{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:06:33Z","timestamp":1793390793018,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL114471"],"award-info":[{"award-number":["HL114471"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL155532"],"award-info":[{"award-number":["HL155532"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1074\/jbc.ra120.016056","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T18:06:44Z","timestamp":1608746804000},"page":"100216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14"],"prefix":"10.1016","volume":"296","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-8513","authenticated-orcid":false,"given":"Donghwa","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Casta\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5342-7126","authenticated-orcid":false,"given":"Lauren K.","family":"Lujan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9194-1361","authenticated-orcid":false,"given":"Jung A.","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-3669","authenticated-orcid":false,"given":"Stephen B.","family":"Liggett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.RA120.016056_bib1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tibs.2011.06.003","article-title":"Emerging paradigms of beta-arrestin-dependent seven transmembrane receptor signaling","volume":"36","author":"Shukla","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.RA120.016056_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cellsig.2017.01.024","article-title":"GPCR desensitization: Acute and prolonged phases","volume":"41","author":"Rajagopal","year":"2018","journal-title":"Cell Signal"},{"key":"10.1074\/jbc.RA120.016056_bib3","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1074\/jbc.270.9.4681","article-title":"Four consecutive serines in the third intracellular loop are the sites for bARK-mediated phosphorylation and desensitization of the a2A-adrenergic receptor","volume":"270","author":"Eason","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/333370a0","article-title":"Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization","volume":"333","author":"Bouvier","year":"1988","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.016056_bib5","doi-asserted-by":"crossref","first-page":"12657","DOI":"10.1016\/S0021-9258(18)63907-9","article-title":"Phosphorylation sites on two domains of the b2-adrenergic receptor are involved in distinct pathways of receptor desensitization","volume":"264","author":"Hausdorff","year":"1989","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1124\/mol.54.1.44","article-title":"Phosphorylation and functional desensitization of the a2A-adrenergic receptor by protein kinase C","volume":"54","author":"Liang","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.RA120.016056_bib7","doi-asserted-by":"crossref","first-page":"ra51","DOI":"10.1126\/scisignal.2001707","article-title":"Distinct phosphorylation sites on the beta(2)-adrenergic receptor establish a barcode that encodes differential functions of beta-arrestin","volume":"4","author":"Nobles","year":"2011","journal-title":"Sci. Signal"},{"key":"10.1074\/jbc.RA120.016056_bib8","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1073\/pnas.262789099","article-title":"Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference","volume":"100","author":"Ahn","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.RA120.016056_bib9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nature12120","article-title":"Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide","volume":"497","author":"Shukla","year":"2013","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.016056_bib10","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1038\/ncomms5801","article-title":"Crystal structure of a common GPCR-binding interface for G protein and arrestin","volume":"5","author":"Szczepek","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1074\/jbc.RA120.016056_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-1953-1","article-title":"Structure of the neurotensin receptor 1 in complex with beta-arrestin 1","volume":"579","author":"Huang","year":"2020","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.016056_bib12","doi-asserted-by":"crossref","first-page":"16346","DOI":"10.1073\/pnas.1918264117","article-title":"Mechanism of beta-arrestin recruitment by the mu-opioid G protein-coupled receptor","volume":"117","author":"Mafi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.RA120.016056_bib13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1600-0854.2007.00551.x","article-title":"Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis","volume":"8","author":"Wolfe","year":"2007","journal-title":"Traffic"},{"key":"10.1074\/jbc.RA120.016056_bib14","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1073\/pnas.90.8.3665","article-title":"Structural basis for receptor subtype-specific regulation revealed by a chimeric b3\/b2-adrenergic receptor","volume":"90","author":"Liggett","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.RA120.016056_bib15","doi-asserted-by":"crossref","first-page":"18082","DOI":"10.1074\/jbc.271.30.18082","article-title":"G\u00a0protein-coupled receptor kinase specificity for phosphorylation and desensitization of a2-adrenergic receptor subtypes","volume":"271","author":"Jewell-Motz","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib16","doi-asserted-by":"crossref","first-page":"28989","DOI":"10.1074\/jbc.M005381200","article-title":"a2A\/a2C-adrenergic receptor third loop chimera show that agonist interaction with receptor-subtype backbone establishes G protein-coupled receptor kinase phosphorylation","volume":"275","author":"Jewell-Motz","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41586-020-1954-0","article-title":"Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc","volume":"579","author":"Staus","year":"2020","journal-title":"Nature"},{"key":"10.1074\/jbc.RA120.016056_bib18","doi-asserted-by":"crossref","first-page":"17409","DOI":"10.1074\/jbc.RA119.010324","article-title":"Genetic code expansion and photocross-linking identify different beta-arrestin binding modes to the angiotensin II type 1 receptor","volume":"294","author":"Gagnon","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib19","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm.2237","article-title":"Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction","volume":"16","author":"Deshpande","year":"2010","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.RA120.016056_bib20","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/10635150390235520","article-title":"A\u00a0simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood","volume":"52","author":"Guindon","year":"2003","journal-title":"Syst. Biol."