{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:37Z","timestamp":1791404917143,"version":"4.3.3"},"reference-count":114,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":2167,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1074\/mcp.m114.038539","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T03:42:21Z","timestamp":1403581341000},"page":"2527-2544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites"],"prefix":"10.1016","volume":"13","author":[{"given":"Stuart D.","family":"Armstrong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Babayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaly","family":"Lhermitte-Vallarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujai","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Blaxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Wastling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Makepeace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M114.038539_bib1","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1371\/journal.pntd.0000114","article-title":"Measuring the burden of neglected tropical diseases: the global burden of disease framework","volume":"1","author":"Mathers","year":"2007","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038539_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0140-6736(96)11094-1","article-title":"Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection","volume":"350","author":"Gardon","year":"1997","journal-title":"Lancet"},{"key":"10.1074\/mcp.M114.038539_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0065-308X(08)00204-2","article-title":"Heartworm disease in animals and humans","volume":"66","author":"McCall","year":"2008","journal-title":"Adv. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0304-4017(94)90121-X","article-title":"Bovine onchocercosis in north Cameroon","volume":"52","author":"Wahl","year":"1994","journal-title":"Vet. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib5","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/S0140-6736(07)60942-8","article-title":"Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study","volume":"369","author":"Osei-Atweneboana","year":"2007","journal-title":"Lancet"},{"key":"10.1074\/mcp.M114.038539_bib6","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.vetpar.2011.04.012","article-title":"Macrocyclic lactone resistance in Dirofilaria immitis","volume":"181","author":"Bourguinat","year":"2011","journal-title":"Vet. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1128\/CMR.00002-13","article-title":"A comprehensive, model-based review of vaccine and repeat infection trials for filariasis","volume":"26","author":"Morris","year":"2013","journal-title":"Clin. Microbiol. Rev"},{"key":"10.1074\/mcp.M114.038539_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1128\/CMR.00057-10","article-title":"Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment","volume":"24","author":"Tamarozzi","year":"2011","journal-title":"Clin. Microbiol. Rev"},{"key":"10.1074\/mcp.M114.038539_bib9","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1126\/science.1145406","article-title":"Draft genome of the filarial nematode parasite Brugia malayi","volume":"317","author":"Ghedin","year":"2007","journal-title":"Science"},{"key":"10.1074\/mcp.M114.038539_bib10","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1096\/fj.12-205096","article-title":"The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets","volume":"26","author":"Godel","year":"2012","journal-title":"FASEB J"},{"key":"10.1074\/mcp.M114.038539_bib11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng.2585","article-title":"Genomics of Loa loa, a Wolbachia-free filarial parasite of humans","volume":"45","author":"Desjardins","year":"2013","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.M114.038539_bib12","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1371\/journal.pbio.0030121","article-title":"The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode","volume":"3","author":"Foster","year":"2005","journal-title":"PLoS Biol"},{"key":"10.1074\/mcp.M114.038539_bib13","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1101\/gr.138420.112","article-title":"Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis","volume":"22","author":"Darby","year":"2012","journal-title":"Genome Res"},{"key":"10.1074\/mcp.M114.038539_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molbiopara.2008.02.007","article-title":"The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products","volume":"160","author":"Hewitson","year":"2008","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib15","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.1011481108","article-title":"Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia","volume":"108","author":"Bennuru","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/mcp.M114.038539_bib16","doi-asserted-by":"crossref","first-page":"e326","DOI":"10.1371\/journal.pntd.0000326","article-title":"Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products","volume":"2","author":"Moreno","year":"2008","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038539_bib17","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1371\/journal.pntd.0000410","article-title":"Brugia