{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:26:37Z","timestamp":1790126797270,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":1897,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1074\/mcp.m115.048959","type":"journal-article","created":{"date-parts":[[2015,4,19]],"date-time":"2015-04-19T20:01:19Z","timestamp":1429473679000},"page":"1770-1780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen*"],"prefix":"10.1016","volume":"14","author":[{"given":"Carlos","family":"Alvarez-Navarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Mart\u00edn-Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eilon","family":"Barnea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Admon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"L\u00f3pez de Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M115.048959_bib1","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/ni859","article-title":"An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides","volume":"3","author":"Saric","year":"2002","journal-title":"Nat. Immunol"},{"key":"10.1074\/mcp.M115.048959_bib2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature01074","article-title":"ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum","volume":"419","author":"Serwold","year":"2002","journal-title":"Nature"},{"key":"10.1074\/mcp.M115.048959_bib3","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/ng.873","article-title":"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility","volume":"43","author":"Evans","year":"2011","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.M115.048959_bib4","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ng.694","article-title":"A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1","volume":"42","author":"Strange","year":"2010","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.M115.048959_bib5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng.2520","article-title":"Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1","volume":"45","author":"Kirino","year":"2013","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.M115.048959_bib6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni1208","article-title":"Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum","volume":"6","author":"Saveanu","year":"2005","journal-title":"Nat. Immunol"},{"key":"10.1074\/mcp.M115.048959_bib7","doi-asserted-by":"crossref","first-page":"901","DOI":"10.4049\/jimmunol.1302855","article-title":"ERAP1-ERAP2 dimerization increases peptide-trimming efficiency","volume":"193","author":"Evnouchidou","year":"2014","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M115.048959_bib8","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1093\/hmg\/ddu307","article-title":"A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy","volume":"23","author":"Kuiper","year":"2014","journal-title":"Hum. Mol .Genet"},{"key":"10.1074\/mcp.M115.048959_bib9","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ng.2667","article-title":"Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci","volume":"45","author":"Cortes","year":"2013","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.M115.048959_bib10","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ng.717","article-title":"Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci","volume":"42","author":"Franke","year":"2010","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.M115.048959_bib11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00439-009-0714-x","article-title":"The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations","volume":"126","author":"Johnson","year":"2009","journal-title":"Hum. Genet"},{"key":"10.1074\/mcp.M115.048959_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2350-12-64","article-title":"Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study","volume":"12","author":"Hill","year":"2011","journal-title":"BMC Med. Genet"},{"key":"10.1074\/mcp.M115.048959_bib13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/mgg3.13","article-title":"A novel haplotype structure in a Chilean population: Implications for ERAP2 protein expression and preeclampsia risk","volume":"1","author":"Vanhille","year":"2013","journal-title":"Mol. Genet. Genomic. Med"},{"key":"10.1074\/mcp.M115.048959_bib14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.survophthal.2005.08.004","article-title":"Birdshot chorioretinopathy","volume":"50","author":"Shah","year":"2005","journal-title":"Surv. Ophthalmol"},{"key":"10.1074\/mcp.M115.048959_bib15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/09273948.2011.619295","article-title":"HLA-A29 and birdshot chorioretinopathy","volume":"19","author":"Br\u00e9zin","year":"2011","journal-title":"Ocul. Immunol. Inflamm"},{"key":"10.1074\/mcp.M115.048959_bib16","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1074\/mcp.M112.019588","article-title":"Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo","volume":"11","author":"Garcia-Medel","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.048959_bib17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/art.38980","article-title":"Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 peptidome through differential processing determined by multiple peptide residues","volume":"67","author":"Sanz-Bravo","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1074\/mcp.M115.048959_bib18","first-page":"11","article-title":"Description of the reference panel of B-lymphoblastoid cell lines for factors of the HLA system: The B-cell line panel designed for the Tenth International Histocompatibility Workshop","author":"Yang","year":"1989","journal-title":"Immunobiology of HLA. Vol. I. Histocompatibility Testting 1987"},{"key":"10.1074\/mcp.M115.048959_bib19","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.4049\/jimmunol.148.6.1941","article-title":"The HLA-A,B \u201cnegative\u201d mutant cell line C1R expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon","volume":"148","author":"Zemmour","year":"1992","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M115.048959_bib20","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1074\/jbc.M113.529610","article-title":"Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands","volume":"289","author":"Mart\u00edn-Esteban","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M115.048959_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/BF02421470","article-title":"Identification of the amino acid residues defining an intralocus determinant in the alpha 1 domain of HLA-A molecules","volume":"30","author":"Lozano","year":"1989","journal-title":"Immunogenetics"},{"key":"10.1074\/mcp.M115.048959_bib22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/intimm\/2.2.113","article-title":"HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in Western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy","volume":"2","author":"Stam","year":"1990","journal-title":"Int. Immunol"},{"key":"10.1074\/mcp.M115.048959_bib23","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.4049\/jimmunol.161.10.5481","article-title":"The same natural ligand is involved in allorecognition of multiple HLA-B27 subtypes by a single T cell clone: Role of peptide and the MHC molecule in alloreactivity","volume":"161","author":"Paradela","year":"1998","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M115.048959_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0021-9673(02)01402-4","article-title":"Microcolumns with self-assembled particle frits for proteomics","volume":"979","author":"Ishihama","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"10.1074\/mcp.M115.048959_bib25","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/mcp.M115.048959_bib26","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/pr101065j","article-title":"Andromeda: a peptide search engine