{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:31:14Z","timestamp":1790947874974,"version":"4.1.0"},"reference-count":170,"publisher":"Elsevier BV","issue":"45","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T00:00:00Z","timestamp":1608940800000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM122976"],"award-info":[{"award-number":["GM122976"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1074\/jbc.ra120.013495","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T21:45:10Z","timestamp":1598996710000},"page":"15378-15397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Replication stress at microsatellites causes DNA double-strand breaks and break-induced replication"],"prefix":"10.1016","volume":"295","author":[{"given":"Rujuta Yashodhan","family":"Gadgil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Romer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin C.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-3768","authenticated-orcid":false,"suffix":"Jr.","given":"S.Dean","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"French J.","family":"Damewood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna R.","family":"Barthelemy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Shin-ya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Hanenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-785X","authenticated-orcid":false,"given":"Michael","family":"Leffak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA120.013495_bib1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.013495_bib2","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/gb-2003-4-2-r13","article-title":"Genome-wide analysis of microsatellite repeats in humans: their abundance and density in specific genomic regions","volume":"4","author":"Subramanian","year":"2003","journal-title":"Genome Biol"},{"key":"10.1074\/jbc.RA120.013495_bib3","doi-asserted-by":"crossref","first-page":"1700077","DOI":"10.1002\/bies.201700077","article-title":"Precarious maintenance of simple DNA repeats in eukaryotes","volume":"39","author":"Neil","year":"2017","journal-title":"Bioessays"},{"key":"10.1074\/jbc.RA120.013495_bib4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.gde.2013.04.009","article-title":"The balancing act of DNA repeat expansions","volume":"23","author":"Kim","year":"2013","journal-title":"Curr. Opin. Genet. Dev"},{"key":"10.1074\/jbc.RA120.013495_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm2854","article-title":"Repeat instability as the basis for human diseases and as a potential target for therapy","volume":"11","author":"L\u00f3pez Castel","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.sbi.2006.05.004","article-title":"DNA structures, repeat expansions and human hereditary disorders","volume":"16","author":"Mirkin","year":"2006","journal-title":"Curr. Opin. Struct. Biol"},{"key":"10.1074\/jbc.RA120.013495_bib7","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature05977","article-title":"Expandable DNA repeats and human disease","volume":"447","author":"Mirkin","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.013495_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/mc.20512","article-title":"Checkpoint responses to unusual structures formed by DNA repeats","volume":"48","author":"Voineagu","year":"2009","journal-title":"Mol. Carcinog"},{"key":"10.1074\/jbc.RA120.013495_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.dnarep.2014.03.017","article-title":"Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability","volume":"19","author":"Wang","year":"2014","journal-title":"DNA Repair (Amst.)"},{"key":"10.1074\/jbc.RA120.013495_bib10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.molcel.2018.08.047","article-title":"Genome-wide identification of structure-forming repeats as principal sites of fork collapse upon ATR inhibition","volume":"72","author":"Shastri","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.dnarep.2015.11.008","article-title":"Disease-associated repeat instability and mismatch repair","volume":"38","author":"Schmidt","year":"2016","journal-title":"DNA Repair (Amst.)"},{"key":"10.1074\/jbc.RA120.013495_bib12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mrfmmm.2015.08.007","article-title":"Evidence for chromosome fragility at the frataxin locus in Friedreich ataxia","volume":"781","author":"Kumari","year":"2015","journal-title":"Mutat. Res"},{"key":"10.1074\/jbc.RA120.013495_bib13","series-title":"Genetic Instabilities and Neurological Diseases","first-page":"617","article-title":"Bending the rules: unusual nucleic acid structures and disease pathology in the repeat expansion diseases","author":"Usdin","year":"2006"},{"key":"10.1074\/jbc.RA120.013495_bib14","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/PL00000734","article-title":"DNA repeat expansions and human disease","volume":"57","author":"Usdin","year":"2000","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.RA120.013495_bib15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2019.06.036","article-title":"CAG repeat not polyglutamine length determines timing of Huntington's disease onset","volume":"178","year":"2019","journal-title":"Cell"},{"key":"10.1074\/jbc.RA120.013495_bib16","doi-asserted-by":"crossref","first-page":"e1006190","DOI":"10.1371\/journal.pgen.1006190","article-title":"A MutS\u03b2-dependent contribution of MutS\u03b1 to repeat expansions in fragile X premutation mice?","volume":"12","author":"Zhao","year":"2016","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA120.013495_bib17","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1093\/hmg\/ddw215","article-title":"Sustained expression of FMR1 mRNA from reactivated fragile X syndrome alleles after treatment with small molecules that prevent trimethylation of H3K27","volume":"25","author":"Kumari","year":"2016","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib18","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.celrep.2016.06.075","article-title":"Stalled DNA replication forks at the endogenous GAA repeats drive repeat expansion in Friedreich's ataxia