{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:20:17Z","timestamp":1792880417817,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":2167,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1074\/mcp.m114.038950","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T02:01:09Z","timestamp":1404439269000},"page":"2736-2751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"title":["Secreted Proteomes of Different Developmental Stages of the Gastrointestinal Nematode Nippostrongylus brasiliensis"],"prefix":"10.1016","volume":"13","author":[{"given":"Javier","family":"Sotillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Sanchez-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Cantacessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Harcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Bouchery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mali","family":"Camberis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiau-Choot","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Giacomin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Mulvenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makedonka","family":"Mitreva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Berriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"LeGros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M.","family":"Maizels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Loukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M114.038950_bib1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMra032492","article-title":"Hookworm infection","volume":"351","author":"Hotez","year":"2004","journal-title":"N. Engl. J"},{"key":"10.1074\/mcp.M114.038950_bib2","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/S0140-6736(09)60233-6","article-title":"Rescuing the bottom billion through control of neglected tropical diseases","volume":"373","author":"Hotez","year":"2009","journal-title":"Lancet"},{"key":"10.1074\/mcp.M114.038950_bib3","series-title":"Global Health Estimates (GHE) 2013: DALYs by age, sex and cause. DALY estimates, 2000\u20132011","year":"2013"},{"key":"10.1074\/mcp.M114.038950_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1912s55","article-title":"Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus","author":"Camberis","year":"2003","journal-title":"Current protocols in immunology"},{"key":"10.1074\/mcp.M114.038950_bib5","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1128\/IAI.68.9.4913-4922.2000","article-title":"Extract of Nippostrongylus brasiliensis stimulates polyclonal type-2 immunoglobulin response by inducing de novo class switch","volume":"68","author":"Ehigiator","year":"2000","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M114.038950_bib6","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/1521-4141(200007)30:7<1977::AID-IMMU1977>3.0.CO;2-3","article-title":"Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses","volume":"30","author":"Holland","year":"2000","journal-title":"Eur. J. Immunol"},{"key":"10.1074\/mcp.M114.038950_bib7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1365-3024.2010.01224.x","article-title":"The immunology of human hookworm infections","volume":"32","author":"McSorley","year":"2010","journal-title":"Parasite Immunol"},{"key":"10.1074\/mcp.M114.038950_bib8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1128\/CMR.05040-11","article-title":"Helminth infections and host immune regulation","volume":"25","author":"McSorley","year":"2012","journal-title":"Clin. Microbiol. Rev"},{"key":"10.1074\/mcp.M114.038950_bib9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4049\/jimmunol.0901841","article-title":"Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells","volume":"184","author":"Ohnmacht","year":"2010","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M114.038950_bib10","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1084\/jem.171.5.1497","article-title":"Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells","volume":"171","author":"Conrad","year":"1990","journal-title":"J. Exp. Med"},{"key":"10.1074\/mcp.M114.038950_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fimmu.2013.00074","article-title":"Development of CD4 T cell dependent immunity against N. brasiliensis infection","volume":"4","author":"Harvie","year":"2013","journal-title":"Front. Immunol"},{"key":"10.1074\/mcp.M114.038950_bib12","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1128\/IAI.00502-09","article-title":"The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites","volume":"78","author":"Harvie","year":"2010","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M114.038950_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/362245a0","article-title":"Disruption of the murine IL-4 gene blocks Th2 cytokine responses","volume":"362","author":"Kopf","year":"1993","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.038950_bib14","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.4049\/jimmunol.139.5.1459","article-title":"Concomitant immunoglobulin E and immunoglobulin G1 formation in Nippostrongylus brasiliensis-infected mice","volume":"139","author":"Lebrun","year":"1987","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M114.038950_bib15","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.038950_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000237717","article-title":"Protective roles of eosinophils in Nippostrongylus brasiliensis