{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T15:34:06Z","timestamp":1766504046777,"version":"build-2065373602"},"reference-count":70,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":571,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000061","name":"HHS | NIH | Fogarty International Center","doi-asserted-by":"publisher","award":["R01 AI0684316","R24 TW007988"],"award-info":[{"award-number":["R01 AI0684316","R24 TW007988"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["NIH K24 AI087399","3D43TW000007\u201322S1"],"award-info":[{"award-number":["NIH K24 AI087399","3D43TW000007\u201322S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1K01AI098527"],"award-info":[{"award-number":["1K01AI098527"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007813","name":"UW | Center for AIDS Research, University of Washington","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100007813","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["TMI-138658"],"award-info":[{"award-number":["TMI-138658"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007436","name":"Familjen Erling-Perssons Stiftelse","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1074\/mcp.ra118.000757","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T23:55:10Z","timestamp":1543622110000},"page":"461-476","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0056-1313","authenticated-orcid":false,"given":"Anna","family":"M\u00e5nberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-7284","authenticated-orcid":false,"given":"Frideborg","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrika","family":"Qundos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon L.","family":"Guthrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzie","family":"Birse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"No\u00ebl-Romas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Lindskog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Bosire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Kiarie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carey","family":"Farquhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam D.","family":"Burgener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4657-8532","authenticated-orcid":false,"given":"Peter","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-7664","authenticated-orcid":false,"given":"Kristina","family":"Broliden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.RA118.000757_bib1","unstructured":"UNAIDS. (2017) Global AIDS Update 2017. Geneva, Switzerland."},{"key":"10.1074\/mcp.RA118.000757_bib2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/QAD.0b013e3282f56b64","article-title":"HIV-neutralizing immunoglobulin A and HIV-specific proliferation are independently associated with reduced HIV acquisition in Kenyan sex workers","volume":"22","author":"Hirbod","year":"2008","journal-title":"AIDS"},{"key":"10.1074\/mcp.RA118.000757_bib3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/mi.2009.89","article-title":"HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis","volume":"2","author":"Tudor","year":"2009","journal-title":"Mucosal Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib4","first-page":"1425","article-title":"Evaluation and diagnostic usefulness of domestic and imported enzyme-linked immunosorbent assays for detection of human immunodeficiency virus type 1 antibody in India","volume":"12","author":"Iqbal","year":"2005","journal-title":"Clin. Diagnostic Lab. Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1067\/mob.2002.125280","article-title":"Antimicrobial components of vaginal fluid","volume":"187","author":"Valore","year":"2002","journal-title":"Am. J. Obstetrics Gynecol"},{"key":"10.1074\/mcp.RA118.000757_bib6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/QAD.0b013e328321809c","article-title":"Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition","volume":"23","author":"Levinson","year":"2009","journal-title":"AIDS"},{"key":"10.1074\/mcp.RA118.000757_bib7","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1097\/QAD.0b013e32832ea643","article-title":"Elevated elafin\/trappin-2 in the female genital tract is associated with protection against HIV acquisition","volume":"23","author":"Iqbal","year":"2009","journal-title":"AIDS"},{"key":"10.1074\/mcp.RA118.000757_bib8","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1021\/pr200596r","article-title":"Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers","volume":"10","author":"Burgener","year":"2011","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA118.000757_bib9","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1021\/pr800406r","article-title":"Identification