{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:36:25Z","timestamp":1788600985759,"version":"build-2803163510"},"reference-count":63,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":3290,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1074\/mcp.m111.008748","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T17:59:35Z","timestamp":1308333575000},"page":"M111.008748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Integrated Transcriptional and Proteomic Analysis with In Vitro Biochemical Assay Reveal the Important Role of CYP3A46 in T-2 Toxin Hydroxylation in Porcine Primary Hepatocytes"],"prefix":"10.1016","volume":"10","author":[{"given":"Jianshe","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangbai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M111.008748_bib1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1128\/mr.57.3.595-604.1993","article-title":"Trichothecene biosynthesis in Fusarium species: Chemistry, genetics, and significance","volume":"57","author":"Desjardins","year":"1993","journal-title":"Microbiol. Rev"},{"key":"10.1074\/mcp.M111.008748_bib2","article-title":"Opinion of the Scientific Committee on Food on Fusarium Toxins Part 5: T-2 Toxin and HT-2 Toxin","author":"EU","year":"2001","journal-title":"Scientific Committee on Food (SCF)"},{"key":"10.1074\/mcp.M111.008748_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0378-4347(87)80058-0","article-title":"Metabolism of three trichothecene mycotoxins, T-2 toxin, diacetoxyscirpenol and deoxynivalenol, by bovine rumen microorganisms","volume":"414","author":"Swanson","year":"1987","journal-title":"J. Chromatogr"},{"key":"10.1074\/mcp.M111.008748_bib4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0278-6915(88)90021-X","article-title":"The role of intestinal microflora in the metabolism of trichothecene mycotoxins","volume":"26","author":"Swanson","year":"1988","journal-title":"Food Chem. Toxicol"},{"key":"10.1074\/mcp.M111.008748_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/03602539308993978","article-title":"Metabolism and pharmacokinetics of T-2 toxin and related trichothecenes","volume":"25","author":"Yagen","year":"1993","journal-title":"Drug Metab. Rev"},{"key":"10.1074\/mcp.M111.008748_bib6","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1021\/jf051501c","article-title":"Determination of 12 type A and B trichothecenes in cereals by liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"53","author":"Kl\u00f6tzel","year":"2005","journal-title":"J. Agric. Food Chem"},{"key":"10.1074\/mcp.M111.008748_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11046-005-0199-7","article-title":"Natural occurrence of 16 Fusarium toxins in grains and feed stuffs of plant origin from Germany","volume":"161","author":"Schollenberger","year":"2006","journal-title":"Mycopathologia"},{"key":"10.1074\/mcp.M111.008748_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0378-4274(03)00116-4","article-title":"Trichothecenes in the environment: Relevance to human health","volume":"143","author":"Sudakin","year":"2003","journal-title":"Toxicol. Lett"},{"key":"10.1074\/mcp.M111.008748_bib9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.anifeedsci.2003.08.008","article-title":"Toxicological evaluation of trichothecenes in animal feed","volume":"114","author":"Eriksen","year":"2004","journal-title":"Anim. Feed Sci. Tech"},{"key":"10.1074\/mcp.M111.008748_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2478\/10004-1254-59-2008-1843","article-title":"T-2 toxin: Incidence and toxicity in poultry","volume":"59","author":"Sokolovi\u0107","year":"2008","journal-title":"Arh. Hig. Rada. Toksikol"},{"key":"10.1074\/mcp.M111.008748_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.toxlet.2004.04.045","article-title":"Report from SCOOP task 3.2.10 \u201ccollection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states\u201d Subtask: Trichothecenes","volume":"153","author":"Schothorst","year":"2004","journal-title":"Toxicol. Lett"},{"key":"10.1074\/mcp.M111.008748_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.toxlet.2004.04.023","article-title":"Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes unraveling a paradox","volume":"153","author":"Pestka","year":"2004","journal-title":"Toxicol. Lett"},{"key":"10.1074\/mcp.M111.008748_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1439-0442.1994.tb00070.x","article-title":"Protective effect of antioxidants against free radical-mediated lipid peroxidation induced by DON or T-2 toxin","volume":"41","author":"Rizzo","year":"1994","journal-title":"Zentralbl Veterinarmed A"},{"key":"10.1074\/mcp.M111.008748_bib14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.taap.2006.08.007","article-title":"T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral