{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T19:11:27Z","timestamp":1775589087542,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":2637,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1074\/mcp.m113.028324","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T05:10:40Z","timestamp":1367471440000},"page":"2126-2135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Metabolomics Reveals That Tumor Xenografts Induce Liver Dysfunction"],"prefix":"10.1016","volume":"12","author":[{"given":"Fei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristopher W.","family":"Krausz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changtao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huichang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia L.","family":"Sowers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M113.028324_bib1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/tx800464q","article-title":"Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity","volume":"22","author":"Chen","year":"2009","journal-title":"Chem. Res. Toxicol"},{"key":"10.1074\/mcp.M113.028324_bib2","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.bcp.2012.02.013","article-title":"Metabolomics reveals the metabolic map of procainamide in humans and mice","volume":"83","author":"Li","year":"2012","journal-title":"Biochem. Pharmacol"},{"key":"10.1074\/mcp.M113.028324_bib3","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1194\/jlr.M027433","article-title":"Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis","volume":"53","author":"Li","year":"2012","journal-title":"J. Lipid Res"},{"key":"10.1074\/mcp.M113.028324_bib4","doi-asserted-by":"crossref","first-page":"19511","DOI":"10.1074\/jbc.M111.221739","article-title":"Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus","volume":"286","author":"Patterson","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M113.028324_bib5","first-page":"5601","article-title":"Metabolomics analysis for biomarker discovery: advances and challenges","volume":"19","author":"Monteiro","year":"2013","journal-title":"Curr. Med. Chem"},{"key":"10.1074\/mcp.M113.028324_bib6","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nature07762","article-title":"Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression","volume":"457","author":"Sreekumar","year":"2009","journal-title":"Nature"},{"key":"10.1074\/mcp.M113.028324_bib7","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1093\/bioinformatics\/btp558","article-title":"Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification","volume":"25","author":"Nam","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M113.028324_bib8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s11306-011-0302-7","article-title":"Urine metabolite profiling offers potential early diagnosis of oral cancer","volume":"8","author":"Xie","year":"2012","journal-title":"Metabolomics"},{"key":"10.1074\/mcp.M113.028324_bib9","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1007\/s00216-011-5245-3","article-title":"Identification of serum biomarkers of hepatocarcinoma through liquid chromatography\/mass spectrometry-based metabonomic method","volume":"401","author":"Chen","year":"2011","journal-title":"Anal. Bioanal. Chem"},{"key":"10.1074\/mcp.M113.028324_bib10","article-title":"Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma","volume":"10","author":"Chen","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M113.028324_bib11","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1021\/pr201001a","article-title":"Distinct urinary metabolic profile of human colorectal cancer","volume":"11","author":"Cheng","year":"2012","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M113.028324_bib12","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1158\/0008-5472.CAN-11-3105","article-title":"Kidney tumor biomarkers revealed by simultaneous multiple matrix metabolomics analysis","volume":"72","author":"Ganti","year":"2012","journal-title":"Cancer Res"},{"key":"10.1074\/mcp.M113.028324_bib13","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1016\/j.jchromb.2011.06.018","article-title":"Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice","volume":"879","author":"Li","year":"2011","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci"},{"key":"10.1074\/mcp.M113.028324_bib14","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1088\/0031-9155\/56\/3\/002","article-title":"Tumour xenograft detection through quantitative analysis of the metabolic profile of urine in mice","volume":"56","author":"Moroz","year":"2011","journal-title":"Phys. Med. Biol"},{"key":"10.1074\/mcp.M113.028324_bib15","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1002\/ijc.25294","article-title":"A metabonomic approach to chemosensitivity prediction of cisplatin plus 5-fluorouracil in a human xenograft model of gastric cancer","volume":"127","author":"Wang","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1074\/mcp.M113.028324_bib16","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1158\/1078-0432.CCR-07-0662","article-title":"Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging","volume":"13","author":"Cotrim","year":"2007","journal-title":"Clin. Cancer Res"},{"key":"10.1074\/mcp.M113.028324_bib17","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1210\/me.2007-0150","article-title":"Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation","volume":"21","author":"Zhen","year":"2007","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/mcp.M113.028324_bib18","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/s10545-008-9976-z","article-title":"Detection of urinary hexanoylglycine in the diagnosis of MCAD deficiency from newborn screening","volume":"31","author":"Downing","year":"2008","journal-title":"J. Inherit. Metab. Dis"},{"issue":"Suppl 1","key":"10.1074\/mcp.M113.028324_bib19","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1177\/1358836X0501000104","article-title":"Asymmetric dimethylarginine (ADMA) and cardiovascular disease: insights from prospective clinical trials","volume":"10","author":"Boger","year":"2005","journal-title":"Vasc. Med"},{"key":"10.1074\/mcp.M113.028324_bib20","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1152\/ajpregu.90506.2008","article-title":"Asymmetric dimethylarginine, oxidative stress, and vascular nitric oxide synthase in essential hypertension","volume":"296","author":"Wang","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol"},{"key":"10.1074\/mcp.M113.028324_bib21","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.atherosclerosis.2010.11.014","article-title":"Time course of asymmetric dimethylarginine (ADMA) and oxidative stress in fructose-hypertensive rats: a model related to metabolic syndrome","volume":"214","author":"Korandji","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1074\/mcp.M113.028324_bib22","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.4161\/cc.9.17.12721","article-title":"The autophagic tumor stroma model of cancer: role of oxidative stress and ketone production in fueling tumor cell metabolism","volume":"9","author":"Pavlides","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1074\/mcp.M113.028324_bib23","doi-asserted-by":"crossref","first-page":"17992","DOI":"10.1073\/pnas.1008260107","article-title":"Tumors induce complex DNA damage in distant proliferative tissues in vivo","volume":"107","author":"Redon","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M113.028324_bib24","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1080\/15287394.2010.511545","article-title":"Toxicometabolomics of urinary biomarkers for human gastric cancer in a mouse model","volume":"73","author":"Kim","year":"2010","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1074\/mcp.M113.028324_bib25","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1021\/pr200800w","article-title":"Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues","volume":"10","author":"Somashekar","year":"2011","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M113.028324_bib26","first-page":"149","article-title":"Carbon-13 magnetic resonance spectroscopy of glucose metabolism in SCC-VII tumors","volume":"15","author":"Furusawa","year":"1997","journal-title":"Radiat. Med"},{"key":"10.1074\/mcp.M113.028324_bib27","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/mrm.24355","article-title":"EPR oxygen imaging and hyperpolarized (13) C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate","volume":"69","author":"Matsumoto","year":"2013","journal-title":"Magn. Reson. Med"},{"key":"10.1074\/mcp.M113.028324_bib28","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/ng.223","article-title":"Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle","volume":"40","author":"Hartong","year":"2008","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.M113.028324_bib29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nm0311-291","article-title":"Metabolism unhinged: IDH mutations in cancer","volume":"17","author":"Prensner","year":"2011","journal-title":"Nat. Med"},{"key":"10.1074\/mcp.M113.028324_bib30","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1021\/ac701807v","article-title":"UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation","volume":"80","author":"Patterson","year":"2008","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M113.028324_bib31","doi-asserted-by":"crossref","first-page":"7085","DOI":"10.1038\/sj.onc.1204903","article-title":"Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?","volume":"20","author":"Lorimore","year":"2001","journal-title":"Oncogene"},{"key":"10.1074\/mcp.M113.028324_bib32","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3109\/03602539709002246","article-title":"Regulation of cytochromes P450 during inflammation and infection","volume":"29","author":"Morgan","year":"1997","journal-title":"Drug Metab. Rev"},{"key":"10.1074\/mcp.M113.028324_bib33","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/clpt.2008.55","article-title":"Inflammation and altered drug clearance in cancer: transcriptional repression of a human CYP3A4 transgene in tumor-bearing mice","volume":"83","author":"Robertson","year":"2008","journal-title":"Clin. Pharmacol. Ther"},{"key":"10.1074\/mcp.M113.028324_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.bjc.6604101","article-title":"Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies","volume":"98","author":"Sharma","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1074\/mcp.M113.028324_bib35","doi-asserted-by":"crossref","first-page":"24784","DOI":"10.1074\/jbc.M111.329318","article-title":"Abcb11 deficiency induces cholestasis coupled to impaired beta-fatty acid oxidation in mice","volume":"287","author":"Zhang","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M113.028324_bib36","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/excr.1999.4702","article-title":"Bioactive lysophospholipids and their G protein-coupled receptors","volume":"253","author":"Moolenaar","year":"1999","journal-title":"Exp. Cell Res"},{"key":"10.1074\/mcp.M113.028324_bib37","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/hep.24193","article-title":"Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice","volume":"53","author":"Matsubara","year":"2011","journal-title":"Hepatology"}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620325263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620325263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M113.028324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:40:05Z","timestamp":1761525605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620325263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S1535947620325263"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m113.028324","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics Reveals That Tumor Xenografts Induce Liver Dysfunction","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M113.028324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2013 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}