of differentially expressed proteins in the cervical mucosa of HIV-1-resistant sex workers","volume":"7","author":"Burgener","year":"2008","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA118.000757_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.virol.2014.04.015","article-title":"Increased Serpin A5 levels in the cervicovaginal fluid of HIV-1 exposed seronegatives suggest that a subtle balance between serine proteases and their inhibitors may determine susceptibility to HIV-1 infection","volume":"458\u2013459","author":"Van Raemdonck","year":"2014","journal-title":"Virology"},{"key":"10.1074\/mcp.RA118.000757_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/mi.2012.7","article-title":"A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers","volume":"5","author":"Lajoie","year":"2012","journal-title":"Mucosal Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib12","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/mi.2015.51","article-title":"Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells","volume":"9","author":"Arnold","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib13","doi-asserted-by":"crossref","first-page":"8793","DOI":"10.1128\/JVI.00756-15","article-title":"Molecular signatures of immune activation and epithelial barrier remodeling are enhanced during the luteal phase of the menstrual cycle: implications for HIV susceptibility","volume":"89","author":"Birse","year":"2015","journal-title":"J. Virology"},{"key":"10.1074\/mcp.RA118.000757_bib14","first-page":"590","article-title":"Genital Injury Signatures and Microbiome Alterations Associated With Depot Medroxyprogesterone Acetate Usage and Intravaginal Drying Practices","volume":"215","author":"Birse","year":"2017","journal-title":"J. Infectious Dis"},{"key":"10.1074\/mcp.RA118.000757_bib15","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/mi.2015.86","article-title":"Cervicovaginal microbiome dysbiosis is associated with proteome changes related to alterations of the cervicovaginal mucosal barrier","volume":"9","author":"Borgdorff","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib16","doi-asserted-by":"crossref","first-page":"e1005889","DOI":"10.1371\/journal.ppat.1005889","article-title":"Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract","volume":"12","author":"Zevin","year":"2016","journal-title":"PLoS Pathogens"},{"key":"10.1074\/mcp.RA118.000757_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/sextrans-2011-050114","article-title":"Distinct HIV discordancy patterns by epidemic size in stable sexual partnerships in sub-Saharan Africa","volume":"88","author":"Chemaitelly","year":"2012","journal-title":"Sexually Transmitted Infections"},{"key":"10.1074\/mcp.RA118.000757_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00002030-198902000-00002","article-title":"T-cell response towards HIV in infected individuals with and without zidovudine therapy, and in HIV-exposed sexual partners","volume":"3","author":"Ranki","year":"1989","journal-title":"AIDS"},{"key":"10.1074\/mcp.RA118.000757_bib19","doi-asserted-by":"crossref","first-page":"982","DOI":"10.4049\/jimmunol.1000221","article-title":"Low-level exposure to HIV induces virus-specific T cell responses and immune activation in exposed HIV-seronegative individuals","volume":"185","author":"Restrepo","year":"2010","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib20","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1097\/QAD.0b013e328359b99b","article-title":"Cervicovaginal HIV-1-neutralizing immunoglobulin A detected among HIV-1-exposed seronegative female partners in HIV-1-discordant couples","volume":"26","author":"Choi","year":"2012","journal-title":"AIDS"},{"key":"10.1074\/mcp.RA118.000757_bib21","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1128\/CVI.00179-12","article-title":"HIV-1-specific enzyme-linked immunosorbent spot assay responses in HIV-1-exposed uninfected partners in discordant relationships compared to those in low-risk controls","volume":"19","author":"Guthrie","year":"2012","journal-title":"Clin. Vaccine Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib22","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/infdis\/jiu621","article-title":"Plasma cytokine levels and risk of HIV type 1 (HIV-1) transmission and acquisition: a nested case-control study among