infection","volume":"114","author":"Shin","year":"1997","journal-title":"Int. Arch. Allergy Immunol"},{"key":"10.1074\/mcp.M114.038950_bib17","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1186\/gb-2004-5-6-r39","article-title":"Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites","volume":"5","author":"Harcus","year":"2004","journal-title":"Genome Biol"},{"key":"10.1074\/mcp.M114.038950_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/ng.2875","article-title":"Genome of the human hookworm Necator americanus","author":"Tang","year":"2014","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.M114.038950_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/expr.1996.0090","article-title":"Nippostrongylus brasiliensis: cytokine responses and nematode expulsion in normal and IL-4-deficient mice","volume":"84","author":"Lawrence","year":"1996","journal-title":"Exp. Parasitol"},{"key":"10.1074\/mcp.M114.038950_bib20","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nbt.1883","article-title":"Full-length transcriptome assembly from RNA-Seq data without a reference genome","volume":"29","author":"Grabherr","year":"2011","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/mcp.M114.038950_bib21","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/nprot.2013.084","article-title":"De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis","volume":"8","author":"Haas","year":"2013","journal-title":"Nat. Protoc"},{"key":"10.1074\/mcp.M114.038950_bib22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1017\/S0031182000059588","article-title":"Characterization of proteolytic enzymes from larval and adult Nippostrongylus brasiliensis","volume":"103","author":"Healer","year":"1991","journal-title":"Parasitology"},{"key":"10.1074\/mcp.M114.038950_bib23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molbiopara.2008.02.007","article-title":"The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products","volume":"160","author":"Hewitson","year":"2008","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038950_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-3024.2007.01019.x","article-title":"Identification of antigenic proteins from Echinostoma caproni (Trematoda) recognized by mouse immunoglobulins M, A, and G using an immunoproteomic approach","volume":"30","author":"Sotillo","year":"2008","journal-title":"Parasite Immunol"},{"key":"10.1074\/mcp.M114.038950_bib25","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1002\/1522-2683(200011)21:17<3666::AID-ELPS3666>3.0.CO;2-6","article-title":"A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption\/ionization and electrospray ionization-mass spectrometry","volume":"21","author":"Yan","year":"2000","journal-title":"Electrophoresis"},{"key":"10.1074\/mcp.M114.038950_bib26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1074\/mcp.M800206-MCP200","article-title":"Proteomics analysis of the excretory\/secretory component of the blood-feeding stage of the hookworm, Ancylostoma caninum","volume":"8","author":"Mulvenna","year":"2009","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/mcp.M114.038950_bib27","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1074\/mcp.M112.019844","article-title":"A deep exploration of the transcriptome and \u201cexcretory\/secretory\u201d proteome of adult Fascioloides magna","volume":"11","author":"Cantacessi","year":"2012","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/mcp.M114.038950_bib28","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/pmic.200900437","article-title":"Scaffold: a bioinformatic tool for validating MS\/MS-based proteomic studies","volume":"10","author":"Searle","year":"2010","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M114.038950_bib29","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1021\/ac025747h","article-title":"Empirical statistical model to estimate the accuracy of peptide identifications made by MS\/MS and database search","volume":"74","author":"Keller","year":"2002","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M114.038950_bib30","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"Nesvizhskii","year":"2003","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M114.038950_bib31","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization, and analysis in functional genomics research","volume":"21","author":"Conesa","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M114.038950_bib32","doi-asserted-by":"crossref","first-page":"W29","DOI":"10.1093\/nar\/gkr367","article-title":"HMMER web server: interactive sequence similarity searching","volume":"39","author":"Finn","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M114.038950_bib33","doi-asserted-by":"crossref","first-page":"D225","DOI":"10.1093\/nar\/gkq1189","article-title":"CDD: a Conserved Domain Database for the functional annotation of proteins","volume":"39","author":"Marchler-Bauer","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M114.038950_bib34","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nprot.2007.131","article-title":"Locating proteins in the cell using TargetP, SignalP, and related tools","volume":"2","author":"Emanuelsson","year":"2007","journal-title":"Nat. Protoc"},{"key":"10.1074\/mcp.M114.038950_bib35","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol"},{"key":"10.1074\/mcp.M114.038950_bib36","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/pmic.200300771","article-title":"Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence","volume":"4","author":"Blom","year":"2004","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M114.038950_bib37","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/bioinformatics\/btf870","article-title":"SimiTri - visualizing similarity relationships for groups of sequences","volume":"19","author":"Parkinson","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M114.038950_bib38","doi-asserted-by":"crossref","first-page":"e684","DOI":"10.1371\/journal.pntd.0000684","article-title":"Massively parallel sequencing and analysis of the Necator americanus transcriptome","volume":"4","author":"Cantacessi","year":"2010","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038950_bib39","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.jprot.2011.06.002","article-title":"Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins","volume":"74","author":"Hewitson","year":"2011","journal-title":"J. Proteomics"},{"key":"10.1074\/mcp.M114.038950_bib40","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1371\/journal.pntd.0000410","article-title":"Brugia malayi excreted\/secreted proteins at the host\/parasite interface: stage- and gender-specific proteomic profiling","volume":"3","author":"Bennuru","year":"2009","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038950_bib41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/32160","article-title":"A molecular evolutionary framework for the phylum Nematoda","volume":"392","author":"Blaxter","year":"1998","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.038950_bib42","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/bioinformatics\/bti263","article-title":"ProtTest: selection of best-fit models of protein evolution","volume":"21","author":"Abascal","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M114.038950_bib43","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura","year":"2011","journal-title":"Mol. Biol. Evol"},{"key":"10.1074\/mcp.M114.038950_bib44","series-title":"\u201cCreating the CIPRES Science Gateway for inference of large phylogenetic trees\u201d","first-page":"1","author":"Miller","year":"1968"},{"key":"10.1074\/mcp.M114.038950_bib45","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1074\/jbc.271.12.6672","article-title":"Cloning and characterization of Ancylostoma-secreted protein. A novel protein associated with the transition to parasitism by infective hookworm larvae","volume":"271","author":"Hawdon","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M114.038950_bib46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0166-6851(01)00374-7","article-title":"Expression and immune recognition of Brugia malayi VAL-1, a homolog of vespid venom allergens and Ancylostoma secreted proteins","volume":"118","author":"Murray","year":"2001","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038950_bib47","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1128\/IAI.00192-08","article-title":"Hookworm-induced persistent changes to the immunological environment of the lung","volume":"76","author":"Reece","year":"2008","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M114.038950_bib48","doi-asserted-by":"crossref","first-page":"e1004","DOI":"10.1371\/journal.pntd.0001004","article-title":"A portrait of the transcriptome of the neglected trematode, Fasciola gigantica - biological and biotechnological implications","volume":"5","author":"Young","year":"2011","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038950_bib49","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jprot.2013.06.017","article-title":"The transcriptome of Echinostoma caproni adults: further characterization of the secretome and identification of new potential drug targets","volume":"89","author":"Garg","year":"2013","journal-title":"J. Proteomics"},{"key":"10.1074\/mcp.M114.038950_bib50","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.010157","article-title":"Life cycle stage-resolved proteomic analysis of the excretome\/secretome from Strongyloides ratti - identification of stage-specific proteases","volume":"10","author":"Soblik","year":"2011","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/mcp.M114.038950_bib51","doi-asserted-by":"crossref","first-page":"e45974","DOI":"10.1371\/journal.pone.0045974","article-title":"Extracellular vesicles from parasitic helminths contain specific excretory\/secretory proteins and are internalized in intestinal host cells","volume":"7","author":"Marcilla","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/mcp.M114.038950_bib52","doi-asserted-by":"crossref","first-page":"e24619","DOI":"10.1371\/journal.pone.0024619","article-title":"Protist-type lysozymes of the nematode Caenorhabditis elegans contribute to resistance against pathogenic Bacillus thuringiensis","volume":"6","author":"Boehnisch","year":"2011","journal-title":"PLoS One"},{"key":"10.1074\/mcp.M114.038950_bib53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature03481","article-title":"The genome of the social amoeba Dictyostelium discoideum","volume":"435","author":"Eichinger","year":"2005","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.038950_bib54","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.exppara.2011.10.003","article-title":"Characterization of Angiostrongylus cantonensis excretory-secretory proteins as potential diagnostic