{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:48:23Z","timestamp":1790358503613,"version":"4.1.0"},"reference-count":93,"publisher":"Elsevier BV","issue":"44","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG054025"],"award-info":[{"award-number":["R01AG054025"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS094557"],"award-info":[{"award-number":["R01NS094557"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["RFA1AG055771"],"award-info":[{"award-number":["RFA1AG055771"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG060718"],"award-info":[{"award-number":["R01AG060718"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17CSA33620007"],"award-info":[{"award-number":["17CSA33620007"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1074\/jbc.ra120.014630","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T22:45:16Z","timestamp":1596235516000},"page":"14807-14825","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Modulating disease-relevant tau oligomeric strains by small molecules"],"prefix":"10.1016","volume":"295","author":[{"given":"Filippa","family":"Lo Cascio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-452X","authenticated-orcid":false,"given":"Mauro","family":"Montalbano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicha","family":"Puangmalai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salome","family":"McAllen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4402-5798","authenticated-orcid":false,"given":"Antonio","family":"Palumbo Piccionello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-8640","authenticated-orcid":false,"given":"Rakez","family":"Kayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA120.014630_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1750-3639.1991.tb00661.x","article-title":"Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections","volume":"1","author":"Braak","year":"1991","journal-title":"Brain Pathol."},{"key":"10.1074\/jbc.RA120.014630_bib2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.neuron.2014.05.004","article-title":"The intersection of amyloid \u03b2 and tau at synapses in Alzheimer's disease","volume":"82","author":"Spires-Jones","year":"2014","journal-title":"Neuron."},{"key":"10.1074\/jbc.RA120.014630_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0404.1996.tb05866.x","article-title":"Evolution of the neuropathology of Alzheimer's disease","volume":"165","author":"Braak","year":"1996","journal-title":"Acta Neurol. Scand. Suppl."},{"key":"10.1074\/jbc.RA120.014630_bib4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1750-3639.2008.00147.x","article-title":"Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium","volume":"18","author":"Alafuzoff","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1074\/jbc.RA120.014630_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer's disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.RA120.014630_bib6","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.parkreldis.2015.09.020","article-title":"Tauopathies as clinicopathological entities","volume":"22","author":"Irwin","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1074\/jbc.RA120.014630_bib7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature."},{"key":"10.1074\/jbc.RA120.014630_bib8","doi-asserted-by":"crossref","first-page":"e45457","DOI":"10.7554\/eLife.45457","article-title":"Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models","volume":"8","author":"Silva","year":"2019","journal-title":"Elife."},{"key":"10.1074\/jbc.RA120.014630_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00401-002-0644-3","article-title":"Dementia with Lewy bodies from the perspective of tauopathy","volume":"105","author":"Iseki","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.1074\/jbc.RA120.014630_bib10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1074\/jbc.RA120.014630_bib11","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.2174\/1381612822666160518142226","article-title":"Therapeutic approaches targeting pathological tau aggregates","volume":"22","author":"Gerson","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1074\/jbc.RA120.014630_bib12","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.cell.2011.10.011","article-title":"The seeds of neurodegeneration: prion-like spreading in ALS","volume":"147","author":"Polymenidou","year":"2011","journal-title":"Cell."},{"key":"10.1074\/jbc.RA120.014630_bib13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jmb.2011.12.061","article-title":"Propagation of the prion phenomenon: beyond the seeding principle","volume":"421","author":"M\u00fcnch","year":"2012","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.RA120.014630_bib14","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1001\/jamaneurol.2013.1453","article-title":"Mechanisms of protein seeding in neurodegenerative diseases","volume":"70","author":"Walker","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1074\/jbc.RA120.014630_bib15","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/embor.2013.137","article-title":"Seeded strain-like transmission of \u03b2-amyloid morphotypes in APP transgenic mice","volume":"14","author":"Heilbronner","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1074\/jbc.RA120.014630_bib16","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.cell.2013.08.035","article-title":"Molecular structure of \u03b2-amyloid fibrils in Alzheimer's disease brain tissue","volume":"154","author":"Lu","year":"2013","journal-title":"Cell."