HIV-1-serodiscordant couples","volume":"211","author":"Kahle","year":"2015","journal-title":"J. Infectious Dis"},{"key":"10.1074\/mcp.RA118.000757_bib23","first-page":"13883","article-title":"Increased frequency of circulating Tc22\/Th22 cells and polyfunctional CD38(-) T cells in HIV-exposed uninfected subjects","volume":"5","author":"Oliveira","year":"2015","journal-title":"Sci. Reports"},{"key":"10.1074\/mcp.RA118.000757_bib24","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(08)70254-8","article-title":"Vaginal microbicides and the prevention of HIV transmission","volume":"8","author":"Cutler","year":"2008","journal-title":"Lancet Infectious Dis"},{"key":"10.1074\/mcp.RA118.000757_bib25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cyto.2011.03.016","article-title":"Baseline variation and associations between subject characteristics and five cytokine biomarkers of vaginal safety among healthy non-pregnant women in microbicide trials","volume":"55","author":"Fichorova","year":"2011","journal-title":"Cytokine"},{"key":"10.1074\/mcp.RA118.000757_bib26","doi-asserted-by":"crossref","first-page":"e0143109","DOI":"10.1371\/journal.pone.0143109","article-title":"Immune Activation in the Female Genital Tract: Expression Profiles of Soluble Proteins in Women at High Risk for HIV Infection","volume":"11","author":"Francis","year":"2016","journal-title":"PloS One"},{"key":"10.1074\/mcp.RA118.000757_bib27","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/pmic.201200580","article-title":"Antibody-based profiling of cerebrospinal fluid within multiple sclerosis","volume":"13","author":"Haggmark","year":"2013","journal-title":"Proteomics"},{"key":"10.1074\/mcp.RA118.000757_bib28","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1021\/pr700890b","article-title":"Antibody suspension bead arrays within serum proteomics","volume":"7","author":"Schwenk","year":"2008","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA118.000757_bib29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0010-7824(99)00013-X","article-title":"Prostate-specific antigen in vaginal fluid as a biologic marker of condom failure","volume":"59","author":"Macaluso","year":"1999","journal-title":"Contraception"},{"key":"10.1074\/mcp.RA118.000757_bib30","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1128\/JVI.03347-12","article-title":"A systems biology examination of the human female genital tract shows compartmentalization of immune factor expression","volume":"87","author":"Burgener","year":"2013","journal-title":"J. Virol"},{"key":"10.1074\/mcp.RA118.000757_bib31","first-page":"e3620","article-title":"Production of tissue microarrays, immunohistochemistry staining and digitalization within the human protein atlas","volume":"63","author":"Kampf","year":"2012","journal-title":"J. Vis. Exp"},{"key":"10.1074\/mcp.RA118.000757_bib32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","article-title":"R: a language for data analysis and graphics","volume":"5","author":"Ihaka","year":"1996","journal-title":"J. Computational Graphical Statistics"},{"key":"10.1074\/mcp.RA118.000757_bib33","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1021\/acs.jproteome.5b01131","article-title":"Multidimensional normalization to minimize plate effects of suspension bead array data","volume":"15","author":"Hong","year":"2016","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA118.000757_bib34","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Roy. Statistical Soc"},{"key":"10.1074\/mcp.RA118.000757_bib35","first-page":"1","article-title":"Fitting Linear Mixed-Effects Models Using lme4","volume":"67","author":"Douglas","year":"2015","journal-title":"J. Statistical Software"},{"key":"10.1074\/mcp.RA118.000757_bib36","unstructured":"National Institute of Environmental Health Sciences. Principal Variance Component Analysis. https:\/\/www.niehs.nih.gov\/research\/resources\/software\/biostatistics\/pvca\/ Accessed April 10, 2017."},{"key":"10.1074\/mcp.RA118.000757_bib37","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"Nesvizhskii","year":"2003","journal-title":"Anal. Chem"},{"key":"10.1074\/mcp.RA118.000757_bib38","unstructured":"How does normalisation work in Progenesis QI for proteomics?, http:\/\/www.nonlinear.com\/progenesis\/qi-for-proteomics\/v3.0\/faq\/how-normalisation-works.aspx Accessed February 2018."},{"key":"10.1074\/mcp.RA118.000757_bib39","unstructured":"Human Protein Atlas. TTR. https:\/\/www.proteinatlas.org\/ENSG00000118271-TTR\/antibody Accessed March 10, 2018."