{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:21:34Z","timestamp":1793121694271,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":1503,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1074\/mcp.m115.055731","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T22:39:14Z","timestamp":1464388754000},"page":"2628-2640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":127,"title":["Plasma-derived Extracellular Vesicles Contain Predictive Biomarkers and Potential Therapeutic Targets for Myocardial Ischemic (MI) Injury"],"prefix":"10.1016","volume":"15","author":[{"given":"Esther Sok Hwee","family":"Cheow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Chin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuen Neng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"de Kleijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Sorokin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siu Kwan","family":"Sze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M115.055731_bib1","first-page":"e28","article-title":"Heart disease and stroke statistics\u20132014 update: a report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"10.1074\/mcp.M115.055731_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.arr.2014.12.001","article-title":"Aging and dyslipidemia: A review of potential mechanisms","volume":"19","author":"Liu","year":"2015","journal-title":"Ageing Res. Rev"},{"key":"10.1074\/mcp.M115.055731_bib3","first-page":"645","article-title":"Cardiovascular disease","author":"Gaziano","year":"2006","journal-title":"Disease control priorities in developing countries"},{"key":"10.1074\/mcp.M115.055731_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The inflammatory response in myocardial infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovascular Res"},{"key":"10.1074\/mcp.M115.055731_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat. Rev. Cardiol"},{"key":"10.1074\/mcp.M115.055731_bib6","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/01.CIR.95.3.684","article-title":"Complement C5a, TGF-\u03b21, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion","volume":"95","author":"Birdsall","year":"1997","journal-title":"Circulation"},{"key":"10.1074\/mcp.M115.055731_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.atherosclerosis.2014.12.002","article-title":"Expression of anaphylatoxin receptors on platelets in patients with coronary heart disease","volume":"238","author":"Patzelt","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1074\/mcp.M115.055731_bib8","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/01.CIR.0000087447.12918.85","article-title":"Pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to primary percutaneous coronary intervention in acute myocardial infarction the complement inhibition in myocardial infarction treated with angioplasty (COMMA) trial","volume":"108","author":"Granger","year":"2003","journal-title":"Circulation"},{"key":"10.1074\/mcp.M115.055731_bib9","first-page":"23","article-title":"pexelizumab and survival in cardiac surgery","volume":"3","author":"Testa","year":"2011","journal-title":"HSR Proc. Intensive Care Cardiovascular Anesthesia"},{"key":"10.1074\/mcp.M115.055731_bib10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10557-014-6511-3","article-title":"Reduced oxidative stress in STEMI patients treated by primary percutaneous coronary intervention and with antioxidant therapy: a systematic review","volume":"28","author":"Ekel\u00f8f","year":"2014","journal-title":"Cardiovascular Drugs Therapy"},{"key":"10.1074\/mcp.M115.055731_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1161\/01.RES.54.3.277","article-title":"Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase","volume":"54","author":"Jolly","year":"1984","journal-title":"Circ. Res"},{"key":"10.1074\/mcp.M115.055731_bib12","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/01.RES.65.3.607","article-title":"Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial\u201c stunning\u201d is a manifestation of reperfusion injury","volume":"65","author":"Bolli","year":"1989","journal-title":"Circ. Res"},{"key":"10.1074\/mcp.M115.055731_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/jbt.21668","article-title":"Preventive Effects of Zingerone on Altered Lipid Peroxides and Nonenzymatic Antioxidants in the Circulation of Isoproterenol-Induced Myocardial Infarcted Rats","volume":"29","author":"Hemalatha","year":"2015","journal-title":"Journal of biochemical and molecular toxicology"},{"key":"10.1074\/mcp.M115.055731_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1755-1536-6-11","article-title":"Neutrophil roles in left ventricular remodeling following myocardial infarction","volume":"6","author":"Ma","year":"2013","journal-title":"Fibrogenesis & Tissue Repair"},{"key":"10.1074\/mcp.M115.055731_bib15","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1093\/cvr\/cvu082.97","article-title":"P160Neutrophils modulate healing after myocardial infarction","volume":"103","author":"Horckmans","year":"2014","journal-title":"Cardiovascular Res"},{"key":"10.1074\/mcp.M115.055731_bib16","doi-asserted-by":"crossref","first-page":"G44","DOI":"10.1152\/ajpgi.00413.2010","article-title":"Hydrogen sulfide preconditioning or neutrophil depletion attenuates ischemia-reperfusion-induced mitochondrial dysfunction in rat small intestine","volume":"302","author":"Liu","year":"2012","journal-title":"Am. J. Physiol. Gastrointestinal Liver Physiol"},{"key":"10.1074\/mcp.M115.055731_bib17","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/0002-8703(86)90461-8","article-title":"Reduction of myocardial infarct size by neutrophil depletion: effect of duration of occlusion","volume":"112","author":"Jolly","year":"1986","journal-title":"Am. Heart J"},{"key":"10.1074\/mcp.M115.055731_bib18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrrheum.2014.19","article-title":"Emerging role of extracellular vesicles in inflammatory diseases","volume":"10","author":"Buzas","year":"2014","journal-title":"Nat. Rev. Rheumatol"},{"key":"10.1074\/mcp.M115.055731_bib19","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00281-010-0233-9","article-title":"Exosomes: immune properties and potential clinical implementations","volume":"33","author":"Chaput","year":"2011","journal-title":"Semin Immunopathol"},{"key":"10.1074\/mcp.M115.055731_bib20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","article-title":"Membrane vesicles as conveyors of immune responses","volume":"9","author":"Th\u00e9ry","year":"2009","journal-title":"Nat. Rev. Immunol"},{"key":"10.1074\/mcp.M115.055731_bib21","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/leu.2011.389","article-title":"Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies&quest","volume":"26","author":"Ratajczak","year":"2012","journal-title":"Leukemia"},{"key":"10.1074\/mcp.M115.055731_bib22","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/sj.leu.2404132","article-title":"Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery","volume":"20","author":"Ratajczak","year":"2006","journal-title":"Leukemia"},{"key":"10.1074\/mcp.M115.055731_bib23","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1182\/blood-2004-03-1095","article-title":"Tissue-factor\u2013bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation","volume":"106","author":"del Conde","year":"2005","journal-title":"Blood"},{"key":"10.1074\/mcp.M115.055731_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/MMBR.00031-09","article-title":"Virulence and immunomodulatory roles of bacterial outer membrane vesicles","volume":"74","author":"Ellis","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev"},{"key":"10.1074\/mcp.M115.055731_bib25","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1093\/hmg\/dds317","article-title":"Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy","volume":"21","author":"Lee","year":"2012","journal-title":"Human Mol. Gen"},{"key":"10.1074\/mcp.M115.055731_bib26","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/mcp.M115.055731_bib27","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1161\/CIRCRESAHA.110.233056","article-title":"Microparticles in hemostasis and thrombosis","volume":"108","author":"Owens","year":"2011","journal-title":"Circulation Res"},{"key":"10.1074\/mcp.M115.055731_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4161\/org.7.2.15782","article-title":"The role of microvesicles in tissue repair","volume":"7","author":"Tetta","year":"2011","journal-title":"Organogenesis"},{"key":"10.1074\/mcp.M115.055731_bib29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s40291-013-0042-7","article-title":"Circulating Extracellular Vesicles in Cancer Diagnosis and Monitoring","volume":"17","author":"Choi","year":"2013","journal-title":"Mol. Diagnosis Ther"},{"key":"10.1074\/mcp.M115.055731_bib30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1161\/CIRCRESAHA.110.233163","article-title":"Microparticles, vascular function, and atherothrombosis","volume":"109","author":"Rautou","year":"2011","journal-title":"Circulation Res"},{"key":"10.1074\/mcp.M115.055731_bib31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fphys.2012.00124","article-title":"Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?","volume":"3","author":"Bellingham","year":"2012","journal-title":"Frontiers Physiol"},{"key":"10.1074\/mcp.M115.055731_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.scr.2011.01.001","article-title":"Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction","volume":"6","author":"Timmers","year":"2011","journal-title":"Stem