{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:19:18Z","timestamp":1775078358511,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":2668,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1074\/mcp.m112.025031","type":"journal-article","created":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T20:14:47Z","timestamp":1365711287000},"page":"1965-1979","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Protein Sets Define Disease States and Predict In Vivo Effects of Drug Treatment"],"prefix":"10.1016","volume":"12","author":[{"given":"David","family":"Meierhofer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Weidner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludger","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes A.","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Ting","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank C.","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M112.025031_bib1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1126\/science.1124619","article-title":"Mass spectrometry and protein analysis","volume":"312","author":"Domon","year":"2006","journal-title":"Science"},{"key":"10.1074\/mcp.M112.025031_bib2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrmicro2243","article-title":"Mass spectrometry tools for the classification and identification of bacteria","volume":"8","author":"Sauer","year":"2010","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1074\/mcp.M112.025031_bib3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nchembio736","article-title":"Mass spectrometry-based proteomics turns quantitative","volume":"1","author":"Ong","year":"2005","journal-title":"Nat. Chem. Biol"},{"key":"10.1074\/mcp.M112.025031_bib4","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1038\/nprot.2006.427","article-title":"A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)","volume":"1","author":"Ong","year":"2006","journal-title":"Nat. Protoc"},{"key":"10.1074\/mcp.M112.025031_bib5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1021\/pr900435z","article-title":"The effects of rosiglitazone and high glucose on protein expression in endothelial cells","volume":"9","author":"Millioni","year":"2010","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M112.025031_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/oby.2009.208","article-title":"Proteomic Analysis of Human Adipose Tissue After Rosiglitazone Treatment Shows Coordinated Changes to Promote Glucose Uptake","volume":"18","author":"Ahmed","year":"2010","journal-title":"Obesity"},{"key":"10.1074\/mcp.M112.025031_bib7","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1073\/pnas.0609836104","article-title":"Large-scale phosphorylation analysis of mouse liver","volume":"104","author":"Vill\u00e9n","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M112.025031_bib8","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.cell.2010.12.001","article-title":"A tissue-specific atlas of mouse protein phosphorylation and expression","volume":"143","author":"Huttlin","year":"2010","journal-title":"Cell"},{"key":"10.1074\/mcp.M112.025031_bib9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2008.05.033","article-title":"SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function","volume":"134","author":"Kr\u00fcger","year":"2008","journal-title":"Cell"},{"key":"10.1074\/mcp.M112.025031_bib10","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1056\/NEJMcibr1012075","article-title":"Rosiglitazone, PPARgamma, and type 2 diabetes","volume":"363","author":"Kahn","year":"2010","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/mcp.M112.025031_bib11","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.1116971109","article-title":"Amorfrutins are potent antidiabetic dietary natural products","volume":"109","author":"Weidner","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M112.025031_bib12","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nmeth.1647","article-title":"Large-scale phosphosite quantification in tissues by a spike-in SILAC method","volume":"8","author":"Monetti","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.M112.025031_bib13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-1-59745-188-8_21","article-title":"Tandem affinity purification combined with mass spectrometry to identify components of protein complexes","volume":"439","author":"Kaiser","year":"2008","journal-title":"Methods Mol. Biol"},{"key":"10.1074\/mcp.M112.025031_bib14","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/nprot.2008.150","article-title":"The SCX\/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry","volume":"3","author":"Vill\u00e9n","year":"2008","journal-title":"Nat. Protoc"},{"key":"10.1074\/mcp.M112.025031_bib15","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1021\/pr900748n","article-title":"Combination of FASP and StageTip-based fractionation allows in-depth analysis of the hippocampal membrane proteome","volume":"8","author":"Wi\u015bniewski","year":"2009","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M112.025031_bib16","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nprot.2009.36","article-title":"A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics","volume":"4","author":"Cox","year":"2009","journal-title":"Nat. Protoc"},{"key":"10.1074\/mcp.M112.025031_bib17","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1074\/mcp.M800588-MCP200","article-title":"Large-scale proteomics analysis of the human kinome","volume":"8","author":"Oppermann","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M112.025031_bib18","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M112.025031_bib19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0092-8674(03)00926-7","article-title":"Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria","volume":"115","author":"Mootha","year":"2003","journal-title":"Cell"},{"key":"10.1074\/mcp.M112.025031_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2105-11-121","article-title":"Mayday\u2013integrative analytics for expression data","volume":"11","author":"Battke","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/mcp.M112.025031_bib21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2144\/03342mt01","article-title":"TM4: a free, open-source system for microarray data management and analysis","volume":"34","author":"Saeed","year":"2003","journal-title":"BioTechniques"},{"key":"10.1074\/mcp.M112.025031_bib22","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"10.1074\/mcp.M112.025031_bib23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/msb.2009.98","article-title":"A side effect resource to capture phenotypic effects of drugs","volume":"6","author":"Kuhn","year":"2010","journal-title":"Mol. Syst. Biol"},{"key":"10.1074\/mcp.M112.025031_bib24","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/bioinformatics\/btp026","article-title":"KEA: kinase enrichment analysis","volume":"25","author":"Lachmann","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M112.025031_bib25","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/0003-9861(69)90231-8","article-title":"The circular