{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T21:23:28Z","timestamp":1773523408514,"version":"3.50.1"},"reference-count":73,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":3219,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1074\/mcp.m110.005520","type":"journal-article","created":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T23:55:37Z","timestamp":1313538937000},"page":"M110.005520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Monitoring a Nuclear Factor-\u03baB Signature of Drug Resistance in Multiple Myeloma"],"prefix":"10.1016","volume":"10","author":[{"given":"Yun","family":"Xiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth R.","family":"Remily-Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasco","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Yarde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Q.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Mathews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Boucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Cubitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted J.","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A.","family":"Eschrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth H.","family":"Shain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Dalton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Hazlehurst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Koomen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M110.005520_bib1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3816\/CLM.2009.n.056","article-title":"Treatment of multiple myeloma: a comprehensive review","volume":"9","author":"Kyle","year":"2009","journal-title":"Clin. Lymphoma Myeloma"},{"key":"10.1074\/mcp.M110.005520_bib2","first-page":"995","article-title":"Development and characterization of a melphalan-resistant human multiple myeloma cell line","volume":"51","author":"Bellamy","year":"1991","journal-title":"Cancer Res"},{"key":"10.1074\/mcp.M110.005520_bib3","first-page":"1021","article-title":"Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line","volume":"59","author":"Hazlehurst","year":"1999","journal-title":"Cancer Res"},{"key":"10.1074\/mcp.M110.005520_bib4","first-page":"69","article-title":"Cell adhesion is a key determinant in de novo multidrug resistance (MDR): new targets for the prevention of acquired MDR","volume":"1","author":"Shain","year":"2001","journal-title":"Mol. Cancer Therapeutics"},{"key":"10.1074\/mcp.M110.005520_bib5","first-page":"7900","article-title":"Genotypic and phenotypic comparisons of de-novo and acquired melphalan resistance in an isogenic multiple myeloma cell line model","volume":"63","author":"Hazlehurst","year":"2003","journal-title":"Cancer Res"},{"key":"10.1074\/mcp.M110.005520_bib6","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1182\/blood-2004-11-4286","article-title":"The FA\/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells","volume":"106","author":"Chen","year":"2005","journal-title":"Blood"},{"key":"10.1074\/mcp.M110.005520_bib7","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1158\/0008-5472.CAN-09-2616","article-title":"Targeting the Fanconi anemia\/BRCA pathway circumvents drug resistance in multiple myeloma","volume":"69","author":"Yarde","year":"2009","journal-title":"Cancer Res"},{"key":"10.1074\/mcp.M110.005520_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ccr.2007.07.003","article-title":"Promiscuous mutations activate the non-canonical NF-kB pathway in multiple myeloma","volume":"12","author":"Keats","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1074\/mcp.M110.005520_bib9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.leukres.2004.05.014","article-title":"Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells","volume":"29","author":"Yinjun","year":"2005","journal-title":"Leukemia Res"},{"key":"10.1074\/mcp.M110.005520_bib10","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1200\/JCO.2003.06.001","article-title":"Overcoming drug resistance in multiple myeloma: the emergence of therapeutic approaches to induce apoptosis","volume":"21","author":"Yang","year":"2003","journal-title":"J. Clin. Oncol"},{"key":"10.1074\/mcp.M110.005520_bib11","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1056\/NEJMoa0801479","article-title":"Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma","volume":"359","author":"San Miguel","year":"2008","journal-title":"New Engl. J. Med"},{"key":"10.1074\/mcp.M110.005520_bib12","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1182\/blood-2010-02-271676","article-title":"Once- versus twice-weekly bortezomib induction therapy with CyBorD in newly diagnosed multiple myeloma","volume":"115","author":"Reeder","year":"2010","journal-title":"Blood"},{"key":"10.1074\/mcp.M110.005520_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1074-7613(00)80011-4","article-title":"Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells","volume":"10","author":"Catlett-Falcone","year":"1999","journal-title":"Immunity"},{"key":"10.1074\/mcp.M110.005520_bib14","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/sj.leu.2402222","article-title":"Induction of chemoresistance in HL-60 cells concomitantly causes a resistance to apoptosis and the synthesis of P-glycoprotein","volume":"15","author":"Campone","year":"2001","journal-title":"Leukemia"},{"key":"10.1074\/mcp.M110.005520_bib15","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1038\/onc.2008.307","article-title":"Bcl-2 family proteins and cancer","volume":"27","author":"Yip","year":"2008","journal-title":"Oncogene"},{"key":"10.1074\/mcp.M110.005520_bib16","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1038\/sj.onc.1206945","article-title":"Alterations