},{"key":"10.1074\/mcp.RA118.000757_bib40","unstructured":"Human Protein Atlas. SPRR3. https:\/\/www.proteinatlas.org\/ENSG00000163209-SPRR3\/antibody Accessed March 10, 2018."},{"key":"10.1074\/mcp.RA118.000757_bib41","unstructured":"Human Protein Atlas. KLK10. https:\/\/www.proteinatlas.org\/ENSG00000129451-KLK10\/tissue Accessed March 10, 2018."},{"key":"10.1074\/mcp.RA118.000757_bib42","unstructured":"Human Protein Atlas. CAPG. https:\/\/www.proteinatlas.org\/ENSG00000042493-CAPG\/antibody Accessed March 10, 2018."},{"key":"10.1074\/mcp.RA118.000757_bib43","unstructured":"Human Protein Atlas. PI3. https:\/\/www.proteinatlas.org\/ENSG00000124102-PI3\/antibody Accessed March 10, 2018."},{"key":"10.1074\/mcp.RA118.000757_bib44","unstructured":"Human Protein Atlas. PI3. https:\/\/www.proteinatlas.org\/ENSG00000124102-PI3\/antibody Accessed March 10, 2018"},{"key":"10.1074\/mcp.RA118.000757_bib45","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1126\/science.aai9383","article-title":"Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women","volume":"356","author":"Klatt","year":"2017","journal-title":"Science"},{"key":"10.1074\/mcp.RA118.000757_bib46","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nm.4506","article-title":"Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women","volume":"24","author":"McKinnon","year":"2018","journal-title":"Nat. Med"},{"key":"10.1074\/mcp.RA118.000757_bib47","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng1493","article-title":"Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity","volume":"37","author":"Descargues","year":"2005","journal-title":"Nat. Genetics"},{"key":"10.1074\/mcp.RA118.000757_bib48","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1515\/BC.2008.171","article-title":"Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense","volume":"389","author":"Shaw","year":"2008","journal-title":"Biol. Chem"},{"key":"10.1074\/mcp.RA118.000757_bib49","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1515\/BC.2008.069","article-title":"A potential role for tissue kallikrein-related peptidases in human cervico-vaginal physiology","volume":"389","author":"Shaw","year":"2008","journal-title":"Biol. Chem"},{"key":"10.1074\/mcp.RA118.000757_bib50","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/jid.2011.90","article-title":"Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema","volume":"131","author":"Marenholz","year":"2011","journal-title":"J. Investigative Dermatol"},{"key":"10.1074\/mcp.RA118.000757_bib51","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/jmv.20011","article-title":"Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3","volume":"72","author":"Lehr","year":"2004","journal-title":"J. Med. Virol"},{"key":"10.1074\/mcp.RA118.000757_bib52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/0004563215617212","article-title":"Evaluation of menstrual cycle-related changes in 85 clinical laboratory analytes","volume":"53","author":"Masuda","year":"2016","journal-title":"Ann. Clin. Biochem"},{"key":"10.1074\/mcp.RA118.000757_bib53","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/jcbfm.2014.54","article-title":"Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction","volume":"34","author":"Woollard","year":"2014","journal-title":"J. Cerebral Blood Flow Metabolism"},{"key":"10.1074\/mcp.RA118.000757_bib54","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI118926","article-title":"Constitutive and inducible expression of SKALP\/elafin provides anti-elastase defense in human epithelia","volume":"98","author":"Pfundt","year":"1996","journal-title":"J. Clin. Investigation"},{"key":"10.1074\/mcp.RA118.000757_bib55","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2567.2009.03165.x","article-title":"Trappin-2\/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tract","volume":"129","author":"Ghosh","year":"2010","journal-title":"Immunology"},{"key":"10.1074\/mcp.RA118.000757_bib56","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1128\/JVI.06561-11","article-title":"Anti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cells","volume":"86","author":"Drannik","year":"2012","journal-title":"J. Virol"},{"key":"10.1074\/mcp.RA118.000757_bib57","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1600-0897.2010.00949.x","article-title":"New approaches to making the microenvironment of the female reproductive tract hostile to HIV","volume":"65","author":"Fahey","year":"2011","journal-title":"Am. J. Reproductive Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib58","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/cid\/civ298","article-title":"Genital