{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:23:59Z","timestamp":1792185839848,"version":"4.4.0"},"reference-count":111,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":2321,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1074\/mcp.m113.029538","type":"journal-article","created":{"date-parts":[[2014,3,8]],"date-time":"2014-03-08T20:54:14Z","timestamp":1394312054000},"page":"1299-1317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Quantitative Proteomics of the Neisseria Gonorrhoeae Cell Envelope and Membrane Vesicles for the Discovery of Potential Therapeutic Targets"],"prefix":"10.1016","volume":"13","author":[{"given":"Ryszard A.","family":"Zielke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor H.","family":"Wierzbicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob V.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Gafken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra E.","family":"Sikora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M113.029538_bib1","first-page":"253","article-title":"Emergence and spread of multi-drug resistant Neisseria gonorrhoeae","volume":"8","author":"Lusti-Narasimhan","year":"2011","journal-title":"J. Sex. Med"},{"key":"10.1074\/mcp.M113.029538_bib2","first-page":"1","article-title":"Summary of notifiable diseases\u2013United States, 2006","volume":"55","author":"McNabb","year":"2008","journal-title":"MMWR Morb. Mortal. Wkly Rep"},{"key":"10.1074\/mcp.M113.029538_bib3","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1128\/CMR.17.4.965-981.2004","article-title":"The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women","volume":"17","author":"Edwards","year":"2004","journal-title":"Clin. Microbiol. Rev"},{"key":"10.1074\/mcp.M113.029538_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/sti.75.1.3","article-title":"From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection","volume":"75","author":"Fleming","year":"1999","journal-title":"Sex. Transm. Infect"},{"key":"10.1074\/mcp.M113.029538_bib5","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2010","volume":"59","author":"Workowski","year":"2010","journal-title":"MMWR Recomm. Rep"},{"key":"10.1074\/mcp.M113.029538_bib6","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3201\/eid1308.060948","article-title":"Threat to cefixime treatment for gonorrhea","volume":"13","author":"Yokoi","year":"2007","journal-title":"Emerg. Infect. Dis"},{"key":"10.1074\/mcp.M113.029538_bib7","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/sti.2010.042317","article-title":"Recommended antimicrobial treatment of uncomplicated gonorrhoea in 2009 in 11 East European countries: implementation of a Neisseria gonorrhoeae antimicrobial susceptibility programme in this region is crucial","volume":"86","author":"Unemo","year":"2010","journal-title":"Sex. Transm. Infect"},{"key":"10.1074\/mcp.M113.029538_bib8","doi-asserted-by":"crossref","DOI":"10.2807\/ese.16.14.19833-en","article-title":"Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010","volume":"16","author":"Ison","year":"2011","journal-title":"Euro. Surveill"},{"key":"10.1074\/mcp.M113.029538_bib9","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1517\/14656566.2012.690396","article-title":"The use of cephalosporins for gonorrhea: an update on the rising problem of resistance","volume":"13","author":"Stoltey","year":"2012","journal-title":"Expert opin. Pharmaco"},{"key":"10.1074\/mcp.M113.029538_bib10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fmicb.2011.00124","article-title":"Vaccines for gonorrhea: can we rise to the challenge?","volume":"2","author":"Zhu","year":"2011","journal-title":"Front. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib11","series-title":"Neisseria gonorrhoeae","first-page":"32","article-title":"Global action plan to control the spread and impact of antimicrobial resistance","author":"Organization","year":"2012"},{"key":"10.1074\/mcp.M113.029538_bib12","article-title":"Gonorrhea Treatment Guildlines","author":"Prevention","year":"2013","journal-title":"PMCID"},{"key":"10.1074\/mcp.M113.029538_bib13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/mdr.2012.0001","article-title":"The lytic transglycosylases of Neisseria gonorrhoeae","volume":"18","author":"Chan","year":"2012","journal-title":"Microb. Drug. Resist"},{"key":"10.1074\/mcp.M113.029538_bib14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrmicro2097","article-title":"Pathogenic Neisseriae: surface modulation, pathogenesis and infection control","volume":"7","author":"Virji","year":"2009","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2217\/17460913.3.3.287","article-title":"Identification and characterization of gonococcal iron transport systems as potential vaccine antigens","volume":"3","author":"Cornelissen","year":"2008","journal-title":"Future Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/MMBR.00031-09","article-title":"Virulence and immunomodulatory roles of bacterial outer membrane vesicles","volume":"74","author":"Ellis","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev"},{"key":"10.1074\/mcp.M113.029538_bib17","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1365-2958.1992.tb01522.x","article-title":"The interaction of naturally elaborated blebs from serum-susceptible and serum-resistant strains of Neisseria gonorrhoeae with normal human serum","volume":"6","author":"Pettit","year":"1992","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib18","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1365-2958.1992.tb01521.x","article-title":"Characterization of naturally elaborated blebs from serum-susceptible and serum-resistant strains of Neisseria gonorrhoeae","volume":"6","author":"Pettit","year":"1992","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.micro.091208.073413","article-title":"Biological functions and biogenesis of secreted bacterial outer membrane vesicles","volume":"64","author":"Kulp","year":"2010","journal-title":"Annu. Rev. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib20","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1056\/NEJM198506273122606","article-title":"Gonococcal infection: a model of molecular pathogenesis","volume":"312","author":"Britigan","year":"1985","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/mcp.M113.029538_bib21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/mas.20175","article-title":"Proteomics in gram-negative bacterial outer membrane vesicles","volume":"27","author":"Lee","year":"2008","journal-title":"Mass Spectrom. Rev"},{"key":"10.1074\/mcp.M113.029538_bib22","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1128\/IAI.73.4.1964-1970.2005","article-title":"Biofilm Formation by Neisseria gonorrhoeae","volume":"73","author":"Greiner","year":"2005","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib23","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1086\/593336","article-title":"Gonococcal cervicitis: a role for biofilm in pathogenesis","volume":"198","author":"Steichen","year":"2008","journal-title":"J. Infect. Dis"},{"key":"10.1074\/mcp.M113.029538_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fmicb.2011.00075","article-title":"The composition and metabolic phenotype of Neisseria gonorrhoeae biofilms","volume":"2","author":"Falsetta","year":"2011","journal-title":"Front. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib25","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1128\/iai.55.6.1359-1364.1987","article-title":"Induction and repression of outer membrane proteins by anaerobic growth of Neisseria gonorrhoeae","volume":"55","author":"Clark","year":"1987","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib26","first-page":"851","article-title":"Influence of iron-limited and replete continuous culture on the physiology and virulence of Neisseria gonorrhoeae","volume":"135","author":"Keevil","year":"1989","journal-title":"J. Gen. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib27","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1348-0421.2007.tb04012.x","article-title":"Comparative proteome analysis of the outer membrane proteins of in vitro-induced multi-drug resistant Neisseria gonorrhoeae","volume":"51","author":"Yoo","year":"2007","journal-title":"Microbiol. Immunol"},{"key":"10.1074\/mcp.M113.029538_bib28","doi-asserted-by":"crossref","first-page":"e38303","DOI":"10.1371\/journal.pone.0038303","article-title":"Proteomic analysis of Neisseria gonorrhoeae biofilms shows shift to anaerobic respiration and changes in nutrient transport and outermembrane proteins","volume":"7","author":"Phillips","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/mcp.M113.029538_bib29","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1128\/iai.15.2.560-567.1977","article-title":"In vitro interaction of Neisseria gonorrhoeae type 1 and type 4 with tissue culture cells","volume":"15","author":"Brodeur","year":"1977","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/infdis\/169.3.532","article-title":"Human experimentation with Neisseria gonorrhoeae: rationale, methods, and implications for the biology of infection and vaccine development","volume":"169","author":"Cohen","year":"1994","journal-title":"J. Infect. Dis"},{"key":"10.1074\/mcp.M113.029538_bib31","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1128\/jb.96.3.596-605.1968","article-title":"Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 months in vitro","volume":"96","author":"Kellogg","year":"1968","journal-title":"J. Bacteriol"},{"key":"10.1074\/mcp.M113.029538_bib32","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1084\/jem.137.3.571","article-title":"Studies on gonococcus infection. IV. Pili: their role in attachment of gonococci to tissue culture cells","volume":"137","author":"Swanson","year":"1973","journal-title":"J. Exp. Med"},{"key":"10.1074\/mcp.M113.029538_bib33","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1128\/iai.33.2.555-564.1981","article-title":"Ability of Neisseria gonorrhoeae Neisseria meningitidis, and commensal Neisseria species to obtain iron from transferrin and iron compounds","volume":"33","author":"Mickelsen","year":"1981","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib34","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1128\/jb.85.6.1274-1279.1963","article-title":"Neisseria gonorrhoeae. I. Virulence Genetically Linked to Clonal Variation","volume":"85","author":"Kellogg","year":"1963","journal-title":"J. Bacteriol"},{"key":"10.1074\/mcp.M113.029538_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/9780471729259.mc04a01s8","article-title":"Laboratory maintenance of Neisseria gonorrhoeae","author":"Spence","year":"2008","journal-title":"Curr. Protoc. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib36","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3181\/00379727-145-38025","article-title":"Factors affecting autolysis of Neisseria gonorrhoeae","volume":"145","author":"Morse","year":"1974","journal-title":"Proc. Soc. Exp. Biol. Med"},{"key":"10.1074\/mcp.M113.029538_bib37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/iai.46.1.176-181.1984","article-title":"Anaerobic growth of Neisseria gonorrhoeae coupled to nitrite reduction","volume":"46","author":"Knapp","year":"1984","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib38","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1365-2958.2010.07481.x","article-title":"The Neisseria gonorrhoeae photolyase orthologue phrB is required for proper DNA supercoiling but does not function in photo-reactivation","volume":"79","author":"Cahoon","year":"2011","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib39","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1365-2958.2004.04040.x","article-title":"Proteomic screening and identification of differentially distributed membrane proteins in Escherichia coli","volume":"52","author":"Lai","year":"2004","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib40","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1046\/j.1432-1327.2000.01296.x","article-title":"Proteomic analysis of the Escherichia coli outer membrane","volume":"267","author":"Molloy","year":"2000","journal-title":"Eur. J. Biochem"},{"key":"10.1074\/mcp.M113.029538_bib41","doi-asserted-by":"crossref","first-page":"16555","DOI":"10.1074\/jbc.M110.211078","article-title":"Proteomic analysis of the Vibrio cholerae type II secretome reveals new proteins, including three related serine proteases","volume":"286","author":"Sikora","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M113.029538_bib42","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0076-6879(06)11009-5","article-title":"TM4 microarray software suite","volume":"411","author":"Saeed","year":"2006","journal-title":"Methods Enzymol"},{"key":"10.1074\/mcp.M113.029538_bib43","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/bioinformatics\/bti057","article-title":"PSORTb v. 2.0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis","volume":"21","author":"Gardy","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M113.029538_bib44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.6026\/97320630002417","article-title":"SOSUI-GramN: high performance prediction for sub-cellular localization of proteins in gram-negative bacteria","volume":"2","author":"Imai","year":"2008","journal-title":"Bioinformation"},{"key":"10.1074\/mcp.M113.029538_bib45","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1110\/ps.03479604","article-title":"Predicting subcellular localization of proteins for Gram-negative bacteria by support vector machines based on n-peptide compositions","volume":"13","author":"Yu","year":"2004","journal-title":"Protein Sci"},{"key":"10.1074\/mcp.M113.029538_bib46","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/prot.21018","article-title":"Prediction of protein subcellular localization","volume":"64","author":"Yu","year":"2006","journal-title":"Proteins"},{"key":"10.1074\/mcp.M113.029538_bib47","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.M113.029538_bib48","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/1471-2105-6-167","article-title":"Prediction of twin-arginine signal peptides","volume":"6","author":"Bendtsen","year":"2005","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/mcp.M113.029538_bib49","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1126\/science.278.5338.631","article-title":"A genomic perspective on protein families","volume":"278","author":"Tatusov","year":"1997","journal-title":"Science"},{"key":"10.1074\/mcp.M113.029538_bib50","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-12-444","article-title":"WebMGA: a customizable web server for fast metagenomic sequence analysis","volume":"12","author":"Wu","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1074\/mcp.M113.029538_bib51","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-1119(89)90359-4","article-title":"Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension","volume":"77","author":"Horton","year":"1989","journal-title":"Gene"},{"key":"10.1074\/mcp.M113.029538_bib52","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1128\/IAI.71.11.6279-6291.2003","article-title":"Low-level pilin expression allows for substantial DNA transformation competence in Neisseria gonorrhoeae","volume":"71","author":"Long","year":"2003","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib53","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1128\/jb.184.4.919-927.2002","article-title":"Roles of the recJ and recN genes in homologous recombination and DNA repair pathways of Neisseria gonorrhoeae","volume":"184","author":"Skaar","year":"2002","journal-title":"J. Bacteriol"},{"key":"10.1074\/mcp.M113.029538_bib54","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1128\/jb.175.18.5899-5906.1993","article-title":"Nonpolar mutagenesis of the ipa genes defines IpaB IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells","volume":"175","author":"Menard","year":"1993","journal-title":"J. Bacteriol"},{"key":"10.1074\/mcp.M113.029538_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/9780471729259.mc04a02s23","article-title":"Genetic manipulation of Neisseria gonorrhoeae","author":"Dillard","year":"2011","journal-title":"Curr. Protoc. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib56","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1006\/jmbi.2001.5251","article-title":"Crystal structure of the soluble domain of the major anaerobically induced outer membrane protein (AniA) from pathogenic Neisseria: a new class of copper-containing nitrite reductases","volume":"315","author":"Boulanger","year":"2002","journal-title":"J. Mol. Biol"},{"key":"10.1074\/mcp.M113.029538_bib57","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1128\/iai.56.2.499-504.1988","article-title":"Selection and immunochemical analysis of lipooligosaccharide mutants of Neisseria gonorrhoeae","volume":"56","author":"Dudas","year":"1988","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib58","first-page":"13","article-title":"Immunological basis of serum resistance of Neisseria gonorrhoeae","volume":"128","author":"Schneider","year":"1982","journal-title":"J. Gen. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib59","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1084\/jem.165.5.1344","article-title":"Gonococcal pilin variants in experimental gonorrhea","volume":"165","author":"Swanson","year":"1987","journal-title":"J. Exp. Med"},{"key":"10.1074\/mcp.M113.029538_bib60","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1046\/j.1365-2958.1998.00710.x","article-title":"The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteers","volume":"27","author":"Cornelissen","year":"1998","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fmicb.2011.00123","article-title":"Experimental gonococcal infection in male volunteers: cumulative experience with Neisseria gonorrhoeae strains FA1090 and MS11mkC","volume":"2","author":"Hobbs","year":"2011","journal-title":"Front. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib62","unstructured":"Neisseria gonorrhoeae group Sequencing Project, Broad Institute of Harvard and MIT (http:\/\/www.broadinstitute.org\/)."},{"key":"10.1074\/mcp.M113.029538_bib63","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1074\/mcp.M112.024711","article-title":"The Escherichia coli peripheral inner membrane proteome","volume":"12","author":"Papanastasiou","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M113.029538_bib64","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1128\/jb.171.5.2499-2505.1989","article-title":"Export and intercellular transfer of DNA via membrane blebs of Neisseria gonorrhoeae","volume":"171","author":"Dorward","year":"1989","journal-title":"J. Bacteriol"},{"key":"10.1074\/mcp.M113.029538_bib65","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/jb.119.1.250-257.1974","article-title":"Isolation and characterization of the outer membrane of Neisseria gonorrhoeae","volume":"119","author":"Johnston","year":"1974","journal-title":"J. Bacteriol"},{"key":"10.1074\/mcp.M113.029538_bib66","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1128\/iai.36.1.277-283.1982","article-title":"Purification and partial characterization of the major outer membrane protein of Neisseria gonorrhoeae","volume":"36","author":"Blake","year":"1982","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib67","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1002\/pmic.200800273","article-title":"Bacterial membrane proteomics","volume":"8","author":"Poetsch","year":"2008","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M113.029538_bib68","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1074\/mcp.M400129-MCP200","article-title":"Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents","volume":"3","author":"Ross","year":"2004","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M113.029538_bib69","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1128\/MMBR.68.2.207-233.2004","article-title":"Proteomics of protein secretion by Bacillus subtilis: separating the \u201csecrets\u201d of the secretome","volume":"68","author":"Tjalsma","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev"},{"key":"10.1074\/mcp.M113.029538_bib70","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1002\/pmic.201000823","article-title":"The cell surface proteome of Staphylococcus aureus","volume":"11","author":"Dreisbach","year":"2011","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M113.029538_bib71","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1002\/pmic.200900338","article-title":"Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles","volume":"9","author":"Lee","year":"2009","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M113.029538_bib72","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1002\/pmic.201000212","article-title":"Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa","volume":"11","author":"Choi","year":"2011","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M113.029538_bib73","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1002\/pmic.200700196","article-title":"Global proteomic profiling of native outer membrane vesicles derived from Escherichia coli","volume":"7","author":"Lee","year":"2007","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M113.029538_bib74","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1074\/mcp.M700295-MCP200","article-title":"Proteomics characterization of outer membrane vesicles from the extraintestinal pathogenic Escherichia coli \u0394tolR IHE3034 mutant","volume":"7","author":"Berlanda Scorza","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M113.029538_bib75","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1016\/j.vaccine.2006.03.013","article-title":"Proteomic analysis of Neisseria lactamica and Neisseria meningitidis outer membrane vesicle vaccine antigens","volume":"24","author":"Vaughan","year":"2006","journal-title":"Vaccine"},{"key":"10.1074\/mcp.M113.029538_bib76","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4161\/hv.5.5.7367","article-title":"Proteomic study via a non-gel based approach of meningococcal outer membrane vesicle vaccine obtained from strain CU385: a road map for discovering new antigens","volume":"5","author":"Gil","year":"2009","journal-title":"Hum. Vaccines"},{"key":"10.1074\/mcp.M113.029538_bib77","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/pr070192y","article-title":"Proteomic analysis of microvesicles derived from human colorectal cancer