cells","volume":"16","author":"Gerhardt","year":"2016","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.RA120.013495_bib19","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.cell.2007.11.037","article-title":"A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders","volume":"131","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"10.1074\/jbc.RA120.013495_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1534\/genetics.109.104695","article-title":"Fork stalling and template switching as a mechanism for polyalanine tract expansion affecting the DYC mutant of HOXD13, a new murine model of synpolydactyly","volume":"183","author":"Cocquempot","year":"2009","journal-title":"Genetics"},{"key":"10.1074\/jbc.RA120.013495_bib21","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/ng.399","article-title":"The DNA replication FoSTeS\/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans","volume":"41","author":"Zhang","year":"2009","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib22","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/hmg\/ddr074","article-title":"FoSTeS, MMBIR and NAHR at the human proximal Xp region and the mechanisms of human Xq isochromosome formation","volume":"20","author":"Koumbaris","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib23","doi-asserted-by":"crossref","first-page":"e1003358","DOI":"10.1371\/journal.pgen.1003358","article-title":"Microhomology-mediated mechanisms underlie non-recurrent disease-causing microdeletions of the FOXL2 gene or its regulatory domain","volume":"9","author":"Verdin","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA120.013495_bib24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ajhg.2015.06.002","article-title":"Decoding NF1 intragenic copy-number variations","volume":"97","author":"Hsiao","year":"2015","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib25","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1038\/ejhg.2016.75","article-title":"PMS2 inactivation by a complex rearrangement involving an HERV retroelement and the inverted 100-kb duplicon on 7p22.1","volume":"24","author":"Vogt","year":"2016","journal-title":"Eur. J. Hum. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib26","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41594-018-0103-z","article-title":"Break-induced replication sparks CGG-repeat instability","volume":"25","author":"Deshpande","year":"2018","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/jbc.RA120.013495_bib27","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1002\/ajmg.a.36178","article-title":"Evidence for replicative mechanism in a CHD7 rearrangement in a patient with CHARGE syndrome","volume":"161A","author":"Vatta","year":"2013","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1074\/jbc.RA120.013495_bib28","doi-asserted-by":"crossref","first-page":"e1005050","DOI":"10.1371\/journal.pgen.1005050","article-title":"Complex genomic rearrangements at the PLP1 locus include triplication and quadruplication","volume":"11","author":"Beck","year":"2015","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA120.013495_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1534\/genetics.109.111039","article-title":"Double-strand break repair pathways protect against CAG\/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces cerevisiae","volume":"184","author":"Sundararajan","year":"2010","journal-title":"Genetics"},{"key":"10.1074\/jbc.RA120.013495_bib30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.molcel.2007.06.012","article-title":"An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae","volume":"27","author":"Zhang","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib31","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.4161\/cc.3.11.1246","article-title":"Structure-forming CAG\/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: implications for trinucleotide repeat expansion diseases","volume":"3","author":"Freudenreich","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1074\/jbc.RA120.013495_bib32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/hmg\/9.1.93","article-title":"CGG\/CCG repeats exhibit orientation-dependent instability and orientation-independent fragility in Saccharomyces cerevisiae","volume":"9","author":"Balakumaran","year":"2000","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib33","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.279.5352.853","article-title":"Expansion and length-dependent fragility of CTG repeats in yeast","volume":"279","author":"Freudenreich","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.RA120.013495_bib34","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1038\/emboj.2008.205","article-title":"Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair","volume":"27","author":"Kim","year":"2008","journal-title":"EMBO J"},{"key":"10.1074\/jbc.RA120.013495_bib35","doi-asserted-by":"crossref","first-page":"9936","DOI":"10.1073\/pnas.0804510105","article-title":"Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins","volume":"105","author":"Voineagu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/jbc.RA120.013495_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nsmb.3334","article-title":"The role of break-induced replication in large-scale expansions of (CAG)n\/(CTG)n repeats","volume":"24","author":"Kim","year":"2017","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/jbc.RA120.013495_bib37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.dnarep.2015.04.020","article-title":"The hidden side of unstable DNA repeats: mutagenesis at a distance","volume":"32","author":"Shah","year":"2015","journal-title":"DNA Repair (Amst.)"