{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:05:19Z","timestamp":1790154319232,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":2167,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1074\/mcp.m114.040113","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T02:00:06Z","timestamp":1403920806000},"page":"2584-2592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Targeting Synaptic Pathology with a Novel Affinity Mass Spectrometry Approach"],"prefix":"10.1016","volume":"13","author":[{"given":"Ann","family":"Brinkmalm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Brinkmalm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Honer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Jakobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna R.","family":"Mallucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"\u00d6hrfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M114.040113_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0022-510X(87)90057-8","article-title":"A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease","volume":"78","author":"Davies","year":"1987","journal-title":"J. Neurol. Sci"},{"key":"10.1074\/mcp.M114.040113_bib2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bcp.2014.01.015","article-title":"Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease","volume":"88","author":"Overk","year":"2014","journal-title":"Biochem. Pharmacol"},{"key":"10.1074\/mcp.M114.040113_bib3","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol"},{"key":"10.1074\/mcp.M114.040113_bib4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/WNL.56.1.127","article-title":"Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease","volume":"56","author":"Masliah","year":"2001","journal-title":"Neurology"},{"key":"10.1074\/mcp.M114.040113_bib5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/BF01273157","article-title":"Synaptic pathology in Alzheimer's disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele","volume":"103","author":"Blennow","year":"1996","journal-title":"J. Neural Transm"},{"key":"10.1074\/mcp.M114.040113_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann. Neurol"},{"key":"10.1074\/mcp.M114.040113_bib7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/362318a0","article-title":"SNAP receptors implicated in vesicle targeting and fusion","volume":"362","author":"Sollner","year":"1993","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.040113_bib8","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/npp.2009.228","article-title":"A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia","volume":"35","author":"Barakauskas","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1074\/mcp.M114.040113_bib9","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1073\/pnas.0610222104","article-title":"A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse","volume":"104","author":"Jeans","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M114.040113_bib10","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1002\/j.1460-2075.1994.tb06834.x","article-title":"Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly","volume":"13","author":"Hayashi","year":"1994","journal-title":"EMBO J"},{"key":"10.1074\/mcp.M114.040113_bib11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.neuro.26.041002.131412","article-title":"The synaptic vesicle cycle","volume":"27","author":"Sudhof","year":"2004","journal-title":"Annu. Rev. Neurosci"},{"key":"10.1074\/mcp.M114.040113_bib12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/26412","article-title":"Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution","volume":"395","author":"Sutton","year":"1998","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.040113_bib13","series-title":"MRM-based quantitation of SNAP-25 protein isoforms in cells and human brain samples","author":"Barakauskas","year":"2011"},{"key":"10.1074\/mcp.M114.040113_bib14","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0092-8674(93)90466-4","article-title":"The syntaxin family of vesicular transport receptors","volume":"74","author":"Bennett","year":"1993","journal-title":"Cell"},{"key":"10.1074\/mcp.M114.040113_bib15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/cne.21505","article-title":"Heterogeneous expression of SNAP-25 in rat and human brain","volume":"506","author":"Garbelli","year":"2008","journal-title":"J. Comp. Neurol"},{"key":"10.1074\/mcp.M114.040113_bib16","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1083\/jcb.109.6.3039","article-title":"The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations","volume":"109","author":"Oyler","year":"1989","journal-title":"J. Cell Biol"},{"key":"10.1074\/mcp.M114.040113_bib17","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1523\/JNEUROSCI.10-04-01380.1990","article-title":"Distinct patterns of expression of two VAMP genes within the rat brain","volume":"10","author":"Trimble","year":"1990","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M114.040113_bib18","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/cne.22558","article-title":"Differential expression of SNAP-25 family proteins in the mouse brain","volume":"519","author":"Yamamori","year":"2011","journal-title":"J. Comp. Neurol"},{"key":"10.1074\/mcp.M114.040113_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.1074\/mcp.M114.040113_bib20","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/emboj\/21.3.202","article-title":"Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration","volume":"21","author":"Mallucci","year":"2002","journal-title":"EMBO J"},{"key":"10.1074\/mcp.M114.040113_bib21","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature11058","article-title":"Sustained translational repression by eIF2alpha-P mediates prion neurodegeneration","volume":"485","author":"Moreno","year":"2012","journal-title":"Nature"},{"key":"10.1074\/mcp.M114.040113_bib22","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1007\/s11064-011-0527-x","article-title":"Identification of novel alpha-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method","volume":"36","author":"\u00d6hrfelt","year":"2011","journal-title":"Neurochem. Res"},{"key":"10.1074\/mcp.M114.040113_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0306-4522(96)00489-7","article-title":"Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia","volume":"78","author":"Honer","year":"1997","journal-title":"Neuroscience"},{"key":"10.1074\/mcp.M114.040113_bib24","doi-asserted-by":"crossref","first-page":"9582","DOI":"10.1021\/bi9012403","article-title":"N-terminal