malayi excreted\/secreted proteins at the host\/parasite interface: stage- and gender-specific proteomic profiling","volume":"3","author":"Bennuru","year":"2009","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038539_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1051\/parasite\/1992675144","article-title":"Maturation of the filaria Litomosoides sigmodontis in BALB\/c mice; comparative susceptibility of nine other inbred strains","volume":"67","author":"Petit","year":"1992","journal-title":"Ann. Parasitol. Hum. Comp"},{"key":"10.1074\/mcp.M114.038539_bib19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1051\/parasite\/1989644268","article-title":"[Litomosoides, parasites of rodents; taxonomic consequences]","volume":"64","author":"Bain","year":"1989","journal-title":"Ann. Parasitol. Hum. Comp"},{"key":"10.1074\/mcp.M114.038539_bib20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0169-4758(00)01738-5","article-title":"Litomosoides sigmodontis in mice: reappraisal of an old model for filarial research","volume":"16","author":"Hoffmann","year":"2000","journal-title":"Parasitol. Today"},{"key":"10.1074\/mcp.M114.038539_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0020-7519(01)00350-2","article-title":"Litomosoides sigmodontis cystatin acts as an immunomodulator during experimental filariasis","volume":"32","author":"Pfaff","year":"2002","journal-title":"Int. J. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib22","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.4049\/jimmunol.174.8.4924","article-title":"Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo","volume":"174","author":"Taylor","year":"2005","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M114.038539_bib23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4049\/jimmunol.1100335","article-title":"Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-beta","volume":"188","author":"Hubner","year":"2012","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M114.038539_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1017\/S0031182099005533","article-title":"Parasitology and immunology of mice vaccinated with irradiated Litomosoides sigmodontis larvae","volume":"120","author":"LeGoff","year":"2000","journal-title":"Parasitology"},{"key":"10.1074\/mcp.M114.038539_bib25","doi-asserted-by":"crossref","first-page":"e1968","DOI":"10.1371\/journal.pntd.0001968","article-title":"Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes","volume":"6","author":"Babayan","year":"2012","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038539_bib26","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1093\/gbe\/evt125","article-title":"Phylogenomics and analysis of shared genes suggest a single transition to mutualism in Wolbachia of nematodes","volume":"5","author":"Comandatore","year":"2013","journal-title":"Genome Biol. Evol"},{"key":"10.1074\/mcp.M114.038539_bib27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanhausser","year":"2011","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.038539_bib28","doi-asserted-by":"crossref","first-page":"D1063","DOI":"10.1093\/nar\/gks1262","article-title":"The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013","volume":"41","author":"Vizcaino","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M114.038539_bib29","series-title":"R: A Language and Environment for Statistical Computing","year":"2013"},{"key":"10.1074\/mcp.M114.038539_bib30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"10.1074\/mcp.M114.038539_bib31","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nprot.2009.2","article-title":"Protein structure prediction on the Web: a case study using the Phyre server","volume":"4","author":"Kelley","year":"2009","journal-title":"Nat. Protoc"},{"key":"10.1074\/mcp.M114.038539_bib32","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gki442","article-title":"InterProScan: protein domains identifier","volume":"33","author":"Quevillon","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M114.038539_bib33","doi-asserted-by":"crossref","first-page":"e36911","DOI":"10.1371\/journal.pone.0036911","article-title":"VENNTURE\u2013a novel Venn diagram investigational tool for multiple pharmacological dataset analysis","volume":"7","author":"Martin","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/mcp.M114.038539_bib34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.M114.038539_bib35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/protein\/gzh037","article-title":"Feature-based prediction of non-classical and leaderless protein