targets","volume":"130","author":"Morassutti","year":"2012","journal-title":"Exp. Parasitol"},{"key":"10.1074\/mcp.M114.038950_bib55","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00436-010-1923-x","article-title":"Excretory\/secretory proteome of the adult stage of Echinostoma caproni","volume":"107","author":"Sotillo","year":"2010","journal-title":"Parasitol. Res"},{"key":"10.1074\/mcp.M114.038950_bib56","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0891-5849(90)90074-S","article-title":"Reactive oxygen intermediates metabolizing enzymes in Ancylostoma ceylanicum and Nippostrongylus brasiliensis","volume":"8","author":"Batra","year":"1990","journal-title":"Free Radic. Biol. Med"},{"key":"10.1074\/mcp.M114.038950_bib57","doi-asserted-by":"crossref","first-page":"e1003492","DOI":"10.1371\/journal.ppat.1003492","article-title":"Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity","volume":"9","author":"Hewitson","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1074\/mcp.M114.038950_bib58","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1365-3024.2011.01278.x","article-title":"A calcium-activated apyrase from Teladorsagia circumcincta: an excretory\/secretory antigen capable of modulating host immune responses?","volume":"33","author":"Nisbet","year":"2011","journal-title":"Parasite Immunol"},{"key":"10.1074\/mcp.M114.038950_bib59","doi-asserted-by":"crossref","first-page":"30583","DOI":"10.1074\/jbc.273.46.30583","article-title":"Purification, cloning, and expression of an apyrase from the bed bug Cimex lectularius. A new type of nucleotide-binding enzyme","volume":"273","author":"Valenzuela","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M114.038950_bib60","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1017\/S0031182010001241","article-title":"A calcium-activated nucleotidase secreted from Ostertagia ostertagi 4th-stage larvae is a member of the novel salivary apyrases present in blood-feeding arthropods","volume":"138","author":"Zarlenga","year":"2011","journal-title":"Parasitology"},{"key":"10.1074\/mcp.M114.038950_bib61","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.1074\/jbc.274.14.9312","article-title":"Cloning, expression, and properties of a nonneuronal secreted acetylcholinesterase from the parasitic nematode Nippostrongylus brasiliensis","volume":"274","author":"Hussein","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M114.038950_bib62","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0020-7519(96)00040-9","article-title":"Why do some nematode parasites of the alimentary tract secrete acetylcholinesterase?","volume":"26","author":"Lee","year":"1996","journal-title":"Int. J. Parasitol"},{"key":"10.1074\/mcp.M114.038950_bib63","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1756-3305-6-156","article-title":"TIMPs of parasitic helminths - a large-scale analysis of high-throughput sequence datasets","volume":"6","author":"Cantacessi","year":"2013","journal-title":"Parasit. Vectors"},{"key":"10.1074\/mcp.M114.038950_bib64","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1471-2164-6-58","article-title":"Investigating hookworm genomes by comparative analysis of two Ancylostoma species","volume":"6","author":"Mitreva","year":"2005","journal-title":"BMC Genomics"},{"key":"10.1074\/mcp.M114.038950_bib65","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4269\/ajtmh.2002.66.238","article-title":"Molecular cloning and purification of Ac-TMP, a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookworms","volume":"66","author":"Zhan","year":"2002","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"10.1074\/mcp.M114.038950_bib66","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1371\/journal.pntd.0000439","article-title":"The hookworm tissue inhibitor of metalloproteases (Ac-TMP-1) modifies dendritic cell function and induces generation of CD4 and CD8 suppressor T cells","volume":"3","author":"Cuellar","year":"2009","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/mcp.M114.038950_bib67","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.exppara.2007.11.014","article-title":"Necator americanus: the Na-ASP-2 protein secreted by the infective larvae induces neutrophil recruitment in vivo and in vitro","volume":"118","author":"Bower","year":"2008","journal-title":"Exp. Parasitol"},{"key":"10.1074\/mcp.M114.038950_bib68","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jaci.2012.04.027","article-title":"Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths","volume":"130","author":"Diemert","year":"2012","journal-title":"J. Allergy Clin. Immunol"},{"key":"10.1074\/mcp.M114.038950_bib69","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/pro.5560040701","article-title":"The astacin family of metalloendopeptidases","volume":"4","author":"Bond","year":"1995","journal-title":"Protein Sci"},{"key":"10.1074\/mcp.M114.038950_bib70","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.exppara.2013.01.006","article-title":"Molecular cloning and characterisation of in vitro immune response against astacin-like metalloprotease Ace-MTP-2 from Ancylostoma ceylanicum","volume":"133","author":"Baska","year":"2013","journal-title":"Exp. Parasitol"},{"key":"10.1074\/mcp.M114.038950_bib71","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1017\/S0031182010001113","article-title":"The astacin metalloprotease moulting enzyme NAS-36 is required for normal cuticle ecdysis in free-living and parasitic