{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:52:12Z","timestamp":1792853532676,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":1597,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2009\u20130090895, 2012\u20130009544, 2015M3A9E6028949, 2015M3A9E6028947, 2012M3A9B9036675, 2014M3C7A1046047"],"award-info":[{"award-number":["2009\u20130090895, 2012\u20130009544, 2015M3A9E6028949, 2015M3A9E6028947, 2012M3A9B9036675, 2014M3C7A1046047"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["IBS-R013-G1\u20132015-a00"],"award-info":[{"award-number":["IBS-R013-G1\u20132015-a00"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","award":["800\u201320140542"],"award-info":[{"award-number":["800\u201320140542"]}],"id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1074\/mcp.m115.053249","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T23:33:10Z","timestamp":1457739190000},"page":"1681-1691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Quantitative Proteomics Reveals \u03b22 Integrin-mediated Cytoskeletal Rearrangement in Vascular Endothelial Growth Factor (VEGF)-induced Retinal Vascular Hyperpermeability"],"prefix":"10.1016","volume":"15","author":[{"given":"Dong Hyun","family":"Jo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingi","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehyun","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hee","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daehee","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M115.053249_bib1","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.ophtha.2014.06.011","article-title":"Monthly versus as-needed ranibizumab injections in patients with retinal vein occlusion: The SHORE study","volume":"121","author":"Campochiaro","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1074\/mcp.M115.053249_bib2","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.ophtha.2014.03.021","article-title":"Neutralization of vascular endothelial growth factor slows progression of retinal nonperfusion in patients with diabetic macular edema","volume":"121","author":"Campochiaro","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1074\/mcp.M115.053249_bib3","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ajo.2011.01.040","article-title":"Levels of VEGF but not VEGF(165b) are increased in the vitreous of patients with retinal vein occlusion","volume":"152","author":"Ehlken","year":"2011","journal-title":"Am. J. Ophthalmol"},{"key":"10.1074\/mcp.M115.053249_bib4","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1167\/iovs.08-2870","article-title":"Concentration gradient of vascular endothelial growth factor in the vitreous of eyes with diabetic macular edema","volume":"50","author":"Shimada","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/mcp.M115.053249_bib5","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/S0161-6420(96)30420-X","article-title":"Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate","volume":"103","author":"Tolentino","year":"1996","journal-title":"Ophthalmology"},{"key":"10.1074\/mcp.M115.053249_bib6","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/jcbfm.2009.78","article-title":"Decursin inhibits VEGF-mediated inner blood-retinal barrier breakdown by suppression of VEGFR-2 activation","volume":"29","author":"Kim","year":"2009","journal-title":"J. Cereb. Blood Flow Metab"},{"key":"10.1074\/mcp.M115.053249_bib7","doi-asserted-by":"crossref","first-page":"e68659","DOI":"10.1371\/journal.pone.0068659","article-title":"Rk1, a ginsenoside, is a new blocker of vascular leakage acting through actin structure remodeling","volume":"8","author":"Maeng","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.M115.053249_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/187152212800389012","article-title":"How to overcome diabetic retinopathy: focusing on blood-retinal barrier","volume":"12","author":"Jo","year":"2012","journal-title":"Immunol. Endocr. Metab. Agents Med. Chem"},{"key":"10.1074\/mcp.M115.053249_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ophtha.2012.07.038","article-title":"Vascular endothelial growth factor A in intraocular vascular disease","volume":"120","author":"Miller","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1074\/mcp.M115.053249_bib10","doi-asserted-by":"crossref","first-page":"e33456","DOI":"10.1371\/journal.pone.0033456","article-title":"Inhibitory activity of bevacizumab to differentiation of retinoblastoma cells","volume":"7","author":"Heo","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.M115.053249_bib11","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1172\/JCI65157","article-title":"Targeted deletion of Vegfa in adult mice induces vision loss","volume":"122","author":"Kurihara","year":"2012","journal-title":"J. Clin. Invest"},{"key":"10.1074\/mcp.M115.053249_bib12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.devcel.2011.11.002","article-title":"VEGF-induced vascular permeability is mediated by