secretion","volume":"17","author":"Bendtsen","year":"2004","journal-title":"Protein Eng. Des. Sel"},{"key":"10.1074\/mcp.M114.038539_bib36","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1432-1033.1996.00779.x","article-title":"Computational method to predict mitochondrially imported proteins and their targeting sequences","volume":"241","author":"Claros","year":"1996","journal-title":"Eur. J. Biochem"},{"key":"10.1074\/mcp.M114.038539_bib37","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/emboj.2013.79","article-title":"Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology","volume":"32","author":"Steentoft","year":"2013","journal-title":"EMBO J"},{"key":"10.1074\/mcp.M114.038539_bib38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/protein\/gzh013","article-title":"Prediction of proprotein convertase cleavage sites","volume":"17","author":"Duckert","year":"2004","journal-title":"Protein Eng. Des. Sel"},{"key":"10.1074\/mcp.M114.038539_bib39","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature10553","article-title":"Ascaris suum draft genome","volume":"479","author":"Jex","year":"2011","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.038539_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-62703-646-7_6","article-title":"Clustal Omega, accurate alignment of very large numbers of sequences","volume":"1079","author":"Sievers","year":"2014","journal-title":"Methods Mol. Biol"},{"key":"10.1074\/mcp.M114.038539_bib41","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/sysbio\/sys029","article-title":"MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space","volume":"61","author":"Ronquist","year":"2012","journal-title":"Syst. Biol"},{"key":"10.1074\/mcp.M114.038539_bib42","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","article-title":"WebLogo: a sequence logo generator","volume":"14","author":"Crooks","year":"2004","journal-title":"Genome Res"},{"key":"10.1074\/mcp.M114.038539_bib43","doi-asserted-by":"crossref","first-page":"17339","DOI":"10.1016\/S0021-9258(18)41931-X","article-title":"Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus","volume":"267","author":"Lustigman","year":"1992","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M114.038539_bib44","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1111\/j.1742-4658.2008.06494.x","article-title":"The secretory omega-class glutathione transferase OvGST3 from the human pathogenic parasite Onchocerca volvulus","volume":"275","author":"Liebau","year":"2008","journal-title":"FEBS J"},{"key":"10.1074\/mcp.M114.038539_bib45","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1017\/S0031182000061564","article-title":"Major sperm protein and actin genes in free-living and parasitic nematodes","volume":"98","author":"Scott","year":"1989","journal-title":"Parasitology"},{"key":"10.1074\/mcp.M114.038539_bib46","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0169-4758(95)80173-1","article-title":"The microfilarial sheath and its proteins","volume":"11","author":"Zahner","year":"1995","journal-title":"Parasitol. Today"},{"key":"10.1074\/mcp.M114.038539_bib47","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0166-6851(93)90212-G","article-title":"The filarial antigens Av33\/Ov33\u20133 show striking similarities to the major pepsin inhibitor from Ascaris suum","volume":"57","author":"Willenbucher","year":"1993","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0166-6851(99)00113-9","article-title":"Molecular cloning and demonstration of an aminopeptidase activity in a filarial nematode glycoprotein","volume":"104","author":"Harnett","year":"1999","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib49","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1016\/j.molimm.2008.02.006","article-title":"A novel ML protein from Manduca sexta may function as a key accessory protein for lipopolysaccharide signaling","volume":"45","author":"Ao","year":"2008","journal-title":"Mol. Immunol"},{"key":"10.1074\/mcp.M114.038539_bib50","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.bbalip.2009.02.001","article-title":"Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking","volume":"1791","author":"Storch","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/mcp.M114.038539_bib51","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0378-1119(96)00040-6","article-title":"Onchocerca volvulus: identification of cDNAs encoding a putative phosphatidyl-ethanolamine-binding protein and a putative partially processed mRNA precursor","volume":"174","author":"Erttmann","year":"1996","journal-title":"Gene"},{"key":"10.1074\/mcp.M114.038539_bib52","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/infdis\/160.3.521","article-title":"Onchocerca volvulus recombinant antigen: physical characterization and clinical correlates with serum reactivity","volume":"160","author":"Gallin","year":"1989","journal-title":"J. Infect. Dis"},{"key":"10.1074\/mcp.M114.038539_bib53","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0166-6851(92)90176-K","article-title":"A