},{"key":"10.1074\/jbc.RA120.016056_bib21","doi-asserted-by":"crossref","first-page":"15007","DOI":"10.1073\/pnas.0906034106","article-title":"Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway b2-adrenergic receptor physiologic signaling","volume":"106","author":"Wang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.RA120.016056_bib22","doi-asserted-by":"crossref","first-page":"12213","DOI":"10.1096\/fj.201802627RR","article-title":"Differential long-term regulation of TAS2R14 by structurally distinct agonists","volume":"33","author":"Woo","year":"2019","journal-title":"FASEB J."},{"key":"10.1074\/jbc.RA120.016056_bib23","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1073\/pnas.1917194117","article-title":"\u03b2-arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates","volume":"117","author":"Woo","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.RA120.016056_bib24","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1165\/rcmb.2016-0373OC","article-title":"Coupling of airway smooth muscle bitter taste receptors to intracellular signaling and relaxation is via Galphai1,2,3","volume":"56","author":"Kim","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1074\/jbc.RA120.016056_bib25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1165\/rcmb.2018-0189OC","article-title":"Biased TAS2R bronchodilators inhibit airway smooth muscle growth by downregulating phosphorylated extracellular signal-regulated kinase 1\/2","volume":"60","author":"Kim","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1074\/jbc.RA120.016056_bib26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80706-0","article-title":"T2Rs function as bitter taste receptors","volume":"100","author":"Chandrashekar","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.RA120.016056_bib27","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1096\/fj.12-215087","article-title":"Extraoral bitter taste receptors as mediators of off-target drug effects","volume":"26","author":"Clark","year":"2012","journal-title":"FASEB J."},{"key":"10.1074\/jbc.RA120.016056_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cellsig.2017.02.002","article-title":"Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system","volume":"41","author":"An","year":"2017","journal-title":"Cell Signal"},{"key":"10.1074\/jbc.RA120.016056_bib29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nm0711-776b","article-title":"Bronchodilator activity of bitter tastants in human tissue","volume":"17","author":"Deshpande","year":"2011","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.RA120.016056_bib30","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1165\/rcmb.2013-0439RC","article-title":"Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells","volume":"50","author":"Robinett","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"10.1074\/jbc.RA120.016056_bib31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/jnc.12071","article-title":"Identification of phosphorylation sites in the COOH-terminal tail of the mu-opioid receptor","volume":"124","author":"Chen","year":"2013","journal-title":"J.\u00a0Neurochem."},{"key":"10.1074\/jbc.RA120.016056_bib32","doi-asserted-by":"crossref","first-page":"14152","DOI":"10.1074\/jbc.272.22.14152","article-title":"Two homologous phosphorylation domains differentially contribute to desensitization and internalization of the m2 muscarinic acetylcholine receptor","volume":"272","author":"Pals-Rylaarsdam","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib33","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1165\/rcmb.2011-0061OC","article-title":"Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors","volume":"45","author":"Robinett","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"10.1074\/jbc.RA120.016056_bib34","doi-asserted-by":"crossref","first-page":"15038","DOI":"10.1074\/jbc.M900388200","article-title":"G\u00a0protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor","volume":"284","author":"Namkung","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib35","doi-asserted-by":"crossref","first-page":"36659","DOI":"10.1074\/jbc.M006788200","article-title":"Hierarchical phosphorylation of delta-opioid receptor regulates agonist-induced receptor desensitization and internalization","volume":"275","author":"Kouhen","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib36","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1124\/mol.57.3.539","article-title":"Identification of threonine residues controlling the agonist-dependent phosphorylation and desensitization of the rat A(3) adenosine receptor","volume":"57","author":"Palmer","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.RA120.016056_bib37","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1074\/jbc.M308281200","article-title":"The role of phosphorylation in D1 dopamine receptor desensitization: Evidence for a novel mechanism of arrestin association","volume":"279","author":"Kim","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib38","doi-asserted-by":"crossref","first-page":"26215","DOI":"10.1016\/S0021-9258(18)47181-5","article-title":"A\u00a0proline-rich region of the third intracellular loop imparts phenotypic b1- versus b2-adrenergic receptor coupling and