FAK","volume":"22","author":"Chen","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1074\/mcp.M115.053249_bib13","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm1742","article-title":"Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability","volume":"14","author":"Jones","year":"2008","journal-title":"Nat. Med"},{"key":"10.1074\/mcp.M115.053249_bib14","first-page":"2337","article-title":"Retinal vascular permeability suppression by topical application of a novel VEGFR2\/Src kinase inhibitor in mice and rabbits","volume":"118","author":"Scheppke","year":"2008","journal-title":"J. Clin. Invest"},{"key":"10.1074\/mcp.M115.053249_bib15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.M115.053249_bib16","doi-asserted-by":"crossref","first-page":"18189","DOI":"10.1038\/srep18189","article-title":"Integrated analysis of global proteome, phosphoproteome, and glycoproteome enables complementary interpretation of disease-related protein networks","volume":"5","author":"Park","year":"2015","journal-title":"Sci. Rep"},{"key":"10.1074\/mcp.M115.053249_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chroma.2013.12.084","article-title":"A fully automated dual-online multifunctional ultrahigh pressure liquid chromatography system for high-throughput proteomics analysis","volume":"1329","author":"Lee","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1074\/mcp.M115.053249_bib18","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1074\/mcp.M700419-MCP200","article-title":"Postexperiment monoisotopic mass filtering and refinement (PE-MMR) of tandem mass spectrometric data increases accuracy of peptide identification in LC\/MS\/MS","volume":"7","author":"Shin","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.053249_bib19","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1074\/mcp.M110.003731","article-title":"The generating function of CID, ETD, and CID\/ETD pairs of tandem mass spectra: applications to database search","volume":"9","author":"Kim","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.053249_bib20","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1021\/pr070492f","article-title":"Nonlinear fitting method for determining local false discovery rates from decoy database searches","volume":"7","author":"Tang","year":"2008","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M115.053249_bib21","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1021\/pr070230d","article-title":"Proteomic parsimony through bipartite graph analysis improves accuracy and transparency","volume":"6","author":"Zhang","year":"2007","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M115.053249_bib22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1074\/mcp.M113.035501","article-title":"A protein profile of visceral adipose tissues linked to early pathogenesis of type 2 diabetes mellitus","volume":"13","author":"Kim","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.053249_bib23","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and related tools","volume":"44","author":"Vizca\u00edno","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M115.053249_bib24","doi-asserted-by":"crossref","first-page":"rs4","DOI":"10.1126\/scisignal.2003266","article-title":"A systems approach for decoding mitochondrial retrograde signaling pathways","volume":"6","author":"Chae","year":"2013","journal-title":"Sci. Signal"},{"key":"10.1074\/mcp.M115.053249_bib25","series-title":"Applied Smoothing Techniques for Data Analysis: The Kernel Approach with S-Plus Illustrations","first-page":"25","author":"Bowman","year":"1997"},{"key":"10.1074\/mcp.M115.053249_bib26","doi-asserted-by":"crossref","first-page":"17296","DOI":"10.1073\/pnas.0508647102","article-title":"A data integration methodology for systems biology","volume":"102","author":"Hwang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M115.053249_bib27","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genome-wide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M115.053249_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc"},{"key":"10.1074\/mcp.M115.053249_bib29","doi-asserted-by":"crossref","first-page":"e82140","DOI":"10.1371\/journal.pone.0082140","article-title":"Proteomic interactions in the mouse vitreous-retina complex","volume":"8","author":"Skeie","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.M115.053249_bib30","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1021\/pr300389r","article-title":"Retinal proteome analysis in a mouse model of oxygen-induced retinopathy","volume":"11","author":"Kim","year":"2012","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M115.053249_bib31","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1021\/pr500558y","article-title":"Involvement of GABA transporters in atropine-treated myopic retina as revealed by iTRAQ quantitative proteomics","volume":"13","author":"Barathi","year":"2014","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M115.053249_bib32","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.002469","article-title":"Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells","volume":"10","author":"Reidel","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.053249_bib33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","article-title":"Structure