{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:16:01Z","timestamp":1790421361236,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":1658,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1074\/mcp.m115.054585","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T20:43:05Z","timestamp":1449607385000},"page":"1072-1082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Immunohistochemical Markers Distinguishing Cholangiocellular Carcinoma (CCC) from Pancreatic Ductal Adenocarcinoma (PDAC) Discovered by Proteomic Analysis of Microdissected Cells"],"prefix":"10.1016","volume":"15","author":[{"given":"Juliet","family":"Padden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Ahrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"K\u00e4lsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Bertram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik A.","family":"Megger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Bracht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Eisenacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peri","family":"Kocabayoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut E.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"Sipos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo A.","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Sitek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M115.054585_bib1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1055\/s-2005-858576","article-title":"[Liver metastases: incidence and histogenesis]","volume":"43","author":"Kasper","year":"2005","journal-title":"Z. Gastroenterol"},{"key":"10.1074\/mcp.M115.054585_bib2","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.humpath.2009.10.029","article-title":"Agrin immunohistochemistry facilitates the determination of primary versus metastatic origin of liver carcinomas","volume":"41","author":"Somoracz","year":"2010","journal-title":"Hum. Pathol"},{"key":"10.1074\/mcp.M115.054585_bib3","unstructured":".German S3-Guideline \u201cS3-Leitlinie zum exokrinen Pankreaskarzinom\u201d (2013) Version 1.0, AWMF registration number: 032\/010OL.,"},{"key":"10.1074\/mcp.M115.054585_bib4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1634\/theoncologist.2011-0386","article-title":"Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping","volume":"17","author":"Borger","year":"2012","journal-title":"Oncologist"},{"key":"10.1074\/mcp.M115.054585_bib5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/hep.22310","article-title":"Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment","volume":"48","author":"Blechacz","year":"2008","journal-title":"Hepatology"},{"key":"10.1074\/mcp.M115.054585_bib6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.humpath.2006.08.025","article-title":"Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts","volume":"38","author":"Ney","year":"2007","journal-title":"Hum. Pathol"},{"key":"10.1074\/mcp.M115.054585_bib7","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.humpath.2011.11.012","article-title":"The novel monoclonal antibody HPC2 and N-cadherin distinguish pancreatic ductal adenocarcinoma from cholangiocarcinoma","volume":"43","author":"Hooper","year":"2012","journal-title":"Hum. Pathol"},{"key":"10.1074\/mcp.M115.054585_bib8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.humpath.2013.10.004","article-title":"Immunohistochemical distinction between intrahepatic cholangiocarcinoma and pancreatic ductal adenocarcinoma","volume":"45","author":"Lok","year":"2014","journal-title":"Hum. Pathol"},{"key":"10.1074\/mcp.M115.054585_bib9","series-title":"WHO classification of tumours of the digestive system","author":"Bosman","year":"2010"},{"key":"10.1074\/mcp.M115.054585_bib10","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1074\/mcp.M113.028027","article-title":"Proteomic differences between hepatocellular carcinoma and nontumorous liver tissue investigated by a combined gel-based and label-free quantitative proteomics study","volume":"12","author":"Megger","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.054585_bib11","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1074\/mcp.M113.034942","article-title":"Identification of novel biomarker candidates for the immunohistochemical diagnosis of cholangiocellular carcinoma","volume":"13","author":"Padden","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.054585_bib12","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/hep.22764","article-title":"Detection of novel biomarkers of liver cirrhosis by proteomic analysis","volume":"49","author":"Molleken","year":"2009","journal-title":"Hepatology"},{"key":"10.1074\/mcp.M115.054585_bib13","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1021\/acs.jproteome.5b00053","article-title":"Analysis of disease-associated protein expression using quantitative proteomics-fibulin-5 is expressed in association with hepatic fibrosis","volume":"14","author":"Bracht","year":"2015","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M115.054585_bib14","doi-asserted-by":"crossref","first-page":"D1063","DOI":"10.1093\/nar\/gks1262","article-title":"The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013","volume":"41","author":"Vizcaino","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M115.054585_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate \u2013 a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Roy. Stat. Soc. B Met"},{"key":"10.1074\/mcp.M115.054585_bib16","unstructured":".Gamer, M., Lemon, J., Fellows, I., and P, S., (2010) irr: Various coefficients of interrater reliability and agreement (Version 0.83) [Software]. Available from http:\/\/CRAN.R-project.org\/package=irr, ."