in the apoptotic machinery and their potential role in anticancer drug resistance","volume":"22","author":"Kaufmann","year":"2003","journal-title":"Oncogene"},{"key":"10.1074\/mcp.M110.005520_bib17","first-page":"256","article-title":"BCL-X expression in multiple myeloma: possible indicator of chemoresistance","volume":"58","author":"Tu","year":"1998","journal-title":"Cancer Res"},{"key":"10.1074\/mcp.M110.005520_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/sj.leu.2402768","article-title":"Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein","volume":"17","author":"van de Donk","year":"2003","journal-title":"Leukemia"},{"key":"10.1074\/mcp.M110.005520_bib19","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/sj.leu.2403784","article-title":"Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival","volume":"19","author":"Wuill\u00e8me-Toumi","year":"2005","journal-title":"Leukemia"},{"key":"10.1074\/mcp.M110.005520_bib20","first-page":"3527","article-title":"The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1","volume":"8","author":"Gojo","year":"2002","journal-title":"Clin. Cancer Res"},{"key":"10.1074\/mcp.M110.005520_bib21","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1182\/blood-2004-05-1760","article-title":"VEGF induces MCL-1 upregulation and protects multiple myeloma cells against apoptosis","volume":"104","author":"Le Gouill","year":"2004","journal-title":"Blood"},{"key":"10.1074\/mcp.M110.005520_bib22","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1007\/s00018-008-8637-6","article-title":"Mcl-1 is a potential therapeutic target in multiple types of cancer","volume":"66","author":"Akgul","year":"2009","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/mcp.M110.005520_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2174\/156652408783769580","article-title":"Unique biology of Mcl-1: therapeutic opportunities in cancer","volume":"8","author":"Warr","year":"2008","journal-title":"Curr. Mol. Med"},{"key":"10.1074\/mcp.M110.005520_bib24","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1002\/eji.200424981","article-title":"The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells","volume":"34","author":"Gomez-Bougie","year":"2004","journal-title":"Eur. J. Immunol"},{"key":"10.1074\/mcp.M110.005520_bib25","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/sj.onc.1210771","article-title":"Bfl-1\/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist","volume":"27","author":"Simmons","year":"2008","journal-title":"Oncogene"},{"key":"10.1074\/mcp.M110.005520_bib26","doi-asserted-by":"crossref","first-page":"22781","DOI":"10.1074\/jbc.M201469200","article-title":"Bcl-2 Family Member Bfl-1\/A1 Sequesters Truncated Bid to Inhibit Its Collaboration with Pro-apoptotic Bak or Bax","volume":"277","author":"Werner","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M110.005520_bib27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0092-8674(00)81589-5","article-title":"Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors","volume":"94","author":"Luo","year":"1998","journal-title":"Cell"},{"key":"10.1074\/mcp.M110.005520_bib28","first-page":"290","article-title":"The Fanconi Anemia\/BRCA signaling pathway: disruption in cisplatin-sensitive ovarian cancers","volume":"2","author":"D'Andrea","year":"2003","journal-title":"Cell Cycle"},{"key":"10.1074\/mcp.M110.005520_bib29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrg2159","article-title":"Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins","volume":"8","author":"Wang","year":"2007","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/mcp.M110.005520_bib30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mrfmmm.2009.02.003","article-title":"Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights","volume":"668","author":"Thompson","year":"2009","journal-title":"Mutat. Res"},{"key":"10.1074\/mcp.M110.005520_bib31","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1182\/blood.V100.1.224","article-title":"Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma","volume":"100","author":"Spanswick","year":"2002","journal-title":"Blood"},{"key":"10.1074\/mcp.M110.005520_bib32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrc2342","article-title":"DNA repair pathways as targets for cancer therapy","volume":"8","author":"Helleday","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/mcp.M110.005520_bib33","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3324\/haematol.11435","article-title":"Melphalan-induced DNA damage in vitro as a predictor for clinical outcome in multiple myeloma","volume":"92","author":"Dimopoulos","year":"2007","journal-title":"Haematologica"},{"key":"10.1074\/mcp.M110.005520_bib34","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00109-006-0153-2","article-title":"The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents","volume":"85","author":"Chen","year":"2007","journal-title":"J. Mol. Med"},{"key":"10.1074\/mcp.M110.005520_bib35","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1021\/ac00220a026","article-title":"Fast atom bombardment mass spectrometric quantitative analysis of methionine-enkephalin in human pituitary tissues","volume":"62","author":"Kusmierz","year":"1990","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M110.005520_bib36","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/clinchem\/42.10.1676","article-title":"Isotope dilution\u2013mass spectrometric quantification of specific proteins: model application with apolipoprotein