},{"key":"10.1074\/jbc.RA120.013495_bib38","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1101\/gad.250258.114","article-title":"Chromosome rearrangements via template switching between diverged repeated sequences","volume":"28","author":"Anand","year":"2014","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.RA120.013495_bib39","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.molcel.2016.10.038","article-title":"Mammalian RAD52 functions in break-induced replication repair of collapsed DNA replication forks","volume":"64","author":"Sotiriou","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib40","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/10409238.2017.1314444","article-title":"Break induced replication in eukaryotes: mechanisms, functions, and consequences","volume":"52","author":"Sakofsky","year":"2017","journal-title":"Crit. Rev. Biochem. Mol. Biol"},{"key":"10.1074\/jbc.RA120.013495_bib41","doi-asserted-by":"crossref","first-page":"1700025","DOI":"10.1002\/bies.201700025","article-title":"Break-induced replication links microsatellite expansion to complex genome rearrangements","volume":"39","author":"Leffak","year":"2017","journal-title":"Bioessays"},{"key":"10.1074\/jbc.RA120.013495_bib42","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ajhg.2015.01.021","article-title":"Absence of heterozygosity due to template switching during replicative rearrangements","volume":"96","author":"Carvalho","year":"2015","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib43","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.celrep.2014.04.053","article-title":"Break-induced replication is a source of mutation clusters underlying kataegis","volume":"7","author":"Sakofsky","year":"2014","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.RA120.013495_bib44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1243211","article-title":"Break-induced replication repair of damaged forks induces genomic duplications in human cells","volume":"343","author":"Costantino","year":"2014","journal-title":"Science"},{"key":"10.1074\/jbc.RA120.013495_bib45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nsmb.3361","article-title":"Break-induced replication: an unhealthy choice for stress relief?","volume":"24","author":"Kramara","year":"2017","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/jbc.RA120.013495_bib46","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.tig.2009.05.005","article-title":"Complex human chromosomal and genomic rearrangements","volume":"25","author":"Zhang","year":"2009","journal-title":"Trends Genet"},{"key":"10.1074\/jbc.RA120.013495_bib47","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/nm.2988","article-title":"Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements","volume":"18","author":"Holland","year":"2012","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.RA120.013495_bib48","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/nar\/gkq824","article-title":"Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma","volume":"39","author":"Nambiar","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib49","first-page":"139","article-title":"Chromosomal translocations in cancer","volume":"1786","author":"Nambiar","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA120.013495_bib50","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/jmg.2009.067637","article-title":"Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment","volume":"46","author":"Nagamani","year":"2009","journal-title":"J. Med. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib51","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/gim.2011.13","article-title":"NIPBL rearrangements in Cornelia de Lange syndrome: evidence for replicative mechanism and genotype-phenotype correlation","volume":"14","author":"Pehlivan","year":"2012","journal-title":"Genet. Med"},{"key":"10.1074\/jbc.RA120.013495_bib52","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/em.21943","article-title":"Structural variation mutagenesis of the human genome: Impact on disease and evolution","volume":"56","author":"Lupski","year":"2015","journal-title":"Environ. Mol. Mutagen"},{"key":"10.1074\/jbc.RA120.013495_bib53","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nrg.2015.25","article-title":"Mechanisms underlying structural variant formation in genomic disorders","volume":"17","author":"Carvalho","year":"2016","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib54","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1093\/nar\/gkv029","article-title":"Molecular mechanisms in DM1\u2014a focus on foci","volume":"43","author":"Pettersson","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib55","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nchembio.416","article-title":"Replication-dependent instability at (CTG)\u00b7(CAG) repeat hairpins in human cells","volume":"6","author":"Liu","year":"2010","journal-title":"Nat. Chem. Biol"},{"key":"10.1074\/jbc.RA120.013495_bib56","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1128\/MCB.01265-12","article-title":"Oligodeoxynucleotide Binding to (CTG)\u00b7(CAG) microsatellite repeats inhibits replication fork stalling, hairpin formation, and genome instability","volume":"33","author":"Liu","year":"2013","journal-title":"Mol. Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib57","doi-asserted-by":"crossref","first-page":"22582","DOI":"10.1073\/pnas.1012906108","article-title":"DNA tandem repeat instability in the Escherichia coli chromosome is stimulated by mismatch repair at an adjacent CAG\u00b7CTG trinucleotide repeat","volume":"107","author":"Blackwood","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/jbc.RA120.013495_bib58","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.celrep.2014.01.034","article-title":"RTEL1 inhibits trinucleotide repeat expansions and fragility","volume":"6","author":"Frizzell","year":"2014","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.RA120.013495_bib59","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/jmbi.2001.5174","article-title":"The structure of intramolecular triplex DNA: atomic force microscopy study","volume":"314","author":"Tiner","year":"2001","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.RA120.013495_bib60","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1086\/316939","article-title":"Mutation analysis of the entire PKD1 gene: genetic and diagnostic implications","volume":"68","author":"Rossetti","year":"2001","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib61","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00439-006-0308-9","article-title":"Identification of 54 large deletions\/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations","volume":"121","author":"Kozlowski","year":"2007","journal-title":"Hum. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib62","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ygeno.2007.10.003","article-title":"Analysis of PKD1 for genomic deletion by multiplex ligation-dependent probe assay: absence of hot spots","volume":"91","author":"Kozlowski","year":"2008","journal-title":"Genomics"},{"key":"10.1074\/jbc.RA120.013495_bib63","doi-asserted-by":"crossref","first-page":"33412","DOI":"10.1074\/jbc.M112.402503","article-title":"Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract","volume":"287","author":"Liu","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.013495_bib64","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1128\/MCB.01276-07","article-title":"Unstable spinocerebellar ataxia type 10 (ATTCT)*(AGAAT) repeats are associated with aberrant replication at the ATX10 locus and replication origin-dependent expansion at an ectopic site in human cells","volume":"27","author":"Liu","year":"2007","journal-title":"Mol. Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib65","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1128\/MCB.23.5.1832-1842.2003","article-title":"Multiple functional elements comprise a mammalian chromosomal replicator","volume":"23","author":"Liu","year":"2003","journal-title":"Mol. Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib66","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1093\/nar\/gkt368","article-title":"Activation of a human chromosomal replication origin by protein tethering","volume":"41","author":"Chen","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib67","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/nar\/gkz026","article-title":"Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination","volume":"47","author":"Lewis","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib68","doi-asserted-by":"crossref","first-page":"34970","DOI":"10.1074\/jbc.273.52.34970","article-title":"Generation of destabilized green fluorescent protein as a transcription reporter","volume":"273","author":"Li","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.013495_bib69","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tcb.2009.08.002","article-title":"Fluorescent proteins: a cell biologist's user guide","volume":"19","author":"Snapp","year":"2009","journal-title":"Trends Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib70","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.molcel.2010.01.021","article-title":"Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair","volume":"37","author":"Petermann","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib71","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ab.2005.11.002","article-title":"Structure-independent and quantitative ligation of single-stranded DNA","volume":"349","author":"Li","year":"2006","journal-title":"Anal. Biochem"},{"key":"10.1074\/jbc.RA120.013495_bib72","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/nprot.2010.87","article-title":"Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing","volume":"5","author":"Paruzynski","year":"2010","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.RA120.013495_bib73","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1089\/dna.1998.17.885","article-title":"Multiple initiations in the c-myc replication origin independent of chromosomal location","volume":"17","author":"Trivedi","year":"1998","journal-title":"DNA Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib74","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1093\/nar\/24.10.1887","article-title":"DNA replication initiates non-randomly at multiple sites near the c-myc gene in HeLa cells","volume":"24","author":"Waltz","year":"1996","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib75","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1128\/MCB.06727-11","article-title":"Altered replication in human cells promotes DMPK (CTG)n\u00b7(CAG)n repeat instability","volume":"32","author":"Liu","year":"2012","journal-title":"Mol. Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib76","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1126\/science.aaa8391","article-title":"DNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage","volume":"349","author":"Mayle","year":"2015","journal-title":"Science"},{"key":"10.1074\/jbc.RA120.013495_bib77","doi-asserted-by":"crossref","first-page":"e63149","DOI":"10.1371\/journal.pone.0063149","article-title":"Identification and characterization of SMARCAL1 protein complexes","volume":"8","author":"B\u00e9tous","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA120.013495_bib78","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nrm.2016.177","article-title":"Control of structure-specific endonucleases to maintain genome stability","volume":"18","author":"Deh\u00e9","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib79","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.devcel.2016.11.017","article-title":"A mechanism for controlled breakage of under-replicated chromosomes during mitosis","volume":"39","author":"Duda","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib80","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1083\/jcb.200803173","article-title":"Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway","volume":"183","author":"Franchitto","year":"2008","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib81","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/ncomms2395","article-title":"FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress","volume":"4","author":"Fugger","year":"2013","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.RA120.013495_bib82","doi-asserted-by":"crossref","first-page":"37638","DOI":"10.18632\/oncotarget.5497","article-title":"Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response","volume":"6","author":"Xing","year":"2015","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.RA120.013495_bib83","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.1038\/ncomms7746","article-title":"The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage","volume":"6","author":"Fu","year":"2015","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.RA120.013495_bib84","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.celrep.2014.04.007","article-title":"MUS81-EME2 