{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:58:43Z","timestamp":1788951523539,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":1290,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/https:\/\/dx.doi.org\/10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-IAHU-01"],"award-info":[{"award-number":["ANR-10-IAHU-01"]}],"id":[{"id":"10.13039\/https:\/\/dx.doi.org\/10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1074\/mcp.m116.063867","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T21:40:40Z","timestamp":1484257240000},"page":"457-468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Impact of Cystinosin Glycosylation on Protein Stability by Differential Dynamic Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)"],"prefix":"10.1016","volume":"16","author":[{"given":"Nathalie","family":"Nevo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cerina","family":"Chhuon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzanna","family":"Andrzejewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Lipecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Guillonneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Bailleux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Edelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Antignac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Chiara","family":"Guerrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M116.063867_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMra020552","volume":"347","author":"Gahl","year":"2002","journal-title":"Cystinosis N. Engl. J. Med"},{"key":"10.1074\/mcp.M116.063867_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ng0498-319","article-title":"A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis","volume":"18","author":"Town","year":"1998","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.M116.063867_bib3","doi-asserted-by":"crossref","first-page":"13314","DOI":"10.1074\/jbc.M010562200","article-title":"The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif","volume":"276","author":"Cherqui","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M116.063867_bib4","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1093\/emboj\/20.21.5940","article-title":"Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporter","volume":"20","author":"Kalatzis","year":"2001","journal-title":"EMBO J"},{"key":"10.1074\/mcp.M116.063867_bib5","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1681\/ASN.2014090937","article-title":"Cystinosin is a component of the vacuolar H+-ATPase-Ragulator-Rag Complex controlling mammalian target of rapamycin complex 1 signaling","volume":"27","author":"Andrzejewska","year":"2015","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/mcp.M116.063867_bib6","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/tra.12277","article-title":"Lysosomal targeting of cystinosin requires AP-3","volume":"16","author":"Andrzejewska","year":"2015","journal-title":"Traffic"},{"key":"10.1074\/mcp.M116.063867_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000046043","article-title":"The molecular basis of Dutch infantile nephropathic cystinosis","volume":"89","author":"Heil","year":"2001","journal-title":"Nephron"},{"key":"10.1074\/mcp.M116.063867_bib8","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/hmg\/ddh152","article-title":"Molecular pathogenesis of cystinosis: effect of CTNS mutations on the transport activity and subcellular localization of cystinosin","volume":"13","author":"Kalatzis","year":"2004","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/mcp.M116.063867_bib9","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00467-011-1904-z","article-title":"Natural history of adolescent-onset cystinosis","volume":"26","author":"Midgley","year":"2011","journal-title":"Pediatr. Nephrol"},{"key":"10.1074\/mcp.M116.063867_bib10","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1146\/annurev.bi.41.070172.003325","article-title":"Glycoproteins","volume":"41","author":"Marshall","year":"1972","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/mcp.M116.063867_bib11","doi-asserted-by":"crossref","first-page":"31039","DOI":"10.1074\/jbc.274.43.31039","article-title":"Asparagine-linked oligosaccharides protect Lamp-1 and Lamp-2 from intracellular proteolysis","volume":"274","author":"Kundra","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.M116.063867_bib12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1021\/pr800641v","article-title":"Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC","volume":"8","author":"Doherty","year":"2009","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.M116.063867_bib13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/bfgp\/3.4.382","article-title":"The dynamics of the proteome: strategies for measuring protein turnover on a proteome-wide scale","volume":"3","author":"Beynon","year":"2005","journal-title":"Brief Funct. Genomic Proteomic"},{"key":"10.1074\/mcp.M116.063867_bib14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanh\u00e4usser","year":"2011","journal-title":"Nature"},{"key":"10.1074\/mcp.M116.063867_bib15","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1128\/JVI.73.4.2886-2892.1999","article-title":"Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors","volume":"73","author":"Zufferey","year":"1999","journal-title":"J. Virol"},{"key":"10.1074\/mcp.M116.063867_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1074\/mcp.M200046-MCP200","article-title":"Dynamics of protein turnover, a missing dimension in proteomics","volume":"1","author":"Pratt","year":"2002","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M116.063867_bib17","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizca\u00edno","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.M116.063867_bib18","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/mcp.M116.063867_bib19","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M113.031591","article-title":"MaxLFQ allows accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction","author":"Cox","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M116.063867_bib20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Meth"},{"key":"10.1074\/mcp.M116.063867_bib21","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1093\/hmg\/8.13.2507","article-title":"Severity of phenotype in cystinosis varies with mutations in the CTNS gene: predicted effect on the model of cystinosin","volume":"8","author":"Attard","year":"1999","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/mcp.M116.063867_bib22","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/tra.12358","article-title":"N-Glycan-based ER molecular chaperone and protein quality control system: the calnexin binding cycle","volume":"17","author":"Lamriben","year":"2016","journal-title":"Traffic"},{"key":"10.1074\/mcp.M116.063867_bib23","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/j.1600-0854.2007.00643.x","article-title":"Integral and associated lysosomal membrane proteins","volume":"8","author":"Schr\u00f6der","year":"2007","journal-title":"Traffic"},{"key":"10.1074\/mcp.M116.063867_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1083\/jcb.200910042","article-title":"Stringent requirement for HRD1, SEL1L, and OS-9\/XTP3-B for disposal of ERAD-LS substrates","volume":"188","author":"Bernasconi","year":"2010","journal-title":"J. Cell Biol"},{"key":"10.1074\/mcp.M116.063867_bib25","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1091\/mbc.e11-08-0663","article-title":"IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin","volume":"23","author":"Chiang","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/mcp.M116.063867_bib26","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1091\/mbc.e14-03-0805","article-title":"OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation","volume":"25","author":"Dersh","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/mcp.M116.063867_bib27","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nchembio.1651","article-title":"The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis","volume":"10","author":"Hebert","year":"2014","journal-title":"Nat. Chem. Biol"},{"key":"10.1074\/mcp.M116.063867_bib28","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1073\/pnas.91.3.913","article-title":"Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control","volume":"91","author":"Hammond","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.M116.063867_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1091\/mbc.5.3.253","article-title":"How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum","volume":"5","author":"Helenius","year":"1994","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/mcp.M116.063867_bib30","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/sj.cdd.4402200","article-title":"Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium","volume":"14","author":"H\u00f8yer-Hansen","year":"2007","journal-title":"Cell Death Differentiation"},{"key":"10.1074\/mcp.M116.063867_bib31","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.cell.2011.07.021","article-title":"Rescue of \u0394F508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway","volume":"146","author":"Gee","year":"2011","journal-title":"Cell"},{"key":"10.1074\/mcp.M116.063867_bib32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ceb.2010.10.002","article-title":"ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER","volume":"23","author":"Bernasconi","year":"2011","journal-title":"Curr. Opin. Cell Biol"}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620324257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620324257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M116.063867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:37:23Z","timestamp":1761525443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620324257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S1535947620324257"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m116.063867","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Cystinosin Glycosylation on Protein Stability by Differential Dynamic Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M116.063867","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}