},{"key":"10.1074\/jbc.RA120.014630_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cell.2013.05.057","article-title":"Distinct \u03b1-synuclein strains differentially promote tau inclusions in neurons","volume":"154","author":"Guo","year":"2013","journal-title":"Cell."},{"key":"10.1074\/jbc.RA120.014630_bib18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.biopsych.2017.12.018","article-title":"\u03b1-Synuclein oligomers induce a unique toxic tau strain","volume":"84","author":"Castillo-Carranza","year":"2018","journal-title":"Biol. Psychiatry."},{"key":"10.1074\/jbc.RA120.014630_bib19","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.neuron.2014.04.047","article-title":"Distinct tau prion strains propagate in cells and mice and define different tauopathies","volume":"82","author":"Sanders","year":"2014","journal-title":"Neuron."},{"key":"10.1074\/jbc.RA120.014630_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrn2786","article-title":"Prion-like mechanisms in neurodegenerative diseases","volume":"11","author":"Frost","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1074\/jbc.RA120.014630_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature23002","article-title":"Cryo-EM structures of tau filaments from Alzheimer's disease","volume":"547","author":"Fitzpatrick","year":"2017","journal-title":"Nature."},{"key":"10.1074\/jbc.RA120.014630_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-018-0454-y","article-title":"Structures of filaments from Pick's disease reveal a novel tau protein fold","volume":"561","author":"Falcon","year":"2018","journal-title":"Nature."},{"key":"10.1074\/jbc.RA120.014630_bib23","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/srep00700","article-title":"Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau","volume":"2","author":"Lasagna-Reeves","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1074\/jbc.RA120.014630_bib24","doi-asserted-by":"crossref","first-page":"10039","DOI":"10.1021\/bi1016233","article-title":"Preparation and characterization of neurotoxic tau oligomers","volume":"49","author":"Lasagna-Reeves","year":"2010","journal-title":"Biochemistry."},{"key":"10.1074\/jbc.RA120.014630_bib25","doi-asserted-by":"crossref","first-page":"23063","DOI":"10.1074\/jbc.M111.237974","article-title":"Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease","volume":"286","author":"Patterson","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.RA120.014630_bib26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-med-042915-103753","article-title":"Update on Alzheimer's disease therapy and prevention strategies","volume":"68","author":"Graham","year":"2017","journal-title":"Annu. Rev. Med."},{"key":"10.1074\/jbc.RA120.014630_bib27","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.3390\/ijms19041160","article-title":"An overview on the clinical development of tau-based therapeutics","volume":"19","author":"Medina","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1074\/jbc.RA120.014630_bib28","doi-asserted-by":"crossref","first-page":"77sr1","DOI":"10.1126\/scitranslmed.3002369","article-title":"Alzheimer's disease: the challenge of the second century","volume":"3","author":"Holtzman","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1074\/jbc.RA120.014630_bib29","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s40263-019-00657-9","article-title":"Emerging developments in targeting proteotoxicity in neurodegenerative diseases","volume":"33","author":"McAlary","year":"2019","journal-title":"CNS Drugs."},{"key":"10.1074\/jbc.RA120.014630_bib30","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s12276-020-0418-9","article-title":"New fluid biomarkers tracking non-amyloid-\u03b2 and non-tau pathology in Alzheimer's disease","volume":"52","author":"Park","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1074\/jbc.RA120.014630_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt231","article-title":"Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias","volume":"6","author":"Murray","year":"2014","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1074\/jbc.RA120.014630_bib32","doi-asserted-by":"crossref","first-page":"8613209","DOI":"10.1155\/2018\/8613209","article-title":"Inhibition of protein aggregation by several antioxidants","volume":"2018","author":"Hasanba\u0161i\u0107","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1074\/jbc.RA120.014630_bib33","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrd4593","article-title":"Targeting protein aggregation for the treatment of degenerative diseases","volume":"14","author":"Eisele","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.RA120.014630_bib34","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.4155\/fmc.12.124","article-title":"Natural products as a rich source of tau-targeting drugs for Alzheimer's disease","volume":"4","author":"Calcul","year":"2012","journal-title":"Future Med. Chem."},{"key":"10.1074\/jbc.RA120.014630_bib35","series-title":"Neuroprotection in Alzheimer's Disease","first-page":"97","article-title":"Chapter 6 - The potential of small molecules in preventing tau oligomer formation and toxicity","author":"Gerson","year":"2017"},{"key":"10.1074\/jbc.RA120.014630_bib36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainres.2009.01.066","article-title":"Curcumin blocks brain tumor formation","volume":"1266","author":"Purkayastha","year":"2009","journal-title":"Brain Res."},{"key":"10.1074\/jbc.RA120.014630_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Cancer Res. Treat."