{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:29:27Z","timestamp":1791214167712,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":1658,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1074\/mcp.m115.048504","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T23:58:13Z","timestamp":1442620693000},"page":"1105-1116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["Serum Albumin Domain Structures in Human Blood Serum by Mass Spectrometry and Computational Biology"],"prefix":"10.1016","volume":"15","author":[{"given":"Adam","family":"Belsom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juri","family":"Rappsilber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M115.048504_bib1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.sbi.2008.07.001","article-title":"Overcoming the challenges of membrane protein crystallography","volume":"18","author":"Carpenter","year":"2008","journal-title":"Curr. Opin. Struct. Biol"},{"key":"10.1074\/mcp.M115.048504_bib2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1047-8477(03)00043-1","article-title":"Membrane protein crystallization","volume":"142","author":"Caffrey","year":"2003","journal-title":"J. Struct. Biol"},{"key":"10.1074\/mcp.M115.048504_bib3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1021\/ac991081o","article-title":"A generic strategy to analyze the spatial organization of multi-protein complexes by cross-linking and mass spectrometry","volume":"72","author":"Rappsilber","year":"1999","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M115.048504_bib4","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1126\/science.1217737","article-title":"High-resolution protein structure determination by serial femtosecond crystallography","volume":"337","author":"Boutet","year":"2012","journal-title":"Science"},{"key":"10.1074\/mcp.M115.048504_bib5","doi-asserted-by":"crossref","first-page":"e00573","DOI":"10.7554\/eLife.00573","article-title":"Direct detection pays off for electron cryo-microscopy","volume":"2","author":"Grigorieff","year":"2013","journal-title":"Elife"},{"key":"10.1074\/mcp.M115.048504_bib6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature07814","article-title":"Protein structure determination in living cells by in-cell NMR spectroscopy","volume":"458","author":"Sakakibara","year":"2009","journal-title":"Nature"},{"key":"10.1074\/mcp.M115.048504_bib7","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.1183649","article-title":"NMR structure determination for larger proteins using backbone-only data","volume":"327","author":"Raman","year":"2010","journal-title":"Science"},{"key":"10.1074\/mcp.M115.048504_bib8","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.cell.2012.04.012","article-title":"Three-dimensional structures of membrane proteins from genomic sequencing","volume":"149","author":"Hopf","year":"2012","journal-title":"Cell"},{"key":"10.1074\/mcp.M115.048504_bib9","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/mas.20082","article-title":"Chemical cross-linking and mass spectrometry to map three-dimensional protein structures and protein-protein interactions","volume":"25","author":"Sinz","year":"2006","journal-title":"Mass Spectrom. Rev"},{"key":"10.1074\/mcp.M115.048504_bib10","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jsb.2010.10.014","article-title":"The beginning of a beautiful friendship: Cross-linking\/mass spectrometry and modelling of proteins and multi-protein complexes","volume":"173","author":"Rappsilber","year":"2011","journal-title":"J. Struct. Biol"},{"key":"10.1074\/mcp.M115.048504_bib11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.sbi.2013.02.008","article-title":"Mass spectrometry supported determination of protein complex structure","volume":"23","author":"Walzthoeni","year":"2013","journal-title":"Curr. Opin. Struct. Biol"},{"key":"10.1074\/mcp.M115.048504_bib12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nature01511","article-title":"Mass spectrometry-based proteomics","volume":"422","author":"Aebersold","year":"2003","journal-title":"Nature"},{"key":"10.1074\/mcp.M115.048504_bib13","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/emboj.2009.401","article-title":"Architecture of the RNA polymerase II\u2013TFIIF complex revealed by cross-linking and mass spectrometry","volume":"29","author":"Chen","year":"2010","journal-title":"EMBO J"},{"key":"10.1074\/mcp.M115.048504_bib14","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1126\/science.1221483","article-title":"Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry","volume":"337","author":"Herzog","year":"2012","journal-title":"Science"},{"key":"10.1074\/mcp.M115.048504_bib15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1039\/b803218a","article-title":"Photocrosslinkers illuminate interactions in living