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Pathol."},{"key":"10.1074\/mcp.M111.015529_bib81","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0140-6736(88)91894-6","article-title":"Primary biliary cirrhosis: Identification of two major M2 mitochondrial autoantigens","volume":"1","author":"Yeaman","year":"1988","journal-title":"Lancet"},{"key":"10.1074\/mcp.M111.015529_bib82","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1084\/jem.172.3.961","article-title":"Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis","volume":"172","author":"Courvalin","year":"1990","journal-title":"J. Exp. Med."},{"key":"10.1074\/mcp.M111.015529_bib83","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.4049\/jimmunol.145.12.4338","article-title":"Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis","volume":"145","author":"Szostecki","year":"1990","journal-title":"J. Immunol."},{"key":"10.1074\/mcp.M111.015529_bib84","doi-asserted-by":"crossref","first-page":"29198","DOI":"10.1074\/jbc.271.46.29198","article-title":"Identification and characterization of a leukocyte-specific component of the nuclear body","volume":"271","author":"Bloch","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/mcp.M111.015529_bib85","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.3748\/wjg.v16.i29.3616","article-title":"Primary biliary cirrhosis: What do autoantibodies tell us?","volume":"16","author":"Hu","year":"2010","journal-title":"World J. 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