cloned antigen for serological diagnosis of Wuchereria bancrofti microfilaremia with daytime blood samples","volume":"56","author":"Dissanayake","year":"1992","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(00)00339-X","article-title":"Temperature is a cue for gene expression in the post-infective L3 of the parasitic nematode Brugia pahangi","volume":"112","author":"Hunter","year":"2001","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib55","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.molbiopara.2004.01.001","article-title":"Developmental regulation and secretion of nematode-specific cysteine-glycine domain proteins in Trichinella spiralis","volume":"134","author":"Gare","year":"2004","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib56","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1399-3011.1981.tb02993.x","article-title":"Purification and properties of rat skin acid phosphatases","volume":"18","author":"Makinen","year":"1981","journal-title":"Int. J. Pept. Protein Res"},{"key":"10.1074\/mcp.M114.038539_bib57","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ydbio.2004.12.012","article-title":"Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine","volume":"279","author":"Fukushige","year":"2005","journal-title":"Dev. Biol"},{"key":"10.1074\/mcp.M114.038539_bib58","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jmb.2005.01.054","article-title":"Structure of MFP2 and its function in enhancing MSP polymerization in Ascaris sperm amoeboid motility","volume":"347","author":"Grant","year":"2005","journal-title":"J. Mol. Biol"},{"key":"10.1074\/mcp.M114.038539_bib59","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1006\/expr.1995.1064","article-title":"Brugia malayi: localisation and differential expression of extracellular and cytoplasmic CuZn superoxide dismutases in adults and microfilariae","volume":"80","author":"Ou","year":"1995","journal-title":"Exp. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib60","doi-asserted-by":"crossref","first-page":"40845","DOI":"10.1074\/jbc.M504434200","article-title":"Characterization of a novel filarial serine protease inhibitor, Ov-SPI-1, from Onchocerca volvulus, with potential multifunctional roles during development of the parasite","volume":"280","author":"Ford","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M114.038539_bib61","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0166-6851(98)00173-X","article-title":"Molecular cloning of the 22\u201324 kDa excretory-secretory 22U protein of Dirofilaria immitis and other filarial nematode parasites","volume":"98","author":"Frank","year":"1999","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib62","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00436-005-1375-x","article-title":"Cloning and characterization of a novel immunogenic protein 3 (NIP3) from Brugia malayi by immuno screening of a phage-display cDNA expression library","volume":"97","author":"Gnanasekar","year":"2005","journal-title":"Parasitol. Res"},{"key":"10.1074\/mcp.M114.038539_bib63","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature05050","article-title":"Sperm chromatin proteomics identifies evolutionarily conserved fertility factors","volume":"443","author":"Chu","year":"2006","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.038539_bib64","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1126\/science.282.5396.2041","article-title":"Caenorhabditis elegans is a nematode","volume":"282","author":"Blaxter","year":"1998","journal-title":"Science"},{"key":"10.1074\/mcp.M114.038539_bib65","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2174\/187152811797200641","article-title":"Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases","volume":"10","author":"Beeton","year":"2011","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"10.1074\/mcp.M114.038539_bib66","doi-asserted-by":"crossref","first-page":"39600","DOI":"10.1074\/jbc.M005632200","article-title":"A family of secreted mucins from the parasitic nematode Toxocara canis bears diverse mucin domains but shares similar flanking six-cysteine repeat motifs","volume":"275","author":"Loukas","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M114.038539_bib67","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.3390\/md8122893","article-title":"Screening and cDNA cloning of Kv1 potassium channel toxins in sea anemones","volume":"8","author":"Yamaguchi","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1074\/mcp.M114.038539_bib68","series-title":"The physiology and biochemistry of free-living and plant-parasitic nematodes","first-page":"25","article-title":"The