{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:28:42Z","timestamp":1790684922503,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI104844"],"award-info":[{"award-number":["R01 AI104844"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1074\/jbc.ra120.014676","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T17:45:13Z","timestamp":1603993513000},"page":"18589-18603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding"],"prefix":"10.1016","volume":"295","author":[{"given":"Maria C.","family":"Bewley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lovely","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1209-1221","authenticated-orcid":false,"given":"Mashanipalya G.","family":"Jagadeeshaprasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6860-5108","authenticated-orcid":false,"given":"D. Channe","family":"Gowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Flanagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA120.014676_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.med.45.1.283","article-title":"Malaria, the red cell, and the endothelium","volume":"45","author":"Pasloske","year":"1994","journal-title":"Annu. Rev. Med"},{"key":"10.1074\/jbc.RA120.014676_bib2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1128\/CMR.13.3.439","article-title":"Molecular aspects of severe malaria","volume":"13","author":"Chen","year":"2000","journal-title":"Clin. Microbiol. Rev"},{"key":"10.1074\/jbc.RA120.014676_bib3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/415673a","article-title":"The pathogenic basis of malaria","volume":"415","author":"Miller","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.014676_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0092-8674(95)90054-3","article-title":"Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes","volume":"82","author":"Baruch","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.RA120.014676_bib5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0092-8674(95)90055-1","article-title":"The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes","volume":"82","author":"Su","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.RA120.014676_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0092-8674(95)90056-X","article-title":"Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes","volume":"82","author":"Smith","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.RA120.014676_bib7","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature01097","article-title":"Genome sequence of the human malaria parasite Plasmodium falciparum","volume":"419","author":"Gardner","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.014676_bib8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/sj.embor.7401063","article-title":"Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites","volume":"8","author":"Dzikowski","year":"2007","journal-title":"EMBO Rep"},{"key":"10.1074\/jbc.RA120.014676_bib9","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1111\/j.1365-2958.2007.05736.x","article-title":"Variable switching rates of malaria virulence genes are associated with chromosomal position","volume":"64","author":"Frank","year":"2007","journal-title":"Mol. Microbiol"},{"key":"10.1074\/jbc.RA120.014676_bib10","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1073\/pnas.93.8.3497","article-title":"Plasmodium falciparum erythrocyte membrane protein 1 is a parasitized erythrocyte receptor for adherence to CD36, thrombospondin, and intercellular adhesion molecule 1","volume":"93","author":"Baruch","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA120.014676_bib11","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1172\/JCI119794","article-title":"Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells","volume":"100","author":"McCormick","year":"1997","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.RA120.014676_bib12","doi-asserted-by":"crossref","first-page":"5849","DOI":"10.1128\/IAI.69.9.5849-5856.2001","article-title":"Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors","volume":"69","author":"Heddini","year":"2001","journal-title":"Infect. Immun"},{"key":"10.1074\/jbc.RA120.014676_bib13","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature12216","article-title":"Severe malaria is associated with parasite binding to endothelial protein C receptor","volume":"498","author":"Turner","year":"2013","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.014676_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00615-16","article-title":"Interaction between endothelial protein C receptor and intercellular adhesion molecule 1 to mediate binding of Plasmodium falciparum-infected erythrocytes to endothelial cells","volume":"7","author":"Avril","year":"2016","journal-title":"MBio"},{"key":"10.1074\/jbc.RA120.014676_bib15","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1093\/infdis\/jix230","article-title":"Parasites causing cerebral falciparum malaria bind multiple endothelial receptors and express EPCR and ICAM-1-binding PfEMP1","volume":"215","author":"Tuikue Ndam","year":"2017","journal-title":"J. Infect. Dis"},{"key":"10.1074\/jbc.RA120.014676_bib16","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.pt.2004.09.002","article-title":"Variant surface antigens, virulence genes and the pathogenesis of malaria","volume":"20","author":"Deitsch","year":"2004","journal-title":"Trends Parasitol"},{"key":"10.1074\/jbc.RA120.014676_bib17","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1111\/cmi.12183","article-title":"Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes","volume":"15","author":"Smith","year":"2013","journal-title":"Cell Microbiol"},{"key":"10.1074\/jbc.RA120.014676_bib18","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.mib.2006.06.006","article-title":"A family affair: var genes, PfEMP1 binding, and malaria