},{"key":"10.1074\/jbc.RA120.014630_bib38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/abr.abr_147_16","article-title":"Role of curcumin in disease prevention and treatment","volume":"7","author":"Rahmani","year":"2018","journal-title":"Adv. Biomed. Res."},{"key":"10.1074\/jbc.RA120.014630_bib39","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.3390\/ijms19061637","article-title":"Use of curcumin, a natural polyphenol for targeting molecular pathways in treating age-related neurodegenerative diseases","volume":"19","author":"Maiti","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1074\/jbc.RA120.014630_bib40","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3390\/ijms21020661","article-title":"Curcumin affects HSP60 folding activity and levels in neuroblastoma cells","volume":"21","author":"Caruso Bavisotto","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1074\/jbc.RA120.014630_bib41","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1586\/14737175.2015.1044981","article-title":"Clinical development of curcumin in neurodegenerative disease","volume":"15","author":"Hu","year":"2015","journal-title":"Exp. Rev. Neurother."},{"key":"10.1074\/jbc.RA120.014630_bib42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/alzrt146","article-title":"Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study","volume":"4","author":"Ringman","year":"2012","journal-title":"Alzheimers Res. Ther."},{"key":"10.1074\/jbc.RA120.014630_bib43","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/jcm9020430","article-title":"Curcumin's nanomedicine formulations for therapeutic application in neurological diseases","volume":"9","author":"Salehi","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1074\/jbc.RA120.014630_bib44","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.2147\/IJN.S208332","article-title":"Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders","volume":"14","author":"Yavarpour-Bali","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1074\/jbc.RA120.014630_bib45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/07315724.2014.950392","article-title":"Beyond yellow curry: assessing commercial curcumin absorption technologies","volume":"34","author":"Douglass","year":"2015","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1074\/jbc.RA120.014630_bib46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.nano.2009.05.009","article-title":"Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells","volume":"6","author":"Das","year":"2010","journal-title":"Nanomedicine."},{"key":"10.1074\/jbc.RA120.014630_bib47","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.1016\/j.biomaterials.2010.04.062","article-title":"The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation","volume":"31","author":"Mohanty","year":"2010","journal-title":"Biomaterials."},{"key":"10.1074\/jbc.RA120.014630_bib48","doi-asserted-by":"crossref","first-page":"19011","DOI":"10.1038\/s41598-019-55419-w","article-title":"Toxic tau oligomers modulated by novel curcumin derivatives","volume":"9","author":"Lo Cascio","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1074\/jbc.RA120.014630_bib49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-4939-7816-8_9","article-title":"Preparation and characterization of tau oligomer strains","volume":"1779","author":"Sengupta","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1074\/jbc.RA120.014630_bib50","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/2051-5960-2-73","article-title":"Characterization of tau oligomeric seeds in progressive supranuclear palsy","volume":"2","author":"Gerson","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1074\/jbc.RA120.014630_bib51","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41419-020-2503-3","article-title":"Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies","volume":"11","author":"Puangmalai","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1074\/jbc.RA120.014630_bib52","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/acn3.382","article-title":"Tau oligomers in cerebrospinal fluid in Alzheimer's disease","volume":"4","author":"Sengupta","year":"2017","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1074\/jbc.RA120.014630_bib53","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jmb.2011.07.021","article-title":"Conformational transformation and selection of synthetic prion strains","volume":"413","author":"Ghaemmaghami","year":"2011","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.RA120.014630_bib54","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1073\/pnas.0409079102","article-title":"Strain-specified characteristics of mouse synthetic prions","volume":"102","author":"Legname","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.RA120.014630_bib55","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1074\/jbc.M114.589309","article-title":"Conformation determines the seeding potencies of native and recombinant Tau aggregates","volume":"290","author":"Falcon","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.RA120.014630_bib56","doi-asserted-by":"crossref","first-page":"fcz004","DOI":"10.1093\/braincomms\/fcz004","article-title":"Neurotoxic tau oligomers after single versus repetitive mild traumatic brain injury","volume":"1","author":"Bittar","year":"2019","journal-title":"Brain Commun."