broncholitis","volume":"217","author":"Li","year":"2006","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1074\/mcp.M111.008748_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0041-008X(88)90233-5","article-title":"Alteration of multiple cell membrane functions in L-6 myoblasts by T-2 toxin: An important mechanism of action","volume":"92","author":"Bunner","year":"1988","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1074\/mcp.M111.008748_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11046-004-7321-0","article-title":"Immunopathological effect of the mycotoxins cyclopiazonic acid and T-2 toxin on broiler chicken","volume":"159","author":"Kamalavenkatesh","year":"2005","journal-title":"Mycopathologia"},{"key":"10.1074\/mcp.M111.008748_bib17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tox.2008.08.020","article-title":"Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells","volume":"254","author":"Bouaziz","year":"2008","journal-title":"Toxicology"},{"key":"10.1074\/mcp.M111.008748_bib18","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0041-0101(86)90180-7","article-title":"Metabolism of T-2 mycotoxin by cultured cells","volume":"24","author":"Trusal","year":"1986","journal-title":"Toxicon"},{"key":"10.1074\/mcp.M111.008748_bib19","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1021\/jf00071a027","article-title":"Disposition of T-2 toxin, a trichothecene mycotoxin, in intravascularly dosed swine","volume":"34","author":"Corley","year":"1986","journal-title":"J. Agric. Food Chem"},{"key":"10.1074\/mcp.M111.008748_bib20","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1128\/am.27.2.423-424.1974","article-title":"In vitro metabolism of T-2 toxin","volume":"27","author":"Ellison","year":"1974","journal-title":"Appl. Microbiol"},{"key":"10.1074\/mcp.M111.008748_bib21","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/oxfordjournals.jbchem.a131854","article-title":"Metabolism of trichothecene mycotoxins I","volume":"82","author":"Ohta","year":"1977","journal-title":"J. Biochem"},{"key":"10.1074\/mcp.M111.008748_bib22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3109\/03602530903125807","article-title":"Metabolic pathways of trichothecenes","volume":"42","author":"Wu","year":"2010","journal-title":"Drug Metab. Rev"},{"key":"10.1074\/mcp.M111.008748_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tifs.2009.08.002","article-title":"Chemical and biological transformations for detoxification of trichothecene mycotoxins in human and animal food chains: A review","volume":"21","author":"He","year":"2010","journal-title":"Trends in Food Sci. Technol"},{"key":"10.1074\/mcp.M111.008748_bib24","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0168-8278(99)80049-X","article-title":"Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: Comparison with other hepatic cellular models","volume":"31","author":"Donato","year":"1999","journal-title":"J. Hepatol"},{"key":"10.1074\/mcp.M111.008748_bib25","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1586\/14789450.2.5.767","article-title":"Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology","volume":"2","author":"Heijne","year":"2005","journal-title":"Expert Rev. Proteomics"},{"key":"10.1074\/mcp.M111.008748_bib26","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1074\/mcp.M800561-MCP200","article-title":"Proteomics identification of azaspiracid toxin biomarkers in blue mussels, Mytilus edulis","volume":"8","author":"Nzoughet","year":"2009","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/mcp.M111.008748_bib27","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1074\/mcp.M300122-MCP200","article-title":"Proteomic study for the cellular responses to Cd2+ in Schizosaccharomyces pombe through amino acid-coded mass tagging and liquid chromatography tandem mass spectrometry","volume":"3","author":"Bae","year":"2004","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/mcp.M111.008748_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0091-679X(08)61797-5","article-title":"Preparation of isolated rat liver cells","volume":"13","author":"Seglen","year":"1976","journal-title":"Methods Cell Biol"},{"key":"10.1074\/mcp.M111.008748_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.catcom.2010.08.003","article-title":"The catalytic activity of cytochrome P450 3A22 is critical for the metabolism of T-2 toxin in porcine reservoirs","volume":"12","author":"Ge","year":"2010","journal-title":"Catal. Comm"},{"key":"10.1074\/mcp.M111.008748_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1074\/mcp.M111.008748_bib31","first-page":"21","article-title":"Cytochrome P450 Protocols, 2nd Edition","volume":"320","author":"Phillips","year":"2005","journal-title":"Methods in Molecular