cells","volume":"6","author":"Choi","year":"2007","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M113.029538_bib78","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1365-2958.2005.04859.x","article-title":"Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis\/trans isomerase (PPIase) activity and is involved in persistence in macrophages","volume":"58","author":"Leuzzi","year":"2005","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib79","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1128\/IAI.73.4.2222-2231.2005","article-title":"Function of neisserial outer membrane phospholipase a in autolysis and assessment of its vaccine potential","volume":"73","author":"Bos","year":"2005","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib80","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev-biochem-061408-144611","article-title":"\u03b2-barrel membrane protein assembly by the Bam complex","volume":"80","author":"Hagan","year":"2011","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/mcp.M113.029538_bib81","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.micro.61.080706.093245","article-title":"Biogenesis of the gram-negative bacterial outer membrane","volume":"61","author":"Bos","year":"2007","journal-title":"Annu. Rev. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib82","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1046\/j.1365-2958.1996.457984.x","article-title":"A novel peptidoglycan-linked lipoprotein (ComL) that functions in natural transformation competence of Neisseria gonorrhoeae","volume":"19","author":"Fussenegger","year":"1996","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib83","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1365-2958.2007.05745.x","article-title":"Identification of a new OmpA-like protein in Neisseria gonorrhoeae involved in the binding to human epithelial cells and in vivo colonization","volume":"64","author":"Serino","year":"2007","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib84","doi-asserted-by":"crossref","first-page":"11222","DOI":"10.1074\/jbc.M111.338830","article-title":"Neisseria gonorrhoeae virulence factor NG1686 is a bifunctional M23B family metallopeptidase that influences resistance to hydrogen peroxide and colony morphology","volume":"287","author":"Stohl","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M113.029538_bib85","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00399-13","article-title":"Neisseria gonorrhoeae metalloprotease NGO1686 is required for full piliation, and piliation is required for resistance to H2O2- and neutrophil-mediated killing","volume":"4","author":"Stohl","year":"2013","journal-title":"MBio"},{"key":"10.1074\/mcp.M113.029538_bib86","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1128\/JB.00625-13","article-title":"Comparative proteome analysis of spontaneous outer membrane vesicles and purified outer membranes of Neisseria meningitidis","volume":"195","author":"Lappann","year":"2013","journal-title":"J. Bacteriol"},{"key":"10.1074\/mcp.M113.029538_bib87","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.1093\/emboj\/19.20.5332","article-title":"Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells","volume":"19","author":"Muller","year":"2000","journal-title":"EMBO J"},{"key":"10.1074\/mcp.M113.029538_bib88","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1111\/j.1365-2958.2010.07307.x","article-title":"Biochemical and functional characterization of Helicobacter pylori vesicles","volume":"77","author":"Olofsson","year":"2010","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib89","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/325458a0","article-title":"Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease","volume":"325","author":"Pohlner","year":"1987","journal-title":"Nature"},{"key":"10.1074\/mcp.M113.029538_bib90","doi-asserted-by":"crossref","first-page":"38383","DOI":"10.1074\/jbc.M508063200","article-title":"Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B","volume":"280","author":"Post","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M113.029538_bib91","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/pmic.200500164","article-title":"Outer membrane vesicles from group B Neisseria meningitidis \u0394gna33 mutant: proteomic and immunological comparison with detergent-derived outer membrane vesicles","volume":"6","author":"Ferrari","year":"2006","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M113.029538_bib92","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.1128\/IAI.71.10.5576-5582.2003","article-title":"A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection","volume":"71","author":"Jerse","year":"2003","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib93","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1086\/522964","article-title":"Regulation of the MtrC-MtrD-MtrE efflux-pump system modulates the in vivo fitness of Neisseria gonorrhoeae","volume":"196","author":"Warner","year":"2007","journal-title":"J. Infect. Dis"},{"key":"10.1074\/mcp.M113.029538_bib94","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2958.2008.06424.x","article-title":"Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness","volume":"70","author":"Warner","year":"2008","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib95","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1128\/iai.60.11.4695-4703.1992","article-title":"Isolation and nucleotide sequence of the gene (aniA) encoding the major anaerobically induced outer membrane protein of Neisseria