},{"key":"10.1074\/jbc.RA120.014630_bib57","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ebiom.2016.03.035","article-title":"The role of amyloid-\u03b2 oligomers in toxicity, propagation, and immunotherapy","volume":"6","author":"Sengupta","year":"2016","journal-title":"EBioMedicine."},{"key":"10.1074\/jbc.RA120.014630_bib58","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1021\/cb500505m","article-title":"Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity","volume":"9","author":"Mannini","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"10.1074\/jbc.RA120.014630_bib59","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1039\/C9SC01331H","article-title":"Atomic resolution map of the soluble amyloid \u03b2 assembly toxic surfaces","volume":"10","author":"Ahmed","year":"2019","journal-title":"Chem. Sci."},{"key":"10.1074\/jbc.RA120.014630_bib60","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1091\/mbc.e16-10-0737","article-title":"Rab GTPases: master regulators that establish the secretory and endocytic pathways","volume":"28","author":"Pfeffer","year":"2017","journal-title":"Mol. Biol. Cell."},{"key":"10.1074\/jbc.RA120.014630_bib61","doi-asserted-by":"crossref","first-page":"E4376","DOI":"10.1073\/pnas.1411649111","article-title":"Proteopathic tau seeding predicts tauopathy in vivo","volume":"111","author":"Holmes","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1074\/jbc.RA120.014630_bib62","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00401-017-1707-9","article-title":"Roles of tau protein in health and disease","volume":"133","author":"Guo","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1074\/jbc.RA120.014630_bib63","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1515\/tnsci-2015-0023","article-title":"Tau-mediated synaptic damage in Alzheimer's disease","volume":"6","author":"Jadhav","year":"2015","journal-title":"Transl. Neurosci."},{"key":"10.1074\/jbc.RA120.014630_bib64","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.biopsych.2014.12.019","article-title":"Pathological interface between oligomeric \u03b1-synuclein and tau in synucleinopathies","volume":"78","author":"Sengupta","year":"2015","journal-title":"Biol. Psychiatry."},{"key":"10.1074\/jbc.RA120.014630_bib65","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1001\/jamaneurol.2016.3338","article-title":"Tau positron emission tomographic imaging in the Lewy body diseases","volume":"73","author":"Gomperts","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1074\/jbc.RA120.014630_bib66","doi-asserted-by":"crossref","first-page":"257","DOI":"10.14336\/AD.2017.0112","article-title":"Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies","volume":"8","author":"Castillo-Carranza","year":"2017","journal-title":"Aging Dis."},{"key":"10.1074\/jbc.RA120.014630_bib67","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00401-018-1937-5","article-title":"TIA1 regulates the generation and response to toxic tau oligomers","volume":"137","author":"Jiang","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1074\/jbc.RA120.014630_bib68","doi-asserted-by":"crossref","first-page":"e31302","DOI":"10.1371\/journal.pone.0031302","article-title":"Trans-synaptic spread of tau pathology in vivo","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS ONE."},{"key":"10.1074\/jbc.RA120.014630_bib69","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s40478-017-0488-7","article-title":"What is the evidence that tau pathology spreads through prion-like propagation?","volume":"5","author":"Mudher","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1074\/jbc.RA120.014630_bib70","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.neuron.2016.09.055","article-title":"Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo","volume":"92","author":"Kaufman","year":"2016","journal-title":"Neuron."},{"key":"10.1074\/jbc.RA120.014630_bib71","doi-asserted-by":"crossref","first-page":"9535","DOI":"10.1073\/pnas.1301175110","article-title":"Brain homogenates from human tauopathies induce tau inclusions in mouse brain","volume":"110","author":"Clavaguera","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.RA120.014630_bib72","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0166-19.2019","article-title":"Introduction of tau oligomers into cortical neurons alters action potential dynamics and disrupts synaptic transmission and plasticity","volume":"6","author":"Hill","year":"2019","journal-title":"eNeuro."},{"key":"10.1074\/jbc.RA120.014630_bib73","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41467-019-13787-x","article-title":"Transmission of tauopathy strains is independent of their isoform composition","volume":"11","author":"He","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1074\/jbc.RA120.014630_bib74","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s00018-019-03349-1","article-title":"Mechanisms of secretion and spreading of pathological tau protein","volume":"77","author":"Brunello","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.RA120.014630_bib75","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/WCO.0b013e32835a3ee0","article-title":"Cellular mechanisms of protein aggregate propagation","volume":"25","author":"Holmes","year":"2012","journal-title":"Curr. Opin. Neurol."