Cell Res"},{"key":"10.1074\/mcp.M115.055731_bib33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.scr.2009.12.003","article-title":"Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury","volume":"4","author":"Lai","year":"2010","journal-title":"Stem Cell Res"},{"key":"10.1074\/mcp.M115.055731_bib34","article-title":"Simultaneous enrichment of plasma soluble and extracellular vesicular glycoproteins using prolonged ultracentrifugation-ERLIC approach","author":"Cheow","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.055731_bib35","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.009381","article-title":"Detection, evaluation and minimization of nonenzymatic deamidation in proteomic sample preparation","volume":"10","author":"Hao","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.055731_bib36","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1021\/pr500903b","article-title":"Evaluation of the effect of trypsin digestion buffers on artificial deamidation","volume":"14","author":"Hao","year":"2014","journal-title":"Journal of proteome research"},{"key":"10.1074\/mcp.M115.055731_bib37","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/pmic.201400515","article-title":"FunRich: An open access standalone functional enrichment and interaction network analysis tool","volume":"15","author":"Pathan","year":"2015","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M115.055731_bib38","doi-asserted-by":"crossref","first-page":"D1063","DOI":"10.1093\/nar\/gks1262","article-title":"The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013","volume":"41","author":"Vizca\u00edno","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M115.055731_bib39","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1161\/CIRCRESAHA.113.300858","article-title":"Microvesicles as cell\u2013cell messengers in cardiovascular diseases","volume":"114","author":"Loyer","year":"2014","journal-title":"Circulation Res"},{"key":"10.1074\/mcp.M115.055731_bib40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.blre.2012.12.002","article-title":"Extracellular vesicles in physiological and pathological conditions","volume":"27","author":"Yuana","year":"2013","journal-title":"Blood Rev"},{"key":"10.1074\/mcp.M115.055731_bib41","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.addr.2012.07.019","article-title":"Roles of exosomes and microvesicles in disease pathogenesis","volume":"65","author":"Ohno","year":"2013","journal-title":"Advanced Drug Delivery Rev"},{"key":"10.1074\/mcp.M115.055731_bib42","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1074\/mcp.M500084-MCP200","article-title":"Comparison of label-free methods for quantifying human proteins by shotgun proteomics","volume":"4","author":"Old","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M115.055731_bib43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nri3622","article-title":"Regulation of immune responses by extracellular vesicles","volume":"14","author":"Robbins","year":"2014","journal-title":"Nat. Rev. Immunol"},{"key":"10.1074\/mcp.M115.055731_bib44","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.4049\/jimmunol.170.6.3037","article-title":"Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo","volume":"170","author":"Skokos","year":"2003","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M115.055731_bib45","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1182\/blood-2004-01-0361","article-title":"Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis","volume":"104","author":"Gasser","year":"2004","journal-title":"Blood"},{"key":"10.1074\/mcp.M115.055731_bib46","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1182\/blood.V99.11.3962","article-title":"Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor\u2013dependent procoagulant activity","volume":"99","author":"Sabatier","year":"2002","journal-title":"Blood"},{"key":"10.1074\/mcp.M115.055731_bib47","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.4049\/jimmunol.153.7.3245","article-title":"Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide","volume":"153","author":"Satta","year":"1994","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.M115.055731_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1385\/IR:30:1:073","article-title":"The role of complement activation in atherosclerosis","volume":"30","author":"Niculescu","year":"2004","journal-title":"Immunologic Res"},{"key":"10.1074\/mcp.M115.055731_bib49","series-title":"Introduction to Translational Cardiovascular Research","first-page":"279","article-title":"Repair of the Infarcted