Biology"},{"key":"10.1074\/mcp.M111.008748_bib32","doi-asserted-by":"crossref","first-page":"10817","DOI":"10.1073\/pnas.89.22.10817","article-title":"High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein","volume":"89","author":"Fisher","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M111.008748_bib33","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/nprot.2009.122","article-title":"Chromatographic assays of drug oxidation by human cytochrome P450 3A4","volume":"4","author":"Sohl","year":"2009","journal-title":"Nat. Protoc"},{"key":"10.1074\/mcp.M111.008748_bib34","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.catcom.2010.12.031","article-title":"CYP3As catalyze nifedipine oxidation in pig liver microsomes: Enzyme kinetics, inhibition and functional expression","volume":"12","author":"Jiang","year":"2011","journal-title":"Catal. Comm"},{"key":"10.1074\/mcp.M111.008748_bib35","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1093\/bioinformatics\/btg290","article-title":"Pathway studio-the analysis and navigation of molecular networks","volume":"19","author":"Nikitin","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M111.008748_bib36","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0168-8278(97)80454-0","article-title":"Tissue inhibitor of metalloproteinase-1 in the liver of patients with chronic liver disease","volume":"26","author":"Murawaki","year":"1997","journal-title":"J. Hepatol"},{"key":"10.1074\/mcp.M111.008748_bib37","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.4049\/jimmunol.166.7.4737","article-title":"Reduced early alcohol-induced liver injury in CD14-deficient mice","volume":"166","author":"Yin","year":"2001","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M111.008748_bib38","first-page":"909","article-title":"Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice","volume":"38","author":"Sass","year":"2003","journal-title":"Hepatology"},{"key":"10.1074\/mcp.M111.008748_bib39","doi-asserted-by":"crossref","first-page":"G902","DOI":"10.1152\/ajpgi.00124.2006","article-title":"Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis","volume":"291","author":"Yang","year":"2006","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol"},{"key":"10.1074\/mcp.M111.008748_bib40","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev.pharmtox.38.1.389","article-title":"In vitro and in vivo drug interactions involving human CYP3A","volume":"38","author":"Thummel","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"10.1074\/mcp.M111.008748_bib41","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0021-9673(01)94171-8","article-title":"Analysis of some metabolites of T-2 toxin, diacetoxyscirpenol and deoxynivalenol, by thermospray high-performance liquid chromatography-mass spectrometry","volume":"394","author":"Voyksner","year":"1987","journal-title":"J. Chromatogr"},{"key":"10.1074\/mcp.M111.008748_bib42","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1128\/aem.39.6.1172-1177.1980","article-title":"T-2 metabolites in the excreta of broiler chickens administered 3H-labeled T-2 toxin","volume":"38","author":"Yoshizawa","year":"1980","journal-title":"Appl. Environ. Microb"},{"key":"10.1074\/mcp.M111.008748_bib43","first-page":"479","article-title":"Natural occurrence of mycotoxins in foods and feeds: An updated review","volume":"149","author":"Pittet","year":"1998","journal-title":"Rev. Med. Vet"},{"key":"10.1074\/mcp.M111.008748_bib44","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.tox.2009.01.012","article-title":"Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture","volume":"258","author":"K\u00f6nigs","year":"2009","journal-title":"Toxicology"},{"key":"10.1074\/mcp.M111.008748_bib45","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1074\/mcp.M200008-MCP200","article-title":"Discordant protein and mRNA expression in lung adenocarcinomas","volume":"1","author":"Chen","year":"2002","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/mcp.M111.008748_bib46","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1074\/mcp.M200001-MCP200","article-title":"Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae","volume":"1","author":"Griffin","year":"2002","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/mcp.M111.008748_bib47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tox.2009.06.002","article-title":"Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells","volume":"262","author":"Chaudhari","year":"2009","journal-title":"Toxicology"},{"key":"10.1074\/mcp.M111.008748_bib48","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3109\/03602530903125807","article-title":"Metabolic pathways of trichothecenes","volume":"42","author":"Wu","year":"2010","journal-title":"Drug Metab. Rev"},{"key":"10.1074\/mcp.M111.008748_bib49","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0278-6915(87)90206-7","article-title":"The cytochrome P-450-dependent hydroxylation of T-2 toxin in various animal species","volume":"25","author":"Kobayashi","year":"1987","journal-title":"Food