nematodes","volume":"138","author":"Stepek","year":"2011","journal-title":"Parasitology"},{"key":"10.1074\/mcp.M114.038950_bib72","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1348-0421.2010.00289.x","article-title":"Strongyloides stercoralis excretory\/secretory protein strongylastacin specifically recognized by IgE antibodies in infected human sera","volume":"55","author":"Varatharajalu","year":"2011","journal-title":"Microbiol. Immunol"},{"key":"10.1074\/mcp.M114.038950_bib73","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1128\/IAI.74.2.961-967.2006","article-title":"Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration","volume":"74","author":"Williamson","year":"2006","journal-title":"Infect. Immun"},{"key":"10.1074\/mcp.M114.038950_bib74","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1645\/GE-46R","article-title":"Effect of vaccination with a recombinant fusion protein encoding an astacinlike metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvae","volume":"89","author":"Hotez","year":"2003","journal-title":"J. Parasitol"},{"key":"10.1074\/mcp.M114.038950_bib75","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.parint.2005.02.002","article-title":"Identification of an astacin-like metallo-proteinase transcript from the infective larvae of Strongyloides stercoralis","volume":"54","author":"Gomez Gallego","year":"2005","journal-title":"Parasitol. Int"},{"key":"10.1074\/mcp.M114.038950_bib76","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1242\/dev.01454","article-title":"A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans","volume":"131","author":"Davis","year":"2004","journal-title":"Development"},{"key":"10.1074\/mcp.M114.038950_bib77","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2307\/3284145","article-title":"Developmentally regulated zinc metalloproteinases from third- and fourth-stage larvae of the ovine nematode Haemonchus contortus","volume":"82","author":"Gamble","year":"1996","journal-title":"J. Parasitol"},{"key":"10.1074\/mcp.M114.038950_bib78","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.molbiopara.2004.03.015","article-title":"A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling","volume":"136","author":"Guiliano","year":"2004","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1074\/mcp.M114.038950_bib79","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.biotechadv.2009.02.005","article-title":"A portrait of the \u201dSCP\/TAPS\u201c proteins of eukaryotes - developing a framework for fundamental research and biotechnological outcomes","volume":"27","author":"Cantacessi","year":"2009","journal-title":"Biotechnol. Adv"},{"key":"10.1074\/mcp.M114.038950_bib80","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.4049\/jimmunol.0800531","article-title":"Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, can directly bind and activate antigen-presenting cells","volume":"182","author":"He","year":"2009","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M114.038950_bib81","doi-asserted-by":"crossref","first-page":"10008","DOI":"10.1016\/S0021-9258(17)36982-X","article-title":"A hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin CD11b\/CD18","volume":"269","author":"Moyle","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M114.038950_bib82","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.biotechadv.2011.11.002","article-title":"Hookworm SCP\/TAPS protein structure - A key to understanding host-parasite interactions and developing new interventions","volume":"30","author":"Osman","year":"2012","journal-title":"Biotechnol. Adv"},{"key":"10.1074\/mcp.M114.038950_bib83","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1101\/gr.50823006","article-title":"Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with","volume":"16","author":"O'Rourke","year":"2006","journal-title":"M. nematophilum. Genome Res"},{"key":"10.1074\/mcp.M114.038950_bib84","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0960-9822(03)00108-8","article-title":"Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans","volume":"13","author":"Ookuma","year":"2003","journal-title":"Curr. Biol"},{"key":"10.1074\/mcp.M114.038950_bib85","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1242\/dev.00363","article-title":"Global analysis of dauer gene expression in Caenorhabditis elegans","volume":"130","author":"Wang","year":"2003","journal-title":"Development"},{"key":"10.1074\/mcp.M114.038950_bib86","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijpara.2012.11.005","article-title":"The hookworm pharmacopoeia for inflammatory diseases","volume":"43","author":"Navarro","year":"2013","journal-title":"Int. J. Parasitol"}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153594762032819X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153594762032819X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M114.038950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:41:17Z","timestamp":1761525677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153594762032819X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":86,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S153594762032819X"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m114.038950","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Secreted Proteomes of Different Developmental Stages of the Gastrointestinal Nematode Nippostrongylus brasiliensis","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M114.038950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}