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Chem."},{"key":"10.1074\/mcp.M600356-MCP200_bib79","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/pmic.200400994","article-title":"Large-scale evaluation of quantitative reproducibility and proteome coverage using acid cleavable isotope coded affinity tag mass spectrometry for proteomic profiling","volume":"5","author":"Molloy","year":"2005","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M600356-MCP200_bib80","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S1044-0305(03)00204-6","article-title":"Quantitative proteomic analysis of chromatin-associated factors","volume":"14","author":"Shiio","year":"2003","journal-title":"J. Am. Soc. 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Med."},{"key":"10.1074\/mcp.M600356-MCP200_bib83","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.febslet.2004.07.011","article-title":"Downregulation of peroxiredoxin V stimulates formation of etoposide-induced double-strand DNA breaks","volume":"572","author":"Kropotov","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1074\/mcp.M600356-MCP200_bib84","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1096\/fasebj.11.2.9039962","article-title":"The G-protein Gi regulates mitosis but not DNA synthesis in growth factor-activated fibroblasts: a role for the nuclear translocation of Gi","volume":"11","author":"Crouch","year":"1997","journal-title":"FASEB J."},{"key":"10.1074\/mcp.M600356-MCP200_bib85","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1083\/jcb.200409150","article-title":"G protein \u03b2 interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus","volume":"169","author":"Kino","year":"2005","journal-title":"J. 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