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New Biol."},{"key":"10.1074\/jbc.REV120.014405_bib62","first-page":"53","article-title":"Squid rhodopsin and retinochrome","volume":"243","author":"Kito","year":"1973","journal-title":"Nature-New Biol."},{"key":"10.1074\/jbc.REV120.014405_bib63","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/gb-2005-6-3-213","article-title":"The opsins","volume":"6","author":"Terakita","year":"2005","journal-title":"Genome Biol."},{"key":"10.1074\/jbc.REV120.014405_bib64","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1016\/j.visres.2003.09.012","article-title":"Origin of the vertebrate visual cycle: II. Visual cycle proteins are localized in whole brain including photoreceptor cells of a primitive chordate","volume":"43","author":"Tsuda","year":"2003","journal-title":"Vis. Res."},{"key":"10.1074\/jbc.REV120.014405_bib65","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0042-6989(89)90026-6","article-title":"Retinal-binding protein as a shuttle for retinal in the rhodopsin-retinochrome system of the squid visual cells","volume":"29","author":"Terakita","year":"1989","journal-title":"Vis. Res."},{"key":"10.1074\/jbc.REV120.014405_bib66","doi-asserted-by":"crossref","first-page":"16848","DOI":"10.1016\/S0021-9258(18)45461-0","article-title":"Biochemical characterization of the retinoid isomerase system of the eye","volume":"262","author":"Bernstein","year":"1987","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.REV120.014405_bib67","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.preteyeres.2010.03.002","article-title":"Membrane-binding and enzymatic properties of RPE65","volume":"29","author":"Kiser","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1074\/jbc.REV120.014405_bib68","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1006\/exer.1994.1055","article-title":"Cytoplasmic retinal localization of an evolutionary homolog of the visual pigments","volume":"58","author":"Pandey","year":"1994","journal-title":"Exp. Eye Res."},{"key":"10.1074\/jbc.REV120.014405_bib69","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.2727688","article-title":"Membranes as the energy source in the endergonic transformation of vitamin A to 11-cis-retinol","volume":"244","author":"Deigner","year":"1989","journal-title":"Science"},{"key":"10.1074\/jbc.REV120.014405_bib70","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/232187c0","article-title":"Crystal structure of the visual chromophores, 11-cis and all-trans retinal","volume":"232","author":"Gilardi","year":"1971","journal-title":"Nature"},{"key":"10.1074\/jbc.REV120.014405_bib71","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/229558a0","article-title":"Implications of torsional potential of retinal isomers for visual excitation","volume":"229","author":"Honig","year":"1971","journal-title":"Nature"},{"key":"10.1074\/jbc.REV120.014405_bib72","doi-asserted-by":"crossref","first-page":"11370","DOI":"10.1021\/bi001061c","article-title":"Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins","volume":"39","author":"McBee","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.REV120.014405_bib73","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1021\/bi034002i","article-title":"A\u00a0cleavable affinity biotinylating agent reveals a retinoid binding role for RPE65","volume":"42","author":"Jahng","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.REV120.014405_bib74","doi-asserted-by":"crossref","first-page":"12805","DOI":"10.1021\/bi035370p","article-title":"Lecithin retinol acyltransferase is a founder member of a novel family of enzymes","volume":"42","author":"Jahng","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.REV120.014405_bib75","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1021\/bi00217a001","article-title":"Membrane phospholipids as an energy source in the operation of the visual cycle","volume":"30","author":"Rando","year":"1991","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.REV120.014405_bib76","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1074\/jbc.274.6.3834","article-title":"Molecular and biochemical characterization of lecithin retinol acyltransferase","volume":"274","author":"Ruiz","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.REV120.014405_bib77","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1021\/acs.biochem.6b00319","article-title":"Lecithin:Retinol acyltransferase: a key enzyme involved in the retinoid (visual) cycle","volume":"55","author":"Sears","year":"2016","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.REV120.014405_bib78","doi-asserted-by":"crossref","first-page":"12235","DOI":"10.1073\/pnas.94.22.12235","article-title":"Genetic control of abscisic acid biosynthesis in maize","volume":"94","author":"Tan","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.REV120.014405_bib79","doi-asserted-by":"crossref","first-page":"158590","DOI":"10.1016\/j.bbalip.2019.158590","article-title":"Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs)","volume":"1865","author":"Daruwalla","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids."},{"key":"10.1074\/jbc.REV120.014405_bib80","doi-asserted-by":"crossref","first-page":"30212","DOI":"10.1074\/jbc.M115.696799","article-title":"Utilization of dioxygen by carotenoid cleavage oxygenases","volume":"290","author":"Sui","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.REV120.014405_bib81","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nchembio.1799","article-title":"Catalytic mechanism of a retinoid isomerase essential for vertebrate vision","volume":"11","author":"Kiser","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1074\/jbc.REV120.014405_bib82","doi-asserted-by":"crossref","first-page":"17325","DOI":"10.1073\/pnas.0906600106","article-title":"Crystal structure of native RPE65, the retinoid isomerase of the visual cycle","volume":"106","author":"Kiser","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.REV120.014405_bib83","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1074\/jbc.M109.027458","article-title":"RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization","volume":"285","author":"Redmond","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.REV120.014405_bib84","doi-asserted-by":"crossref","first-page":"19914","DOI":"10.1073\/pnas.2004116117","article-title":"Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase","volume":"117","author":"Daruwalla","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.\u00a0S. A."