disease","volume":"9","author":"Kraemer","year":"2006","journal-title":"Curr. Opin. Microbiol"},{"key":"10.1074\/jbc.RA120.014676_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/bs.apar.2015.02.004","article-title":"PfEMP1: a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis","volume":"88","author":"Hviid","year":"2015","journal-title":"Adv. Parasitol"},{"key":"10.1074\/jbc.RA120.014676_bib20","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/MOH.0b013e3283313de0","article-title":"Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention","volume":"16","author":"Rowe","year":"2009","journal-title":"Curr. Opin. Hematol"},{"key":"10.1074\/jbc.RA120.014676_bib21","doi-asserted-by":"crossref","first-page":"E3270","DOI":"10.1073\/pnas.1524294113","article-title":"Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass","volume":"113","author":"Bernabeu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA120.014676_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004537","article-title":"Differential PfEMP1 expression is associated with cerebral malaria pathology","volume":"10","author":"Tembo","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.RA120.014676_bib23","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/tmi.13313","article-title":"Monitoring maternal and newborn health outcomes globally: a brief history of key events and initiatives","volume":"24","author":"Moller","year":"2019","journal-title":"Trop. Med. Int. Health"},{"key":"10.1074\/jbc.RA120.014676_bib24","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.pcl.2017.03.004","article-title":"Malaria in children","volume":"64","author":"Cohee","year":"2017","journal-title":"Pediatr. Clin. North Am"},{"key":"10.1074\/jbc.RA120.014676_bib25","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0035-9203(83)90081-0","article-title":"Malaria infection of the placenta in The Gambia, West Africa; its incidence and relationship to stillbirth, birthweight and placental weight","volume":"77","author":"McGregor","year":"1983","journal-title":"Trans. R. Soc. Trop. Med. Hyg"},{"key":"10.1074\/jbc.RA120.014676_bib26","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1086\/315449","article-title":"The impact of placental malaria on gestational age and birth weight","volume":"181","author":"Menendez","year":"2000","journal-title":"J. Infect. Dis"},{"key":"10.1074\/jbc.RA120.014676_bib27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4269\/ajtmh.2003.68.1.0680115","article-title":"Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes","volume":"68","author":"Rogerson","year":"2003","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"10.1074\/jbc.RA120.014676_bib28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.placenta.2003.10.019","article-title":"The sick placenta: the role of malaria","volume":"25","author":"Brabin","year":"2004","journal-title":"Placenta"},{"key":"10.1074\/jbc.RA120.014676_bib29","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/27570","article-title":"Maternal antibodies block malaria","volume":"395","author":"Fried","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.014676_bib30","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025551","article-title":"Malaria during pregnancy","volume":"7","author":"Fried","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"10.1074\/jbc.RA120.014676_bib31","doi-asserted-by":"crossref","first-page":"40344","DOI":"10.1074\/jbc.M006398200","article-title":"Characterization of proteoglycans of human placenta and identification of unique chondroitin sulfate proteoglycans of the intervillous spaces that mediate the adherence of Plasmodium falciparum-infected erythrocytes to the placenta","volume":"275","author":"Achur","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.014676_bib32","doi-asserted-by":"crossref","first-page":"40357","DOI":"10.1074\/jbc.M006399200","article-title":"Structural requirements for the adherence of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate proteoglycans of human placenta","volume":"275","author":"Alkhalil","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.014676_bib33","doi-asserted-by":"crossref","first-page":"11705","DOI":"10.1074\/jbc.M211015200","article-title":"The low sulfated chondroitin sulfate proteoglycans of human placenta have sulfate group-clustered domains that can efficiently bind Plasmodium falciparum-infected erythrocytes","volume":"278","author":"Achur","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.014676_bib34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2958.2003.03570.x","article-title":"Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria","volume":"49","author":"Salanti","year":"2003","journal-title":"Mol. Microbiol"},{"key":"10.1074\/jbc.RA120.014676_bib35","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1084\/jem.20041579","article-title":"Evidence for the involvement of VAR2CSA in pregnancy-associated malaria","volume":"200","author":"Salanti","year":"2004","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.RA120.014676_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-33767-3","article-title":"Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development","volume":"8","author":"Benavente","year":"2018","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA120.014676_bib37","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1128\/IAI.71.5.2455-2461.2003","article-title":"Chondroitin sulfate proteoglycan expression and binding of Plasmodium falciparum-infected erythrocytes in the human placenta during