inflammation and the risk of HIV acquisition in women","volume":"61","author":"Masson","year":"2015","journal-title":"Clinical Infectious Dis"},{"key":"10.1074\/mcp.RA118.000757_bib59","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1586\/erm.10.110","article-title":"Systematic antibody and antigen-based proteomic profiling with microarrays","volume":"11","author":"Ayoglu","year":"2011","journal-title":"Expert Rev. Mol. Diagnostics"},{"key":"10.1074\/mcp.RA118.000757_bib60","doi-asserted-by":"crossref","first-page":"e0150672","DOI":"10.1371\/journal.pone.0150672","article-title":"Analysis of the cerebrospinal fluid proteome in Alzheimer's disease","volume":"11","author":"Khoonsari","year":"2016","journal-title":"PloS One"},{"key":"10.1074\/mcp.RA118.000757_bib61","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/biot.201300341","article-title":"Antibody performance in western blot applications is context-dependent","volume":"9","author":"Algenas","year":"2014","journal-title":"Biotechnol. J"},{"key":"10.1074\/mcp.RA118.000757_bib62","doi-asserted-by":"crossref","first-page":"e1006402","DOI":"10.1371\/journal.ppat.1006402","article-title":"Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants","volume":"13","author":"Introini","year":"2017","journal-title":"PLoS Pathogens"},{"key":"10.1074\/mcp.RA118.000757_bib63","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.4049\/jimmunol.1102736","article-title":"Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus","volume":"188","author":"Sharkey","year":"2012","journal-title":"J. Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib64","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2016.12.013","article-title":"Lactobacillus-deficient cervicovaginal bacterial communities are associated with increased HIV acquisition in young South African women","volume":"46","author":"Gosmann","year":"2017","journal-title":"Immunity"},{"key":"10.1074\/mcp.RA118.000757_bib65","doi-asserted-by":"crossref","first-page":"e12863","DOI":"10.1111\/aji.12863","article-title":"The vaginal microbiome amplifies sex hormone-associated cyclic changes in cervicovaginal inflammation and epithelial barrier disruption","volume":"80","author":"Bradley","year":"2018","journal-title":"Am. J. Reproductive Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib66","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/sextrans-2014-051601","article-title":"Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study","volume":"90","author":"Masson","year":"2014","journal-title":"Sexually Transmitted Infections"},{"key":"10.1074\/mcp.RA118.000757_bib67","doi-asserted-by":"crossref","first-page":"e8276","DOI":"10.1371\/journal.pone.0008276","article-title":"Sexually transmitted infections among HIV-1-discordant couples","volume":"4","author":"Guthrie","year":"2009","journal-title":"PloS one"},{"key":"10.1074\/mcp.RA118.000757_bib68","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/aji.12269","article-title":"Hormone regulation of the mucosal environment in the reproductive tract and the prevention of HIV infection","volume":"71","author":"Wira","year":"2014","journal-title":"Am. J. Reproductive Immunol"},{"key":"10.1074\/mcp.RA118.000757_bib69","doi-asserted-by":"crossref","first-page":"S351","DOI":"10.1086\/655964","article-title":"Innate molecular and anatomic mucosal barriers against HIV infection in the genital tract of HIV-exposed seronegative individuals","volume":"202","author":"Broliden","year":"2010","journal-title":"J. Infectious Dis"},{"key":"10.1074\/mcp.RA118.000757_bib70","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizcaino","year":"2016","journal-title":"Nucleic Acids Res"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153594762031851X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153594762031851X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.RA118.000757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:32:16Z","timestamp":1761525136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153594762031851X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S153594762031851X"],"URL":"https:\/\/doi.org\/10.1074\/mcp.ra118.000757","relation":{},"ISSN":["1535-9476"],"issn-type":[{"type":"print","value":"1535-9476"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.RA118.000757","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 M\u00e5nberg et al.","name":"copyright","label":"Copyright"}]}}