{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T16:29:25Z","timestamp":1787416165618,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":2841,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1074\/mcp.m112.018713","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:33:58Z","timestamp":1348187638000},"page":"1885-1897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Identification of New Autoantigens by Protein Array Indicates a Role for IL4 Neutralization in Autoimmune Hepatitis"],"prefix":"10.1016","volume":"11","author":[{"given":"Chiara","family":"Zingaretti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Arig\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Cardaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Moro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacristina","family":"Crosti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Sinisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Sugliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cheroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Marabita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Nogarotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul Jean Pierre","family":"Bonnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Marcatili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Marconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalinda","family":"Zignego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Muratori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Invernizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Colombatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizia","family":"Brunetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferruccio","family":"Bonino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"De Francesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Geginat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Muratori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Abrignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Bombaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M112.018713_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jaut.2007.07.010","article-title":"Naturally occurring B-cell autoreactivity: a critical overview","volume":"29","author":"Avrameas","year":"2007","journal-title":"J. Autoimmun."},{"key":"10.1074\/mcp.M112.018713_bib2","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1056\/NEJMra021194","article-title":"Thyroiditis","volume":"348","author":"Pearce","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/mcp.M112.018713_bib3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1053\/j.gastro.2010.04.053","article-title":"Advances in the diagnosis, pathogenesis, and management of autoimmune hepatitis","volume":"139","author":"Czaja","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1074\/mcp.M112.018713_bib4","first-page":"390916","article-title":"Autoimmune hepatitis: a review of current diagnosis and treatment","volume":"2011","author":"Makol","year":"2011","journal-title":"Hepat. Res. Treat."},{"key":"10.1074\/mcp.M112.018713_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1055\/s-2007-979469","article-title":"Interpreting serological tests in diagnosing autoimmune liver diseases","volume":"27","author":"Invernizzi","year":"2007","journal-title":"Semin. Liver Dis."},{"key":"10.1074\/mcp.M112.018713_bib6","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.3748\/wjg.14.3374","article-title":"Autoimmune liver serology: current diagnostic and clinical challenges","volume":"14","author":"Bogdanos","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1074\/mcp.M112.018713_bib7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jhep.2004.08.002","article-title":"Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group","volume":"41","author":"Vergani","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1074\/mcp.M112.018713_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/hep.22322","article-title":"Simplified criteria for the diagnosis of autoimmune hepatitis","volume":"48","author":"Hennes","year":"2008","journal-title":"Hepatology"},{"key":"10.1074\/mcp.M112.018713_bib9","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/hep.21583","article-title":"A sensitive bead assay for antimitochondrial antibodies: chipping away at AMA-negative primary biliary cirrhosis","volume":"45","author":"Oertelt","year":"2007","journal-title":"Hepatology"},{"key":"10.1074\/mcp.M112.018713_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1740-2557-1-2","article-title":"Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease","volume":"1","author":"Zachou","year":"2004","journal-title":"J. Autoimmune Dis."},{"key":"10.1074\/mcp.M112.018713_bib11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1021\/pr900131e","article-title":"Novel autoimmune hepatitis-specific autoantigens identified using protein microarray technology","volume":"9","author":"Song","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1074\/mcp.M112.018713_bib12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jprot.2011.08.018","article-title":"A novel polyclonal antibody library for expression profiling of poorly characterized, membrane and secreted human proteins","volume":"75","author":"Grifantini","year":"2011","journal-title":"J. Proteomics"},{"key":"10.1074\/mcp.M112.018713_bib13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0076-6879(06)11009-5","article-title":"TM4 microarray software suite","volume":"411","author":"Saeed","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1074\/mcp.M112.018713_bib14","doi-asserted-by":"crossref","first-page":"e6332","DOI":"10.1371\/journal.pone.0006332","article-title":"Protein array profiling of tic patient sera reveals a broad range and enhanced immune response against Group A Streptococcus antigens","volume":"4","author":"Bombaci","year":"2009","journal-title":"PLoS One"},{"key":"10.1074\/mcp.M112.018713_bib15","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1056\/NEJMoa0903068","article-title":"Identification of a novel antibody associated with autoimmune pancreatitis","volume":"361","author":"Frulloni","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/mcp.M112.018713_bib16","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1073\/pnas.082099299","article-title":"Diagnosis of multiple cancer types by shrunken centroids of gene expression","volume":"99","author":"Tibshirani","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/mcp.M112.018713_bib17","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1093\/bioinformatics\/bti623","article-title":"ROCR: visualizing classifier