{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:05:29Z","timestamp":1761599129320},"reference-count":50,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":2317,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1074\/jbc.x114.572115","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:26:11Z","timestamp":1396916771000},"page":"13691-13700","source":"Crossref","is-referenced-by-count":1,"title":["Master Molecule, Heal Thyself"],"prefix":"10.1016","volume":"289","author":[{"given":"Errol C.","family":"Friedberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.X114.572115_bib1","series-title":"Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms","author":"Friedberg","year":"1997"},{"key":"10.1074\/jbc.X114.572115_bib2","series-title":"DNA Repair and Mutagenesis","author":"Friedberg","year":"2006"},{"key":"10.1074\/jbc.X114.572115_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cr.2007.113","article-title":"A brief history of the DNA repair field","volume":"18","author":"Friedberg","year":"2008","journal-title":"Cell Res"},{"key":"10.1074\/jbc.X114.572115_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1101\/SQB.1968.033.01.031","article-title":"Endonuclease II of E. coli","volume":"33","author":"Friedberg","year":"1968","journal-title":"Cold Spring Harbor Symp. Quant. Biol"},{"key":"10.1074\/jbc.X114.572115_bib5","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1073\/pnas.62.3.934","article-title":"Endonuclease II of E. coli. I. Isolation and purification","volume":"62","author":"Friedberg","year":"1969","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.X114.572115_bib6","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.1016\/S0021-9258(18)63556-2","article-title":"Endonuclease II of E. coli. II. Enzyme properties and studies on the degradation of alkylated and native deoxyribonucleic acid","volume":"244","author":"Friedberg","year":"1969","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.X114.572115_bib7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0006-291X(69)90859-6","article-title":"Endonucleolytic cleavage of UV-irradiated DNA controlled by the v+ gene in phage T4","volume":"37","author":"Friedberg","year":"1969","journal-title":"Biochem. Biophys. Res. Comm"},{"key":"10.1074\/jbc.X114.572115_bib8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1128\/jb.106.2.500-507.1971","article-title":"Dark repair of ultraviolet irradiated deoxyribonucleic acid by bacteriophage T4. Purification and characterization of a dimer-specific phage-induced endonuclease","volume":"106","author":"Friedberg","year":"1971","journal-title":"J. Bacteriol"},{"key":"10.1074\/jbc.X114.572115_bib9","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1073\/pnas.67.4.1839","article-title":"T4 Endonuclease involved in repair of DNA","volume":"67","author":"Yasuda","year":"1970","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.X114.572115_bib10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1128\/jvi.13.3.765-767.1974","article-title":"In vitro repair of UV-irradiated Micrococcus luteus bacteriophage NI transfecting DNA","volume":"13","author":"Mahler","year":"1974","journal-title":"J. Virol"},{"key":"10.1074\/jbc.X114.572115_bib11","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1073\/pnas.71.7.2777","article-title":"The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria","volume":"71","author":"Clayton","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.X114.572115_bib12","series-title":"DNA Repair and Mutagenesis in Eukaryotes","first-page":"121","article-title":"The molecular mechanism of pyrimidine dimer excision in S. cerevisiae. I. Studies with intact cells and cell-free systems","author":"Reynolds","year":"1980"},{"key":"10.1074\/jbc.X114.572115_bib13","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1128\/jb.146.2.692-704.1981","article-title":"Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae. II. The incision of UV-irradiated DNA in vivo","volume":"146","author":"Reynolds","year":"1981","journal-title":"J. Bacteriol"},{"key":"10.1074\/jbc.X114.572115_bib14","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1128\/jb.147.2.705-708.1981","article-title":"Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae. III. The excision of dimers in cell-free extracts","volume":"147","author":"Reynolds","year":"1981","journal-title":"J. Bacteriol"},{"key":"10.1074\/jbc.X114.572115_bib15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1128\/jb.152.1.323-331.1982","article-title":"Molecular cloning of eukaryotic genes required for excision repair of UV-irradiated DNA: isolation and partial characterization of the RAD3 gene of Saccharomyces cerevisiae","volume":"152","author":"Naumovski","year":"1982","journal-title":"J. Bacteriol"},{"key":"10.1074\/jbc.X114.572115_bib16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0378-1119(85)90177-5","article-title":"The RAD2 gene of Saccharomyces cerevisiae: nucleotide sequence and transcript