},{"key":"10.1074\/mcp.M115.054585_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/mcp.M115.054585_bib18","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1074\/mcp.M115.054585_bib19","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1021\/pr9006365","article-title":"Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry","volume":"9","author":"Tabb","year":"2010","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M115.054585_bib20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.bbapap.2013.07.017","article-title":"Comparison of label-free and label-based strategies for proteome analysis of hepatoma cell lines","volume":"1844","author":"Megger","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/mcp.M115.054585_bib21","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1038\/onc.2013.524","article-title":"Protein kinase C and cancer: what we know and what we do not","volume":"33","author":"Garg","year":"2014","journal-title":"Oncogene"},{"key":"10.1074\/mcp.M115.054585_bib22","first-page":"6724","article-title":"Expression of CD44 in pancreatic cancer and its significance","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol"},{"key":"10.1074\/mcp.M115.054585_bib23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bbrc.2008.10.034","article-title":"Emerging functional roles of cathepsin E","volume":"377","author":"Zaidi","year":"2008","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/mcp.M115.054585_bib24","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s13277-014-2732-0","article-title":"RAB34 was a progression- and prognosis-associated biomarker in gliomas","volume":"36","author":"Wang","year":"2015","journal-title":"Tumour Biol"},{"key":"10.1074\/mcp.M115.054585_bib25","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cellsig.2014.02.012","article-title":"Annexins \u2013 scaffolds modulating PKC localization and signaling","volume":"26","author":"Hoque","year":"2014","journal-title":"Cell. Signal"},{"key":"10.1074\/mcp.M115.054585_bib26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.2400","article-title":"The role of annexins in tumor development and progression","volume":"216","author":"Mussunoor","year":"2008","journal-title":"J. Pathol"},{"key":"10.1074\/mcp.M115.054585_bib27","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.3748\/wjg.v10.i10.1466","article-title":"Overexpression of annexin 1 in pancreatic cancer and its clinical significance","volume":"10","author":"Bai","year":"2004","journal-title":"World J. Gastroenterol"},{"key":"10.1074\/mcp.M115.054585_bib28","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.3748\/wjg.v19.i16.2456","article-title":"Annexin A1: a new immunohistological marker of cholangiocarcinoma","volume":"19","author":"Hongsrichan","year":"2013","journal-title":"World J. Gastroenterol"},{"key":"10.1074\/mcp.M115.054585_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.febslet.2004.10.078","article-title":"Specific association of annexin 1 with plasma membrane-resident and internalized EGF receptors mediated through the protein core domain","volume":"578","author":"Radke","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1074\/mcp.M115.054585_bib30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/hep.510310217","article-title":"Annexin 1 expression and phosphorylation are upregulated during liver regeneration and transformation in antithrombin III SV40 T large antigen transgenic mice","volume":"31","author":"de Coupade","year":"2000","journal-title":"Hepatology"},{"key":"10.1074\/mcp.M115.054585_bib31","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/his.12229","article-title":"Annexin A10 is an immunohistochemical marker for adenocarcinoma of the upper gastrointestinal tract and pancreatobiliary system","volume":"63","author":"Lu","year":"2013","journal-title":"Histopathology"},{"key":"10.1074\/mcp.M115.054585_bib32","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/oxfordjournals.molbev.a004120","article-title":"Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins","volume":"19","author":"Iglesias","year":"2002","journal-title":"Mol. Biol. Evol"},{"key":"10.1074\/mcp.M115.054585_bib33","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1042\/BJ20041918","article-title":"Structure-function relationship in annexin A13, the founder member of the vertebrate family of annexins","volume":"389","author":"Turnay","year":"2005","journal-title":"Biochem. J"},{"key":"10.1074\/mcp.M115.054585_bib34","first-page":"61","article-title":"Identification of annexin A13 as a regulator of chemotherapy resistance using random homozygous gene perturbation","volume":"32","author":"Reiske","year":"2010","journal-title":"Anal. Quant. Cytol. Histol"},{"key":"10.1074\/mcp.M115.054585_bib35","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/01.pas.0000149708.12335.6a","article-title":"Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2","volume":"29","author":"Chu","year":"2005","journal-title":"Am. J. Surg. Pathol"}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620336628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620336628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M115.054585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:50:20Z","timestamp":1761526220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620336628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S1535947620336628"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m115.054585","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunohistochemical Markers Distinguishing Cholangiocellular Carcinoma (CCC) from Pancreatic Ductal Adenocarcinoma (PDAC) Discovered by Proteomic Analysis of Microdissected Cells","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M115.054585","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}