{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:47:15Z","timestamp":1790167635225,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":4949,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1074\/mcp.m600372-mcp200","type":"journal-article","created":{"date-parts":[[2006,11,23]],"date-time":"2006-11-23T20:25:14Z","timestamp":1164313514000},"page":"346-355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Proteomics Analysis and Protein Expression during Sporozoite Excystation of Cryptosporidium parvum (Coccidia, Apicomplexa)"],"prefix":"10.1016","volume":"6","author":[{"given":"William J.","family":"Snelling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Cherie","family":"Millar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Tosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Pozio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.G.","family":"Dooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm J.","family":"Lowery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M600372-MCP200_bib1","first-page":"223","article-title":"Detection of Cryptosporidium parvum infection in childhood using various techniques.","volume":"8","author":"Doganci","year":"2002","journal-title":"Med. Sci. Monit."},{"key":"10.1074\/mcp.M600372-MCP200_bib2","series-title":"Cryptosporidium and Cryptosporidiosis","first-page":"1","article-title":"General biology of Cryptosporidium","author":"Fayer","year":"1997"},{"key":"10.1074\/mcp.M600372-MCP200_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1128\/CMR.17.1.72-97.2004","article-title":"Cryptosporidium taxonomy: recent advances and implications for public health.","volume":"17","author":"Xiao","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1074\/mcp.M600372-MCP200_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0166-6851(01)00328-0","article-title":"Apical organelles of Apicomplexa: biology and isolation by subcellular fractionation.","volume":"117","author":"Blackman","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pt.2005.01.007","article-title":"Cryptosporidium excystation and invasion: getting to the guts of the matter.","volume":"21","author":"Smith","year":"2005","journal-title":"Trends Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1472-765X.2006.01936.x","article-title":"Under the microscope: Cryptosporidium.","volume":"42","author":"Sunnotel","year":"2006","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1074\/mcp.M600372-MCP200_bib7","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1128\/IAI.68.3.1710-1713.2000","article-title":"Intestinal epithelial cell apoptosis following Cryptosporidium parvum infection.","volume":"68","author":"McCole","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1074\/mcp.M600372-MCP200_bib8","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0020-7519(00)00135-1","article-title":"Epidemiology of Cryptosporidium: transmission, detection, and identification.","volume":"30","author":"Fayer","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib9","first-page":"185","article-title":"Molecular epidemiology of human cryptosporidiosis.","volume":"47","author":"Caccio","year":"2005","journal-title":"Parassitologia"},{"key":"10.1074\/mcp.M600372-MCP200_bib10","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1073\/pnas.0408563102","article-title":"Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion.","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/mcp.M600372-MCP200_bib11","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1046\/j.1365-3024.2000.00343.x","article-title":"Host cell-mediated responses to infection with Cryptosporidium.","volume":"22","author":"McDonald","year":"2000","journal-title":"Parasite Immunol."},{"key":"10.1074\/mcp.M600372-MCP200_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.molbiopara.2006.04.006","article-title":"Characterization of the glycosylphosphatidylinositol anchor of the immunodominant Cryptosporidium parvum 17-kDa antigen.","volume":"149","author":"Priest","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJM199407213310304","article-title":"A massive outbreak in Milwaukee of cryptosporidium infection transmitted through the public water supply.","volume":"331","author":"MacKenzie","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/mcp.M600372-MCP200_bib14","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3201\/eid0904.020417","article-title":"Cost of illness in the 1993 waterborne Cryptosporidium outbreak, Milwaukee, Wisconsin.","volume":"9","author":"Corso","year":"2003","journal-title":"Emerg. Infect. Dis."},{"key":"10.1074\/mcp.M600372-MCP200_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/expr.2000.4574","article-title":"Cryptosporidium parvum: functional complementation of a parasite transcriptional coactivator CpMBF1 in yeast.","volume":"96","author":"Zhu","year":"2000","journal-title":"Exp. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib16","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/09603120500155716","article-title":"Outbreaks associated with recreational water in the United States.","volume":"15","author":"Craun","year":"2005","journal-title":"Int. J. Environ. Health Res."