cells","volume":"4","author":"Tanaka","year":"2008","journal-title":"Mol. Biosyst"},{"key":"10.1074\/mcp.M115.048504_bib16","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1074\/mcp.M112.018374","article-title":"Mapping the structural topology of the yeast 19S proteasomal regulatory particle using chemical cross-linking and probabilistic modeling","volume":"11","author":"Kao","year":"2012","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/mcp.M115.048504_bib17","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2013.11.008","article-title":"Genetically Encoded Chemical Probes in Cells Reveal the Binding Path of Urocortin-I to CRF Class B GPCR","volume":"155","author":"Coin","year":"2013","journal-title":"Cell"},{"key":"10.1074\/mcp.M115.048504_bib18","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.1073\/pnas.090099097","article-title":"High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry","volume":"97","author":"Young","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1074\/mcp.M115.048504_bib19","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1016\/j.jmb.2013.06.026","article-title":"A pseudo-atomic model for the capsid shell of bacteriophage lambda using chemical cross-linking\/mass spectrometry and molecular modeling","volume":"425","author":"Singh","year":"2013","journal-title":"J. Mol. Biol"},{"issue":"9","key":"10.1074\/mcp.M115.048504_bib20","doi-asserted-by":"crossref","first-page":"e73411","DOI":"10.1371\/journal.pone.0073411","article-title":"Cross-link guided molecular modeling with ROSETTA","volume":"8","author":"Kahraman","year":"2013","journal-title":"Plos One"},{"key":"10.1074\/mcp.M115.048504_bib21","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/jms.1776","article-title":"Chemical cross-linking with a diazirine photoactivatable cross-linker investigated by MALDI- and ESI-MS\/MS","volume":"45","author":"Gomes","year":"2010","journal-title":"J. Mass Spectrom"},{"key":"10.1074\/mcp.M115.048504_bib22","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1074\/mcp.M700274-MCP200","article-title":"Structural Analysis of Multiprotein Complexes by Cross-linking, Mass Spectrometry, and Database Searching","volume":"6","author":"Maiolica","year":"2007","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/mcp.M115.048504_bib23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1021\/ac026117i","article-title":"Stop and Go Extraction Tips for Matrix-Assisted Laser Desorption\/Ionization, Nanoelectrospray, and LC\/MS Sample Pretreatment in Proteomics","volume":"75","author":"Rappsilber","year":"2002","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M115.048504_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0021-9673(02)01402-4","article-title":"Microcolumns with self-assembled particle frits for proteomics","volume":"979","author":"Ishihama","year":"2002","journal-title":"J. Chromatog. A"},{"key":"10.1074\/mcp.M115.048504_bib25","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/mcp.M115.048504_bib26","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nmeth.2103","article-title":"False discovery rate estimation for cross-linked peptides identified by mass spectrometry","volume":"9","author":"Walzthoeni","year":"2012","journal-title":"Nature Methods"},{"key":"10.1074\/mcp.M115.048504_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nbt.2839","article-title":"ProteomeXchange provides globally coordinated proteomics data submission and dissemination","volume":"32","author":"Vizca\u00edno","year":"2014","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/mcp.M115.048504_bib28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/protein\/12.6.439","article-title":"Crystal structure of human serum albumin at 2.5 \u00c5 resolution","volume":"12","author":"Sugio","year":"1999","journal-title":"Protein Engineering"},{"key":"10.1074\/mcp.M115.048504_bib29","unstructured":".Schrodinger, L., (2010) The PyMOL Molecular Graphics System, Version 1.3r1,"},{"key":"10.1074\/mcp.M115.048504_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2105-12-43","article-title":"DoBo: Protein domain boundary prediction by integrating evolutionary signals and machine learning","volume":"12","author":"Eickholt","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/mcp.M115.048504_bib31","doi-asserted-by":"crossref","first-page":"i247","DOI":"10.1093\/bioinformatics\/btt209","article-title":"ThreaDom: extracting protein domain boundary information from multiple threading alignments","volume":"29","author":"Xue","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M115.048504_bib32","doi-asserted-by":"crossref","first-page":"W349","DOI":"10.1093\/nar\/gkt381","article-title":"Scalable web services for the PSIPRED Protein Analysis Workbench","volume":"41","author":"Buchan","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M115.048504_bib33","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/prot.22123","article-title":"Guiding conformation space