},{"key":"10.1074\/jbc.REV120.014405_bib85","doi-asserted-by":"crossref","first-page":"19000","DOI":"10.1073\/pnas.0807805105","article-title":"NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide","volume":"105","author":"Oberhauser","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.REV120.014405_bib86","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1074\/jbc.274.10.6085","article-title":"The endogenous chromophore of retinal G protein-coupled receptor opsin from the pigment epithelium","volume":"274","author":"Hao","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.REV120.014405_bib87","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0076-6879(00)16739-4","article-title":"Analysis of chromophore of RGR: retinal G-protein-coupled receptor from pigment epithelium","volume":"316","author":"Hao","year":"2000","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.REV120.014405_bib88","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF00238300","article-title":"Histochemical localization of retinochrome and rhodopsin studied by fluorescence microscopy","volume":"233","author":"Ozaki","year":"1983","journal-title":"Cell Tissue Res."},{"key":"10.1074\/jbc.REV120.014405_bib89","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature09789","article-title":"Crystal structure of metarhodopsin II","volume":"471","author":"Choe","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.REV120.014405_bib90","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/14656566.2018.1448060","article-title":"Pharmacotherapy of retinal disease with visual cycle modulators","volume":"19","author":"Hussain","year":"2018","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1074\/jbc.REV120.014405_bib91","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-vision-111815-114407","article-title":"Retinoids and retinal diseases","volume":"2","author":"Kiser","year":"2016","journal-title":"Annu. Rev. Vis. Sci."},{"key":"10.1074\/jbc.REV120.014405_bib92","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.pharmtox.47.120505.105225","article-title":"Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents","volume":"47","author":"Travis","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.REV120.014405_bib93","doi-asserted-by":"crossref","first-page":"13016","DOI":"10.1074\/jbc.AW118.003228","article-title":"Visual cycle proteins: structure, function, and roles in human retinal disease","volume":"293","author":"Tsin","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1074\/jbc.REV120.014405_bib94","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0002-9394(00)00737-6","article-title":"Molecular genetics of Oguchi disease, fundus albipunctatus, and other forms of stationary night blindness: LVII Edward Jackson Memorial Lecture","volume":"130","author":"Dryja","year":"2000","journal-title":"Am. J. Ophthalmol."},{"key":"10.1074\/jbc.REV120.014405_bib95","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/9707","article-title":"Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus","volume":"22","author":"Yamamoto","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.REV120.014405_bib96","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ng0297-216","article-title":"Retinopathy induced in mice by targeted disruption of the rhodopsin gene","volume":"15","author":"Humphries","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.REV120.014405_bib97","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0888-7543(91)90119-Y","article-title":"Autosomal dominant retinitis pigmentosa: four new mutations in rhodopsin, one of them in the retinal attachment site","volume":"11","author":"Keen","year":"1991","journal-title":"Genomics"},{"key":"10.1074\/jbc.REV120.014405_bib98","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1126\/science.1990431","article-title":"Transducin activation by rhodopsin without a covalent bond to the 11-cis-retinal chromophore","volume":"251","author":"Zhukovsky","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.REV120.014405_bib99","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.str.2013.01.011","article-title":"Kinetic, energetic, and mechanical differences between dark-state rhodopsin and opsin","volume":"21","author":"Kawamura","year":"2013","journal-title":"Structure"},{"key":"10.1074\/jbc.REV120.014405_bib100","doi-asserted-by":"crossref","first-page":"7226","DOI":"10.1021\/acs.analchem.9b00546","article-title":"Differentiating between inactive and active states of rhodopsin by\u00a0atomic force microscopy in native membranes","volume":"91","author":"Senapati","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1074\/jbc.REV120.014405_bib101","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/ng0793-280","article-title":"Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness","volume":"4","author":"Dryja","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.REV120.014405_bib102","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1056\/NEJM199011083231903","article-title":"Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa","volume":"323","author":"Dryja","year":"1990","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1074\/jbc.REV120.014405_bib103","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/ng0692-209","article-title":"A\u00a0null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive retinitis pigmentosa","volume":"1","author":"Rosenfeld","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.REV120.014405_bib104","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1172\/JCI66176","article-title":"Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization","volume":"123","author":"Zhang","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1074\/jbc.REV120.014405_bib105","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/ng1097-194","article-title":"Mutations in RPE65 cause autosomal recessive childhood-onset severe retinal dystrophy","volume":"17","author":"Gu","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.REV120.014405_bib106","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ng1097-139","article-title":"Mutations in RPE65 cause Leber's congenital amaurosis","volume":"17","author":"Marlhens","year":"1997","journal-title":"Nat. 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Med."},{"key":"10.1074\/jbc.REV120.014405_bib114","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(09)61836-5","article-title":"Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial","volume":"374","author":"Maguire","year":"2009","journal-title":"Lancet"},{"key":"10.1074\/jbc.REV120.014405_bib115","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/humu.1133","article-title":"Spectrum of ABCA4 (ABCR) gene mutations in Spanish patients with autosomal recessive macular dystrophies","volume":"17","author":"Paloma","year":"2001","journal-title":"Hum. Mutat."},{"key":"10.1074\/jbc.REV120.014405_bib116","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.ejhg.5200221","article-title":"Spectrum of ABCR gene mutations in autosomal recessive macular dystrophies","volume":"6","author":"Rozet","year":"1998","journal-title":"Eur. J. Hum. 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