},{"key":"10.1074\/mcp.M600372-MCP200_bib17","first-page":"217","article-title":"The unusual architecture and predicted function of the mitochondrion organelle in Cryptosporidium parvum and hominis species: the strong paradigm of the structure-function relationship.","volume":"47","author":"Putignani","year":"2005","journal-title":"Parassitologia"},{"key":"10.1074\/mcp.M600372-MCP200_bib18","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1074\/mcp.M600139-MCP200","article-title":"Analysis of the Salmonella typhimurium proteome through environmental response towards infectious conditions.","volume":"5","author":"Adkins","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M600372-MCP200_bib19","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/nature02977","article-title":"The genome of Cryptosporidium hominis.","volume":"431","author":"Xu","year":"2004","journal-title":"Nature"},{"key":"10.1074\/mcp.M600372-MCP200_bib20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1126\/science.1094786","article-title":"Complete genome sequence of the apicomplexan, Cryptosporidium parvum.","volume":"304","author":"Abrahamsen","year":"2004","journal-title":"Science"},{"key":"10.1074\/mcp.M600372-MCP200_bib21","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1101\/gr.2615304","article-title":"Comparative analysis of Apicomplexa and genomic diversity in eukaryotes.","volume":"14","author":"Templeton","year":"2004","journal-title":"Genome Res."},{"key":"10.1074\/mcp.M600372-MCP200_bib22","first-page":"56S","article-title":"Cryptosporidium parvum: synchronized excystation in vitro and evaluation of sporozoite infectivity with a new lectin-based assay.","volume":"46","author":"Gut","year":"1999","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1074\/mcp.M600372-MCP200_bib23","first-page":"61","article-title":"Characterization of post-translationally modified recombinant protein using liquid chromatography\/mass spectrometry.","volume":"103","author":"Wu","year":"2000","journal-title":"Dev. Biol. (Basel)"},{"key":"10.1074\/mcp.M600372-MCP200_bib24","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1074\/mcp.M400129-MCP200","article-title":"Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents.","volume":"3","author":"Ross","year":"2004","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M600372-MCP200_bib25","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1074\/mcp.M400182-MCP200","article-title":"Proteome dynamics during C2C12 myoblast differentiation.","volume":"4","author":"Kislinger","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M600372-MCP200_bib26","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.ijpara.2006.02.023","article-title":"Quantitative and qualitative comparisons of Cryptosporidium faecal purification procedures for the isolation of oocysts suitable for proteomic analysis.","volume":"36","author":"Truong","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2307\/3282084","article-title":"Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic Percoll gradients.","volume":"73","author":"Arrowood","year":"1987","journal-title":"J. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib28","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1128\/AEM.66.7.2972-2980.2000","article-title":"Comparison of Cryptosporidium parvum viability and infectivity assays following ozone treatment of oocysts.","volume":"66","author":"Bukhari","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1074\/mcp.M600372-MCP200_bib29","doi-asserted-by":"crossref","first-page":"6061","DOI":"10.1128\/IAI.72.10.6061-6067.2004","article-title":"Cryptosporidium parvum at different developmental stages modulates host cell apoptosis in vitro.","volume":"72","author":"Mele","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1074\/mcp.M600372-MCP200_bib30","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1128\/iai.62.5.1927-1939.1994","article-title":"Bovine antibody against Cryptosporidium parvum elicits a circumsporozoite precipitate-like reaction and has immunotherapeutic effect against persistent cryptosporidiosis in SCID mice.","volume":"62","author":"Riggs","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1074\/mcp.M600372-MCP200_bib31","first-page":"140","article-title":"Purification and characterization of a deoxyriboendonuclease from Mycobacterium smegmatis.","volume":"39","author":"Mandal","year":"2006","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1074\/mcp.M600372-MCP200_bib32","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/pmic.200401143","article-title":"Different techniques for urinary protein analysis of normal and lung cancer patients.","volume":"5","author":"Tantipaiboonwong","year":"2005","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M600372-MCP200_bib33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/ng1101","article-title":"The study of macromolecular complexes by quantitative proteomics.","volume":"33","author":"Ranish","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1074\/mcp.M600372-MCP200_bib34","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1126\/science.1073634","article-title":"S-Nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death.","volume":"297","author":"Gu","year":"2002","journal-title":"Science"},{"key":"10.1074\/mcp.M600372-MCP200_bib35","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1128\/IAI.70.5.2605-2613.2002","article-title":"Chlamydia trachomatis disrupts N-cadherin-dependent cell-cell junctions and sequester \u03b2-catenin in human cervical epithelial cells.","volume":"70","author":"Prozialeck","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1074\/mcp.M600372-MCP200_bib36","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1021\/ac010617e","article-title":"An automated multidimensional protein identification technology for shotgun proteomics.","volume":"73","author":"Wolters","year":"2001","journal-title":"Anal. Chem."},{"key":"10.1074\/mcp.M600372-MCP200_bib37","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1094\/MPMI-19-0150","article-title":"Proteomic comparison of needles from blister rust-resistant and susceptible Pinus strobus seedlings reveals upregulation of putative disease resistance proteins.","volume":"19","author":"Smith","year":"2006","journal-title":"Mol. Plant-Microbe Interact."