performance in R","volume":"21","author":"Sing","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M112.018713_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM197807062990101","article-title":"Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis","volume":"299","author":"Jensen","year":"1978","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/mcp.M112.018713_bib19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/08916939908994768","article-title":"Detection of anti-LKM-1(anti-CYP2D6) by an enzyme-linked immunosorbent assay in adult patients with chronic liver diseases","volume":"30","author":"Miyakawa","year":"1999","journal-title":"Autoimmunity"},{"key":"10.1074\/mcp.M112.018713_bib20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.immunol.17.1.701","article-title":"The IL-4 receptor: signaling mechanisms and biologic functions","volume":"17","author":"Nelms","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/mcp.M112.018713_bib21","doi-asserted-by":"crossref","first-page":"7456","DOI":"10.4049\/jimmunol.176.12.7456","article-title":"IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets","volume":"176","author":"Andrews","year":"2006","journal-title":"J. Immunol."},{"key":"10.1074\/mcp.M112.018713_bib22","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.289.5485.1760","article-title":"Printing proteins as microarrays for high-throughput function determination","volume":"289","author":"MacBeath","year":"2000","journal-title":"Science"},{"key":"10.1074\/mcp.M112.018713_bib23","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.016253","article-title":"Rapid identification of monospecific monoclonal antibodies using a human proteome microarray","volume":"11","author":"Jeong","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M112.018713_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2249.2002.01960.x","article-title":"Distinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis","volume":"130","author":"Al-Bukhari","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"10.1074\/mcp.M112.018713_bib25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0896-8411(03)00082-9","article-title":"Linear epitopes of two different autoantigens\u2014La\/SSB and myelin basic protein\u2014with a high degree of molecular similarity, cause different humoral immune responses","volume":"21","author":"Terzoglou","year":"2003","journal-title":"J. Autoimmun."},{"key":"10.1074\/mcp.M112.018713_bib26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.biophys.33.110502.140348","article-title":"Disease-related misassembly of membrane proteins","volume":"33","author":"Sanders","year":"2004","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1074\/mcp.M112.018713_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/10408360500523837","article-title":"Autoantibodies to intracellular autoantigens and their B-cell epitopes: molecular probes to study the autoimmune response","volume":"43","author":"Routsias","year":"2006","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1074\/mcp.M112.018713_bib28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1046\/j.1365-2249.1998.00690.x","article-title":"IL-4: role in disease and regulation of production","volume":"113","author":"Choi","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"10.1074\/mcp.M112.018713_bib29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.immuni.2008.03.001","article-title":"Th17 cell differentiation: the long and winding road","volume":"28","author":"McGeachy","year":"2008","journal-title":"Immunity"},{"key":"10.1074\/mcp.M112.018713_bib30","doi-asserted-by":"crossref","first-page":"e18909","DOI":"10.1371\/journal.pone.0018909","article-title":"Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression","volume":"6","author":"Zhao","year":"2011","journal-title":"PLoS One"},{"key":"10.1074\/mcp.M112.018713_bib31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1172\/JCI119878","article-title":"GAD-reactive CD4+ Th1 cells induce diabetes in NOD\/SCID mice","volume":"101","author":"Zekzer","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1074\/mcp.M112.018713_bib32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/PL00000207","article-title":"Reduced hepatic ischemia\/reperfusion injury by IL-4: potential anti-inflammatory role of STAT6","volume":"49","author":"Kato","year":"2000","journal-title":"Inflamm. Res."},{"key":"10.1074\/mcp.M112.018713_bib33","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0002-9440(10)65208-X","article-title":"IL-13 activates STAT6 and inhibits liver injury induced by ischemia\/reperfusion","volume":"155","author":"Yoshidome","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1074\/mcp.M112.018713_bib34","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/labinvest.2008.61","article-title":"Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway","volume":"88","author":"Aoudjehane","year":"2008","journal-title":"Lab. Invest."},{"key":"10.1074\/mcp.M112.018713_bib35","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.4049\/jimmunol.171.6.3233","article-title":"Crucial role of IL-4\/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes","volume":"171","author":"Jaruga","year":"2003","journal-title":"J. Immunol."},{"key":"10.1074\/mcp.M112.018713_bib36","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1126\/science.8085155","article-title":"An interleukin-4-induced transcription factor: IL-4 Stat","volume":"265","author":"Hou","year":"1994","journal-title":"Science"},{"key":"10.1074\/mcp.M112.018713_bib37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/jmbi.2001.5243","article-title":"The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters","volume":"315","author":"Zhang","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1074\/mcp.M112.018713_bib38","series-title":"Handbook of Mathematics and Computational Science.","author":"Harris","year":"1998"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620334782?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620334782?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M112.018713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:51:14Z","timestamp":1761526274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620334782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1535947620334782"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m112.018713","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of New Autoantigens by Protein Array Indicates a Role for IL4 Neutralization in Autoimmune Hepatitis","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M112.018713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}