diabetes","volume":"27S","author":"Ghosh","year":"2019","journal-title":"Mol. Metab"},{"key":"10.1074\/jbc.RA120.012849_bib58","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1210\/er.2007-0039","article-title":"The unfolded protein response: a pathway that links insulin demand with \u03b2-cell failure and diabetes","volume":"29","author":"Scheuner","year":"2008","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.RA120.012849_bib59","doi-asserted-by":"crossref","first-page":"32798","DOI":"10.1074\/jbc.M114.575191","article-title":"Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet \u03b2 cell","volume":"289","author":"Johnson","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.012849_bib60","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.peptides.2011.06.025","article-title":"Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice","volume":"32","author":"Chen","year":"2011","journal-title":"Peptides"},{"key":"10.1074\/jbc.RA120.012849_bib61","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-4939-2522-3_15","article-title":"Cross talk between ER stress, oxidative stress, and inflammation in health and disease","volume":"1292","author":"Dandekar","year":"2015","journal-title":"Methods Mol. Biol"},{"key":"10.1074\/jbc.RA120.012849_bib62","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1248\/bpb.b17-00342","article-title":"ER stress and disease: toward prevention and treatment","volume":"40","author":"Kaneko","year":"2017","journal-title":"Biol. Pharm. Bull"},{"key":"10.1074\/jbc.RA120.012849_bib63","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.biocel.2010.08.007","article-title":"Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells","volume":"42","author":"Zhang","year":"2010","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"10.1074\/jbc.RA120.012849_bib64","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bcp.2016.02.001","article-title":"Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models","volume":"105","author":"Zhang","year":"2016","journal-title":"Biochem. Pharmacol"},{"key":"10.1074\/jbc.RA120.012849_bib65","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/hep.26272","article-title":"Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by liver X receptor \u03b1 through a sterol regulatory element-binding protein 1c-dependent mechanism in mice","volume":"58","author":"Wu","year":"2013","journal-title":"Hepatology"},{"key":"10.1074\/jbc.RA120.012849_bib66","doi-asserted-by":"crossref","first-page":"e2813","DOI":"10.1002\/dmrr.2813","article-title":"Ghrelin mitigates \u03b2-cell mass loss during insulitis in an animal model of autoimmune diabetes mellitus, the BioBreeding\/Worcester rat","volume":"33","author":"Baena-Nieto","year":"2017","journal-title":"Diabetes Metab. Res. Rev"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817499583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817499583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA120.012849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T16:53:15Z","timestamp":1640969595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817499583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":66,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0021925817499583"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra120.012849","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tectorigenin enhances PDX1 expression and protects pancreatic \u03b2-cells by activating ERK and reducing ER stress","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA120.012849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}