cuticle","author":"Blaxter","year":"1998"},{"key":"10.1074\/mcp.M114.038539_bib69","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bbamcr.2008.01.024","article-title":"Nucleotide- and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade","volume":"1783","author":"Yegutkin","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/mcp.M114.038539_bib70","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.imbio.2006.11.011","article-title":"The contribution of gC1qR\/p33 in infection and inflammation","volume":"212","author":"Peerschke","year":"2007","journal-title":"Immunobiology"},{"key":"10.1074\/mcp.M114.038539_bib71","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0166-6851(94)90122-8","article-title":"Identification and characterization of an Onchocerca volvulus cDNA clone encoding a highly immunogenic calponin-like protein","volume":"65","author":"Irvine","year":"1994","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib72","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0166-6851(94)00161-8","article-title":"The Onchocerca volvulus homologue of the multifunctional polypeptide protein disulfide isomerase","volume":"68","author":"Wilson","year":"1994","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib73","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1242\/dev.075135","article-title":"Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans","volume":"139","author":"Mancuso","year":"2012","journal-title":"Development"},{"key":"10.1074\/mcp.M114.038539_bib74","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0166-6851(97)00230-2","article-title":"Thioredoxin peroxidase from Onchocerca volvulus: a major hydrogen peroxide detoxifying enzyme in filarial parasites","volume":"91","author":"Lu","year":"1998","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib75","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1756-3305-5-140","article-title":"First analysis of the secretome of the canine heartworm, Dirofilaria immitis","volume":"5","author":"Geary","year":"2012","journal-title":"Parasit. Vectors"},{"key":"10.1074\/mcp.M114.038539_bib76","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-3024.2011.01350.x","article-title":"Future prospects and challenges of vaccines against filariasis","volume":"34","author":"Babayan","year":"2012","journal-title":"Parasite Immunol"},{"key":"10.1074\/mcp.M114.038539_bib77","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/cm.970150206","article-title":"In vitro induction of crawling in the amoeboid sperm of the nematode parasite, Ascaris suum","volume":"15","author":"Sepsenwol","year":"1990","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1074\/mcp.M114.038539_bib78","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/toxsci\/kfq273","article-title":"The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans","volume":"118","author":"Morgan","year":"2010","journal-title":"Toxicol. Sci"},{"key":"10.1074\/mcp.M114.038539_bib79","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/j.1939-4640.2001.tb02579.x","article-title":"Effects of dietary selenium on sperm motility in healthy men","volume":"22","author":"Hawkes","year":"2001","journal-title":"J. Androl"},{"key":"10.1074\/mcp.M114.038539_bib80","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1073\/pnas.1109912109","article-title":"Nematode sperm maturation triggered by protease involves sperm-secreted serine protease inhibitor (Serpin)","volume":"109","author":"Zhao","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/mcp.M114.038539_bib81","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2307\/3278471","article-title":"Dipetalonema viteae in the experimentally infected jird, Meriones unguiculatus. I. Insemination, development from egg to microfilaria, reinsemination, and longevity of mated and unmated worms","volume":"60","author":"Johnson","year":"1974","journal-title":"J. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib82","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1089\/ars.2007.1550","article-title":"Nucleoredoxin, a novel thioredoxin family member involved in cell growth and differentiation","volume":"9","author":"Funato","year":"2007","journal-title":"Antioxid. Redox. Signal"},{"key":"10.1074\/mcp.M114.038539_bib83","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1128\/IAI.71.7.4119-4126.2003","article-title":"Thioredoxin from Brugia malayi: defining a 16-kilodalton class of thioredoxins from nematodes","volume":"71","author":"Kunchithapautham","year":"2003","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M114.038539_bib84","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/379723a0","article-title":"Longevity in Caenorhabditis elegans reduced by mating but not gamete production","volume":"379","author":"Gems","year":"1996","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.038539_bib85","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1006\/expr.1994.1110","article-title":"Brugia malayi: the diagnostic potential of recombinant excretory\/secretory antigens","volume":"79","author":"Kumari","year":"1994","journal-title":"Exp. