{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:41:45Z","timestamp":1787611305600,"version":"build-2736575974"},"reference-count":97,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":1690,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1026527"],"award-info":[{"award-number":["1026527"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1355158"],"award-info":[{"award-number":["1355158"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1306528"],"award-info":[{"award-number":["1306528"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-14-1-0061"],"award-info":[{"award-number":["W81XWH-14-1-0061"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1074\/mcp.m115.055079","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T22:59:20Z","timestamp":1443567560000},"page":"412-430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Analysis of Proteins That Rapidly Change Upon Mechanistic\/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)"],"prefix":"10.1016","volume":"15","author":[{"given":"Farr","family":"Niere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Namjoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehwang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey A.","family":"Dilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Schoenhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris V.","family":"Zemelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehia","family":"Mechref","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly F.","family":"Raab-Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M115.055079_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","article-title":"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery","volume":"110","author":"Kim","year":"2002","journal-title":"Cell"},{"key":"10.1074\/mcp.M115.055079_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1073\/pnas.012605299","article-title":"A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus","volume":"99","author":"Tang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M115.055079_bib3","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1523\/JNEUROSCI.0995-04.2004","article-title":"Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression","volume":"24","author":"Hou","year":"2004","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib4","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev"},{"key":"10.1074\/mcp.M115.055079_bib5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrn3068","article-title":"Fighting neurodegeneration with rapamycin: mechanistic insights","volume":"12","author":"Bove","year":"2011","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib6","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0092-8674(04)00115-1","article-title":"Translational control by MAPK signaling in long-term synaptic plasticity and memory","volume":"116","author":"Kelleher","year":"2004","journal-title":"Cell"},{"key":"10.1074\/mcp.M115.055079_bib7","doi-asserted-by":"crossref","first-page":"9760","DOI":"10.1523\/JNEUROSCI.1427-04.2004","article-title":"Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites","volume":"24","author":"Takei","year":"2004","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib8","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1523\/JNEUROSCI.0599-05.2005","article-title":"Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation","volume":"25","author":"Tsokas","year":"2005","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib9","doi-asserted-by":"crossref","first-page":"18802","DOI":"10.1074\/jbc.M512524200","article-title":"Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons","volume":"281","author":"Gong","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M115.055079_bib10","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1128\/MCB.00201-08","article-title":"mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice","volume":"28","author":"Antion","year":"2008","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/mcp.M115.055079_bib11","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1111\/j.1582-4934.2008.00509.x","article-title":"mTOR-dependent signaling in Alzheimer's disease","volume":"12","author":"Pei","year":"2008","journal-title":"J. Cell. Mol. Med"},{"key":"10.1074\/mcp.M115.055079_bib12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbapap.2007.08.015","article-title":"Role of mTOR in physiology and pathology of the nervous system","volume":"1784","author":"Swiech","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/mcp.M115.055079_bib13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1523\/JNEUROSCI.3696-09.2010","article-title":"Dysregulation of mTOR signaling in fragile X syndrome","volume":"30","author":"Sharma","year":"2010","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tins.2009.11.003","article-title":"mTOR signaling: at the crossroads of plasticity, memory and disease","volume":"33","author":"Hoeffer","year":"2010","journal-title":"Trends Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib15","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/hmg\/ddq563","article-title":"Reduced AKT\/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model","volume":"20","author":"Ricciardi","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/mcp.M115.055079_bib16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fnbeh.2011.00076","article-title":"Dysregulated mTORC1-dependent translational control: from brain disorders to psychoactive drugs","volume":"5","author":"Santini","year":"2011","journal-title":"Front Behav. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib17","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/nn.3546","article-title":"mTOR complexes in neurodevelopmental and neuropsychiatric disorders","volume":"16","author":"Costa-Mattioli","year":"2013","journal-title":"Nat. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib18","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0002-9440(10)63687-5","article-title":"Up-regulation of phosphorylated\/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease","volume":"163","author":"An","year":"2003","journal-title":"Am. J. Pathol"},{"key":"10.1074\/mcp.M115.055079_bib19","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1111\/j.1742-4658.2005.04833.x","article-title":"Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain","volume":"272","author":"Li","year":"2005","journal-title":"FEBS J"},{"key":"10.1074\/mcp.M115.055079_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2051-5960-1-3","article-title":"Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease","volume":"1","author":"Yates","year":"2013","journal-title":"Acta Neuropathol. Commun"},{"key":"10.1074\/mcp.M115.055079_bib21","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1523\/JNEUROSCI.5685-08.2009","article-title":"Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice","volume":"29","author":"Zhou","year":"2009","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib22","doi-asserted-by":"crossref","first-page":"8862","DOI":"10.1523\/JNEUROSCI.1617-11.2011","article-title":"Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function","volume":"31","author":"Bateup","year":"2011","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib23","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1523\/JNEUROSCI.0061-11.2011","article-title":"Pten knockdown in vivo increases excitatory drive onto dentate granule cells","volume":"31","author":"Luikart","year":"2011","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a009886","article-title":"Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities","volume":"4","author":"Zoghbi","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"10.1074\/mcp.M115.055079_bib25","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.neuron.2013.03.017","article-title":"Excitatory\/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis","volume":"78","author":"Bateup","year":"2013","journal-title":"Neuron"},{"key":"10.1074\/mcp.M115.055079_bib26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature11628","article-title":"Autism-related deficits via dysregulated eIF4E-dependent translational control","volume":"493","author":"Gkogkas","year":"2013","journal-title":"Nature"},{"key":"10.1074\/mcp.M115.055079_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2014.00001","article-title":"Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures","volume":"7","author":"Weston","year":"2014","journal-title":"Front. Mol. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib28","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neuron.2012.08.002","article-title":"Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy","volume":"75","author":"Pun","year":"2012","journal-title":"Neuron"},{"key":"10.1074\/mcp.M115.055079_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.5698\/1535-7597-14.1.41","article-title":"mTOR strikes again: mTORC1 activation causes epilepsy independent of overt pathological changes","volume":"14","author":"Wong","year":"2014","journal-title":"Epilepsy Curr"},{"key":"10.1074\/mcp.M115.055079_bib30","doi-asserted-by":"crossref","first-page":"e57808","DOI":"10.1371\/journal.pone.0057808","article-title":"Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage","volume":"8","author":"Brewster","year":"2013","journal-title":"PLoS One"},{"key":"10.1074\/mcp.M115.055079_bib31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.nbd.2014.09.011","article-title":"Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis","volume":"73","author":"Sosanya","year":"2015","journal-title":"Neurobiol. Dis"},{"key":"10.1074\/mcp.M115.055079_bib32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1535-7511.2008.00279.x","article-title":"Do we have a cure for tuberous sclerosis complex?","volume":"8","author":"Crino","year":"2008","journal-title":"Epilepsy Curr"},{"key":"10.1074\/mcp.M115.055079_bib33","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1074\/mcp.M115.055079_bib34","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1126\/science.1131693","article-title":"Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites","volume":"314","author":"Raab-Graham","year":"2006","journal-title":"Science"},{"key":"10.1074\/mcp.M115.055079_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1083\/jcb.201212089","article-title":"Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1","volume":"202","author":"Sosanya","year":"2013","journal-title":"J. Cell Biol"},{"key":"10.1074\/mcp.M115.055079_bib36","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/epi.12033","article-title":"Dendritic ion channelopathy in acquired