dichroism of glucagon solutions","volume":"129","author":"Srere","year":"1969","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/mcp.M112.025031_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0009-8981(94)90055-8","article-title":"Biochemical and molecular investigations in respiratory chain deficiencies","volume":"228","author":"Rustin","year":"1994","journal-title":"Clin. Chim. Acta"},{"key":"10.1074\/mcp.M112.025031_bib27","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1203\/01.pdr.0000127016.67809.6b","article-title":"Reduced respiratory control with ADP and changed pattern of respiratory chain enzymes as a result of selective deficiency of the mitochondrial ATP synthase","volume":"55","author":"Mayr","year":"2004","journal-title":"Pediatr. Res"},{"key":"10.1074\/mcp.M112.025031_bib28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1074\/mcp.M900020-MCP200","article-title":"Proteome, phosphoproteome, and hydroxyproteome of liver mitochondria in diabetic rats at early pathogenic stages","volume":"9","author":"Deng","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M112.025031_bib29","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/pmic.200900412","article-title":"Pathway analysis of dilated cardiomyopathy using global proteomic profiling and enrichment maps","volume":"10","author":"Isserlin","year":"2010","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M112.025031_bib30","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1074\/mcp.M110.000398","article-title":"In situ proteomic analysis of human breast cancer epithelial cells using laser capture microdissection: annotation by protein set enrichment analysis and gene ontology","volume":"9","author":"Cha","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M112.025031_bib31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.325_256","article-title":"Insulin resistance. Prosperity's plague","volume":"325","author":"Taubes","year":"2009","journal-title":"Science"},{"key":"10.1074\/mcp.M112.025031_bib32","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1172\/JCI1326","article-title":"Bidirectional modulation of insulin action by amino acids","volume":"101","author":"Patti","year":"1998","journal-title":"J. Clin. Invest"},{"key":"10.1074\/mcp.M112.025031_bib33","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrc1015","article-title":"Does the ribosome translate cancer?","volume":"3","author":"Ruggero","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/mcp.M112.025031_bib34","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrc3214","article-title":"The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention","volume":"12","author":"Peters","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/mcp.M112.025031_bib35","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1056\/NEJMp1008233","article-title":"Revisiting the rosiglitazone story\u2013lessons learned","volume":"363","author":"Rosen","year":"2010","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/mcp.M112.025031_bib36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2337\/diabetes.48.3.609","article-title":"Hemodynamic basis for the acute cardiac effects of troglitazone in isolated perfused rat hearts","volume":"48","author":"Shimoyama","year":"1999","journal-title":"Diabetes"},{"key":"10.1074\/mcp.M112.025031_bib37","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1161\/HYPERTENSIONAHA.111.186593","article-title":"Blood pressure response to controlled diesel exhaust exposure in human subjects","volume":"59","author":"Cosselman","year":"2012","journal-title":"Hypertension"},{"key":"10.1074\/mcp.M112.025031_bib38","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.2337\/diabetes.50.8.1844","article-title":"Nonalcoholic fatty liver disease: a feature of the metabolic syndrome","volume":"50","author":"Marchesini","year":"2001","journal-title":"Diabetes"},{"key":"10.1074\/mcp.M112.025031_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2165\/00128071-200809010-00002","article-title":"Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases","volume":"9","author":"Sertznig","year":"2008","journal-title":"Am. J. Clin. Dermatol"},{"key":"10.1074\/mcp.M112.025031_bib40","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ejhg.2011.96","article-title":"An atlas of tissue-specific conserved coexpression for functional annotation and disease gene prediction","volume":"19","author":"Piro","year":"2011","journal-title":"Eur. J. Hum. Genet"},{"key":"10.1074\/mcp.M112.025031_bib41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0092-8674(95)90411-5","article-title":"Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death","volume":"80","author":"Yang","year":"1995","journal-title":"Cell"},{"key":"10.1074\/mcp.M112.025031_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1097-2765(05)00012-2","article-title":"14\u20133-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation","volume":"6","author":"Datta","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1074\/mcp.M112.025031_bib43","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1093\/nar\/gkt034","article-title":"Genome-wide analysis of LXRalpha activation reveals new transcriptional networks in human atherosclerotic foam cells","volume":"41","author":"Feldmann","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M112.025031_bib44","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1074\/mcp.M111.011015","article-title":"Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer","volume":"10","author":"Michalski","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M112.025031_bib45","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nmeth.1584","article-title":"mProphet: automated data processing and statistical validation for large-scale SRM experiments","volume":"8","author":"Reiter","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.M112.025031_bib46","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrg1618","article-title":"Miniaturization in functional genomics and proteomics","volume":"6","author":"Sauer","year":"2005","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/mcp.M112.025031_bib47","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ng.2383","article-title":"Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes","volume":"44","author":"Morris","year":"2012","journal-title":"Nat. Genet"}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620325639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620325639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M112.025031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:39:04Z","timestamp":1761525544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620325639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S1535947620325639"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m112.025031","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protein Sets Define Disease States and Predict In Vivo Effects of Drug Treatment","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M112.025031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2013 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}