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib86","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/bj20030753","article-title":"Processing, localization and binding activity of zonadhesin suggest a function in sperm adhesion to the zona pellucida during exocytosis of the acrosome","volume":"375","author":"Bi","year":"2003","journal-title":"Biochem. J"},{"key":"10.1074\/mcp.M114.038539_bib87","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2009.01.057","article-title":"DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration","volume":"137","author":"Heiman","year":"2009","journal-title":"Cell"},{"key":"10.1074\/mcp.M114.038539_bib88","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1091\/mbc.12.6.1725","article-title":"Distribution and transport of cholesterol in Caenorhabditis elegans","volume":"12","author":"Matyash","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/mcp.M114.038539_bib89","doi-asserted-by":"crossref","first-page":"e1370","DOI":"10.1371\/journal.pntd.0001370","article-title":"Proteomic analysis of excretory-secretory products of Heligmosomoides polygyrus assessed with next-generation sequencing transcriptomic information","volume":"5","author":"Moreno","year":"2011","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038539_bib90","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1371\/journal.pntd.0000301","article-title":"Needles in the EST haystack: large-scale identification and analysis of excretory-secretory (ES) proteins in parasitic nematodes using expressed sequence tags (ESTs)","volume":"2","author":"Nagaraj","year":"2008","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038539_bib91","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1101\/gad.187815.112","article-title":"Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment","volume":"26","author":"Kang","year":"2012","journal-title":"Genes Dev"},{"key":"10.1074\/mcp.M114.038539_bib92","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gene.2007.07.015","article-title":"Four transthyretin-like genes of the migratory plant-parasitic nematode Radopholus similis: members of an extensive nematode-specific family","volume":"402","author":"Jacob","year":"2007","journal-title":"Gene"},{"key":"10.1074\/mcp.M114.038539_bib93","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.ijpara.2008.04.004","article-title":"Analysis of the transthyretin-like (TTL) gene family in Ostertagia ostertagi\u2013comparison with other strongylid nematodes and Caenorhabditis elegans","volume":"38","author":"Saverwyns","year":"2008","journal-title":"Int. J. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib94","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1756-3305-5-16","article-title":"Efficient in vitro RNA interference and immunofluorescence-based phenotype analysis in a human parasitic nematode, Brugia malayi","volume":"5","author":"Landmann","year":"2012","journal-title":"Parasit. Vectors"},{"key":"10.1074\/mcp.M114.038539_bib95","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0022-5320(76)90002-2","article-title":"Ultrastructure of a neurosensory organ in a root-knot nematode","volume":"56","author":"Wergin","year":"1976","journal-title":"J. Ultrastruct. Res"},{"key":"10.1074\/mcp.M114.038539_bib96","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00436-009-1525-7","article-title":"A diagnostically useful 200-kDa protein is secreted through the surface pores of the filarial parasite Setaria digitata","volume":"105","author":"Madathiparambil","year":"2009","journal-title":"Parasitol. Res"},{"key":"10.1074\/mcp.M114.038539_bib97","first-page":"803","article-title":"Secretion of Hedgehog-related peptides and WNT during Caenorhabditis elegans development","volume":"10","author":"Kolotuev","year":"2009","journal-title":"Traffic"},{"key":"10.1074\/mcp.M114.038539_bib98","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1017\/S0022149X0000938X","article-title":"Immunocytochemical and ultrastructural studies on Dipetalonema viteae (Filarioidea)","volume":"57","author":"Prusse","year":"1983","journal-title":"J. Helminthol"},{"key":"10.1074\/mcp.M114.038539_bib99","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.vetpar.2005.02.005","article-title":"What is new in the Wolbachia\/Dirofilaria interaction?","volume":"133","author":"Kozek","year":"2005","journal-title":"Vet. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib100","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4049\/jimmunol.173.1.437","article-title":"The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4","volume":"173","author":"Brattig","year":"2004","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M114.038539_bib101","doi-asserted-by":"crossref","first-page":"e758","DOI":"10.1371\/journal.pntd.0000758","article-title":"Asymmetric Wolbachia segregation during early Brugia malayi embryogenesis determines its distribution in adult host tissues","volume":"4","author":"Landmann","year":"2010","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038539_bib102","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.ijpara.2011.05.008","article-title":"Interaction of a Wolbachia WSP-like protein with a nuclear-encoded protein of Brugia malayi","volume":"41","author":"Melnikow","year":"2011","journal-title":"Int. J. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib103","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1128\/IAI.00179-11","article-title":"Bacterial virulence in the moonlight: multitasking bacterial moonlighting proteins are virulence determinants in infectious disease","volume":"79","author":"Henderson","year":"2011","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M114.038539_bib104","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1098\/rspb.2010.2367","article-title":"A worm's best friend: recruitment of neutrophils by Wolbachia confounds eosinophil degranulation against the filarial nematode Onchocerca ochengi","volume":"278","author":"Hansen","year":"2011","journal-title":"Proc. R. Soc. B"},{"key":"10.1074\/mcp.M114.038539_bib105","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1399-302X.2006.00286.x","article-title":"Induction of Porphyromonas gingivalis GroEL signaling via binding to Toll-like receptors 2 and 4","volume":"21","author":"Argueta","year":"2006","journal-title":"Oral Microbiol. Immunol"},{"key":"10.1074\/mcp.M114.038539_bib106","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.exppara.2006.12.006","article-title":"Brugia malayi Wolbachia HSP60 IgG antibody and isotype reactivity in different clinical groups infected or exposed to human bancroftian lymphatic filariasis","volume":"116","author":"Suba","year":"2007","journal-title":"Exp. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib107","first-page":"23","article-title":"Vaccination of Jirds, Meriones unguiculatus, against Litomosoides carinii and Brugia pahangi using irradiate larvae of","volume":"33","author":"Storey","year":"1982","journal-title":"L. carinii. Tropenmed. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib108","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.ijpara.2006.04.013","article-title":"Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages","volume":"36","author":"Babayan","year":"2006","journal-title":"Int. J. Parasitol"},{"key":"10.1074\/mcp.M114.038539_bib109","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1128\/IAI.68.9.5454-5458.2000","article-title":"Analysis of genes expressed at the infective larval stage validates utility of Litomosoides sigmodontis as a murine model for filarial vaccine development","volume":"68","author":"Allen","year":"2000","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M114.038539_bib110","doi-asserted-by":"crossref","first-page":"e544","DOI":"10.1371\/journal.pntd.0000544","article-title":"Immunisation with a multivalent, subunit vaccine reduces patent infection in a natural bovine model of onchocerciasis during intense field exposure","volume":"3","author":"Makepeace","year":"2009","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038539_bib111","doi-asserted-by":"crossref","first-page":"e1558","DOI":"10.1371\/journal.pntd.0001558","article-title":"Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis","volume":"6","author":"Ziewer","year":"2012","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038539_bib112","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1017\/S0022149X00034684","article-title":"Immunization of calves against the microfilariae of Onchocerca lienalis","volume":"56","author":"Townson","year":"1982","journal-title":"J. Helminthol"},{"key":"10.1074\/mcp.M114.038539_bib113","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1017\/S0031182001007892","article-title":"Determinants for resistance and susceptibility to microfilaraemia in Litomosoides sigmodontis filariasis","volume":"122","author":"Hoffmann","year":"2001","journal-title":"Parasitology"},{"key":"10.1074\/mcp.M114.038539_bib114","doi-asserted-by":"crossref","first-page":"28415","DOI":"10.1074\/jbc.M600254200","article-title":"The Caenorhabditis elegans CPI-2a cystatin-like inhibitor has an essential regulatory role during oogenesis and fertilization","volume":"281","author":"Hashmi","year":"2006","journal-title":"J. Biol. Chem"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620328048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620328048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M114.038539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:40:36Z","timestamp":1761525636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620328048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":114,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1535947620328048"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m114.038539","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M114.038539","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}