Myocardium","author":"Wang","year":"2015"},{"key":"10.1074\/mcp.M115.055731_bib50","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol"},{"key":"10.1074\/mcp.M115.055731_bib51","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/eji.201445070","article-title":"TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2","volume":"45","author":"Keizer","year":"2015","journal-title":"Eur. J. Immunol"},{"key":"10.1074\/mcp.M115.055731_bib52","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/hc3601.095578","article-title":"Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury","volume":"104","author":"Jordan","year":"2001","journal-title":"Circulation"},{"key":"10.1074\/mcp.M115.055731_bib53","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1073\/pnas.1101748108","article-title":"Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia\/reperfusion injury","volume":"108","author":"Schwaeble","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1074\/mcp.M115.055731_bib54","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/jcp.2005.027235","article-title":"Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction","volume":"59","author":"Meuwissen","year":"2006","journal-title":"J. Clin. Pathol"},{"key":"10.1074\/mcp.M115.055731_bib55","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0002-9149(90)90079-G","article-title":"Elevation of C-reactive protein in \u201cactive\u201d coronary artery disease","volume":"65","author":"Berk","year":"1990","journal-title":"Am. J. Cardiol"},{"key":"10.1074\/mcp.M115.055731_bib56","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/01.CIR.97.20.2007","article-title":"C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction","volume":"97","author":"Ridker","year":"1998","journal-title":"Circulation"},{"key":"10.1074\/mcp.M115.055731_bib57","doi-asserted-by":"crossref","first-page":"C1263","DOI":"10.1152\/ajpcell.1999.277.6.C1263","article-title":"Skeletal muscle reperfusion injury is mediated by neutrophils and the complement membrane attack complex","volume":"277","author":"Kyriakides","year":"1999","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/mcp.M115.055731_bib58","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jss.2003.04.001","article-title":"Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats","volume":"116","author":"Woodruff","year":"2004","journal-title":"J. Surgical Res"},{"key":"10.1074\/mcp.M115.055731_bib59","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/cvr\/28.4.437","article-title":"The complement system in myocardial ischaemia\/reperfusion injury","volume":"28","author":"Kilgore","year":"1994","journal-title":"Cardiovascular Res"},{"key":"10.1074\/mcp.M115.055731_bib60","series-title":"The chemistry and biology of C3a, C4a and C5a and their effects on cells","first-page":"99","author":"Hugli","year":"1983"},{"key":"10.1074\/mcp.M115.055731_bib61","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.RES.63.2.483","article-title":"C5a decreases regional coronary blood flow and myocardial function in pigs: implications for a granulocyte mechanism","volume":"63","author":"Martin","year":"1988","journal-title":"Circulation Res"},{"key":"10.1074\/mcp.M115.055731_bib62","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1161\/01.CIR.88.6.2762","article-title":"Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events","volume":"88","author":"Phillips","year":"1993","journal-title":"Circulation"},{"key":"10.1074\/mcp.M115.055731_bib63","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bbalip.2015.05.007","article-title":"Defective functionality of small, dense HDL3 subpopulations in ST segment elevation myocardial infarction: Relevance of enrichment in lysophosphatidylcholine, phosphatidic acid and serum amyloid A","volume":"1851","author":"Rached","year":"2015","journal-title":"Biochimica et biophysica acta"},{"key":"10.1074\/mcp.M115.055731_bib64","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/ATVBAHA.114.303284","article-title":"Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease The Atherosclerosis Risk in Communities (ARIC) Study","volume":"34","author":"Hoogeveen","year":"2014","journal-title":"Arteriosclerosis, Thrombosis, Vasc. Biol"},{"key":"10.1074\/mcp.M115.055731_bib65","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1056\/NEJMoa1308027","article-title":"Loss-of-function mutations in APOC3 and risk of ischemic vascular disease","volume":"371","author":"J\u00f8rgensen","year":"2014","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/mcp.M115.055731_bib66","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJMoa1307095","article-title":"Loss-of-function mutations in APOC3, triglycerides, and coronary disease","volume":"371","author":"Cohorts","year":"2014","journal-title":"New Engl J Medicine"},{"key":"10.1074\/mcp.M115.055731_bib67","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0167-4838(00)00162-X","article-title":"Apolipoprotein