pregnancy","volume":"71","author":"Agbor-Enoh","year":"2003","journal-title":"Infect. Immun"},{"key":"10.1074\/jbc.RA120.014676_bib38","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1073\/pnas.1000951107","article-title":"Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA","volume":"107","author":"Srivastava","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA120.014676_bib39","doi-asserted-by":"crossref","first-page":"23332","DOI":"10.1074\/jbc.M112.348839","article-title":"Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria","volume":"287","author":"Clausen","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.014676_bib40","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nsmb.1479","article-title":"Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A","volume":"15","author":"Singh","year":"2008","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib41","doi-asserted-by":"crossref","first-page":"21842","DOI":"10.1074\/jbc.C800086200","article-title":"The structure of a chondroitin sulfate-binding domain important in placental malaria","volume":"283","author":"Higgins","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.014676_bib42","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jmb.2009.08.027","article-title":"Structural comparison of two CSPG-binding DBL domains from the VAR2CSA protein important in malaria during pregnancy","volume":"393","author":"Khunrae","year":"2009","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib43","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.jmb.2013.02.014","article-title":"Structural and immunological correlations between the variable blocks of the VAR2CSA domain DBL6\u03f5 from two Plasmodium falciparum parasite lines","volume":"425","author":"Gangnard","year":"2013","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/srep14868","article-title":"Structure of the DBL3X-DBL4\u03b5 region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions","volume":"5","author":"Gangnard","year":"2015","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA120.014676_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020270","article-title":"Var2CSA minimal CSA binding region is located within the N-terminal region","volume":"6","author":"Srivastava","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA120.014676_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088173","article-title":"The antibody response of pregnant Cameroonian women to VAR2CSA ID1-ID2a, a small recombinant protein containing the CSA-binding site","volume":"9","author":"Babakhanyan","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA120.014676_bib47","doi-asserted-by":"crossref","first-page":"15908","DOI":"10.1074\/jbc.M110.191510","article-title":"The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains","volume":"286","author":"D\u00e4hlback","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.RA120.014676_bib48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1126\/science.181.4096.223","article-title":"Principles that govern the folding of protein chains","volume":"181","author":"Anfinsen","year":"1973","journal-title":"Science"},{"key":"10.1074\/jbc.RA120.014676_bib49","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1107\/S1600576717007786","article-title":"ATSAS 2.8: a comprehensive data analysis suite for small-angle scattering from macromolecular solutions","volume":"50","author":"Franke","year":"2017","journal-title":"J. Appl. Crystallogr"},{"key":"10.1074\/jbc.RA120.014676_bib50","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1093\/bioinformatics\/btx846","article-title":"CHROMIXS: automatic and interactive analysis of chromatography-coupled small-angle X-ray scattering data","volume":"34","author":"Panjkovich","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.RA120.014676_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-25355-2","article-title":"Consensus Bayesian assessment of protein molecular mass from solution X-ray scattering data","volume":"8","author":"Hajizadeh","year":"2018","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA120.014676_bib52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jsb.2009.08.009","article-title":"NADPH oxidase activator p67(phox) behaves in solution as a multidomain protein with semi-flexible linkers","volume":"169","author":"Durand","year":"2010","journal-title":"J. Struct. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib53","doi-asserted-by":"crossref","DOI":"10.1038\/srep29040","article-title":"A structure-free method for quantifying conformational flexibility in proteins","volume":"6","author":"Burger","year":"2016","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.RA120.014676_bib54","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera: a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem"},{"key":"10.1074\/jbc.RA120.014676_bib55","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jsb.2011.09.006","article-title":"UCSF Chimera, MODELLER, and IMP: an integrated modeling system","volume":"179","author":"Yang","year":"2012","journal-title":"J. Struct. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000308","article-title":"Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA","volume":"17","author":"Dorin-Semblat","year":"2019","journal-title":"PLoS Biol"},{"key":"10.1074\/jbc.RA120.014676_bib57","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1529\/biophysj.104.058800","article-title":"A coarse-grained molecular model for glycosaminoglycans: application to chondroitin, chondroitin sulfate, and hyaluronic acid","volume":"88","author":"Bathe","year":"2005","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.RA120.014676_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-2836(78)90251-6","article-title":"Chondroitin 4-sulfate: the structure of a sulfated glycosaminoglycan","volume":"125","author":"Winter","year":"1978","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib59","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s42003-019-0429-z","article-title":"Single-molecule imaging and quantification of the immune-variant adhesin VAR2CSA on knobs of Plasmodium falciparum-infected erythrocytes","volume":"2","author":"Sanchez","year":"2019","journal-title":"Commun. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0166-6851(95)02575-8","article-title":"Membrane modifications in erythrocytes parasitized by Plasmodium falciparum","volume":"76","author":"Deitsch","year":"1996","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/jbc.RA120.014676_bib61","doi-asserted-by":"crossref","first-page":"7483","DOI":"10.1016\/j.vaccine.2015.10.011","article-title":"Designing a VAR2CSA-based vaccine to prevent placental malaria","volume":"33","author":"Fried","year":"2015","journal-title":"Vaccine"},{"key":"10.1074\/jbc.RA120.014676_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016622","article-title":"Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates","volume":"6","author":"Avril","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.RA120.014676_bib63","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s42003-019-0704-z","article-title":"Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains","volume":"2","author":"Doritchamou","year":"2019","journal-title":"Commun. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000933","article-title":"Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes\u2013divide and conquer","volume":"6","author":"Rask","year":"2010","journal-title":"PLoS Comput. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib65","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molbiopara.2014.07.006","article-title":"The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis research","volume":"195","author":"Smith","year":"2014","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/jbc.RA120.014676_bib66","doi-asserted-by":"crossref","first-page":"20124","DOI":"10.1073\/pnas.1911900116","article-title":"Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes","volume":"116","author":"Lennartz","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.RA120.014676_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12837","article-title":"The structural basis for CD36 binding by the malaria parasite","volume":"7","author":"Hsieh","year":"2016","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.RA120.014676_bib68","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.chom.2014.11.007","article-title":"Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria","volume":"17","author":"Lau","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1074\/jbc.RA120.014676_bib69","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1038\/nprot.2006.468","article-title":"In-gel digestion for mass spectrometric characterization of proteins and proteomes","volume":"1","author":"Shevchenko","year":"2006","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.RA120.014676_bib70","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1021\/pr901043e","article-title":"Identification of phosphorylation sites within the signaling adaptor APPL1 by mass spectrometry","volume":"9","author":"Gant-Branum","year":"2010","journal-title":"J. Proteome Res"},{"key":"10.1074\/jbc.RA120.014676_bib71","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1021\/pr500319y","article-title":"Large-scale identification of phosphorylation sites for profiling protein kinase selectivity","volume":"13","author":"Imamura","year":"2014","journal-title":"J. Proteome Res"},{"key":"10.1074\/jbc.RA120.014676_bib72","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1074\/mcp.M113.035485","article-title":"Phosphoprotein secretome of tumor cells as a source of candidates for breast cancer biomarkers in plasma","volume":"13","author":"Zawadzka","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/jbc.RA120.014676_bib73","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbapap.2004.06.007","article-title":"Chondroitin sulfate proteoglycans of bovine cornea: structural characterization and assessment for the adherence of Plasmodium falciparum-infected erythrocytes","volume":"1701","author":"Achur","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.RA120.014676_bib74","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jsb.2006.06.010","article-title":"Visualizing density maps with UCSF Chimera","volume":"157","author":"Goddard","year":"2007","journal-title":"J. Struct. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib75","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42166","article-title":"New tools for automated high-resolution cryo-EM structure determination in RELION-3","volume":"7","author":"Zivanov","year":"2018","journal-title":"Elife"},{"key":"10.1074\/jbc.RA120.014676_bib76","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jsb.2016.04.010","article-title":"Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy","volume":"195","author":"de la Rosa-Trevin","year":"2016","journal-title":"J. Struct. Biol"},{"key":"10.1074\/jbc.RA120.014676_bib77","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.RA120.014676_bib78","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1107\/S1399004715002576","article-title":"Ambiguity assessment of small-angle scattering curves from monodisperse systems","volume":"71","author":"Petoukhov","year":"2015","journal-title":"Acta Crystallogr. D Biol. Crystallogr"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817507218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817507218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA120.014676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T04:52:11Z","timestamp":1629953531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817507218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":78,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0021925817507218"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra120.014676","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.04.16.045096","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA120.014676","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Bewley et al.","name":"copyright","label":"Copyright"}]}}