mapping","volume":"36","author":"Nicolet","year":"1985","journal-title":"Gene"},{"key":"10.1074\/jbc.X114.572115_bib17","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1021\/bi00464a031","article-title":"Characterization of the RAD10 gene of S. cerevisiae and purification of Rad10 protein","volume":"29","author":"Bardwell","year":"1990","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.X114.572115_bib18","first-page":"2161","article-title":"The molecular cloning and nucleotide sequence analysis of the RAD1 gene of Saccharomyces cerevisiae","volume":"4","author":"Yang","year":"1984","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.X114.572115_bib19","first-page":"1180","article-title":"The RAD4 gene of S. cerevisiae: molecular cloning and partial characterization of a gene which is inactivated in E. coli","volume":"7","author":"Fleer","year":"1987","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.X114.572115_bib20","series-title":"A Biography of Paul Berg\u2013The Recombinant DNA Controversy Revisited","author":"Friedberg","year":"2014"},{"key":"10.1074\/jbc.X114.572115_bib21","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1128\/MCB.17.2.635","article-title":"The RAD7, RAD16 and RAD23 genes of S. cerevisiae: requirement for transcription-independent nucleotide excision repair in vitro and interactions between the gene products","volume":"17","author":"Wang","year":"1997","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.X114.572115_bib22","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1073\/pnas.80.15.4818","article-title":"A DNA repair gene required for the incision of damaged DNA is essential for viability in S. cerevisiae","volume":"80","author":"Naumovski","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.X114.572115_bib23","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1073\/pnas.90.11.4907","article-title":"Nucleotide excision repair of DNA in cell-free extracts of the yeast Saccharomyces cerevisiae","volume":"90","author":"Wang","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.X114.572115_bib24","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/0092-8674(93)90624-Y","article-title":"Dual roles of a multiprotein complex from Saccharomyces cerevisiae in transcription and DNA repair","volume":"75","author":"Feaver","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.X114.572115_bib25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/368074a0","article-title":"Requirement for RNA polymerase II transcription factor b (TFIIH) during nucleotide excision repair in the yeast Saccharomyces cerevisiae","volume":"368","author":"Wang","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.X114.572115_bib26","first-page":"3569","article-title":"Yeast nucleotide excision repair proteins Rad2 and Rad4 interact with RNA polymerase II basal transcription factor b","volume":"14","author":"Bardwell","year":"1994","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.X114.572115_bib27","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1073\/pnas.91.9.3926","article-title":"Yeast Rad3 protein binds directly to both Ssl2 and Ssl1 proteins: implications for the structure and function of transcription\/repair Factor b","volume":"91","author":"Bardwell","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.X114.572115_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1749-6632.1994.tb52829.x","article-title":"Recent insights on DNA repair: the mechanism of damaged nucleotide excision in eukaryotes and its relationship to other cellular processes","volume":"726","author":"Bardwell","year":"1994","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1074\/jbc.X114.572115_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1098\/rstb.1995.0010","article-title":"Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription","volume":"347","author":"Friedberg","year":"1995","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci"},{"key":"10.1074\/jbc.X114.572115_bib30","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0092-8674(92)90384-O","article-title":"Xeroderma pigmentosum, Cockayne syndrome, essential genes, helicases and DNA repair: what's the relationship?","volume":"71","author":"Friedberg","year":"1992","journal-title":"Cell"},{"key":"10.1074\/jbc.X114.572115_bib31","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1126\/science.8091230","article-title":"Specific cleavage of model recombination and repair intermediates by the yeast Rad1\/Rad10 DNA endonuclease","volume":"265","author":"Bardwell","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.X114.572115_bib32","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1128\/MCB.15.4.2245","article-title":"RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae","volume":"15","author":"Ivanov","year":"1995","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.X114.572115_bib33","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0092-8674(95)90028-4","article-title":"The Cockayne syndrome group A gene encodes a WD-repeat protein which interacts with CSB protein and a subunit of RNA Pol II transcription factor IIH (TFIIH)","volume":"82","author":"Henning","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.X114.572115_bib34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1128\/jvi.16.2.315-321.1975","article-title":"N-Glycosidase activity in extracts of Bacillus subtilis and its inhibition following infection with bacteriophage PBS2","volume":"16","author":"Friedberg","year":"1975","journal-title":"J. Virol"},{"key":"10.1074\/jbc.X114.572115_bib35","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1021\/bi00633a024","article-title":"Partial purification and characterization of a uracil DNA-glycosidase from B. subtilis","volume":"16","author":"Cone","year":"1977","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.X114.572115_bib36","doi-asserted-by":"crossref","first-page":"10354","DOI":"10.1016\/S0021-9258(19)70472-4","article-title":"Inhibitor of uracil DNA glycosylase induced by bacteriophage PBS2","volume":"255","author":"Cone","year":"1980","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.X114.572115_bib37","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/285634a0","article-title":"Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus","volume":"285","author":"Haseltine","year":"1980","journal-title":"Nature"},{"key":"10.1074\/jbc.X114.572115_bib38","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/286182a0","article-title":"A pyrimidine dimer-DNA glycosylase activity associated with the V gene product of bacteriophage T4","volume":"286","author":"Radany","year":"1980","journal-title":"Nature"},{"key":"10.1074\/jbc.X114.572115_bib39","first-page":"771","article-title":"Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53\u2212\/\u2212 mice","volume":"59","author":"Cheo","year":"1999","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.X114.572115_bib40","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/21447","article-title":"The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase \u03b7","volume":"399","author":"Masutani","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.X114.572115_bib41","doi-asserted-by":"crossref","first-page":"11922","DOI":"10.1073\/pnas.96.21.11922","article-title":"Human and mouse homologs of E. coli DinB (DNA polymerase IV), novel members of the UmuC\/DinB superfamily","volume":"96","author":"Gerlach","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.X114.572115_bib42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0092-8674(01)00509-8","article-title":"Error-prone DNA polymerases: novel structures and benefits of infidelity","volume":"107","author":"Friedberg","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.X114.572115_bib43","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0092-8674(00)81970-4","article-title":"Novel DNA polymerases offer clues to the molecular basis of mutagenesis","volume":"98","author":"Friedberg","year":"1999","journal-title":"Cell"},{"key":"10.1074\/jbc.X114.572115_bib44","doi-asserted-by":"crossref","first-page":"53298","DOI":"10.1074\/jbc.M409155200","article-title":"Quantitative analysis of translesion DNA synthesis across a benzo [a]pyrene-guanine adduct in mammalian cells","volume":"279","author":"Avkin","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.X114.572115_bib45","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1126\/science.1070236","article-title":"Specialized DNA polymerases, cellular survival and the genesis of mutations","volume":"296","author":"Friedberg","year":"2002","journal-title":"Science"},{"key":"10.1074\/jbc.X114.572115_bib46","doi-asserted-by":"crossref","first-page":"10312","DOI":"10.1093\/nar\/gkt793","article-title":"Mismatch repair protein MSH2 regulates translesion DNA synthesis in UV irradiated human cells","volume":"41","author":"Lv","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.X114.572115_bib47","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1038\/emboj.2013.148","article-title":"DNA polymerase kappa\u2013dependent DNA synthesis at stalled replication forks is required for checkpoint activation after replicative stress","volume":"32","author":"B\u00e9tous","year":"2013","journal-title":"EMBO J"},{"key":"10.1074\/jbc.X114.572115_bib48","series-title":"The Writing Life of James D. Watson","author":"Friedberg","year":"2005"},{"key":"10.1074\/jbc.X114.572115_bib49","series-title":"From Rags to Riches. The Phenomenal Rise of The University of Texas Southwestern Medical Center at Dallas","author":"Friedberg","year":"2007"},{"key":"10.1074\/jbc.X114.572115_bib50","series-title":"Sydney Brenner\u2013A Biography","author":"Friedberg","year":"2010"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820387135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820387135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.X114.572115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T01:16:55Z","timestamp":1639703815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820387135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":50,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0021925820387135"],"URL":"https:\/\/doi.org\/10.1074\/jbc.x114.572115","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}