and function of the blood-brain barrier","volume":"37","author":"Abbott","year":"2010","journal-title":"Neurobiol. Dis"},{"key":"10.1074\/mcp.M115.053249_bib34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brainresrev.2005.03.007","article-title":"Critical role of actin in modulating BBB permeability","volume":"50","author":"Lai","year":"2005","journal-title":"Brain Res. Brain Res. Rev"},{"key":"10.1074\/mcp.M115.053249_bib35","first-page":"339","article-title":"Blood-neural barrier: intercellular communication at glio-vascular interface","volume":"39","author":"Kim","year":"2006","journal-title":"J. Biochem. Mol. Biol"},{"key":"10.1074\/mcp.M115.053249_bib36","doi-asserted-by":"crossref","first-page":"e3554","DOI":"10.1371\/journal.pone.0003554","article-title":"Endogenous VEGF is required for visual function: evidence for a survival role on Muller cells and photoreceptors","volume":"3","author":"Saint-Geniez","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.M115.053249_bib37","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1167\/iovs.06-0804","article-title":"Effect of VEGF-A on expression of profibrotic growth factor and extracellular matrix genes in the retina","volume":"48","author":"Kuiper","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/mcp.M115.053249_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0014-4835(05)80079-X","article-title":"Fibronectin, laminin, vitronectin and their receptors at newly-formed capillaries in proliferative diabetic retinopathy","volume":"60","author":"Casaroli Marano","year":"1995","journal-title":"Exp. Eye Res"},{"key":"10.1074\/mcp.M115.053249_bib39","first-page":"258","article-title":"Fibronectin overexpression in retinal microvessels of patients with diabetes","volume":"37","author":"Roy","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/mcp.M115.053249_bib40","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.2337\/db11-1541","article-title":"Human apolipoprotein(A) kringle V inhibits ischemia-induced retinal neovascularization via suppression of fibronectin-mediated angiogenesis","volume":"61","author":"Lim","year":"2012","journal-title":"Diabetes"},{"key":"10.1074\/mcp.M115.053249_bib41","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1161\/ATVBAHA.108.172015","article-title":"Integrins: the keys to unlocking angiogenesis","volume":"28","author":"Silva","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/mcp.M115.053249_bib42","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrc2353","article-title":"Integrins in angiogenesis and lymphangiogenesis","volume":"8","author":"Avraamides","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/mcp.M115.053249_bib43","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.scr.2013.12.008","article-title":"Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and \u03b2-2 integrin signaling","volume":"12","author":"Hayakawa","year":"2014","journal-title":"Stem Cell Res"},{"key":"10.1074\/mcp.M115.053249_bib44","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1002\/art.22263","volume":"54","author":"Margheri","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1074\/mcp.M115.053249_bib45","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1167\/iovs.02-0773","article-title":"Fibronectin fragments promote human retinal endothelial cell adhesion and proliferation and ERK activation through \u03b15\u03b21 integrin and PI 3-kinase","volume":"44","author":"Wilson","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/mcp.M115.053249_bib46","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1172\/JCI76492","article-title":"Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune cross-talk","volume":"124","author":"Dejda","year":"2014","journal-title":"J. Clin. Invest"},{"key":"10.1074\/mcp.M115.053249_bib47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0002-9440(10)64363-5","article-title":"The \u03b1(1)\u03b2(1) and \u03b1(2)\u03b2(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis","volume":"160","author":"Senger","year":"2002","journal-title":"Am. J. Pathol"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620336069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620336069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M115.053249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:50:12Z","timestamp":1761526212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620336069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S1535947620336069"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m115.053249","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative Proteomics Reveals \u03b22 Integrin-mediated Cytoskeletal Rearrangement in Vascular Endothelial Growth Factor (VEGF)-induced Retinal Vascular Hyperpermeability","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M115.053249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}