Chem. Toxicol"},{"key":"10.1074\/mcp.M111.008748_bib50","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0278-6915(89)90158-0","article-title":"Comparative effects of T-2 toxin and diacetoxyscirpenol on drug metabolizing enzymes in rat tissues","volume":"27","author":"Galtier","year":"1989","journal-title":"Food Chem. Toxicol"},{"key":"10.1074\/mcp.M111.008748_bib51","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1080\/02652030050207819","article-title":"The effects of T-2 toxin exposure on liver drug metabolizing enzymes in rabbit","volume":"17","author":"Guerre","year":"2000","journal-title":"Food Addit. Contam"},{"key":"10.1074\/mcp.M111.008748_bib52","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tox.2008.02.003","article-title":"Subclinical doses of T-2 toxin impair acquired immune response and liver cytochrome P450 in pigs","volume":"247","author":"Meissonnier","year":"2008","journal-title":"Toxicology"},{"key":"10.1074\/mcp.M111.008748_bib53","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/oxfordjournals.jbchem.a132175","article-title":"Metabolism of trichothecene mycotoxins II","volume":"84","author":"Ohta","year":"1978","journal-title":"J. Biochem"},{"key":"10.1074\/mcp.M111.008748_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pharmtox.39.1.1","article-title":"Cytochrome P-450 3A4: Regulation and role in drug metabolism","volume":"39","author":"Guengerich","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"10.1074\/mcp.M111.008748_bib55","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1172\/JCI33435","article-title":"Knockout of cytochrome p450 3a yields new mouse models for understanding xenobiotic metabolism","volume":"117","author":"van Herwaarden","year":"2007","journal-title":"J. Clin. Invest"},{"key":"10.1074\/mcp.M111.008748_bib56","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1006\/bbrc.2001.4505","article-title":"Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43","volume":"281","author":"Westlind","year":"2001","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/mcp.M111.008748_bib57","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1124\/dmd.32.4.376","article-title":"Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs","volume":"32","author":"Sakuma","year":"2004","journal-title":"Drug Metab. Dispos"},{"key":"10.1074\/mcp.M111.008748_bib58","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1126\/science.1099736","article-title":"Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone","volume":"305","author":"Williams","year":"2004","journal-title":"Science"},{"key":"10.1074\/mcp.M111.008748_bib59","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1046\/j.1365-2052.1998.00225.x","article-title":"Mapping of porcine genes belonging to two different cytochrome P450 subfamilies","volume":"29","author":"Nissen","year":"1998","journal-title":"Anim. Genet"},{"key":"10.1074\/mcp.M111.008748_bib60","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/0006-2952(86)90111-5","article-title":"Metabolism of T-2 toxin by rat liver carboxylesterase","volume":"35","author":"Johnsen","year":"1986","journal-title":"Biochem. Pharmacol"},{"key":"10.1074\/mcp.M111.008748_bib61","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/molecules13020412","article-title":"Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs","volume":"13","author":"Hosokawa","year":"2008","journal-title":"Molecules"},{"key":"10.1074\/mcp.M111.008748_bib62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/aem.50.1.115-119.1985","article-title":"Modification of in vitro metabolism of T-2 toxin by esterase inhibitors","volume":"50","author":"Wei","year":"1985","journal-title":"Appl. Environ. Microbiol"},{"key":"10.1074\/mcp.M111.008748_bib63","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fct.2006.07.028","article-title":"Degradation of trichothecene mycotoxins by chicken intestinal microbes","volume":"45","author":"Young","year":"2007","journal-title":"Food Chem. Toxicol"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620301626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620301626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M111.008748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:14:04Z","timestamp":1761524044000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620301626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":63,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S1535947620301626"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m111.008748","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated Transcriptional and Proteomic Analysis with In Vitro Biochemical Assay Reveal the Important Role of CYP3A46 in T-2 Toxin Hydroxylation in Porcine Primary Hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M111.008748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"M111.008748"}}