sequestration","volume":"269","author":"Green","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib39","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1016\/S0021-9258(18)42894-3","article-title":"Sites in the third intracellular loop of the a2A-adrenergic receptor confer short term agonist -promoted desensitization: Evidence for a receptor kinase-mediated mechanism","volume":"267","author":"Liggett","year":"1992","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib40","doi-asserted-by":"crossref","first-page":"25473","DOI":"10.1016\/S0021-9258(19)74065-4","article-title":"Subtype-selective desensitization of a2-adrenergic receptors: Different mechanisms control short and long term agonist-promoted desensitization of a2C10, a2C4 and a2C2","volume":"267","author":"Eason","year":"1992","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib41","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(00)80705-9","article-title":"A\u00a0novel family of mammalian taste receptors","volume":"100","author":"Adler","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.RA120.016056_bib42","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.tips.2011.04.003","article-title":"Novel bronchodilators for the treatment of chronic obstructive pulmonary disease","volume":"32","author":"Matera","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.RA120.016056_bib43","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0095-2019","article-title":"The future of bronchodilation: Looking for new classes of bronchodilators","volume":"28","author":"Cazzola","year":"2019","journal-title":"Eur. Respir. Rev."},{"key":"10.1074\/jbc.RA120.016056_bib44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0140-6736(95)91265-7","article-title":"Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients","volume":"346","author":"Grove","year":"1995","journal-title":"Lancet"},{"key":"10.1074\/jbc.RA120.016056_bib45","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/thx.50.5.497","article-title":"Subsensitivity of bronchodilator and systemic b2 adrenoceptor responses after regular twice daily treatment with eformoterol dry power in asthmatic patients","volume":"50","author":"Newnham","year":"1995","journal-title":"Thorax"},{"key":"10.1074\/jbc.RA120.016056_bib46","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/0091-6749(85)90786-9","article-title":"Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: A comparison between budesonide and terbutaline","volume":"76","author":"Kraan","year":"1985","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1074\/jbc.RA120.016056_bib47","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJM199210223271703","article-title":"Long-term effects of a long acting b2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma","volume":"327","author":"Cheung","year":"1992","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1074\/jbc.RA120.016056_bib48","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1136\/thx.51.11.1100","article-title":"Salmeterol tachyphylaxis in steroid treated asthmatic subjects","volume":"51","author":"Booth","year":"1996","journal-title":"Thorax"},{"key":"10.1074\/jbc.RA120.016056_bib49","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1378\/chest.108.5.1235","article-title":"Rapid onset of tolerance to the bronchoprotective effect of salmeterol","volume":"108","author":"Bhagat","year":"1995","journal-title":"Chest"},{"key":"10.1074\/jbc.RA120.016056_bib50","doi-asserted-by":"crossref","first-page":"904","DOI":"10.7326\/0003-4819-144-12-200606200-00126","article-title":"Meta-analysis: Effect of long-acting b-agonists on severe asthma exacerbations and asthma-related deaths","volume":"144","author":"Salpeter","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"10.1074\/jbc.RA120.016056_bib51","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0140-6736(90)93098-A","article-title":"Regular inhaled beta-agonist treatment in bronchial asthma","volume":"336","author":"Sears","year":"1990","journal-title":"Lancet"},{"key":"10.1074\/jbc.RA120.016056_bib52","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.amjmed.2009.07.035","article-title":"Long-acting beta-agonists with and without inhaled corticosteroids and catastrophic asthma events","volume":"123","author":"Salpeter","year":"2010","journal-title":"Am. J. Med."},{"key":"10.1074\/jbc.RA120.016056_bib53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1378\/chest.129.1.15","article-title":"The Salmeterol Multicenter Asthma Research trial: A comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol","volume":"129","author":"Nelson","year":"2006","journal-title":"Chest"},{"key":"10.1074\/jbc.RA120.016056_bib54","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1073\/pnas.0801319105","article-title":"Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors","volume":"105","author":"Einstein","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.RA120.016056_bib55","doi-asserted-by":"crossref","first-page":"17616","DOI":"10.1074\/jbc.M116.722736","article-title":"beta2-Adrenergic receptors chaperone trapped bitter taste receptor 14 to the cell surface as a heterodimer and exert unidirectional desensitization of taste receptor function","volume":"291","author":"Kim","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.RA120.016056_bib56","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1128\/MCB.00572-06","article-title":"Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein","volume":"27","author":"Lee","year":"2007","journal-title":"Mol. Cell Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820002124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820002124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.RA120.016056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T02:35:01Z","timestamp":1634438101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820002124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":56,"alternative-id":["S0021925820002124"],"URL":"https:\/\/doi.org\/10.1074\/jbc.ra120.016056","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.RA120.016056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100216"}}