},{"key":"10.1074\/mcp.M600372-MCP200_bib38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1471-2164-6-145","article-title":"i-Tracker: For quantitative proteomics using iTRAQ\u2122.","volume":"6","author":"Shadforth","year":"2005","journal-title":"BMC Genomics"},{"key":"10.1074\/mcp.M600372-MCP200_bib39","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1021\/ac0481046","article-title":"Discovering known and unanticipated protein modifications using MS\/MS database searching.","volume":"77","author":"Tang","year":"2005","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.M600372-MCP200_bib40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0166-6851(98)00119-4","article-title":"A novel multi-domain mucin-like glycoprotein of Cryptosporidium parvum mediates invasion.","volume":"96","author":"Barnes","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib41","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1046\/j.1432-1327.1999.00682.x","article-title":"Proteasome-dependent cyst formation and stage-specific ubiquitin mRNA accumulation in Entamoeba invadens.","volume":"264","author":"Gonzalez","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/mcp.M600372-MCP200_bib42","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/pmic.200401161","article-title":"Global protein expression analysis in apicomplexan parasites: current status.","volume":"5","author":"Belli","year":"2005","journal-title":"Proteomics"},{"key":"10.1074\/mcp.M600372-MCP200_bib43","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1128\/IAI.71.10.6027-6034.2003","article-title":"Expression of Cpgp40\/15 in Toxoplasma gondii: a surrogate system for the study of Cryptosporidium glycoprotein antigens.","volume":"71","author":"O\u2019Connor","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1074\/mcp.M600372-MCP200_bib44","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/S0020-7519(99)00158-7","article-title":"Identification and characterisation of three antigenic proteins from Cryptosporidium parvum sporozoites using a DNA library expressing poly-histidine tagged peptides.","volume":"29","author":"Tosini","year":"1999","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib45","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1128\/IAI.72.3.1306-1310.2004","article-title":"Cryptosporidium parvum-specific CD4 Th1 cells from sensitized donors responding to both fractionated and recombinant antigenic proteins.","volume":"72","author":"Gomez Morales","year":"2004","journal-title":"Infect Immun."},{"key":"10.1074\/mcp.M600372-MCP200_bib46","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/342438a0","article-title":"Developmental regulation of stage-specific ribosome populations in Plasmodium.","volume":"342","author":"Waters","year":"1989","journal-title":"Nature"},{"key":"10.1074\/mcp.M600372-MCP200_bib47","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1006\/expr.1994.1051","article-title":"Plasmodium: the developmentally regulated ribosome.","volume":"78","author":"Li","year":"1994","journal-title":"Exp. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib48","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.molbiopara.2004.11.011","article-title":"De novo ribosome biosynthesis is transcriptionally regulated in Eimeria tenella, dependent on its life cycle stage.","volume":"139","author":"Schaap","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib49","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0305-0491(92)90033-N","article-title":"Structure and possible function of heat-shock proteins in Falciparum malaria.","volume":"102","author":"Sharma","year":"1992","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1074\/mcp.M600372-MCP200_bib50","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-3024.1995.tb00902.x","article-title":"Heat shock proteins of Toxoplasma gondii.","volume":"17","author":"Lyons","year":"1995","journal-title":"Parasite Immunol."},{"key":"10.1074\/mcp.M600372-MCP200_bib51","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.ijpara.2006.04.006","article-title":"The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth.","volume":"36","author":"Peroval","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib52","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.molbiopara.2003.11.014","article-title":"A new modular protein of Cryptosporidium parvum, with ricin B and LCCL domains, expressed in the sporozoite invasive stage.","volume":"134","author":"Tosini","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/mcp.M600372-MCP200_bib53","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1093\/emboj\/cdg248","article-title":"Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity.","volume":"22","author":"Nakayama","year":"2003","journal-title":"EMBO J."},{"key":"10.1074\/mcp.M600372-MCP200_bib54","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.exppara.2005.11.010","article-title":"Plasmodium falciparum: co-dependent expression and co-localization of the PfCCp multi-adhesion domain proteins.","volume":"112","author":"Pradel","year":"2006","journal-title":"Exp. Parasitol."}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620314213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620314213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M600372-MCP200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:27:43Z","timestamp":1761524863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620314213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1535947620314213"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m600372-mcp200","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomics Analysis and Protein Expression during Sporozoite Excystation of Cryptosporidium parvum (Coccidia, Apicomplexa)","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M600372-MCP200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}