acetylation of the neuronal protein SNAP-25 is revealed by the SMI81 monoclonal antibody","volume":"48","author":"Connell","year":"2009","journal-title":"Biochemistry"},{"key":"10.1074\/mcp.M114.040113_bib25","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0171-9335(99)80029-6","article-title":"Inhibition of neurotransmitter release in the lamprey reticulospinal synapse by antibody-mediated disruption of SNAP-25 function","volume":"78","author":"Low","year":"1999","journal-title":"Eur. J. Cell Biol"},{"key":"10.1074\/mcp.M114.040113_bib26","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/jms.2987","article-title":"An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid beta and amyloid precursor protein in human and cat cerebrospinal fluid","volume":"47","author":"Brinkmalm","year":"2012","journal-title":"J. Mass Spectrom"},{"key":"10.1074\/mcp.M114.040113_bib27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0378-1119(94)90773-0","article-title":"Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25","volume":"139","author":"Bark","year":"1994","journal-title":"Gene"},{"key":"10.1074\/mcp.M114.040113_bib28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2202-12-35","article-title":"Regional and developmental brain expression patterns of SNAP25 splice variants","volume":"12","author":"Prescott","year":"2011","journal-title":"BMC Neurosci"},{"key":"10.1074\/mcp.M114.040113_bib29","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0306-4522(98)00247-4","article-title":"Syntaxin 1A and 1B display distinct distribution patterns in the rat peripheral nervous system","volume":"88","author":"Aguado","year":"1999","journal-title":"Neuroscience"},{"key":"10.1074\/mcp.M114.040113_bib30","doi-asserted-by":"crossref","first-page":"21549","DOI":"10.1074\/jbc.M110.105148","article-title":"A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex","volume":"285","author":"Wiederhold","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M114.040113_bib31","doi-asserted-by":"crossref","first-page":"14417","DOI":"10.1523\/JNEUROSCI.1236-13.2013","article-title":"Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering","volume":"33","author":"Mohrmann","year":"2013","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M114.040113_bib32","doi-asserted-by":"crossref","first-page":"E2812","DOI":"10.1073\/pnas.1310654110","article-title":"Ultrahigh-resolution imaging reveals formation of neuronal SNARE\/Munc18 complexes in situ","volume":"110","author":"Pertsinidis","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M114.040113_bib33","doi-asserted-by":"crossref","first-page":"20777","DOI":"10.1073\/pnas.1321367110","article-title":"Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes","volume":"110","author":"Yang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M114.040113_bib34","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.neurobiolaging.2003.04.005","article-title":"Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals","volume":"24","author":"Honer","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/mcp.M114.040113_bib35","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1038\/tp.2012.38","article-title":"Cognitive reserve, presynaptic proteins and dementia in the elderly","volume":"2","author":"Honer","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1074\/mcp.M114.040113_bib36","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/jnen\/60.10.929","article-title":"Synaptic pathology in prefrontal cortex is present only with severe dementia in Alzheimer disease","volume":"60","author":"Minger","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"10.1074\/mcp.M114.040113_bib37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/bbrc.1997.6940","article-title":"Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease","volume":"236","author":"Shimohama","year":"1997","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/mcp.M114.040113_bib38","doi-asserted-by":"crossref","first-page":"8796","DOI":"10.1523\/JNEUROSCI.1940-04.2004","article-title":"Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission","volume":"24","author":"Bark","year":"2004","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M114.040113_bib39","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1073\/pnas.92.5.1510","article-title":"Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neural development","volume":"92","author":"Bark","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M114.040113_bib40","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.neuroscience.2009.11.009","article-title":"Heterogeneity of glutamatergic and GABAergic release machinery in cerebral cortex: analysis of synaptogyrin, vesicle-associated membrane protein, and syntaxin","volume":"165","author":"Bragina","year":"2010","journal-title":"Neuroscience"},{"key":"10.1074\/mcp.M114.040113_bib41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nmeth.2400","article-title":"Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS","volume":"10","author":"Varjosalo","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.M114.040113_bib42","first-page":"493","article-title":"SNAREs and traffic","volume":"1744","author":"Hong","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/mcp.M114.040113_bib43","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nrm2002","article-title":"SNAREs\u2014engines for membrane fusion","volume":"7","author":"Jahn","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol"}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620328085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620328085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M114.040113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:42:18Z","timestamp":1761525738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620328085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1535947620328085"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m114.040113","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting Synaptic Pathology with a Novel Affinity Mass Spectrometry Approach","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M114.040113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}