A-I","volume":"42","author":"Barr","year":"1996","journal-title":"Clin. Chem"},{"key":"10.1074\/mcp.M110.005520_bib37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1074\/mcp.M500331-MCP200","article-title":"Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins","volume":"5","author":"Anderson","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M110.005520_bib38","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1074\/mcp.M800540-MCP200","article-title":"Multiple reaction monitoring-based, multiplexed, absolute quantitation of 45 proteins in human plasma","volume":"8","author":"Kuzyk","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M110.005520_bib39","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1074\/mcp.M700354-MCP200","article-title":"Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution","volume":"6","author":"Keshishian","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M110.005520_bib40","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nbt1235","article-title":"Protein biomarker discovery and validation: the long and uncertain path to clinical utility","volume":"24","author":"Rifai","year":"2006","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/mcp.M110.005520_bib41","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1021\/pr070202v","article-title":"Integrated pipeline for mass spectrometry-based discovery and confirmation of biomarkers demonstrated in a mouse model of breast cancer","volume":"6","author":"Whiteaker","year":"2007","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M110.005520_bib42","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.chroma.2007.03.058","article-title":"Development of an absolute quantification method targeting growth hormone biomarkers using liquid chromatography coupled to isotope dilution mass spectrometry","volume":"1153","author":"Kirsch","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"10.1074\/mcp.M110.005520_bib43","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/pmic.200300670","article-title":"Quantification of C-reactive protein in the serum of patients with rheumatoid arthritis using multiple reaction monitoring mass spectrometry and 13C-labeled peptide standards","volume":"4","author":"Kuhn","year":"2004","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M110.005520_bib44","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1021\/pr049963d","article-title":"Absolute quantification of the model biomarker prostate-specific antigen in serum by LC-MS\/MS using protein cleavage and isotope dilution mass spectrometry","volume":"3","author":"Barnidge","year":"2004","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M110.005520_bib45","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1021\/pr1005197","article-title":"Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometry","volume":"9","author":"Chen","year":"2010","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M110.005520_bib46","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1073\/pnas.0608638104","article-title":"Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks","volume":"104","author":"Wolf-Yadlin","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M110.005520_bib47","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1021\/pr901063t","article-title":"Quantitative analysis of proteome coverage and recovery rates for upstream fractionation methods in proteomics","volume":"9","author":"Fang","year":"2010","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M110.005520_bib48","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1021\/pr901072h","article-title":"Workflow comparison for label-free, quantitative secretome proteomics for cancer biomarker discovery: method evaluation, differential analysis, and verification in serum","volume":"9","author":"Piersma","year":"2010","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M110.005520_bib49","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1021\/pr900927y","article-title":"Comparison of extensive protein fractionation and repetitive LC-MS\/MS analyses on depth of analysis for complex proteomes","volume":"9","author":"Wang","year":"2010","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M110.005520_bib50","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1128\/MCB.19.3.1720","article-title":"Correlation between protein and mRNA abundance in yeast","volume":"19","author":"Gygi","year":"1999","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/mcp.M110.005520_bib51","first-page":"1297","article-title":"Profiling core proteomes of human cell lines by one-dimensional PAGE and liquid chromatography-tandem mass spectrometry","volume":"2","author":"Schirle","year":"2003","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/mcp.M110.005520_bib52","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1021\/ac026154+","article-title":"Absolute quantification of the G protein-coupled receptor rhodopsin by LC\/MS\/MS using proteolysis product peptides and synthetic peptide standards","volume":"75","author":"Barnidge","year":"2003","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M110.005520_bib53","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ymeth.2004.08.018","article-title":"The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modifications","volume":"35","author":"Kirkpatrick","year":"2005","journal-title":"Methods"},{"key":"10.1074\/mcp.M110.005520_bib54","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.1073\/pnas.0832254100","article-title":"Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS","volume":"100","author":"Gerber","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M110.005520_bib55","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1021\/ac035286f","article-title":"Absolute quantification of proteins in solutions and in polyacrylamide gels by mass