promotes replication fork restart","volume":"7","author":"Pepe","year":"2014","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.RA120.013495_bib85","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1083\/jcb.201104003","article-title":"Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes","volume":"195","author":"Regairaz","year":"2011","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib86","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1093\/nar\/gkt1333","article-title":"Substrate specificity of the MUS81-EME2 structure selective endonuclease","volume":"42","author":"Pepe","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib87","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/s41467-017-01180-5","article-title":"MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells","volume":"8","author":"Lema\u00e7on","year":"2017","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.RA120.013495_bib88","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.molcel.2017.11.022","article-title":"Replication fork reversal: players and guardians","volume":"68","author":"Quinet","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib89","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1093\/nar\/27.13.2610","article-title":"DNA structural transitions within the PKD1 gene","volume":"27","author":"Blaszak","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib90","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/nar\/gkh312","article-title":"PKD1 intron 21: triplex DNA formation and effect on replication","volume":"32","author":"Patel","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib91","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1093\/nar\/gkq639","article-title":"How long is too long? Effects of loop size on G-quadruplex stability","volume":"38","author":"Gu\u00e9din","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib92","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1093\/nar\/gkw261","article-title":"Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences","volume":"44","author":"Bacolla","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib93","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00018-009-0131-2","article-title":"Non-B DNA structure-induced genetic instability and evolution","volume":"67","author":"Zhao","year":"2010","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.RA120.013495_bib94","doi-asserted-by":"crossref","first-page":"32433","DOI":"10.1074\/jbc.M704618200","article-title":"A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcription","volume":"282","author":"Belotserkovskii","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.013495_bib95","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nass\/49.1.235","article-title":"Affinity and selectivity of G4 ligands measured by FRET","volume":"49","author":"De Cian","year":"2005","journal-title":"Nucleic Acids Symp. Ser. (Oxf.)"},{"key":"10.1074\/jbc.RA120.013495_bib96","doi-asserted-by":"crossref","first-page":"41487","DOI":"10.1074\/jbc.M406123200","article-title":"Interaction of telomestatin with the telomeric single-strand overhang","volume":"279","author":"Gomez","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.013495_bib97","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1093\/nar\/gkx100","article-title":"Alternative DNA structure formation in the mutagenic human c-MYC promoter","volume":"45","author":"Del Mundo","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib98","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1093\/nar\/gkr612","article-title":"c-MYC promoter G-quadruplex formed at the 5\u2018-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability","volume":"39","author":"Mathad","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib99","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1080\/15257770600809913","article-title":"Structure of the biologically relevant G-quadruplex in the c-MYC promoter","volume":"25","author":"Yang","year":"2006","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1074\/jbc.RA120.013495_bib100","first-page":"3247","article-title":"The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures","volume":"63","author":"Kim","year":"2003","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.RA120.013495_bib101","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.1038\/sj.onc.1206833","article-title":"Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways","volume":"22","author":"Tauchi","year":"2003","journal-title":"Oncogene"},{"key":"10.1074\/jbc.RA120.013495_bib102","doi-asserted-by":"crossref","first-page":"11593","DOI":"10.1073\/pnas.182256799","article-title":"Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription","volume":"99","author":"Siddiqui-Jain","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/jbc.RA120.013495_bib103","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/nar\/gkw006","article-title":"Re-evaluation of G-quadruplex propensity with G4Hunter","volume":"44","author":"Bedrat","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib104","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1021\/bi200397b","article-title":"Structure of even\/odd trinucleotide repeat sequences modulates persistence of non-B conformations and conversion to duplex","volume":"50","author":"Figueroa","year":"2011","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.RA120.013495_bib105","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.biochi.2008.03.011","article-title":"Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds","volume":"90","author":"Pilch","year":"2008","journal-title":"Biochimie"},{"key":"10.1074\/jbc.RA120.013495_bib106","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1038\/s41598-017-03785-8","article-title":"Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole","volume":"7","author":"Nakamura","year":"2017","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA120.013495_bib107","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbrc.2016.01.176","article-title":"G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells","volume":"471","author":"Hasegawa","year":"2016","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.RA120.013495_bib108","doi-asserted-by":"crossref","first-page":"23360","DOI":"10.1074\/jbc.272.37.23360","article-title":"Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities","volume":"272","author":"Bailly","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.013495_bib109","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1073\/pnas.1204105109","article-title":"Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells","volume":"109","author":"Yoon","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/jbc.RA120.013495_bib110","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev-biochem-062917-012405","article-title":"Translesion