epilepsy","volume":"9","author":"Poolos","year":"2012","journal-title":"Epilepsia"},{"key":"10.1074\/mcp.M115.055079_bib37","doi-asserted-by":"crossref","first-page":"161ra152","DOI":"10.1126\/scitranslmed.3004190","article-title":"Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy","volume":"4","author":"Wykes","year":"2012","journal-title":"Sci. Transl. Med"},{"key":"10.1074\/mcp.M115.055079_bib38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/2001-1326-1-29","article-title":"Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer","volume":"1","author":"Seto","year":"2012","journal-title":"Clin. Transl. Med"},{"key":"10.1074\/mcp.M115.055079_bib39","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neuropharm.2013.05.037","article-title":"mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling","volume":"73","author":"Workman","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1074\/mcp.M115.055079_bib40","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1021\/pr800982s","article-title":"Accurate and sensitive peptide identification with Mascot Percolator","volume":"8","author":"Brosch","year":"2009","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M115.055079_bib41","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/pmic.200900437","article-title":"Scaffold: a bioinformatic tool for validating MS\/MS-based proteomic studies","volume":"10","author":"Searle","year":"2010","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M115.055079_bib42","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1021\/ac025747h","article-title":"Empirical statistical model to estimate the accuracy of peptide identifications made by MS\/MS and database search","volume":"74","author":"Keller","year":"2002","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M115.055079_bib43","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"Nesvizhskii","year":"2003","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M115.055079_bib44","doi-asserted-by":"crossref","first-page":"D1160","DOI":"10.1093\/nar\/gkr1101","article-title":"MitoMiner: a data warehouse for mitochondrial proteomics data","volume":"40","author":"Smith","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M115.055079_bib45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc"},{"key":"10.1074\/mcp.M115.055079_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M115.055079_bib47","doi-asserted-by":"crossref","first-page":"e13984","DOI":"10.1371\/journal.pone.0013984","article-title":"Enrichment map: a network-based method for gene-set enrichment visualization and interpretation","volume":"5","author":"Merico","year":"2010","journal-title":"PLoS One"},{"key":"10.1074\/mcp.M115.055079_bib48","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1074\/mcp.M115.055079_bib49","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2105-11-91","article-title":"BisoGenet: a new tool for gene network building, visualization and analysis","volume":"11","author":"Martin","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/mcp.M115.055079_bib50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/2040-2392-4-36","article-title":"SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)","volume":"4","author":"Abrahams","year":"2013","journal-title":"Mol. Autism"},{"key":"10.1074\/mcp.M115.055079_bib51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database","volume":"39","author":"Bertram","year":"2007","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.M115.055079_bib52","doi-asserted-by":"crossref","first-page":"D199","DOI":"10.1093\/nar\/gkt1076","article-title":"Data, information, knowledge, and principle: back to metabolism in KEGG","volume":"42","author":"Kanehisa","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M115.055079_bib53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.18637\/jss.v021.i12","article-title":"Reshaping data with the reshape package","volume":"21","author":"Wickham","year":"2007","journal-title":"J. Stat. Softw"},{"key":"10.1074\/mcp.M115.055079_bib54","doi-asserted-by":"crossref","first-page":"9","DOI":"10.18637\/jss.v028.c01","article-title":"Beanplot: a boxplot alternative for visual comparison of distributions","volume":"28","author":"Kampstra","year":"2008","journal-title":"J. Stat. Softw"},{"key":"10.1074\/mcp.M115.055079_bib55","series-title":"Ggplot2 : elegant graphics for data analysis","first-page":"viii","author":"Wickham","year":"2009"},{"key":"10.1074\/mcp.M115.055079_bib56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.18637\/jss.v040.i01","article-title":"The split-apply-combine strategy for data analysis","volume":"40","author":"Wickham","year":"2011","journal-title":"J. Stat. Softw"},{"key":"10.1074\/mcp.M115.055079_bib57","series-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2015"},{"key":"10.1074\/mcp.M115.055079_bib58","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/mp.2014.165","article-title":"Rapid antidepressants stimulate the decoupling of GABA receptors from GIRK\/Kir3 channels through increased protein stability of 14\u20133-3eta","volume":"20","author":"Workman","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1074\/mcp.M115.055079_bib59","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nmeth.3319","article-title":"Direct visualization of newly synthesized target proteins in situ","volume":"12","author":"tom Dieck","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.M115.055079_bib60","doi-asserted-by":"crossref","first-page":"14223","DOI":"10.1523\/JNEUROSCI.3157-11.2011","article-title":"Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry","volume":"31","author":"Hays","year":"2011","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib61","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1523\/JNEUROSCI.4650-11.2012","article-title":"Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression","volume":"32","author":"Niere","year":"2012","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib62","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1074\/mcp.E113.031658","article-title":"Western blots versus selected reaction monitoring assays: time to turn the tables?","volume":"12","author":"Aebersold","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.055079_bib63","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev.neuro.24.1.299","article-title":"Protein synthesis at synaptic sites on dendrites","volume":"24","author":"Steward","year":"2001","journal-title":"Annu. Rev. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib64","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1073\/pnas.94.10.5395","article-title":"Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation","volume":"94","author":"Weiler","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M115.055079_bib65","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuron.2008.05.014","article-title":"Rapid translation of Arc\/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate","volume":"59","author":"Waung","year":"2008","journal-title":"Neuron"},{"key":"10.1074\/mcp.M115.055079_bib66","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1038\/ncomms5510","article-title":"Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience","volume":"5","author":"Ainsley","year":"2014","journal-title":"Nat. Commun"},{"key":"10.1074\/mcp.M115.055079_bib67","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1600-0854.2010.01118.x","article-title":"Subcellular communication through RNA transport and localized protein synthesis","volume":"11","author":"Donnelly","year":"2010","journal-title":"Traffic"},{"key":"10.1074\/mcp.M115.055079_bib68","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tig.2004.04.008","article-title":"Genomic analysis of essentiality within protein networks","volume":"20","author":"Yu","year":"2004","journal-title":"Trends Genet"},{"key":"10.1074\/mcp.M115.055079_bib69","first-page":"245","article-title":"Network visualization and network analysis","volume":"97","author":"Nikiforova","year":"2007","journal-title":"EXS"},{"key":"10.1074\/mcp.M115.055079_bib70","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0006-8993(67)90217-X","article-title":"Action of triton X-100 on ultrastructure and membrane-bound- enzymes of isolated nerve endings from rat brain","volume":"5","author":"Fiszer","year":"1967","journal-title":"Brain Res"},{"key":"10.1074\/mcp.M115.055079_bib71","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1083\/jcb.74.1.181","article-title":"The structure of postsynaptic densities isolated from dog cerebral cortex. I. Overall morphology and protein composition","volume":"74","author":"Cohen","year":"1977","journal-title":"J. Cell Biol"},{"key":"10.1074\/mcp.M115.055079_bib72","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0092-8674(00)81797-3","article-title":"Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons","volume":"87","author":"Arancio","year":"1996","journal-title":"Cell"},{"key":"10.1074\/mcp.M115.055079_bib73","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1126\/science.1072356","article-title":"SynCAM, a synaptic adhesion molecule that drives synapse assembly","volume":"297","author":"Biederer","year":"2002","journal-title":"Science"},{"key":"10.1074\/mcp.M115.055079_bib74","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jneumeth.2006.05.008","article-title":"Rapid isolation of synaptoneurosomes and postsynaptic densities from adult mouse hippocampus","volume":"158","author":"Villasana","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"10.1074\/mcp.M115.055079_bib75","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.neurobiolaging.2003.04.005","article-title":"Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals","volume":"24","author":"Honer","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/mcp.M115.055079_bib76","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1038\/tp.2012.38","article-title":"Cognitive reserve, presynaptic proteins, and dementia in the elderly","volume":"2","author":"Honer","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1074\/mcp.M115.055079_bib77","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/(SICI)1522-2683(19990101)20:4\/5<928::AID-ELPS928>3.0.CO;2-Z","article-title":"Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down syndrome and Alzheimer's disease","volume":"20","author":"Greber","year":"1999","journal-title":"Electrophoresis"},{"key":"10.1074\/mcp.M115.055079_bib78","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nn783","article-title":"Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis","volume":"5","author":"Washbourne","year":"2002","journal-title":"Nat. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib79","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1074\/mcp.M113.030676","article-title":"The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depression","volume":"12","author":"Han","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.055079_bib80","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev-cellbio-101011-155818","article-title":"The membrane fusion enigma: SNAREs, Sec1\/Munc18 proteins, and their accomplices \u2013 guilty as charged?","volume":"28","author":"Rizo","year":"2012","journal-title":"Annu. Rev. Cell Dev. Biol"},{"key":"10.1074\/mcp.M115.055079_bib81","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.nlm.2005.08.014","article-title":"Gene targeting of presynaptic proteins in synaptic plasticity and memory: across the great divide","volume":"85","author":"Powell","year":"2006","journal-title":"Neurobiol. Learn. Mem"},{"key":"10.1074\/mcp.M115.055079_bib82","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.neuron.2012.02.036","article-title":"The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging","volume":"74","author":"Cajigas","year":"2012","journal-title":"Neuron"},{"key":"10.1074\/mcp.M115.055079_bib83","doi-asserted-by":"crossref","first-page":"19113","DOI":"10.1073\/pnas.1017235108","article-title":"Dendritic SNAREs add a new twist to the old neuron theory","volume":"108","author":"Ovsepian","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M115.055079_bib84","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/nn1566","article-title":"Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2","volume":"8","author":"Tavazoie","year":"2005","journal-title":"Nat. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib85","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature10658","article-title":"Mutations causing syndromic autism define an axis of synaptic pathophysiology","volume":"480","author":"Auerbach","year":"2011","journal-title":"Nature"},{"key":"10.1074\/mcp.M115.055079_bib86","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/cdd.2014.227","article-title":"Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis","volume":"22","author":"Fossati","year":"2015","journal-title":"Cell Death Differ"},{"key":"10.1074\/mcp.M115.055079_bib87","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/embor.2013.75","article-title":"Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses","volume":"14","author":"Antonucci","year":"2013","journal-title":"EMBO Rep"},{"issue":"2","key":"10.1074\/mcp.M115.055079_bib88","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.neuron.2011.10.007","article-title":"SnapShot: genetics of autism","volume":"72","author":"Aldinger","year":"2011","journal-title":"Neuron"},{"key":"10.1074\/mcp.M115.055079_bib89","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/mp.2011.57","article-title":"SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism","volume":"17","author":"Durand","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1074\/mcp.M115.055079_bib90","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.neuron.2009.07.017","article-title":"A role for SNAP25 in internalization of kainate receptors and synaptic plasticity","volume":"63","author":"Selak","year":"2009","journal-title":"Neuron"},{"key":"10.1074\/mcp.M115.055079_bib91","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neuroscience.2008.02.066","article-title":"Kainate receptors in epilepsy and excitotoxicity","volume":"158","author":"Vincent","year":"2009","journal-title":"Neuroscience"},{"key":"10.1074\/mcp.M115.055079_bib92","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nrn898","article-title":"Snares and Munc18 in synaptic vesicle fusion","volume":"3","author":"Rizo","year":"2002","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib93","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neuron.2008.09.005","article-title":"Calcium channel regulation and presynaptic plasticity","volume":"59","author":"Catterall","year":"2008","journal-title":"Neuron"},{"key":"10.1074\/mcp.M115.055079_bib94","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1523\/JNEUROSCI.4933-08.2010","article-title":"SNAP-25 is a target of protein kinase C phosphorylation critical to NMDA receptor trafficking","volume":"30","author":"Lau","year":"2010","journal-title":"J. Neurosci"},{"key":"10.1074\/mcp.M115.055079_bib95","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1038\/ncomms3136","article-title":"SNAP-25 regulates spine formation through postsynaptic binding to p140Cap","volume":"4","author":"Tomasoni","year":"2013","journal-title":"Nat. Commun"},{"key":"10.1074\/mcp.M115.055079_bib96","first-page":"683920","article-title":"Neuroprotective function of DJ-1 in Parkinson's disease","author":"Ariga","year":"2013","journal-title":"Oxid. Med. Cell Longev"},{"key":"10.1074\/mcp.M115.055079_bib97","doi-asserted-by":"crossref","first-page":"7012","DOI":"10.1073\/pnas.1319221111","article-title":"Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase","volume":"111","author":"Miller-Fleming","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A"}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153594762033680X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153594762033680X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M115.055079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:52:29Z","timestamp":1761526349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153594762033680X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":97,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S153594762033680X"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m115.055079","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of Proteins That Rapidly Change Upon Mechanistic\/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M115.055079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}