integrated into the MaxQuant environment","volume":"10","author":"Cox","year":"2011","journal-title":"J. Proteome. Res"},{"key":"10.1074\/mcp.M115.048959_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00251-011-0579-8","article-title":"NetMHCcons: a consensus method for the major histocompatibility complex class I predictions","volume":"64","author":"Karosiene","year":"2012","journal-title":"Immunogenetics"},{"key":"10.1074\/mcp.M115.048959_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","article-title":"A simple method for displaying the hydropathic character of a protein","volume":"157","author":"Kyte","year":"1982","journal-title":"J. Mol. Biol"},{"key":"10.1074\/mcp.M115.048959_bib29","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1182\/blood-2012-02-412593","article-title":"MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements","volume":"119","author":"Granados","year":"2012","journal-title":"Blood"},{"key":"10.1074\/mcp.M115.048959_bib30","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1038\/ncomms4600","article-title":"Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides","volume":"5","author":"Granados","year":"2014","journal-title":"Nat. Commun"},{"key":"10.1074\/mcp.M115.048959_bib31","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1093\/hmg\/ddp371","article-title":"Investigating the genetic association between ERAP1 and ankylosing spondylitis","volume":"18","author":"Harvey","year":"2009","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/mcp.M115.048959_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/art.39072","article-title":"ERAP1 gene expression is influenced by non-synonymous polymorphisms associated with predisposition to spondyloarthritis","author":"Costantino","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1074\/mcp.M115.048959_bib33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ni1409","article-title":"In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides","volume":"8","author":"Hammer","year":"2007","journal-title":"Nat. Immunol"},{"key":"10.1074\/mcp.M115.048959_bib34","doi-asserted-by":"crossref","first-page":"e1001157","DOI":"10.1371\/journal.pgen.1001157","article-title":"Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation","volume":"6","author":"Andres","year":"2010","journal-title":"PLoS. Genet"},{"key":"10.1074\/mcp.M115.048959_bib35","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.febslet.2006.02.041","article-title":"Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)\/ER-aminopeptidase-1","volume":"580","author":"Goto","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1074\/mcp.M115.048959_bib36","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1074\/mcp.M112.024810","article-title":"The human leukocyte antigen-presented ligandome of B lymphocytes","volume":"12","author":"Hassan","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.048959_bib37","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1074\/mcp.M114.039214","article-title":"Peptide handling by HLA-B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to ERAP1","volume":"13","author":"Garcia-Medel","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.048959_bib38","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.4049\/jimmunol.1003337","article-title":"Cutting edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme","volume":"186","author":"Evnouchidou","year":"2011","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M115.048959_bib39","doi-asserted-by":"crossref","first-page":"15383","DOI":"10.1073\/pnas.1308672110","article-title":"Dipeptides promote folding and peptide binding of MHC class I molecules","volume":"110","author":"Saini","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M115.048959_bib40","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1073\/pnas.1418690112","article-title":"Dipeptides catalyze rapid peptide exchange on MHC class I molecules","volume":"112","author":"Saini","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M115.048959_bib41","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.4049\/jimmunol.0903712","article-title":"Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells","volume":"184","author":"Blanchard","year":"2010","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M115.048959_bib42","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/art.38249","article-title":"Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27","volume":"66","author":"Chen","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1074\/mcp.M115.048959_bib43","doi-asserted-by":"crossref","first-page":"e3658","DOI":"10.1371\/journal.pone.0003658","article-title":"The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1","volume":"3","author":"Evnouchidou","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.M115.048959_bib44","doi-asserted-by":"crossref","first-page":"7745","DOI":"10.1073\/pnas.1101262108","article-title":"Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming","volume":"108","author":"Kochan","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M115.048959_bib45","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nsmb.2021","article-title":"Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1","volume":"18","author":"Nguyen","year":"2011","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/mcp.M115.048959_bib46","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/annrheumdis-2011-200347","article-title":"Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis","volume":"71","author":"Haroon","year":"2012","journal-title":"Ann. Rheum. Dis"},{"key":"10.1074\/mcp.M115.048959_bib47","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/gene.2008.13","article-title":"Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals","volume":"9","author":"Levinson","year":"2008","journal-title":"Genes Immun"},{"key":"10.1074\/mcp.M115.048959_bib48","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3109\/09273948.2010.538798","article-title":"Killer immunoglobulin-like receptor genes in uveitis","volume":"19","author":"Levinson","year":"2011","journal-title":"Ocul .Immunol. Inflamm"},{"key":"10.1074\/mcp.M115.048959_bib49","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-14-1643","article-title":"ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors","author":"Cifaldi","year":"2015","journal-title":"Cancer Res"},{"key":"10.1074\/mcp.M115.048959_bib50","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1399-0039.2008.01051.x","article-title":"Peptides: The cornerstone of HLA-B27 biology and pathogenetic role in spondyloarthritis","volume":"71","author":"Marcilla","year":"2008","journal-title":"Tissue Antigens"},{"key":"10.1074\/mcp.M115.048959_bib51","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.molimm.2013.06.012","article-title":"ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases","volume":"57","author":"Alvarez-Navarro","year":"2014","journal-title":"Mol. Immunol"},{"key":"10.1074\/mcp.M115.048959_bib52","doi-asserted-by":"crossref","first-page":"5526","DOI":"10.4049\/jimmunol.0803663","article-title":"The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum","volume":"183","author":"Hearn","year":"2009","journal-title":"J. Immunol"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620328474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620328474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M115.048959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:42:16Z","timestamp":1761525736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620328474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1535947620328474"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m115.048959","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M115.048959","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}