search with an all-atom energy potential","volume":"73","author":"Brunette","year":"2008","journal-title":"Proteins"},{"key":"10.1074\/mcp.M115.048504_bib34","series-title":"Methods Enzymol","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0076-6879(04)83004-0","article-title":"Protein Structure Prediction Using Rosetta","author":"Rohl","year":"2004"},{"key":"10.1074\/mcp.M115.048504_bib35","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jmb.2004.02.002","article-title":"Prediction and functional analysis of native disorder in proteins from the three kingdoms of life","volume":"337","author":"Ward","year":"2004","journal-title":"J. Mol. Biol"},{"key":"10.1074\/mcp.M115.048504_bib36","doi-asserted-by":"crossref","first-page":"e22060","DOI":"10.1371\/journal.pone.0022060","article-title":"Modeling disordered regions in proteins using Rosetta","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.M115.048504_bib37","doi-asserted-by":"crossref","first-page":"e108438","DOI":"10.1371\/journal.pone.0108438","article-title":"Combining physicochemical and evolutionary information for protein contact prediction","volume":"9","author":"Schneider","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.M115.048504_bib38","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/bioinformatics\/btr638","article-title":"PSICOV: precise structural contact prediction using sparse inverse covariance estimation on large multiple sequence alignments","volume":"28","author":"Jones","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.M115.048504_bib39","doi-asserted-by":"crossref","first-page":"15674","DOI":"10.1073\/pnas.1314045110","article-title":"Assessing the utility of coevolution-based residue-residue contact predictions in a sequence- and structure-rich era","volume":"110","author":"Kamisetty","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M115.048504_bib40","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/jcc.21988","article-title":"Durandal: fast exact clustering of protein decoys","volume":"33","author":"Berenger","year":"2012","journal-title":"J. Comput. Chem"},{"key":"10.1074\/mcp.M115.048504_bib41","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/prot.340170404","article-title":"Recognition of errors in three-dimensional structures of proteins","volume":"17","author":"Sippl","year":"1993","journal-title":"Proteins"},{"key":"10.1074\/mcp.M115.048504_bib42","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.bpj.2011.09.012","article-title":"GOAP: a generalized orientation-dependent, all-atom statistical potential for protein structure prediction","volume":"101","author":"Zhou","year":"2011","journal-title":"Biophys. J"},{"key":"10.1074\/mcp.M115.048504_bib43","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1039\/b501989c","article-title":"Development and application of diazirines in biological and synthetic macromolecular systems","volume":"1","author":"Blencowe","year":"2005","journal-title":"Soft Matter"},{"key":"10.1074\/mcp.M115.048504_bib44","doi-asserted-by":"crossref","first-page":"16446","DOI":"10.1021\/ja067205d","article-title":"Ultrafast Spectroscopic Study of the Photochemistry and Photophysics of Arylhalodiazirines: Direct Observation of Carbene and Zwitterion Formation","volume":"128","author":"Wang","year":"2006","journal-title":"J. Am. Chem. Soc"},{"key":"10.1074\/mcp.M115.048504_bib45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jprot.2013.03.005","article-title":"Quantitative cross-linking\/mass spectrometry using isotope-labelled cross-linkers","volume":"88","author":"Fischer","year":"2013","journal-title":"J. Proteomics"},{"key":"10.1074\/mcp.M115.048504_bib46","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1742-4658.2011.08004.x","article-title":"Macromolecular NMR spectroscopy for the non-spectroscopist","volume":"278","author":"Kwan","year":"2011","journal-title":"FEBS J"},{"key":"10.1074\/mcp.M115.048504_bib47","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1741-7007-5-17","article-title":"Ab initio modeling of small proteins by iterative TASSER simulations","volume":"5","author":"Wu","year":"2007","journal-title":"BMC Biol"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620336653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620336653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M115.048504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:51:03Z","timestamp":1761526263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620336653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S1535947620336653"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m115.048504","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum Albumin Domain Structures in Human Blood Serum by Mass Spectrometry and Computational Biology","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M115.048504","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}