and repair DNA polymerases: diverse structure and mechanism","volume":"87","author":"Yang","year":"2018","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.RA120.013495_bib111","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/mc.20509","article-title":"Role of TLS DNA polymerases \u03b7 and \u03ba in processing naturally occurring structured DNA in human cells","volume":"48","author":"B\u00e9tous","year":"2009","journal-title":"Mol. Carcinog"},{"key":"10.1074\/jbc.RA120.013495_bib112","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1083\/jcb.201207066","article-title":"DNA synthesis by Pol \u03b7 promotes fragile site stability by preventing under-replicated DNA in mitosis","volume":"201","author":"Bergoglio","year":"2013","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib113","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1083\/jcb.201006043","article-title":"Phosphorylated Rad18 directs DNA polymerase \u03b7 to sites of stalled replication","volume":"191","author":"Day","year":"2010","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.RA120.013495_bib114","doi-asserted-by":"crossref","first-page":"18361","DOI":"10.1073\/pnas.0505949102","article-title":"Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases \u03b7 and REV1","volume":"102","author":"Garg","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/jbc.RA120.013495_bib115","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.biochem.74.082803.133250","article-title":"Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function","volume":"74","author":"Prakash","year":"2005","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.RA120.013495_bib116","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1038\/sj.emboj.7600383","article-title":"Rad18 guides pol\u03b7 to replication stalling sites through physical interaction and PCNA monoubiquitination","volume":"23","author":"Watanabe","year":"2004","journal-title":"EMBO J"},{"key":"10.1074\/jbc.RA120.013495_bib117","doi-asserted-by":"crossref","first-page":"e1003866","DOI":"10.1371\/journal.pgen.1003866","article-title":"Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues","volume":"9","author":"Axford","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA120.013495_bib118","doi-asserted-by":"crossref","first-page":"14760","DOI":"10.1073\/pnas.2433503100","article-title":"Lesion bypass DNA polymerases replicate across non-DNA segments","volume":"100","author":"Maor-Shoshani","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/jbc.RA120.013495_bib119","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/nar\/gkt830","article-title":"DNA polymerases \u03b6 and Rev1 mediate error-prone bypass of non-B DNA structures","volume":"42","author":"Northam","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molcel.2019.10.005","article-title":"Tunability of DNA polymerase stability during eukaryotic DNA replication","volume":"77","author":"Lewis","year":"2020","journal-title":"Mol Cell"},{"key":"10.1074\/jbc.RA120.013495_bib121","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1093\/nar\/gkq403","article-title":"Role of the ubiquitin-binding domain of Pol\u03b7 in Rad18-independent translesion DNA synthesis in human cell extracts","volume":"38","author":"Schmutz","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib122","doi-asserted-by":"crossref","first-page":"48690","DOI":"10.1074\/jbc.M207957200","article-title":"Involvement of vertebrate pol\u03ba in Rad18-independent postreplication repair of UV damage","volume":"277","author":"Okada","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.013495_bib123","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/genes8020064","article-title":"Mechanisms of post-replication DNA repair","volume":"8","author":"Gao","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1074\/jbc.RA120.013495_bib124","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41594-018-0094-9","article-title":"Mechanisms of genetic instability caused by (CGG)n repeats in an experimental mammalian system","volume":"25","author":"Kononenko","year":"2018","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/jbc.RA120.013495_bib125","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.molcel.2016.10.037","article-title":"RAD52 facilitates mitotic DNA synthesis following replication stress","volume":"64","author":"Bhowmick","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib126","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.1093\/nar\/gkw433","article-title":"FANCJ is essential to maintain microsatellite structure genome-wide during replication stress","volume":"44","author":"Barthelemy","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib127","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/genetics\/156.1.297","article-title":"Estimate of the mutation rate per nucleotide in humans","volume":"156","author":"Nachman","year":"2000","journal-title":"Genetics"},{"key":"10.1074\/jbc.RA120.013495_bib128","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1073\/pnas.0912629107","article-title":"Rate, molecular spectrum, and consequences of human mutation","volume":"107","author":"Lynch","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/jbc.RA120.013495_bib129","doi-asserted-by":"crossref","first-page":"e1003816","DOI":"10.1371\/journal.pgen.1003816","article-title":"Guanine holes are prominent targets for mutation in cancer and inherited