spectrometry","volume":"79","author":"Havlis","year":"2004","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M110.005520_bib56","first-page":"316","article-title":"Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis","volume":"9","author":"Alas","year":"2003","journal-title":"Clin. Cancer Res"},{"key":"10.1074\/mcp.M110.005520_bib57","first-page":"4262","article-title":"Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells","volume":"7","author":"Oshiro","year":"2001","journal-title":"Clin. Cancer Res"},{"key":"10.1074\/mcp.M110.005520_bib58","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1021\/pr801028b","article-title":"Expediting the development of targeted SRM assays: using data from shotgun proteomics to automate method development","volume":"8","author":"Prakash","year":"2009","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M110.005520_bib59","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","article-title":"Skyline: an open source document editor for creating and analyzing targeted proteomics experiments","volume":"26","author":"MacLean","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M110.005520_bib60","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1126\/science.286.5445.1735","article-title":"Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity","volume":"286","author":"Bouillet","year":"1999","journal-title":"Science"},{"key":"10.1074\/mcp.M110.005520_bib61","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1038\/sj.onc.1207648","article-title":"Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage","volume":"23","author":"Michels","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/mcp.M110.005520_bib62","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1074\/mcp.M110.005520_bib63","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1074\/jbc.M008944200","article-title":"Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route","volume":"276","author":"Stoka","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M110.005520_bib64","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1128\/MCB.22.9.3003-3013.2002","article-title":"Calpain-mediated bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis","volume":"22","author":"Mandic","year":"2002","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/mcp.M110.005520_bib65","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1084\/jem.192.10.1391","article-title":"Granzyme B\u2013mediated cytochrome C release is regulated by the Bcl-2 family members Bid and Bax","volume":"192","author":"Heibein","year":"2000","journal-title":"J. Exp. Med"},{"key":"10.1074\/mcp.M110.005520_bib66","article-title":"A database of reaction monitoring mass spectrometry assays for elucidating therapeutic response in cancer","volume":"7","author":"Remily-Wood","year":"2011","journal-title":"Proteomics Clin. Appl"},{"key":"10.1074\/mcp.M110.005520_bib67","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/gb-2003-4-9-117","article-title":"Comparing protein abundance and mRNA expression levels on a genomic scale","volume":"4","author":"Greenbaum","year":"2003","journal-title":"Genome Biol"},{"key":"10.1074\/mcp.M110.005520_bib68","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1200\/JCO.2008.19.1916","article-title":"Gene expression profiles of tumor biology provide a novel approach to prognosis and may guide the selection of therapeutic targets in multiple myeloma","volume":"27","author":"Anguiano","year":"2009","journal-title":"J. Clin. Oncol"},{"key":"10.1074\/mcp.M110.005520_bib69","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/sj.leu.2404612","article-title":"Expression and mutation status of candidate kinases in multiple myeloma","volume":"21","author":"Claudio","year":"2007","journal-title":"Leukemia"},{"key":"10.1074\/mcp.M110.005520_bib70","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.ejca.2005.12.026","article-title":"Signalling and survival pathways in multiple myeloma","volume":"42","author":"Bommert","year":"2006","journal-title":"Eur. J. Cancer"},{"key":"10.1074\/mcp.M110.005520_bib71","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/bmt.2009.335","article-title":"Genetic polymorphisms associated with outcome in multiple myeloma patients receiving high-dose melphalan","volume":"45","author":"Dumontet","year":"2010","journal-title":"Bone Marrow Transplant"},{"key":"10.1074\/mcp.M110.005520_bib72","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00277-009-0831-6","article-title":"Reversal of multidrug resistance by curcumin through FA\/BRCA pathway in multiple myeloma cell line MOLP-2\/R","volume":"89","author":"Xiao","year":"2010","journal-title":"Ann. Hematol"},{"key":"10.1074\/mcp.M110.005520_bib73","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1476-4598-8-133","article-title":"Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors","volume":"8","author":"Landais","year":"2009","journal-title":"Mol. Cancer"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620301006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620301006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M110.005520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:15:32Z","timestamp":1761524132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620301006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":73,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S1535947620301006"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m110.005520","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monitoring a Nuclear Factor-\u03baB Signature of Drug Resistance in Multiple Myeloma","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M110.005520","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"M110.005520"}}