gonorrhoeae","volume":"60","author":"Hoehn","year":"1992","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib96","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1128\/iai.60.11.4704-4708.1992","article-title":"The major anaerobically induced outer membrane protein of Neisseria gonorrhoeae, Pan 1, is a lipoprotein","volume":"60","author":"Hoehn","year":"1992","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib97","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbrc.2012.12.132","article-title":"Recombinant truncated AniA of pathogenic Neisseria elicits a non-native immune response and functional blocking antibodies","volume":"431","author":"Shewell","year":"2013","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/mcp.M113.029538_bib98","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1128\/JB.181.2.541-551.1999","article-title":"cis- and trans-acting elements involved in regulation of aniA, the gene encoding the major anaerobically induced outer membrane protein in Neisseria gonorrhoeae","volume":"181","author":"Householder","year":"1999","journal-title":"J. Bacteriol"},{"key":"10.1074\/mcp.M113.029538_bib99","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1046\/j.1365-2958.2002.03091.x","article-title":"Imp\/OstA is required for cell envelope biogenesis in Escherichia coli","volume":"45","author":"Braun","year":"2002","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib100","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nrmicro2184","article-title":"Transport of lipopolysaccharide across the cell envelope: the long road of discovery","volume":"7","author":"Ruiz","year":"2009","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib101","doi-asserted-by":"crossref","first-page":"9417","DOI":"10.1073\/pnas.0402340101","article-title":"Identification of an outer membrane protein required for the transport of lipopolysaccharide to the bacterial cell surface","volume":"101","author":"Bos","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M113.029538_bib102","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1128\/JB.01593-09","article-title":"Genomic content of Neisseria species","volume":"192","author":"Tobiason","year":"2010","journal-title":"J. Bacteriol"},{"key":"10.1074\/mcp.M113.029538_bib103","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/nar\/29.1.123","article-title":"The comprehensive microbial resource","volume":"29","author":"Peterson","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M113.029538_bib104","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0968-0004(03)00115-4","article-title":"The BON domain: a putative membrane-binding domain","volume":"28","author":"Yeats","year":"2003","journal-title":"Trends Biochem. Sci"},{"key":"10.1074\/mcp.M113.029538_bib105","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1365-2958.2005.04906.x","article-title":"Molecular architecture and function of the Omp85 family of proteins","volume":"58","author":"Gentle","year":"2005","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib106","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-2958.1996.tb02568.x","article-title":"Examination of AsmA and its effect on the assembly of Escherichia coli outer membrane proteins","volume":"21","author":"Deng","year":"1996","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib107","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/iai.32.2.547-552.1981","article-title":"Genetics of serum resistance in Neisseria gonorrhoeae: the sac-1 genetic locus","volume":"32","author":"Cannon","year":"1981","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M113.029538_bib108","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1365-2958.1990.tb00673.x","article-title":"Construction of isogenic gonococci with variable porin structure: effects on susceptibility to human serum and antibiotics","volume":"4","author":"Carbonetti","year":"1990","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib109","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1365-2958.2001.02520.x","article-title":"A variable genetic island specific for Neisseria gonorrhoeae is involved in providing DNA for natural transformation and is found more often in disseminated infection isolates","volume":"41","author":"Dillard","year":"2001","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib110","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1046\/j.1365-2958.2003.03496.x","article-title":"Opposing selective forces for expression of the gonococcal lactoferrin receptor","volume":"48","author":"Anderson","year":"2003","journal-title":"Mol. Microbiol"},{"key":"10.1074\/mcp.M113.029538_bib111","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1099\/13500872-141-3-611","article-title":"Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system","volume":"141","author":"Hagman","year":"1995","journal-title":"Microbiology"}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620331042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620331042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M113.029538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:45:22Z","timestamp":1761525922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620331042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":111,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1535947620331042"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m113.029538","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative Proteomics of the Neisseria Gonorrhoeae Cell Envelope and Membrane Vesicles for the Discovery of Potential Therapeutic Targets","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M113.029538","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}