disease","volume":"9","author":"Bacolla","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA120.013495_bib130","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1371\/journal.pgen.0030052","article-title":"CTG trinucleotide repeat \u201cbig jumps\u201d: large expansions, small mice","volume":"3","author":"Gomes-Pereira","year":"2007","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA120.013495_bib131","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molcel.2009.06.017","article-title":"Large-scale expansions of Friedreich's ataxia GAA repeats in yeast","volume":"35","author":"Shishkin","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib132","doi-asserted-by":"crossref","first-page":"e1003551","DOI":"10.1371\/journal.pgen.1003551","article-title":"Fragile DNA motifs trigger mutagenesis at distant chromosomal loci in Saccharomyces cerevisiae","volume":"9","author":"Saini","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA120.013495_bib133","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.celrep.2018.01.014","article-title":"Distinct mechanisms of nuclease-directed DNA-structure-induced genetic instability in cancer genomes","volume":"22","author":"Zhao","year":"2018","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.RA120.013495_bib134","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3109\/10409238.2014.999192","article-title":"Repeat instability during DNA repair: insights from model systems","volume":"50","author":"Usdin","year":"2015","journal-title":"Crit. Rev. Biochem. Mol. Biol"},{"key":"10.1074\/jbc.RA120.013495_bib135","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1073\/pnas.1009409108","article-title":"Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast","volume":"108","author":"Cherng","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/jbc.RA120.013495_bib136","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/genes7110099","article-title":"The Cell Killing Mechanisms of Hydroxyurea","volume":"7","author":"Singh","year":"2016","journal-title":"Genes (Basel)"},{"key":"10.1074\/jbc.RA120.013495_bib137","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1534\/g3.111.000554","article-title":"Replication stress-induced chromosome breakage is correlated with replication fork progression and is preceded by single-stranded DNA formation","volume":"1","author":"Feng","year":"2011","journal-title":"G3"},{"key":"10.1074\/jbc.RA120.013495_bib138","doi-asserted-by":"crossref","first-page":"10564","DOI":"10.1093\/nar\/gkx684","article-title":"Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress","volume":"45","author":"Venkatachalam","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib139","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbagrm.2007.10.005","article-title":"Human chromosome fragility","volume":"1779","author":"Lukusa","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA120.013495_bib140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mrfmmm.2006.01.019","article-title":"Non-B DNA structure-induced genetic instability","volume":"598","author":"Wang","year":"2006","journal-title":"Mutat. Res"},{"key":"10.1074\/jbc.RA120.013495_bib141","doi-asserted-by":"crossref","first-page":"14648","DOI":"10.1074\/jbc.M109.061853","article-title":"Mechanistic studies of hairpin to duplex conversion for trinucleotide repeat sequences","volume":"285","author":"Avila Figueroa","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.013495_bib142","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.molcel.2014.04.012","article-title":"CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity","volume":"54","author":"Wang","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib143","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cell.2018.07.011","article-title":"Dual roles of poly(dA:dT) tracts in replication initiation and fork collapse","volume":"174","author":"Tubbs","year":"2018","journal-title":"Cell"},{"key":"10.1074\/jbc.RA120.013495_bib144","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/(SICI)1096-8628(19961202)66:1<60::AID-AJMG13>3.0.CO;2-O","article-title":"Inability to induce fragile sites at CTG repeats in congenital myotonic dystrophy","volume":"66","author":"Wenger","year":"1996","journal-title":"Am. J. Med. Genet"},{"key":"10.1074\/jbc.RA120.013495_bib145","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1021\/ja017308q","article-title":"Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex","volume":"124","author":"Kim","year":"2002","journal-title":"J. Am. Chem. Soc"},{"key":"10.1074\/jbc.RA120.013495_bib146","doi-asserted-by":"crossref","first-page":"6070","DOI":"10.1093\/nar\/gki917","article-title":"Facilitation of a structural transition in the polypurine\/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents","volume":"33","author":"Sun","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib147","doi-asserted-by":"crossref","first-page":"e6919","DOI":"10.1371\/journal.pone.0006919","article-title":"The G-quadruplex ligand telomestatin impairs binding of topoisomerase III\u03b1 to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells","volume":"4","author":"Temime-Smaali","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA120.013495_bib148","first-page":"317","article-title":"A 2.5 kb polypyrimidine tract in the PKD1 gene contains at least 23 H-DNA-forming sequences","volume":"1","author":"Van Raay","year":"1996","journal-title":"Microb. Comp. Genomics"},{"key":"10.1074\/jbc.RA120.013495_bib149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2013.12.021","article-title":"To switch or not to switch: at the origin of repeat expansion disease","volume":"53","author":"Mirkin","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molcel.2013.10.029","article-title":"The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells","volume":"53","author":"Gerhardt","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib151","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1101\/gad.285114.116","article-title":"DNA replication origins-where do we begin?","volume":"30","author":"Prioleau","year":"2016","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.RA120.013495_bib152","doi-asserted-by":"crossref","first-page":"e1006201","DOI":"10.1371\/journal.pgen.1006201","article-title":"The