d","volume":"1482","author":"Rassart","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/mcp.M115.055731_bib68","doi-asserted-by":"crossref","first-page":"17","DOI":"10.18632\/aging.100004","article-title":"Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging","volume":"1","author":"Perdomo","year":"2009","journal-title":"Aging"},{"key":"10.1074\/mcp.M115.055731_bib69","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/glia.21010","article-title":"ApoD, a glia-derived apolipoprotein, is required for peripheral nerve functional integrity and a timely response to injury","volume":"58","author":"Ganfornina","year":"2010","journal-title":"Glia"},{"key":"10.1074\/mcp.M115.055731_bib70","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4161\/cc.9.2.10433","article-title":"Apolipoprotein D: an overview of its role in aging and age-related diseases","volume":"9","author":"Muffat","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1074\/mcp.M115.055731_bib71","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1073\/pnas.0800896105","article-title":"Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila","volume":"105","author":"Muffat","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1074\/mcp.M115.055731_bib72","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1172\/JCI26206","article-title":"Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL","volume":"117","author":"Vaisar","year":"2007","journal-title":"J. Clin. Invest"},{"key":"10.1074\/mcp.M115.055731_bib73","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1124\/pr.58.3.1","article-title":"Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis","volume":"58","author":"Kontush","year":"2006","journal-title":"Pharmacological Rev"},{"key":"10.1074\/mcp.M115.055731_bib74","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/01.RES.0000252802.25497.b7","article-title":"Platelets as immune cells bridging inflammation and cardiovascular disease","volume":"100","author":"von Hundelshausen","year":"2007","journal-title":"Circulation Res"},{"key":"10.1074\/mcp.M115.055731_bib75","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/ATVBAHA.110.220467","article-title":"Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction","volume":"31","author":"Liu","year":"2011","journal-title":"Arteriosclerosis, Thrombosis, Vasc. Biol"},{"key":"10.1074\/mcp.M115.055731_bib76","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1182\/blood-2006-03-013151","article-title":"Effect of genetic variations in platelet glycoproteins Ib\u03b1 and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy","volume":"109","author":"Bray","year":"2007","journal-title":"Blood"},{"key":"10.1074\/mcp.M115.055731_bib77","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1084\/jem.187.3.329","article-title":"Adhesion of activated platelets to endothelial cells: evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 (ICAM-1), \u03b1v\u03b23 integrin, and GPIb\u03b1","volume":"187","author":"Bombeli","year":"1998","journal-title":"J. Exp. Med"},{"key":"10.1074\/mcp.M115.055731_bib78","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.2174\/138161207781662885","article-title":"Insights into the platelet releasate","volume":"13","author":"Coppinger","year":"2007","journal-title":"Current Pharmaceut. Design"},{"key":"10.1074\/mcp.M115.055731_bib79","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM198408233110804","article-title":"Fibrinogen as a risk factor for stroke and myocardial infarction","volume":"311","author":"Wilhelmsen","year":"1984","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/mcp.M115.055731_bib80","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1475-2840-13-37","article-title":"Extracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease","volume":"13","author":"Kranendonk","year":"2014","journal-title":"Cardiovasc. Diabetol"},{"key":"10.1074\/mcp.M115.055731_bib81","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620334939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620334939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M115.055731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:48:20Z","timestamp":1761526100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620334939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":81,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S1535947620334939"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m115.055731","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma-derived Extracellular Vesicles Contain Predictive Biomarkers and Potential Therapeutic Targets for Myocardial Ischemic (MI) Injury","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M115.055731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}