},{"key":"10.1074\/jbc.RA120.014630_bib76","doi-asserted-by":"crossref","first-page":"E3138","DOI":"10.1073\/pnas.1301440110","article-title":"Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds","volume":"110","author":"Holmes","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.RA120.014630_bib77","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1038\/s41598-018-24904-z","article-title":"Tau internalization is regulated by 6-O sulfation on heparan sulfate proteoglycans (HSPGs)","volume":"8","author":"Rauch","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1074\/jbc.RA120.014630_bib78","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4155\/ppa-2019-0003","article-title":"Development of tau-directed small molecule modulators for Alzheimer's disease: a recent patent review (2014\u20132018)","volume":"8","author":"Lee","year":"2019","journal-title":"Pharm. Pat. Anal."},{"key":"10.1074\/jbc.RA120.014630_bib79","doi-asserted-by":"crossref","first-page":"10120","DOI":"10.1039\/C8CC05072D","article-title":"Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides","volume":"54","author":"Wang","year":"2018","journal-title":"Chem. Commun. (Camb.)."},{"key":"10.1074\/jbc.RA120.014630_bib80","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1021\/acschemneuro.7b00501","article-title":"Azure C targets and modulates toxic tau oligomers","volume":"9","author":"Lo Cascio","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1074\/jbc.RA120.014630_bib81","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/jcmm.12817","article-title":"The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease","volume":"20","author":"Gadhave","year":"2016","journal-title":"J. Cell Mol. Med."},{"key":"10.1074\/jbc.RA120.014630_bib82","article-title":"A novel small molecule screening platform for disrupting toxic tau oligomers in cells","volume":"510412","author":"Lo","year":"2019","journal-title":"bioRxiv."},{"key":"10.1074\/jbc.RA120.014630_bib83","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1080\/10409238.2016.1226251","article-title":"Potential mechanisms and implications for the formation of tau oligomeric strains","volume":"51","author":"Gerson","year":"2016","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1074\/jbc.RA120.014630_bib84","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1021\/cn500148z","article-title":"The role of tau oligomers in the onset of Alzheimer's disease neuropathology","volume":"5","author":"C\u00e1rdenas-Aguayo","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"10.1074\/jbc.RA120.014630_bib85","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/s41380-018-0342-8","article-title":"Tau PET imaging in neurodegenerative tauopathies\u2014still a challenge","volume":"24","author":"Leuzy","year":"2019","journal-title":"Mol. Psychiatry."},{"key":"10.1074\/jbc.RA120.014630_bib86","doi-asserted-by":"crossref","first-page":"22122","DOI":"10.1074\/jbc.M111.236257","article-title":"Amyloid-\u03b2 annular protofibrils evade fibrillar fate in Alzheimer disease brain","volume":"286","author":"Lasagna-Reeves","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.RA120.014630_bib87","doi-asserted-by":"crossref","first-page":"10278","DOI":"10.1073\/pnas.0401911101","article-title":"Template-assisted filament growth by parallel stacking of tau","volume":"101","author":"Margittai","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.RA120.014630_bib88","doi-asserted-by":"crossref","first-page":"37820","DOI":"10.1074\/jbc.M605336200","article-title":"Side chain-dependent stacking modulates tau filament structure","volume":"281","author":"Margittai","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.RA120.014630_bib89","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/pro.3499","article-title":"Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior","volume":"27","author":"Ghag","year":"2018","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.RA120.014630_bib90","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s40478-018-0615-0","article-title":"Formation of toxic oligomeric assemblies of RNA-binding protein: Musashi in Alzheimer's disease","volume":"6","author":"Sengupta","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1074\/jbc.RA120.014630_bib91","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1007\/s12035-020-01913-6","article-title":"Polymorphic \u03b1-synuclein strains modified by dopamine and docosahexaenoic acid interact differentially with tau protein","volume":"57","author":"Sengupta","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1074\/jbc.RA120.014630_bib92","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1038\/nprot.2012.099","article-title":"Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex","volume":"7","author":"Beaudoin","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1074\/jbc.RA120.014630_bib93","doi-asserted-by":"crossref","first-page":"e13035","DOI":"10.1111\/acel.13035","article-title":"Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration","volume":"18","author":"Montalbano","year":"2019","journal-title":"Aging Cell."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817488934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817488934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA120.014630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T12:30:29Z","timestamp":1727440229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817488934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":93,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0021925817488934"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra120.014630","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulating disease-relevant tau oligomeric strains by small molecules","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA120.014630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}