replication of frataxin gene is assured by activation of dormant origins in the presence of a GAA-repeat expansion","volume":"12","author":"Stevanoni","year":"2016","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA120.013495_bib153","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/genes8010024","article-title":"Translesion synthesis: insights into the selection and switching of DNA polymerases","volume":"8","author":"Zhao","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1074\/jbc.RA120.013495_bib154","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.molcel.2017.08.010","article-title":"Replication fork slowing and reversal upon DNA damage require PCNA polyubiquitination and ZRANB3 DNA translocase activity","volume":"67","author":"Vujanovic","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib155","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/10409238.2017.1291576","article-title":"Translesion DNA polymerases in eukaryotes: what makes them tick?","volume":"52","author":"Vaisman","year":"2017","journal-title":"Crit. Rev. Biochem. Mol. Biol"},{"key":"10.1074\/jbc.RA120.013495_bib156","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molcel.2019.09.015","article-title":"Processing of DNA polymerase-blocking lesions during genome replication is spatially and temporally segregated from replication forks","volume":"77","author":"Wong","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib157","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.molcel.2015.10.041","article-title":"Translesion polymerases drive microhomology-mediated break-induced replication leading to complex chromosomal rearrangements","volume":"60","author":"Sakofsky","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.RA120.013495_bib158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dnarep.2017.05.006","article-title":"DNA polymerases \u03b7 and \u03ba exchange with the polymerase delta holoenzyme to complete common fragile site synthesis","volume":"57","author":"Barnes","year":"2017","journal-title":"DNA Repair (Amst.)"},{"key":"10.1074\/jbc.RA120.013495_bib159","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.cell.2013.01.006","article-title":"Identification of early replicating fragile sites that contribute to genome instability","volume":"152","author":"Barlow","year":"2013","journal-title":"Cell"},{"key":"10.1074\/jbc.RA120.013495_bib160","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.tig.2018.04.002","article-title":"Break-induced replication: the where, the why, and the how","volume":"34","author":"Kramara","year":"2018","journal-title":"Trends Genet"},{"key":"10.1074\/jbc.RA120.013495_bib161","doi-asserted-by":"crossref","first-page":"13475","DOI":"10.1073\/pnas.1309800110","article-title":"Break-induced replication occurs by conservative DNA synthesis","volume":"110","author":"Donnianni","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/jbc.RA120.013495_bib162","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1016\/j.celrep.2016.12.003","article-title":"RPA stabilization of single-stranded DNA is critical for break-induced replication","volume":"17","author":"Ruff","year":"2016","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.RA120.013495_bib163","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature12584","article-title":"Migrating bubble during break-induced replication drives conservative DNA synthesis","volume":"502","author":"Saini","year":"2013","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.013495_bib164","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/nar\/gki177","article-title":"The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells","volume":"33","author":"Kemp","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib165","doi-asserted-by":"crossref","first-page":"e1003979","DOI":"10.1371\/journal.pgen.1003979","article-title":"Genome-wide screen reveals replication pathway for quasi-palindrome fragility dependent on homologous recombination","volume":"9","author":"Zhang","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.RA120.013495_bib166","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1073\/pnas.93.10.4827","article-title":"Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest","volume":"93","author":"Huang","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/jbc.RA120.013495_bib167","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/35037717","article-title":"Defying death after DNA damage","volume":"407","author":"Rich","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.013495_bib168","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.1900642","article-title":"Recombinase-mediated gene activation and site-specific integration in mammalian cells","volume":"251","author":"O'Gorman","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.RA120.013495_bib169","doi-asserted-by":"crossref","first-page":"8131","DOI":"10.1093\/nar\/gkq697","article-title":"RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription","volume":"38","author":"Kanagaraj","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.013495_bib170","doi-asserted-by":"crossref","DOI":"10.1002\/0471142956.cy0941s65","article-title":"Kinetic viability assays using DRAQ7 probe","author":"Wlodkowic","year":"2013","journal-title":"Curr. Protoc. Cytom"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817503683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817503683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA120.013495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T12:16:23Z","timestamp":1640952983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817503683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":170,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0021925817503683"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra120.013495","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Replication stress at microsatellites causes DNA double-strand breaks and break-induced replication","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA120.013495","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Gadgil et al.","name":"copyright","label":"Copyright"}]}}